ASMS 2026: Photochemical Tissue Processing for MALDI Lipid Imaging

Kermit K. Murray and Kadeem O. Hayes Abstract A photochemical tissue region modification system for the MALDI imaging workflow. Introduction The standard MALDI imaging workflow comprises tissue sectioning, washing, and matrix application by spray or sublimation prior to analysis. We are developing a new instrument for tissue photochemical processing that produces biomarker compounds to facilitate …

ASMS 2024: Deep Ultraviolet and Infrared Laser Ablation of Carbonic Anhydrase II

Deep Ultraviolet and Infrared Laser Ablation of Carbonic Anhydrase II Neda Feizi1; Kadeem O Hayes2; Blessing Chisom Egbejiogu2; Kelcey B. Hines2; Kermit K. Murray2; Touradj Solouki11Baylor University, Waco, TX; 2Louisiana State University, Baton Rouge, LA IntroductionIntegrating ion mobility-mass spectrometry (IM-MS) with laser ablation (LA) holds great appeal for acquiring spatially resolved details on protein conformations. …

ASMS 2023: Are Native Conformations of Proteins Preserved Throughout Laser Ablation?

MP252 AuthorsNeda Feizi Gilandeh1; Blessing Chisom Egbejiogu2; Kyle L. Wilhelm1; Kermit K. Murray2; Touradj Solouki1 Institutes1Baylor University, Waco, TX; 2Louisiana State University, Baton Rouge, LA IntroductionNative electrospray ionization mass spectrometry (n-ESI/MS) combined with ion mobility spectrometry (IMS) provides an opportunity to study indigenous forms of proteins in biological samples. Recently, we reported on combining n-ESI/MS …