/r/genomics/

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  • RNA-seq normalisation for time-dependent data
    by /u/Embarrassed-Dog8452
    submitted by /u/Embarrassed-Dog8452 [link] [comments]
  • U.S. Fertility Doctors Report Low Approval of Polygenic Embryo Screening and High Concern Over Accuracy, Ethics, and Eugenics
    by /u/mindfulywandering
    submitted by /u/mindfulywandering [link] [comments]
  • Is it normal to have this much anxiety and panic in the morning 10 mg five weeks? I can’t function. In the morning.
    by /u/Dense_Assist8382
    submitted by /u/Dense_Assist8382 [link] [comments]
  • The world’s fastest, most feature-complete LOWESS algorithm for Python
    by /u/amir_valizadeh
    submitted by /u/amir_valizadeh [link] [comments]
  • Phd in Multiomics (Need Guidance with resources)
    by /u/Mindless_Farm3706
    submitted by /u/Mindless_Farm3706 [link] [comments]
  • Best practice for evidence summarization for gene panels in a disease context?
    by /u/Klutzy-Aardvark4361
    I’m working on a repeatable way to go from “gene list + disease context” → a citation-backed evidence summary (pathways, PPIs, disease associations, druggability). I’m trying to avoid a purely manual process. What’s the most reliable workflow you’ve seen (or use yourself)? Preferred databases/sources What you treat as high-confidence evidence vs “hypothesis” Any standard output format you like (Markdown, JSON, report, etc.) I’m especially interested in how you keep this reproducible when rerunning panels later. submitted by /u/Klutzy-Aardvark4361 [link] [comments]
  • Kivvi
    by /u/GenomeJuggler
    submitted by /u/GenomeJuggler [link] [comments]
  • I got sick of checking 10 different journals every morning, so I built a tool to aggregate them into one clean feed.
    by /u/ozturan
    submitted by /u/ozturan [link] [comments]
  • Blind Analyses
    by /u/antiugly297
    Hi all, I am beginning to work on developing polygenic risk scores from a genome wide association study. I am very interested in controlling for different forms of biases in my analyses and am interested in performing a blind analysis. I will be using PRS-CSx (a Python based command line tool) and Plink. Is anyone aware of software that will copy the files generated by these packages and then generate random numbers while keeping some kind of code book or way to reverse the blinding? If not, is anyone familiar with any other quantitative geneticists implementing this strategy? submitted by […]
  • microRNA analysis in chondrosarcoma
    by /u/vibeisvibing
    I recently performed NGS on 60 paired chondrosarcoma and normal tissue samples. My data is structured as follows: Patient1 (chondrosarcoma), Patient1 (normal), Patient2 (chondrosarcoma), Patient2 (normal), … mir1, expression1, expression2, … Each column represents the expression of microRNAs in a specific patient’s sample (tumor or normal). I have already performed DESeq2 analysis and identified around 50 significantly deregulated microRNAs. I would like guidance on the next steps. I have already planned Cox regression analysis for OS (overall survival) and RFS (recurrence-free survival). Are there additional statistical tests I should consider? What other analyses can help narrow down potential biomarker candidates? […]
  • SLC46A1 folate experts?
    by /u/Regular_Tailor
    Hi y'all, Is anyone a researcher looking at this gene? SLC46A1 I have a bunch of the uncommon variants in this gene and some issues with systemic folate uptake, but I haven't found any reduction of function studies. submitted by /u/Regular_Tailor [link] [comments]
  • Correlational relationship between microRNA and Gene targets
    by /u/TimeIsATrick
    submitted by /u/TimeIsATrick [link] [comments]

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