- by /u/tinymagiciannThere is a lot more information encoded in DNA than proteins. And we have a lot more DNA sequencing data. So if protein models like alphafold can be really useful, DNA models can be even more useful There are four applications I’m excited about: State-specific promoters (CAR-T, AAV gene therapy, and ddRNAi drugs) Discover new disease-causing targets through in silico mutagenesis Resolving variants of unknown significance Biosecurity More of my thoughts can be found here https://www.aditharun.com/p/dna-foundation-models submitted by /u/tinymagiciann [link] [comments]
- by /u/floxikWas thinking of Nebula Genomics but looks like it's now DNA Complete and some people aren't getting results back for months. Other options I found are sequencing.com which seems to be popular, and a newer one Nucleus Genomics. I could also go straight to the labs via Illumina, GeneDX, Vertias, Dante Labs. Which one did you do and how happy were you with your results? submitted by /u/floxik [link] [comments]
- by /u/I_MATCH_ORBSsubmitted by /u/I_MATCH_ORBS [link] [comments]
- by /u/shouldBeDoingNotThisJust over a month ago I created a weekly Bioinformatics/Genomics blog called Byte-Sized Omics after getting lots of interest on the r/bioinformatics subreddit. Some of the things I plan on writing about are guides and tutorials for common workflow, lessons learned from previous projects, showcase new tools and methods, and possibly some commentary on career development. The goal is to make this blog approachable for early-career bioinformaticians, students, and wet-lab scientists who are trying to get more comfortable with the computational side of things, while still being valuable for those with more experience. I just posted a tutorial on running […]
- by /u/RunSerious5843So, I saw an ad or something some time ago advertising genome sequencing. I can’t fin it now or remember the name, but it caught my interest. For my entire life, doctors (including geneticists) have just thrown their hands up and said they don’t know exactly what disability I have. I got fed up withit and stopped going to specialists just to have them look at me the same way my general doctor does and say “You’re doing good. Nothing new to report. Have a nice day.” So I thought if this genome sequencing thing where you can get all […]
- by /u/dacherrrsubmitted by /u/dacherrr [link] [comments]
- by /u/Medium-Turnip9874hi friends, title pretty much says it, but for my phd program we have to take a class making sure we are all at the same general level for kind of fundamental molecular biology stuff, and my background is a lot more molecular genetics than genomics so i'm looking for a textbook rec just for me to do some background reading for my own brain. with some of the statistics side of things if possible, would appreciate if anyone here has a favorite they'd be willing to share the title of… thank you and be well:) submitted by /u/Medium-Turnip9874 [link] […]
- by /u/CollembolansHas anyone used them before???? Might use them for a study. submitted by /u/Collembolans [link] [comments]
- by /u/umd-sciencesubmitted by /u/umd-science [link] [comments]
- by /u/three_martini_lunchHi all I am taking over the sub as moderator. I am cleaning up stock pumping, spam and other low quality or questionable content. Please note the new rules aimed at high quality content related to the scientific discipline of genomics. Please flag posts that do not follow the rules. I am open to additional rules or clarification of the the rules. submitted by /u/three_martini_lunch [link] [comments]
- by /u/Holodoxasubmitted by /u/Holodoxa [link] [comments]
- by /u/Outrageous_Owl_6161What it does: Measures absorbance at 260 nm to estimate nucleic acid concentration. Gives purity ratios (260/280, 260/230) to flag contamination. Key purity ratios: 260/280: ~1.8 = Pure DNA ~2.0 = Pure RNA Lower → protein/phenol contamination likely 260/230: 2.0–2.2 = Clean Lower → carryover of salts, guanidine, phenol, carbohydrates, etc. Why ratios matter: A “high” concentration reading doesn’t mean your sample is clean. Contaminants can inflate or distort readings — bad for downstream PCR, library prep, or sequencing. Limitations: Reads all molecules absorbing at 260 nm (including contaminants), so it’s only an approximation. Doesn’t distinguish between DNA, RNA, or […]
Mass spectrometry websites, social media, journal feeds, and other links and items of interest to the mass spectrometry community.
