- by /u/PFAS123Hello guys, If you are in California (San Diego, Orange County or SF Bay Area) and looking for someone’s help to explore mass specs, set up a lab or want to troubleshoot the mass spec problem, please reach out to me and my team. I provide high level consulting work and also solutions to your need in the fraction of the price that you pay from Big Dawgs. From small molecules to Biopharma to Proteins, I have more than 8+ years of experience and my team members have experience more than 30+ years in mass spec. If there is a […]
- by /u/formanzHi everyone, we would like to buy some standards of synthetic cannabinoids and NSOs, but Cayman is quite expensive for us (at least for now). Do anyone have experience with LGC Chemicals distributor and brands like TRC or LoGiCal (sold by LGC)? Any comments will be appreciated, thank you! Have a nice day! submitted by /u/formanz [link] [comments]
- by /u/Heiduk00submitted by /u/Heiduk00 [link] [comments]
- by /u/ForwardDaikon6761Hi, I have a question about the stability of ascorbic acid in a 0.1% H3PO4 solution. The solution has a concentration of 0.02 mg/mL. Over the course of a few hours, the ascorbate peak drops (RSD% = 3%). If I add an EDTA-Fe complex to the standard solution, the degradation stops or at least decreases dramatically. However, I'm not clear on the mechanism. Could someone explain it to me? submitted by /u/ForwardDaikon6761 [link] [comments]
- by /u/CommunityFrostyHey everyone — looking for some advice on a column fouling issue. I’m running an RP-HPLC assay on an Ascentis Express C18 (15 cm Ă— 4.6 mm) for an API (MK-8507) that’s spray-dried in HPMCAS. Mobile phase is 0.1% orthophosphoric acid (A) and ACN (B) with a ~29 min gradient. I keep getting a persistent interference peak right at ~13 min — basically co-eluting with my API. Full spectra matches closely, and the peak sticks around no matter what I do. I’ve already tried flushing the column (forward flow) with: – ACN – IPA – Acetone None of that removed […]
- by /u/peniabipoleI want to calculate HPLC column efficiency and resolution based on the our lab experimental results, but I’m not sure which data I should use. We have 5 different standards and 1 sample, and for each standard there are 3 measurements. For example, if I choose the 1st standard (the lowest concentration), should I use the average of the 3 measurements or ? Also, which standard should I use for best? submitted by /u/peniabipole [link] [comments]
- by /u/Apacukafundaluka12Hi everyone, I’m currently experimenting with deep eutectic solvents (DES), mainly acid-based systems where one of the components is an organic acid. So far, I haven’t had much success..in most cases, simple solvents like methanol or ethanol seem to outperform my DES mixtures in terms of extraction efficiency. I’ve been working primarily with wood samples, but I’m considering switching to other plant matrices to see if the results improve. Does anyone here have experience with DES in similar applications? I’d really appreciate hearing about your insights, tips, or even negative results. anything that could help me better understand what I […]
- by /u/ForwardDaikon6761Hi, is it possible to invert the input frit of an HPLC column with the output frit? submitted by /u/ForwardDaikon6761 [link] [comments]
- by /u/ForwardDaikon6761submitted by /u/ForwardDaikon6761 [link] [comments]
- by /u/TheProudCanadianI have been pitching an investment in a hi-res LCMS for my facility for the past few months. Agilents 6545XT is a frontrunner for our intended applications, but we're also considering the Revident as a more future-proofed option. I am aware there has been no official announcement of a successor to the XT, but what does the community here think about how many years are left before this happens? Edit: should mention we're looking at H1 2027 purchase so whatever lifetime the XT has today, subtract 1 year from that. submitted by /u/TheProudCanadian [link] [comments]
- by /u/alchemicdpaksubmitted by /u/alchemicdpak [link] [comments]
- by /u/Training-Resist-2745submitted by /u/Training-Resist-2745 [link] [comments]
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