LSU – Page 6 – Murray Mass Spectrometry Group

Murray Mass Spectrometry Group

Research group of Kermit Murray at Louisiana State University where we use lasers for sampling and imaging and study the chemistry and physics of laser ablation.

Development of an efficient on-chip digestion system for protein analysis using MALDI-TOF MS

Microfluidics with MALDI analysis for proteomics

J. Lee, S.A. Soper, K.K. Murray, “Microfluidics with MALDI analysis for proteomics–a review,” Anal. Chim. Acta. 649 (2009) 180–190. doi:10.1016/j.aca.2009.07.037. Abstract Various microfluidic devices have been developed for proteomic analyses and many of these have been designed specifically for mass spectrometry detection. In this review, we present an overview of chip fabrication, microfluidic components, and …

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Matrix-assisted laser desorption/ionization with untreated silicon targets

SEM images of MALDI sample spots on a silicon target (detail)

Microfluidic chips for mass spectrometry-based proteomics

UV laser irradiation of IR laser generated particles ablated from nitrobenzyl alcohol

Infrared laser wavelength dependence of particles ablated from glycerol

Surface plot of fluence dependence of particle concentration for ablation of glycerol

Intact and Top-Down Characterization of Biomolecules and Direct Analysis Using Infrared Matrix-Assisted Laser Desorption Electrospray Ionization Coupled to FT-ICR Mass Spectrometry

Matrix-assisted laser desorption ionization of infrared laser ablated particles

IR and UV MALDI-2 laser and mass spectrometer schematic

Direct coupling of polymer-based microchip electrophoresis to online MALDI-MS using a rotating ball inlet

A mixed liquid matrix for infrared matrix-assisted laser desorption/ionization of oligonucleotides