- by /u/smeaa1I have a Xevo QTOF controlled by Lenovo P520 workstation with W2265 CPU, Quadro P1000 GPU and 64Gb RAM. I use it mostly for mapping peptides around 10k Da. The processing time is pretty slow when reprocessing 12-24 hours worth of data. I am wondering if anyone has experience using the GPU-enabled processing features In W_C/UNIFI. Is a RTX 5090 going to bring significant improvement in processing speed over CPU peak processing? submitted by /u/smeaa1 [link] [comments]
- by /u/Wide_Locksmith_6405Hellooo. I am using Compass DataAnalysis (Brucker) and I am struggling to vizualise my mass spectrum IN THE mass spectrum Window… I can have it in " Spectrum view" BUT i want to have in the Mass spectrum Window to be able to use the SmartFormula option. Please find my screen here. Thank you so much for your help https://preview.redd.it/uf8ifp7rm68g1.png?width=1916&format=png&auto=webp&s=bc5fb945b6141129d222fa08732c2406c3e9d14d submitted by /u/Wide_Locksmith_6405 [link] [comments]
- by /u/Getzu82Hey everyone. I'm getting ready to post a job listing for an environmental lab GC-MS position. We are a small city lab and normally we rely on word of mouth to get the news out. Our job listings aren't usually posted outside of the cities website. I got the okay recently to look for other places to advertise our opening. So where are people looking for job listings? I wanna make sure as many people see it as possible when it's live. So far I have indeed and LinkedIn but I can't think of anything else. For reference last job […]
- by /u/JonnybarbsI have a peptide testing company but have too much demand, to develop methods or run tests for at the moment. I’ve been approached by vendors who want over 35 mass + purity tests monthly. Typically my clientele wants a mix of purity, weight or endotoxin presence. I am fully aware that mass spectrometery is not relevant for all of above listed tests but the hope is that similar equipment might be available or potentially purchased. If anyone is interested in earning some extra money, feel free to leave me a direct message. submitted by /u/Jonnybarbs [link] [comments]
- by /u/PlasticFern971I am a PhD student working on a literature review dealing with use non-targeted analysis (NTA) with a certain sample type. A significant portion of this lit review is working with meta analysis. All of the studies working with LC- methods (orbitrap and Qtof) annotate around 50-100 compounds with NTA. One study annotated over 500 compounds, and reported a lot of specific stereoisomers in their findings. Their workflow is very similar to other studies and did not give me reason to believe that they would identify so many more compounds (they also reported ~30x more features in their chromatogram than […]
- by /u/Tight_Isopod6969Hi all, I have modest experience in MS, but it was usually preparing samples, basic maintenance, and running established protocols. I'm now working on method development and I have zero support. I can easily come up with a protocol to detect a range of species, but single drops off very rapidly once I get under 1ug/mL. I'm currently working on a protocol for detecting of statins in biological fluids. I'm first trying to see how low I can go just running diluted statin compounds and metabolites (mainly the acid formed by hydrolysis of the lactone). I'm seeing the same thing, […]
- by /u/MobilePhase1987Hello I was running some Pesticide samples and I use to get these nice beautiful peaks in Xcalibur which I could then run a library search for compound identification. However now all my peaks are no longer integrated and when I select each individual peak, it's only showing 1 ion. I'm pretty sure something is wrong in the settings because all my old chromatograms look the same as the "After" picture. Please help. submitted by /u/MobilePhase1987 [link] [comments]
- by /u/No-Expression4750We are observing retention time shifts (> 0.5 mins, runtime: 28 mins) from our samples over time, across different runs. We reran the calibration curves after cleaning the column and source. Fresh mobile phases were used, and a new guard column was installed. No leaks were observed. The broader TIC We then inspected the data in MassHunter Qualitative Analysis and identified differences in the TCC1 plot (attached). The green traces correspond to samples with the expected retention times, whereas the blue traces do not. My questions are: 1. Could these differences be directly related to the observed retention time shifts? […]
- by /u/Ok-Comfortable-9831I have a Sciex 3200 MD. When Microsoft stopped supporting Windows 10, we needed to look into what Sciex software would be compatible with Windows 11. Sciex now has a new software called Sciex OS that is compatible with windows 11. The problem is that my mass spec is not compatible with Sciex OS. Sciex suggests purchasing a "new" mass spec, which is no little decision to make. Does anyone know a work-around for this issue, maybe a 3rd party software that can function like analyst? submitted by /u/Ok-Comfortable-9831 [link] [comments]
- by /u/grimsby91Hi, I work with a lot of ecotoxicologists who are evaluating effects of a chemical in fish and invertebrates usually administering the dose in water and sometimes food. As a mass spectrometrist, I validate the dose by measurement and also bioaccumulation/pharmacokinetics. I would like to also look for transformation products. Is there some free software that predicts metabolic pathways so I could build a suspect screening library? submitted by /u/grimsby91 [link] [comments]
- by /u/UnfairSource2003How do you select the noise region (Start Time / End Time) for S/N calculation in TargetLynx? Do you usually place the noise window before the peak, after the peak, or elsewhere, and when the values are set to 0 how does the software automatically choose the noise region? submitted by /u/UnfairSource2003 [link] [comments]
- by /u/MassSpecMenderMight look like an old man, but don't be fooled, still as great machine in 2025. submitted by /u/MassSpecMender [link] [comments]
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