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Interaction and biological pathway analysis of proteomic products in patients with premature coronary artery disease
November 5, 2025 by Liting Cai, Chunfang Shan, Yufei Chen, Guoling Wang, Binbin Fang, Hongli Wang, Qian Zhao, Junyi Luo, Dilare Adi, Xiaomei Li, Yining Yang and Fen Liu
Premature coronary artery disease (PCAD) is characterized by early onset, rapid progression, and poor prognosis, which seriously affects patients’ health and quality of life. In this study, we analyzed the pro…
Dimethyl fumarate alleviates inflammation during high altitude hypoxia induced acute lung injury by upregulating Nrf2/SLC7A11 pathway in ferroptosis
November 3, 2025 by Chi Wang, Haoran Guo, Liye Wang, Qi Wang, Ting Liu, Jie Huang, Yujie Wei and Chengbin Wang
This study aims to investigate the impact of high altitude (HA) hypoxia on ferroptosis in lung tissue and the evaluate the preventative effect of Dimethyl fumarate (DMF) on lung inflammation.
Comprehensive proteome profiling of cytochrome P450 isoforms in cancer models
October 31, 2025 by Sadr ul Shaheed, Ahood A. Al-Eidan, Klaus Pors, Laurence Patterson and Chris W. Sutton
Cytochrome P450 (CYP450) enzymes are essential for drug metabolism, xenobiotic detoxification, and procarcinogen activation, playing a pivotal role in both normal physiology and cancer biology. Their expressio…
Identification of adrenocorticotropic hormone–specific therapeutic biomarkers in infantile epileptic spasm syndrome using data-independent acquisition mass spectrometry
October 21, 2025 by Dongfang Zou, Haohua Huang, Zhiqiang Luo, Dezhi Cao, Yan Hu, Xia Zhao, Li Chen, Xufeng Luo and Jianxiang Liao
Infantile epileptic spasm syndrome (IESS) presents significant therapeutic challenges, with the molecular mechanisms underlying variable responses to adrenocorticotropic hormone (ACTH) remaining poorly underst…
Novel proteomic characterization of multiple myeloma bone marrow interstitial fluid links prognosis to coagulation pathways
October 21, 2025 by Sam Cutler, Amy M. Trottier, Robert Liwski, Jason Quinn, Daniel Gaston, Randy Veinotte, Jackie St. Pierre, Darrell White, Nicholas Forward, Alfredo De La Torre and Manal Elnenaei
Multiple myeloma (MM), the second most prevalent hematological malignancy, carries high morbidity with variability in clinical progression among patients. This necessitates accurate risk stratification for eff…

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