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Integrating multimodal data to predict the progression of hormone-sensitive prostate cancer
May 29, 2025 by Xiangfu Lu, Chenxi Pan, Luhan Yao, Jiayu Wan, Xiaolong Xu, Wei Wang, Xiangying Wang, Xiaoyun Liu, Zhonghua Jin, Hongyu Wang, Yi He and Bo Yang
Identifying the population at risk of rapid progression from hormone-sensitive prostate cancer (HSPC) to lethal castration-resistant prostate cancer (CRPC) is a challenge. This work has highlighted important p…
Multi-omics analyses, cell experiments, and network pharmacology tools identified key proteins and candidate drugs for alopecia areata treatment
May 29, 2025 by Lingbo Bi, Jing Wang, Jungang Yang, Zhou Zhuang, Kejun Chen, Zining Xu, Xianbo Zuo, Jingkai Xu, Yujun Sheng and Yong Cui
Alopecia Areata (AA) is an inflammatory non-cicatricial alopecia with a high prevalence. Some patients with AA show an inferior response to treatment. To find key proteins in AA, Genome-wide association study …
From blood drops to biomarkers: a scoping review of microsampling in mass spectrometry-based proteomics
May 18, 2025 by Amanda J. Campbell, Nicolai B. Palstrøm, Lars M. Rasmussen, Jes S. Lindholt and Hans C. Beck
Microsamples are simple blood sampling procedures utilizing small blood draws. Although microsamples are regularly used in some disciplines, proteomic analysis of these samples is an emerging field. Currently,…
Comprehensive analysis of chronic hepatitis B concurrent with non-alcoholic fatty liver disease: a proteomics report based on clinical liver samples
May 13, 2025 by Xin Tong, Yawen Wan, Shengxia Yin, Li Shao, Renling Yao, Xiaoyan Ma, Fajuan Rui, Junping Shi, Chao Wu and Jie Li
In recent years, the prevalence of non-alcoholic fatty liver disease (NAFLD) has risen among patients with chronic hepatitis B (CHB), coinciding with the increasing rates of obesity and metabolic syndrome. Bot…
Multiplex quantification of endocrine proteins in volumetric dried blood spots
May 9, 2025 by William Stauch, Johan Olausson, Annika Bendes, Olof Beck and Jochen M. Schwenk
Circulating proteins are routinely quantified from liquid biopsies to deduce health and disease. Among these are endocrine protein hormones, which regulate human growth, development, metabolism, and reproducti…

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