Clinical Proteomics

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• Associations of plasma protein levels with risk of colorectal cancer: a proteome-wide Mendelian randomization study
  June 4, 2025 by Zhen-Kun Pan, Meng-Hua Wu, Hua Shi, Yong-Jian Ni, Quan-Li Geng and Jin-Sheng Ye
  The treatment of advanced or metastatic colorectal cancer (CRC) poses a global challenge. Mendelian Randomization (MR) has been primarily applied for repurposing licensed drugs and uncovering new therapeutic t…
• Plasma exosome proteomics reveals upregulation of CILP-1 in concave side of paraspinal muscle in adolescent idiopathic scoliosis
  June 3, 2025 by Qi Wang, Chi Wang, Liye Wang, Zhiyun Hao, Ting Liu, Chengbin Wang, Xuesong Zhang and Yan Wang
  There is insufficient attention to the pathogenesis of abnormal radiological changes and molecular mechanism in the paraspinal muscles in AIS patients.
• Integrating multimodal data to predict the progression of hormone-sensitive prostate cancer
  May 29, 2025 by Xiangfu Lu, Chenxi Pan, Luhan Yao, Jiayu Wan, Xiaolong Xu, Wei Wang, Xiangying Wang, Xiaoyun Liu, Zhonghua Jin, Hongyu Wang, Yi He and Bo Yang
  Identifying the population at risk of rapid progression from hormone-sensitive prostate cancer (HSPC) to lethal castration-resistant prostate cancer (CRPC) is a challenge. This work has highlighted important p…
• Multi-omics analyses, cell experiments, and network pharmacology tools identified key proteins and candidate drugs for alopecia areata treatment
  May 29, 2025 by Lingbo Bi, Jing Wang, Jungang Yang, Zhou Zhuang, Kejun Chen, Zining Xu, Xianbo Zuo, Jingkai Xu, Yujun Sheng and Yong Cui
  Alopecia Areata (AA) is an inflammatory non-cicatricial alopecia with a high prevalence. Some patients with AA show an inferior response to treatment. To find key proteins in AA, Genome-wide association study …
• From blood drops to biomarkers: a scoping review of microsampling in mass spectrometry-based proteomics
  May 18, 2025 by Amanda J. Campbell, Nicolai B. Palstrøm, Lars M. Rasmussen, Jes S. Lindholt and Hans C. Beck
  Microsamples are simple blood sampling procedures utilizing small blood draws. Although microsamples are regularly used in some disciplines, proteomic analysis of these samples is an emerging field. Currently,…

• Associations of plasma protein levels with risk of colorectal cancer: a proteome-wide Mendelian randomization study
• Plasma exosome proteomics reveals upregulation of CILP-1 in concave side of paraspinal muscle in adolescent idiopathic scoliosis
• Integrating multimodal data to predict the progression of hormone-sensitive prostate cancer
• Multi-omics analyses, cell experiments, and network pharmacology tools identified key proteins and candidate drugs for alopecia areata treatment
• From blood drops to biomarkers: a scoping review of microsampling in mass spectrometry-based proteomics

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