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Histology-resolved proteomics reveals distinct tumor and stromal profiles in low- and high-grade prostate cancer
April 20, 2025 by Allison L. Hunt, Waleed Barakat, Sasha C. Makohon-Moore, Brian L. Hood, Kelly A. Conrads, Katlin N. Wilson, Tamara Abulez, Jonathan Ogata, Kenneth J. Pienta, Tamara L. Lotan, Haresh Mani, Donald L. Trump, Nicholas W. Bateman and Thomas P. Conrads
Prostate cancer is one of the most frequently diagnosed cancers in men. Prostate tumor staging and disease aggressiveness are evaluated based on the Gleason scoring system, which is further used to direct clin…
Circulatory prostate cancer proteome landscapes and prognostic biomarkers in metastatic castrate resistant prostate cancer
April 18, 2025 by Hyejung Lee, Jincheng Shen, Muhammad Zaki Fadlullah, Anna Neibling, Claire Hanson, Enos Ampaw, Tengda Lin, Matt Larsen, Jennifer Lloyd, Benjamin L. Maughan, Umang Swami, Sumati Gupta, Jonathan Tward, Skyler B. Johnson, Brock O’Neil, Bogdana Schmidt…
Plasma-based high-plex proteomic profiling were performed in prostate cancer (PC) patients using the Olink® Explore Proximity Extension Assay to identify plasma proteins associated in different PC states and t…
Proteomic profiles screening identified novel exosomal protein biomarkers for diagnosis of lung cancer
April 15, 2025 by Weiyan Feng, Ying Lin, Ling Zhang and Weiming Hu
Exosomes play important role in biological functions, including both normal and disease process. Multiple cell types can secret exosomes, which act as message carriers. Increased evidences reveal that exosomes…
An integrated proteomic classifier to distinguish benign from malignant pulmonary nodules
April 7, 2025 by Bin Jia, Tingting Wang, Liangxuan Pan, Xiaoyao Du, Jing Yang, Fei Gao, Lujian Liao, Bianqin Guo and Junqiang Dong
Pulmonary nodule with diameters ranging 8–30 mm has a high occurrence rate, and distinguishing benign from malignant nodules can greatly improve the patient outcome of lung cancer. However, sensitive and speci…
Plasma proteomics in pediatric patients with sepsis– hopes and challenges
March 18, 2025 by Shiyuan Fan and Saizhen Zeng
One of the main causes of morbidity and death in pediatric patients is sepsis. Of the 48.9 million cases of sepsis reported globally, 41.5% involve children under the age of five, with 2.9 million deaths assoc…

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