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Comparative proteomic analysis of human vitreous in rhegmatogenous retinal detachment and diabetic retinopathy reveals a common pathway and potential therapeutic target
November 28, 2024 by Tommaso Brighenti, Giuseppe Neri, Marco Mazzola, Gabriele Tomé, Mariella Scalfati, Daniele Peroni, Romina Belli, Elena Zampedri, Toma Tebaldi, Ugo Borello, Federica Romanelli and Simona Casarosa
The vitreous humor serves as a window into the physiological and pathological processes of the eye, particularly the retina. Diabetic retinopathy (DR), a leading cause of blindness, involves hyperglycemia-indu…
Identification of serum N-glycans signatures in three major gastrointestinal cancers by high-throughput N-glycome profiling
November 28, 2024 by Si Liu, Jianmin Huang, Yuanyuan Liu, Jiajing Lin, Haobo Zhang, Liming Cheng, Weimin Ye and Xin Liu
Alternative N-glycosylation of serum proteins has been observed in colorectal cancer (CRC), esophageal squamous cell carcinoma (ESCC) and gastric cancer (GC), while comparative study among those three cancers …
Changes in amino acid concentrations and the gut microbiota composition are implicated in the mucosal healing of ulcerative colitis and can be used as noninvasive diagnostic biomarkers
November 21, 2024 by Jing Wu, Maojuan Li, Chan Zhou, Jiamei Rong, Fengrui Zhang, Yunling Wen, Jinghong Qu, Rui Wu, Yinglei Miao and Junkun Niu
Mucosal healing is the therapeutic target for ulcerative colitis (UC). While amino acids (AAs) and the gut microbiota are known to be involved in the pathogenesis of UC, their specific roles in mucosal healing…
Serum proteomics for the identification of biomarkers to flag predilection of COVID19 patients to various organ morbidities
November 1, 2024 by Madhan Vishal Rajan, Vipra Sharma, Neelam Upadhyay, Ananya Murali, Sabyasachi Bandyopadhyay and Gururao Hariprasad
COVID19 is a pandemic that has affected millions around the world since March 2020. While many patients recovered completely with mild illness, many patients succumbed to various organ morbidities. This hetero…
SPOT: spatial proteomics through on-site tissue-protein-labeling
October 24, 2024 by Yuanwei Xu, T. Mamie Lih, Angelo M. De Marzo, Qing Kay Li and Hui Zhang
Spatial proteomics seeks to understand the spatial organization of proteins in tissues or at different subcellular localization in their native environment. However, capturing the spatial organization of prote…

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