Clinical Proteomics

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• Plasma proteomics in pediatric patients with sepsis– hopes and challenges
  March 18, 2025 by Shiyuan Fan and Saizhen Zeng
  One of the main causes of morbidity and death in pediatric patients is sepsis. Of the 48.9 million cases of sepsis reported globally, 41.5% involve children under the age of five, with 2.9 million deaths assoc…
• Spatial top-down proteomics for the functional characterization of human kidney
  March 5, 2025 by Kevin J. Zemaitis, James M. Fulcher, Rashmi Kumar, David J. Degnan, Logan A. Lewis, Yen-Chen Liao, Marija Veličković, Sarah M. Williams, Ronald J. Moore, Lisa M. Bramer, Dušan Veličković, Ying Zhu, Mowei Zhou and Ljiljana Paša-Tolić
  The Human Proteome Project has credibly detected nearly 93% of the roughly 20,000 proteins which are predicted by the human genome. However, the proteome is enigmatic, where alterations in amino acid sequences…
• Admission glucose, HbA1c levels and inflammatory cytokines in patients with acute ST-elevation myocardial infarction
  February 17, 2025 by Meisinger Christa, Freuer Dennis, Raake Philip, Linseisen Jakob and Schmitz Timo
  To investigate the association between admission glucose and HbA1c values and inflammatory plasma proteins in hospitalized patients with acute ST-elevation myocardial infarction (STEMI).
• Identification of novel proteomic biomarkers for hypertension: a targeted approach for precision medicine
  February 12, 2025 by Rana S. Aldisi, Alsamman M. Alsamman, Peter Krawitz, Carlo Maj and Hatem Zayed
  Hypertension is a critical public health issue worldwide. The identification of specific proteomic biomarkers in the Qatari population aims to advance personalized treatment strategies.
• Integrated proteomics and N-glycoproteomic characterization of glioblastoma multiform revealed N-glycosylation heterogeneities as well as alterations in sialyation and fucosylation
  February 8, 2025 by Mingjun Hu, Kaiyue Xu, Ge Yang, Bo Yan, Qianqian Yang, Liang Wang, Shisheng Sun and Huijuan Wang
  Glioblastoma multiforme (GBM) is the most common malignant primary brain tumor. Notwithstanding tremendous efforts having been put in multi-omics research to profile the dysregulated molecular mechanisms and c…

• Plasma proteomics in pediatric patients with sepsis– hopes and challenges
• Spatial top-down proteomics for the functional characterization of human kidney
• Admission glucose, HbA1c levels and inflammatory cytokines in patients with acute ST-elevation myocardial infarction
• Identification of novel proteomic biomarkers for hypertension: a targeted approach for precision medicine
• Integrated proteomics and N-glycoproteomic characterization of glioblastoma multiform revealed N-glycosylation heterogeneities as well as alterations in sialyation and fucosylation

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