Clinical Proteomics

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  • Salivary small extracellular vesicles reveal protein signatures in young patients with coronary artery disease
    by Pratibha Sharma, Meetanshi Sancheti, Krishna Kishore Inampudi, Ambuj Roy and Rajinder K. Dhamija
    Saliva-derived small extracellular vesicles (sEVs) are emerging as potential biomarkers for coronary artery disease (CAD). Early identification of these biomarkers is essential for effective management and imp…
  • Assessing the consistency of mass spectrometry, a clinical-laboratory model, and immunohistochemistry in amyloid subtyping: a Brazilian experience
    by Roberta Shcolnik Szor, Jussara Bianchi Castelli, Rodrigo Andrade Schuch, Valdemir Melechco Carvalho and Vanderson Rocha
    Systemic amyloidosis is a potentially fatal protein misfolding disorder usually underdiagnosed in low- and middle-income countries, where limited awareness and restricted access to diagnostic tools contribute …
  • Spatial proteomics to discover aging-associated alterations in the renal tubulointerstitium
    by Dong-Gi Mun, Ganesh P. Pujari, Gunveen Sachdeva, Benjamin J. Madden, M. Cristine Charlesworth, Kenneth L. Johnson, Luisa Ricaurte Archila, Mariam P. Alexander, Aleksandar Denic, Aidan F. Mullan, Vidit Sharma, Nicholas B. Larson, Anthony C. Luehrs, Andrew D. Rule and Akhilesh Pandey
    The preservation of tissue architecture and morphology in formalin-fixed paraffin-embedded (FFPE) tissues enables spatial resolution at the cellular and sub-cellular levels. Laser capture microdissection (LCM)…
  • Quantitative proteomics identifies conserved proteins and altered regulation of mucin-16 in low grade serous ovarian cancers
    by Christopher M. Tarney, Paulette Mhawech-Fauceglia, Jonathan D. Ogata, Julie Oliver, Tamara Abulez, Philip A. Branton, Saeid Movahedi-Lankarani, Brian L. Hood, Kelly A. Conrads, Kendal Rosalik, Kwong-Kwok Wong, David M. Gershenson, Sanghoon Lee, Anil K. Sood, Robert C. Bast Jr., Kathleen M. Darcy…
    Low-grade serous ovarian carcinoma (LGSOC) is a rare and largely chemoresistant subtype of epithelial ovarian cancer. Unlike treatment for high-grade serous ovarian cancer (HGSOC), management options for LGSOC…
  • Dissecting sexual dimorphism in aortic valve stenosis by proteomics
    by Ana Grego, Cláudia Sousa-Mendes, Diana Martins, Carla Sousa, Ana Filipa Ferreira, Francisca Saraiva, Inês Alves, Guadalupe Espadas, Isabel Miranda, Adelino Leite-Moreira, Eduard Sabidó, António S. Barros, Cristina Gavina, Rui Vitorino, Inês Falcão-Pires, Rita Nogueira-Ferreira…
    The treatment of aortic valve stenosis (AVS) remains limited to aortic valve replacement (AVR). No pharmacotherapy has yet proven efficacious, and its development is challenged by sexual dimorphism. Women disp…
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