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  • pH-Activatable Brominated Pentamethine Cyanine Dyes for Imaging-Guided Photodynamic Immunotherapy of Tumors
    by Wangna Tang
    Chem. Sci., 2026, Accepted ManuscriptDOI: 10.1039/D6SC02842J, Edge Article Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Wangna Tang, Yanbing Cao, Ran Wang, Tian Qiu, Ying Qi Hu, Shaoyang Shi, Xiaolong Zeng, Jiangli Fan, Wen Sun, Xiaojun PengPhotodynamic therapy (PDT) has emerged as a minimally invasive antitumor strategy, yet conventional photosensitizers often suffer from off-target phototoxicity under physiological conditions. This study presents a novel pH-activatable brominated pentamethine…The content of this RSS Feed (c) The Royal […]
  • Stereoselective, Borane-catalysed Synthesis of syn-β-Hydroxyketones from α,β-Unsaturated Ketones
    by Julie Macleod
    Chem. Sci., 2026, Accepted ManuscriptDOI: 10.1039/D6SC03052A, Edge Article Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Julie Macleod, Alastair Nimmo, Joseph Cockcroft, Paula Dominguez-Molano, Gary Stephen Nichol, Stephen P. ThomasThe reductive aldol reaction is a powerful tool for the regiocontrolled coupling of α,β-unsaturated compounds with aldehydes. The use of stoichiometric organoborane reductants has previously been reported. Here these reagents…The content of this RSS Feed (c) The Royal Society of Chemistry
  • Tetraphenylborate-Based Anionic Metal−Organic Framework as an Efficient Single-Ion Conductor for Solid-State Sodium Battery
    by Xiaoxin Liu
    Chem. Sci., 2026, Accepted ManuscriptDOI: 10.1039/D6SC03302D, Edge Article Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Xiaoxin Liu, Zhiwei Lu, Qianyi Zhao, Shujun Li, Jie Zhang, Xuenian Chen, Qingchun XiaRechargeable sodium batteries (RSBs) have emerged as a promising contender in the post-lithium electrification era. However, their applications are often complicated by their inherent reactivity with flammable liquid electrolytes, which…The content of this RSS Feed (c) The Royal Society of Chemistry
  • Methyl-Induced Ring-Locking Strategy for Concentration-Independent MR-TADF Emitters toward High-Performance OLEDs with BT. 2020 Blue Gamut
    by Gaoyu Li
    Chem. Sci., 2026, Accepted ManuscriptDOI: 10.1039/D6SC02303G, Edge Article Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Gaoyu Li, Yuyuan Wang, Bo Wu, Jinkun Bian, Haozhi Xie, Zhiwei Ma, Hui Dai, Zhan Yang, Xiangyu Ge, Zhenguo ChiRealizing deep-blue multi-resonance thermally activated delayed fluorescence (MR-TADF) emitters that simultaneously offer high efficiency and resistance to aggregation-caused quenching (ACQ) remains formidably challenging, severely limiting their practical application in BT.2020-compliant…The content of this RSS Feed (c) The Royal Society […]
  • Mastering the Potential of Well-defined ML 1 L 2 Species in Asymmetric Catalysis through Ligand Immobilization (ML het L hom ). Use in Highly Enantioselective Pd-catalyzed Spiroannulation
    by Maria Biosca
    Chem. Sci., 2026, Accepted ManuscriptDOI: 10.1039/D6SC01392A, Edge Article Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Maria Biosca, Pol De La Cruz-Sánchez, Jorge Faiges, Aitor Maestro, C. Oliver Kappe, Sándor B. Ötvös, Miquel A. Pericas, Oscar Pamies, Montserrat DiéguezCatalytic complexes involving different monodentate ligands coordinated to the same metal center offer considerable interest towards the development of new processes and the improvement of the characteristics of known ones….The content of this RSS Feed (c) […]
  • Reversible Ionic Aggregation Kinetics in Concentrated Electrolytes
    by Zachary Anthony Holmes Goodwin
    Chem. Sci., 2026, Accepted ManuscriptDOI: 10.1039/D6SC01986B, Edge Article Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Zachary Anthony Holmes GoodwinHere we develop a formalism for reversible ionic aggregation kinetics in an example concentrated electrolyte, building on previous equilibrium work of McEldrew and co-workers, and thermoreversible polymers and patchy particle…The content of this RSS Feed (c) The Royal Society of Chemistry
  • Golden Immunity: Gold Complexes as Emerging Triggers of Immunogenic Cell Death
    by Marta Redrado
    Chem. Sci., 2026, Accepted ManuscriptDOI: 10.1039/D6SC02555B, Perspective Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Marta Redrado, M. Concepción GimenoCancer immunotherapy has transformed modern oncology, yet its clinical success remains limited by the intrinsically low immunogenicity of many solid tumours. Immunogenic cell death (ICD) has emerged as a powerful…The content of this RSS Feed (c) The Royal Society of Chemistry
  • Design of a site selective heterochromic bimetallic lanthanide coiled coil with nanometre-scale control
    by Louise Slope
    Chem. Sci., 2026, Accepted ManuscriptDOI: 10.1039/D6SC00813E, Edge Article Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Louise Slope, Anokhi Shah, Michael Taylor, Valentina Borghesani, Simon Caulton, Nikolas Brooks, Kate Hadley, Georgina Rose, Robert Hunter, Hassane El Mkami, Graham Smith, Aneika Corrine Leney, Niklaas Jan Buurma, Andrew Lovering, Janet E Lovett, Anna PeacockLanthanide-protein scaffolds hold significant promise for the design of functional biomaterials. Yet the selective incorporation of multiple lanthanide ions with distinct properties into […]
  • Scaling up mechanochemical reactions: linking crystalline phase evolution studied via in situ PXRD with kinetics from MCR-ALS
    by Laura Macchietti
    Chem. Sci., 2026, Advance ArticleDOI: 10.1039/D6SC01158F, Edge Article Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Laura Macchietti, Maria Carta, Francesco Delogu, Fabrizia Grepioni, Franziska Emmerling, Lucia CasaliThe proposed in situ PXRD/MCR-ALS platform resolves complex phase evolution and derives kinetic models to advance mechanochemical scale up.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry
  • Sterically controlled 5-exo-dig cyclization enables synthesis of non-benzenoid polycyclic aromatic hydrocarbons with intriguing (anti)aromaticity and diradical properties
    by Liangliang Chen
    Chem. Sci., 2026, Advance ArticleDOI: 10.1039/D6SC00121A, Edge Article Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Liangliang Chen, Zhichun Shangguan, Tianyu Shi, Liyuan Qin, Yiyun Zeng, Qingqiu Zhu, Jin Chen, Junhong Liang, Wentao Miao, Yurong He, Xiaosong Qiu, Xunchang Wang, Deqing Zhang, Renqiang YangA modular synthetic strategy based on sterically controlled 5-exo-dig cyclization enables the construction of stable non-benzenoid PAHs featuring indacene, pentalene, and azulene motifs, exhibiting tunable (anti)aromaticity and diradical character.To cite this […]
  • Recent progress on Ni-catalysed alkyl-alkyl cross-coupling enabled by asymmetric hydrofunctionalization of alkenes
    by Jiao He
    Chem. Sci., 2026, Accepted ManuscriptDOI: 10.1039/D6SC00960C, Review Article Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Jiao He, Perla Bharath Kumar, Yu-Long Li, Qiong Yu, Wei ShuThe construction of saturated stereogenic centers, which are of significance in cutting-edge fields such as pharmaceutical research and materials science, represents a fundamental objective in organic synthetic chemistry. In this…The content of this RSS Feed (c) The Royal Society of Chemistry
  • A Unified Cobalt-Electrocatalytic Platform for Enantio- and Stereo-selective C−H and C−F Functionalization of gem-Difluoromethylene Allenes
    by Cai Jiating
    Chem. Sci., 2026, Accepted ManuscriptDOI: 10.1039/D6SC02228F, Edge Article Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Cai Jiating, Xinyu Gao, Chuitian Wang, Yang Li, Xiaoxin Tong, Linzai Li, Shi Qin, Mingkai Yang, Qixin Li, Wei Wei, Lei Ma, Mei Wang, Si-Yan Liao, Yugang Huang, Xin Zhao, Shengdong Wang, Zhi Zhou, Hui Gao, Wei Yi, Zhongyi ZengWhile the merger of electrochemistry with enantioselective C−H functionalization has opened new avenues for assembling valuable chiral architectures, the […]
  • Electron transfer from singlet fission dimers: possibilities and limitations
    by Sree Chithra
    Chem. Sci., 2026, Accepted ManuscriptDOI: 10.1039/D6SC00259E, Edge Article Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Sree Chithra, Corentin Pigot, Claire Tonnelé, Ashley J Redman, Sabine Richert, David Casanova, Victor GrayPhotocatalytic production of H2 or hydrocarbons requires multiple electrons, and therefore the absorption of multiple photons and accumulation of photoexcited charges. Alternatively, multiexciton generation (MEG) could loosen this requirement. Despite…The content of this RSS Feed (c) The Royal Society of Chemistry
  • Iron-mediated Reactions of gem-Dihaloalkanes with α,β-Unsaturated Carbonyl Compounds
    by Guangshen Wang
    Chem. Sci., 2026, Accepted ManuscriptDOI: 10.1039/D6SC01614F, Edge Article Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Guangshen Wang, Jing Yao, Jianwei Liu, Tiantian Zhang, Xue Cheng, Li Li, Man-Yi Han, Baosheng LiThe ability to harness divergent reactivity and selectively dictate product outcomes from simple precursors has been a longstanding challenge in organic chemistry especially in radical chemistry. Herein, we developed a…The content of this RSS Feed (c) The Royal Society of Chemistry
  • Air-tolerant solar reforming of pre-treated biomass and plastics in viscous sustainable solvents
    by Dongseok Kim
    Chem. Sci., 2026, Accepted ManuscriptDOI: 10.1039/D6SC01540A, Edge Article Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Dongseok Kim, Papa K. Kwarteng, Erwin ReisnerWe report an air-tolerant solar reforming (SR) system for the valorisation of pre-treated biomass and plastic waste streams. This process operates in low O2-diffusivity solvents such as the robust deep…The content of this RSS Feed (c) The Royal Society of Chemistry
  • Artificial recombinant high-density protein nanocarriers for precision drug delivery
    by Wenpan Li
    Chem. Sci., 2026, Advance ArticleDOI: 10.1039/D5SC09151A, Review Article Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Wenpan Li, Nan Jia, Mengwen Li, Yanhao Jiang, Jianqin LuChemically programmable reconstituted HDL nanocarriers for drug delivery.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry
  • Supramolecular Assembly Strategy of Multinuclear Platinum(II) Complexes for Proof-of-Concept Detection and Extraction of Perfluorohexanoic Acid
    by Nicholas Chun-Ming Yeung
    Chem. Sci., 2026, Accepted ManuscriptDOI: 10.1039/D6SC00989A, Edge Article Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Nicholas Chun-Ming Yeung, Zhen Chen, Ziyong Chen, Eric Ka-Ho Wong, Vivian W. W. YamWide applications of per-/poly-fluoroalkyl substances (PFAS) in manufacturing fluorinated-polymer coatings and products pose serious health and environmental threats due to their highly chemical robustness. The development of efficient sensors for…The content of this RSS Feed (c) The Royal Society of Chemistry
  • Inducing a chiral twist in achiral porphyrins: tailoring molecular interactions for circularly polarized luminescence from chiral microflowers
    by Arunima Cheran
    Chem. Sci., 2026, Advance ArticleDOI: 10.1039/D5SC09327A, Edge Article Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Arunima Cheran, Betsy Marydasan, Saikat Das, Hrishikesan Kalpakassery Pattam, Jatish KumarA facile and novel strategy for induction of chirality in achiral porphyrins through the synergistic use of chiral mandelic acid and Zn(II) ions is reported. The nanostructures exhibit chiral luminescence in both solution and solid states.To cite this article before page numbers are assigned, use the DOI form […]
  • Unravelling Intrinsic Thermal Conduction Mechanism through Phonon Transport Pathway Engineering of Long-Range Ordered Block Copolymers
    by Kuan Zhang
    Chem. Sci., 2026, Accepted ManuscriptDOI: 10.1039/D6SC01804A, Edge Article Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Kuan Zhang, Junliang Zhang, Jiahao An, Junwei GuHighly thermally conductive polymers are playing essential roles in various electronics-related fields. However, the mechanism underlying thermal conduction remains hitherto elusive. Herein, the intrinsic thermal conduction mechanism of polymers was…The content of this RSS Feed (c) The Royal Society of Chemistry
  • Total and Engineered Biosynthesis of Cinatrins: Inhibitors of Phospholipase A2 and Squalene Synthase
    by Henrike Heinemann
    Chem. Sci., 2026, Accepted ManuscriptDOI: 10.1039/D6SC00660D, Edge Article Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Henrike Heinemann, Nick Gerlach, Eric Kuhnert, Jennifer Gerke, Bart Verwaaijen, Jorn Kalinowski, Marc Stadler, Russell CoxAn alkyl citrate biosynthetic gene cluster (ctr) was identified from 47 members of the fungal family of Hypoxylaceae by genome mining. The Hypomontagnella monticulosa MUCL 54604 ctr cluster was deployed…The content of this RSS Feed (c) The Royal Society of Chemistry

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