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  • Distinct Adsorption Behavior and Structures of Cell-Penetrating Peptides at a Model Lipid Membrane Interface: A Heterodyne-Detected Vibrational Sum Frequency Generation Spectroscopy Study
    by Subhadip Roy
    Chem. Sci., 2026, Accepted ManuscriptDOI: 10.1039/D6SC03510H, Edge Article Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Subhadip Roy, Mohammed Ahmed, Aniruddha Adhikari, Erika Kinoshita, Satoshi Nihonyanagi, Tahei TaharaArginine-rich cell-penetrating peptides (CPPs) are widely used as molecular delivery vectors, yet the molecular mechanism of their membrane activity and how they penetrate a cell remains unclear. Here, we investigate…The content of this RSS Feed (c) The Royal Society of Chemistry
  • Machine Learning-Driven Cancer Diagnostics with Improved Robustness and Interpretability
    by Pengfei Li
    Chem. Sci., 2026, Accepted ManuscriptDOI: 10.1039/D6SC02368A, Perspective Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Pengfei Li, Zhen LiuCancer remains one of the leading causes of death worldwide, underscoring the critical need for early diagnosis to improve long-term survival outcomes and reduce mortality rates. Despite significant progress, the…The content of this RSS Feed (c) The Royal Society of Chemistry
  • Cyclic transformation of stable/metastable nucleic acid structures enables dynamic monitoring of ATP in living cells
    by Ming-Li Su
    Chem. Sci., 2026, Accepted ManuscriptDOI: 10.1039/D6SC03635J, Edge Article Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Ming-Li Su, Jun Yang, Wei-Guo Yang, Zhuoxin Ye, Ruiwen Wang, Jia-Min Qin, Daqian Song, Ruo Yuan, Pinyi Ma, Ying Zhuo, Chaoyong Yang, Wenbin LiangThe maintenance of living systems relies on complex signaling networks involving nucleic acids, proteins and small molecules. However, conventional analytical approaches are often limited to endpoint measurements or analyses performed…The content of this RSS Feed […]
  • Supramolecular Purification of Mono-Adamantane Mixtures via Stabilized Three-Shell Matryoshka Assemblies
    by Clara Sabrià
    Chem. Sci., 2026, Accepted ManuscriptDOI: 10.1039/D6SC02321E, Edge Article Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Clara Sabrià, Tània Pèlachs, Inhar Imaz, Daniel Maspoch, Ferran Feixas, Xavi RibasThe adamantane (Ad) core is widely used in pharmaceuticals, where it is regarded as a lipophilic “bullet” that enhances the bioactivity of Ad-bearing drugs. Despite its prevalence, little is known…The content of this RSS Feed (c) The Royal Society of Chemistry
  • Interpretable Machine Learning-based Automated HPLC/MS2 Platform using Ion-Molecule Reactions for the Identification of Functionalities in Analytes
    by Armen G. Beck
    Chem. Sci., 2026, Accepted ManuscriptDOI: 10.1039/D5SC07324C, Edge Article Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Armen G. Beck, Ruth Anyaeche, Prageeth Wijewardhane, Sanjay Iyer, Yue Fu, Judy Kuan-Yu Liu, Jifa Zhang, Kawthar Alzarieni, Erlu Feng, Ryan T Hilger, Christopher J Welch, Hilkka I. Kenttamaa, Gaurav ChopraIdentification of unknown compounds in complex mixtures is a time-consuming and challenging problem in several areas of chemistry. High-performance liquid chromatography (HPLC) coupled to tandem mass spectrometry (MS2) […]
  • Stabilizing O3-Type Layered Oxide Cathodes via Dual-Site Co-Doping for Long-Life Sodium-Ion Batteries
    by Xuejie Bai
    Chem. Sci., 2026, Accepted ManuscriptDOI: 10.1039/D6SC01429A, Edge Article Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Xuejie Bai, Qian Yang, Yaning Wu, Mingyue Li, Genliang Yu, Tongtong Huo, Xiaobo Zhang, Jie Xu, Xunzhu Zhou, Ting Lv, Lin Li, Kaixiang Lei, Shijian ZhengO3-type layered transition metal oxide cathode materials exhibit tremendous potential for commercial application owing to their high theoretical capacity. However, their practical application is fundamentally limited by oxygen loss caused…The content of this […]
  • Linearly Acenaphthylene-Fused Pentacene Exhibiting Efficient Singlet Fission
    by Jacob Arvidson
    Chem. Sci., 2026, Accepted ManuscriptDOI: 10.1039/D5SC08246C, Edge Article Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Jacob Arvidson, Saad Shaikh, Masahiro Tanaka, Tejal Pawale, Andrew Dawson, Xiao Li, Vladimir Nesterov, Yasuhiro Kobori, Somnath Das, Hong WangAcenes are poised to be highly sought after for singlet fission, which is among the most promising strategies for scaling solar power conversion efficiency beyond Shockley–Queisser limit. One critical problem…The content of this RSS Feed (c) The Royal Society […]
  • Redox-Protonation Landscape of Indenyl-Annulated Perylenes. Chemodivergent Switching of Multistate NIR Chromophores
    by Agata Wiencierz-Paś
    Chem. Sci., 2026, Accepted ManuscriptDOI: 10.1039/D6SC01695B, Edge Article Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Agata Wiencierz-Paś, Liliia Moshniaha, Piotr J. Chmielewski, Tadeusz Lis, Mateusz Waliczek, Ryota Kabe, Marcin StępieńIndene-annulated perylenes merge cyclopentadiene-like benzylic acidity with the multielectron redox chemistry of rylene carbonyl scaffolds, creating discrete redox–protonation (“Pourbaix”) spaces in which electron transfer and acid–base processes become intrinsically coupled….The content of this RSS Feed (c) The Royal Society of Chemistry
  • Spatial decoupling of CH4 oxidation and CO2 reduction enables near-stoichiometric dry reforming of methane
    by Wenbin Li
    Chem. Sci., 2026, Accepted ManuscriptDOI: 10.1039/D6SC03014A, Edge Article Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Wenbin Li, Jiyun Ren, Wenjie Guo, Qing Guo, Sai Zhang, Yongquan QuThe practical application of dry reforming of methane (DRM) is hindered by catalyst deactivation, primarily due to the deviation of the ideal 1:1 H2:CO stoichiometry for competitive CH4 and CO2…The content of this RSS Feed (c) The Royal Society of Chemistry
  • Electron-injection-induced global aromaticity enables stable open-shell nanopillars with intense mid-infrared magnetic circular dichroism
    by Kongchuan Wu
    Chem. Sci., 2026, Accepted ManuscriptDOI: 10.1039/D6SC01782G, Edge Article Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Kongchuan Wu, Shicheng Dong, Qiqi Chen, Yuanfeng Pan, Jun Zhu, Jianbin Lin, Hui-Jun ZhangOpen-shell species are central to spintronics and infrared optoelectronics, but remain challenging to stabilize in discrete molecular systems. Herein, we report that electron injection into pillar-shaped, radially π-conjugated [4]cyclonaphthodithiophene diimides…The content of this RSS Feed (c) The Royal Society of Chemistry
  • Automatic identification of compounds in molecular mixtures from liquid-phase infrared spectra
    by Yannah J. U. Melle
    Chem. Sci., 2026, Advance ArticleDOI: 10.1039/D6SC01583B, Edge Article Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Yannah J. U. Melle, Thanh Nguyen, Jeffrey Lopez, Daniel Schwalbe-KodaInterpreting spectroscopy data is a critical bottleneck in automating chemical research and industrial characterization.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry
  • Engineering a redox-active interface for highly reversible aluminum anode-based practical all-solid-state lithium batteries with ultralow N/P ratio
    by Jiawu Cui
    Chem. Sci., 2026, Advance ArticleDOI: 10.1039/D6SC03781J, Edge Article Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Jiawu Cui, Xiaohui Sun, Zhenxin Huang, Xianwei Wang, Zhen Wang, Zhanhui Jia, Chao Wu, Kang Yang, Yuping Wu, Wei Tang, Ya-Ling HeThe Al anode featuring an electrochemically formed redox interface delivers substantially improved electrochemical performance relative to a pristine Al foil electrode.To cite this article before page numbers are assigned, use the DOI form of citation above.The content […]
  • Upcycling of LiFePO4 to high-performance LiMnxFe1−xPO4: activating the Mn redox platform for stable energy storage
    by Zihao Zeng
    Chem. Sci., 2026, Advance ArticleDOI: 10.1039/D6SC03686D, Edge Article Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Zihao Zeng, Xuepeng Qi, Wei Sun, Peng Ge, Yue YangUpcycling LiFePO4 to LiMn0.4Fe0.6PO4/C unlocks a high-voltage Mn plateau, delivering superior rate capability, long cycle life, and significant economic and environmental benefits.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry
  • Unraveling Emission Narrowing Pathways in N-Embedded Polyaromatic Systems via Sequential π-Interlocking for Efficient Electroluminescence
    by Danish Khan
    Chem. Sci., 2026, Accepted ManuscriptDOI: 10.1039/D6SC02898E, Edge Article Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Danish Khan, Seungwon Han, Keerthika P, Pankaj Kumar Gupta, Ankit Kumar, Jun Yeob Lee, Rajendra Kumar KonidenaSurge for complex B-free, narrowband organic emitters has garnered significant attention for OLEDs, but remains challenging due to limited control over vibronic coupling and structural relaxation. Herein, we present a…The content of this RSS Feed (c) The Royal Society of Chemistry
  • Electrophilic N, P co-doped carbon enabling highly reversible iodine redox chemistry for ultra-stable bismuth-based zinc-ion batteries
    by Dandan Ling
    Chem. Sci., 2026, Advance ArticleDOI: 10.1039/D6SC03172B, Edge Article Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Dandan Ling, Yan Ma, Liu Jiang, Tong Zhou, Daohong Zhang, Qiufan WangThe pursuit of high-performance cathode materials is paramount for the deployment of aqueous zinc-ion batteries (ZIBs) in large-scale energy storage.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry
  • Data-Driven Structural Angle Mining Elucidates Hidden Design Rules for Hydrogen Evolution Single-Atom Electrocatalysts
    by Bingqing Ge
    Chem. Sci., 2026, Accepted ManuscriptDOI: 10.1039/D6SC01740A, Edge Article Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Bingqing Ge, Yang Chen, Yidi Wu, Fenfei Wei, Fengyu Li, Lulu Chen, Jian Lin, Xianzhi Fu, Sen LinStructural distortions in modified two-dimensional transition metal dichalcogenides (MX2) influence electrocatalytic activity, yet quantitative and predictive structure-property relationships remain underdeveloped. To bridge this gap, we perform data-driven structural angle mining…The content of this RSS Feed (c) The Royal Society of Chemistry
  • Orthogonal Nanopores Cross-Validation for Multiplex Single-Molecule Profiling
    by Lin-Lin Zhang
    Chem. Sci., 2026, Accepted ManuscriptDOI: 10.1039/D6SC03524H, Edge Article Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Lin-Lin Zhang, Fan Gao, Yi-He Wei, Cheng-Bing Zhong, Bingqing Xia, Liuqing Wen, Yi-Tao Long, Yi-Lun YingMultiplex biomolecule profiling provides comprehensive molecular insights essential for precision health diagnosis. However, the difficulty arises from the fundamental diversity of biomolecules. Their sizes, charges, structures, and chemical compositions differ…The content of this RSS Feed (c) The Royal Society of Chemistry
  • Hydroxyl-radical-specific cascade photogeneration for oxygen-chain photocatalytic therapy
    by Qiang Liu
    Chem. Sci., 2026, Accepted ManuscriptDOI: 10.1039/D6SC03309A, Edge Article Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Qiang Liu, Chenxu Yan, Xie Li, Haiyang Huang, Zheyu Fan, Jizhan Zhang, Weiwei Zhang, Ping Shi, Yuzheng Zhao, Zhiqian Guo, Weihong ZhuHydroxyl radical (•OH), the most potent reactive oxygen species, plays a crucial role in photodynamic therapy (PDT). However, conventional photosensitizers (PSs) produce •OH through the classical Haber-Weiss pathway suffer from…The content of this RSS Feed (c) The […]
  • Crystalline-amorphous homojunction engineering in carbon nitride for solar-driven nitrate into ammonia
    by Yiyang Chen
    Chem. Sci., 2026, Accepted ManuscriptDOI: 10.1039/D6SC01863G, Edge Article Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Yiyang Chen, Yuxiang Zhu, Xiang Zhong, Yuhang Liang, Qiufan Sun, Sai Xu, Jianfeng YaoPhotocatalytic nitrate to ammonia conversion offers a promising route to close the nitrogen cycle, yet is limited by inefficient charge separation and poor reaction selectivity. Here, crystalline-phase-engineered oxygen-doped carbon nitride…The content of this RSS Feed (c) The Royal Society of Chemistry
  • Recent Achievements on Nonflammable Electrolytes with Ethoxy(pentafluoro)cyclotriphosphazene for Stable and Safe Lithium-Ion Batteries
    by Zhiming Zhou
    Chem. Sci., 2026, Accepted ManuscriptDOI: 10.1039/D6SC03275C, Review Article Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Zhiming Zhou, Guojun Chen, Guojun Yu, Xiaohao Liu, Shulei ChouThe increasing demand for high-energy-density lithium-ion batteries (LIBs) has intensified concerns regarding electrolyte flammability, interfacial degradation, and thermal runaway. Phosphazene-based compounds, particularly ethoxy(pentafluoro)cyclotriphosphazene (PFPN), have emerged as promising multifunctional electrolyte…The content of this RSS Feed (c) The Royal Society of Chemistry

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