- by /u/mari_chemistryA very interesting summary of all the actual guidelines for pharmaceutical analytical method validation including EP, USP and ICH. Happy to share 😊 https://amzn.eu/d/gWKlDwP submitted by /u/mari_chemistry [link] [comments]
- by /u/Psychological-War61Which one should i use, the one with higher r2 and 3 data points, or the one with a little lower r2 and 4 data points submitted by /u/Psychological-War61 [link] [comments]
- by /u/Apacukafundaluka12Hi everyone, I’m currently developing an analytical method, and some of my experiments will soon be repeated in another laboratory to confirm that the method works properly. This is my first time going through such a process, so I’d like to ask if anyone has experience with this. What do they usually repeat in such cases? I assume it will be the calibration curve within my linear range and maybe the same type of sample analysis. Any information or tips would be really helpful..I just want to be sure everything goes smoothly. Thanks in advance! submitted by /u/Apacukafundaluka12 [link] [comments]
- by /u/CatfishDaddy99Currently analyzing S,P, and Zn in oil samples in a matrix of mineral oil. Analysis is occurring on a fisher Optim’X wdxrf with oxsas software. In my efforts to build a calibration curve, I’ve noticed that linearity between standards is excellent except for zinc. I can get excellent linearity for all 3 at standards below 2%. But when I run quantitative analysis on the instrument at those levels, it’s still reading a bit too high for zinc. Any ideas on what might be causing the issue or how to resolve it given the software? I’m fairly new to oxsas. submitted […]
- by /u/InnerBasketcase17sources I've come across are conflicting or aren't really sufficient definitions (pigments are "insoluble" in binder; dye is soluble; this doesn't specify the reference of its solubility though). doing this for undergrad seminar presentation. would appreciate insight w/ sources! submitted by /u/InnerBasketcase17 [link] [comments]
- by /u/WesternNational4283submitted by /u/WesternNational4283 [link] [comments]
- by /u/grubbscatsubmitted by /u/grubbscat [link] [comments]
- by /u/grubbscatsubmitted by /u/grubbscat [link] [comments]
- by /u/Remote_Section2313i'm working in food analysis and we're trying to set up some titrations in vegetable oils and fat. For most samples, we have no issues, but we need a method for fat analysis in cocoa beans, which means we have to extract the butter from the beans. Does anybody have experience with this on a lab scale? So far, what we can test: -chemical extraction (adding hexane to the powdered beans, mixing, filtering and evaporating the solvent) -mechanical: pressing the beans with a manual press (or electric or hydraulic, I guess), through a fine filter. submitted by /u/Remote_Section2313 [link] [comments]
- by /u/Ok_Result6108A sample with an estimated content of 55% Fe, 3% Al and 1.4% Ni was analyzed using a method, that is considered linear when the concentration range of Ni is 100 … 500 мg/L. 0.1647 g of sample was weighed and dissolved in 10 ml of 6M HCl. The solution was then transferred to a 100 ml volumetric flask and the flask was filled to the mark. The solution must be diluted for the further analysis. How much of the sample solution, prepared as described above, should be pipetted to a 25 ml flask for the estimated Ni concentration inthe […]
- by /u/Pure-Country-6632I am so lost in my analytical chem lecture, if someone knows how to do an f-test, t-test, or q-test please explain it to me in the most basic terms possible 😭 submitted by /u/Pure-Country-6632 [link] [comments]
- by /u/Training-Resist-2745Hi everyone, We’re running LC-MS on samples with a fairly high salt burden. On C18, this hasn’t been an issue since we divert the injection peak to waste, preventing salt buildup in the MS. Now, since we’re also interested in more polar analytes, we’re considering HILIC as an additional separation mode. What’s less clear to me is how inorganic ions (Na⁺, Cl⁻, SO₄²⁻, Mg²⁺, Ca²⁺, etc.) behave in HILIC. From my understanding, they might be among the last species to elute – but we’d definitely like to avoid sending them into the MS. Has anyone dealt with this in practice? […]
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