- by /u/123squashplayerCan anybody give me advice on setting up kinetic analysis using MassLynx? I'd like to inject sample and record data at defined intervals. Either every n-hours (4 hour intervals), or fixed clock times (1PM, 5PM, 9PM etc) submitted by /u/123squashplayer [link] [comments]
- by /u/Initial-Let-4319Hi everyone! I'm currently looking for a step-by-step manual or SOP on how to operate the Waters Xevo G2 QTOF. I'm especially interested in documents or guides that explain: How to start up and shut down the instrument How to create and configure methods in the software Sample preparation and injection steps Proper glassware handling and cleaning procedures Basic data acquisition and processing If anyone has a document (PDF, Word, or any format), training material, or even personal notes you’d be willing to share, I’d really appreciate it. Thanks in advance! submitted by /u/Initial-Let-4319 [link] [comments]
- by /u/Accomplished-Shop784I’m using Agilent’s Qualitative Analysis software and my MS1 spectra is labeling the m/z, but the corresponding MS2 (product spectra) isn’t labeling anything. The spectrum peak label options say ms peak label m/z, and the MS/MS peak label says m/z. Any help would be great submitted by /u/Accomplished-Shop784 [link] [comments]
- by /u/Adamran15Hello all. I’ve been having issues with the coolant flow rate on my lab’s ICP-MS that’s preventing us from running any samples. We have a model that Agilent doesn’t support any more so we’re on our own to fix these issues as our testing numbers don’t really support the cost of a new instrument. I’ve been troubleshooting the issue for a while and already cleaned out the strainer, checked for any leaks, connected our faucet to the inlet with some other tubing to isolate the instrument from the chiller and the flow rate still fluctuates from about 0.8-1.0 L/min but […]
- by /u/drrobooI have high background levels on an Isoprime IRMS. As a leak check, I tuned the machine to Argon’s mass and then did a 10 minute scan as I blew Argon on all the fittings. It seems obvious there are multiple leaks but also some parts of the scan look a little odd. So, I’m looking for some confirmation on what I’m seeing and info on where to go from here. https://preview.redd.it/0eqiyp905c7f1.png?width=1600&format=png&auto=webp&s=2ac511fec46b8fd83ea9202733f3e3db5bc530ae Why does the baseline, when I’m not blowing Ar on anything, have a wave to it? https://preview.redd.it/c46bxur85c7f1.png?width=1600&format=png&auto=webp&s=4e3decb8213909b250f417b2ee0d5d606a5eede2 https://preview.redd.it/zm8ct7wi5c7f1.png?width=1600&format=png&auto=webp&s=5026aba8274c1784b09884e08cb380ed3aa0011b When the diluter is on, Ar readings jump and become […]
- by /u/MasterpieceSweaty681Our university has recently bought a Waters UPLC and G3 XEVO LC-MS QTOF. I want to do so some multivariate analysis (i.e. PCA and PLS-DA) but cannot afford EZ info. I am looking at either SIMCA from Sartorius or using the PLS-Toobox on MATLAB from Eigenvector. Which is the easiest and most intuitive to use? (I have low patience and have never coded for R or SPSS). Any help is welcomed. submitted by /u/MasterpieceSweaty681 [link] [comments]
- by /u/Mission-Strength9945So I am relatively new to method development and refinement. I am wondering the thought process on choosing an internal standard for an analyte of interest, specifically when it comes to an analyte I do not have a deuterated internal standard for. For example, we have codeine-d6 internal standard for Methylphenidate. I understand that this is tested on method development and validation, but I was wondering the thought process behind this. I understand it is area ratios, so if I were to change the IS I would need to make sure the new IS has similar a similar area along […]
- by /u/Oak2196Hey Guys, i am quiet new to MS and i am looking for a software (open source if possible) to quantify small molecules with LC-MS. I would be very thankful for a recommendation. submitted by /u/Oak2196 [link] [comments]
- by /u/driving_shoobI have a new IDEX calibrant delivery system, a turbo ion source (in unknown condition), a vacumm gauge and many other assorted mass spec parts. The cheaper stuff I think I can sell on Ebay, but where is the best place to sell stuff like the calibrant delivery system? How do I determine what this stuff is worth (some parts I cannot find other people selling it in the same condition or same variation etc.) submitted by /u/driving_shoob [link] [comments]
- by /u/Least-Raspberry2340Hello, Can in-source fragmentation affect recovery and accuracy in an MRM experiment? Thank you. submitted by /u/Least-Raspberry2340 [link] [comments]
- by /u/CarbenoIm relatively new to HPLC-Ms/Ms, im using a Thermo Quantum Access Max with HESI probe. Im getting this peak shape for 1ppm of Trifluralin. Im sure it can be better, other analytes are greatly resolved and present a less noisy shape. Question here is if I have some kind of ABC to know how to fix this issue. My first take would be to play with collision energy, but what about Spray voltage of the ESI probe? Obviously I can start playing with parameters until I get this done but I wondering if there's a way to quickly recognize what […]
- by /u/Nice_Ad_8082MeOH sample; see RT and observed m/z matrix sample; same RT but 'not observed' , zooming in to low energy I see the precursor ion and its isotope I've increased the mass tolerance to 0.1 Da and it's still not processing. Does anyone have suggestions on how to handle this? submitted by /u/Nice_Ad_8082 [link] [comments]
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