- by MS ArticlesThis one took me a couple of rounds of putting it down and coming back to it later.It's a smart concept and a very nice thing to think about as proteomics becomes more trusted as a diagnostic. I think I first thought it was something that it isn't, and that's why I had such a conceptual problem with it. Obviously, I […]
- by MS ArticlesI'm tired of reading today, but I really want to get back to this cool paper.Really deep multi-proteomic type analysis looking for markers for why almost everyone has liver inflammation, but for some people it's a really bad thing that progresses to worse things.You've got secretion proteomics, and neat plasma and depleted plasma, and some SomaScan data from a related […]
- by MS ArticlesOh. This is really cool. I'm so glad that SCIEX is finally getting some traction with their super cool ZenoTOF hardware. The high speed high resolution mass spec world is really super competitive right now. You really can't make a bad choice (aside from Agilent, obviously – hey, I didn't tell them to abandon global proteomics instrument market -they're doing […]
- by MS ArticlesStressful events are a leading factor in development of depression. The medial prefrontal cortex (mPFC) is strongly associated with depression etiology and exposure to uncontrollable stressors results in synaptic dysfunction and loss. Learned helplessness is a behavioral paradigm that measures effects of repeated exposure to uncontrollable, inescapable stress on later responses to escapable stress. We therefore performed a proteomic analysis […]
- by MS ArticlesThe RNA exosome is an essential and ubiquitous RNase with exonucleolytic activity, involved in ribosome biogenesis and RNA quality control in eukaryotes. It is present both in nucleus and cytoplasm, and interacts with specific cofactors in each cell compartment, which are essential for recruitment and activity control of the exosome. Posttranslational modifications are known to regulate enzyme activity and protein […]
- by MS ArticlesReactive oxygen species (ROS) are central regulators of plant growth and stress responses. Cellular ROS levels are tightly controlled by antioxidant systems, including the evolutionarily conserved catalases that detoxify hydrogen peroxide (H2O2) predominantly within peroxisomes. Despite their importance, substantial gaps remain in our understanding of catalase biogenesis, regulation, subcellular targeting, and potential extra-peroxisomal functions. Using affinity purification of the UV-B […]
- by MS ArticlesPublication date: Available online 29 January 2026Source: Journal of Chromatography BAuthor(s): Christof Manuel Schönenberger, Aurelie Berthet, Matthias Briel, Alain Amstutz, Matthias Cavassini, Loïc Sartori, Camille Rime, Davide Staedler, Fiorella Lucarini
- by MS ArticlesChemistry – A European Journal, EarlyView.
- by MS ArticlesAs part of the US HUPO sponsored "Pony Express" series highlighting speakers at the upcoming 2026 US HUPO meeting in St. Louis, Ben and Ben sit down to talk with Dr. William Noble, University of Washington, recipient of the 2026 Gilbert S. Omenn Computational Proteomics Award.keywords: genomics; machine learning; AI; computational; Bridgerton; cocaine monkeys; birding
- by MS ArticlesJournal of Mass Spectrometry, Volume 61, Issue 2, February 2026.
- by MS ArticlesJournal of Mass Spectrometry, Volume 61, Issue 2, February 2026.
- by MS ArticlesPolygenic scores (PGS) summarize the combined effects of common single-nucleotide polymorphisms and contribute to predictions of disease severity, but biological consequences linked to these common variants remain poorly defined. Here, we focused on polygenic liability for a measurable electrophysiologic trait (the QT interval). Prolonged QT interval, measured on patient electrocardiograms, is associated with an increased risk for cardiac arrhythmia. We […]
- by MS ArticlesAre you ready for deep visual lipidomics? No? Okay what about normal spatial lipidomics with deep visual proteomics? The diagram pretty much shows what the paper did, but the co-registration of the spatial data from the laser capture microdissection work (now called deep visual proteomics, y'all, get on the hip terminology) to the lipidomics is a star. This does come from […]
- by MS ArticlesAnalytical ChemistryDOI: 10.1021/acs.analchem.5c04150
- by MS ArticlesAnalytical ChemistryDOI: 10.1021/acs.analchem.5c05700
- by MS ArticlesLoss-of-function mutations in cyclin-dependent kinase 12 (CDK12) define an aggressive subtype of metastatic castration-resistant prostate cancer (mCRPC) characterized by genomic instability, and depletion of CDK12 activity downregulates the expression of long DNA repair genes. While these transcriptional defects are well-documented, potential alterations in chromatin that may topologically affect this silencing and the subsequent adaptive survival mechanisms of tumor cells remain […]
- by MS ArticlesEnvironmental Science & TechnologyDOI: 10.1021/acs.est.5c08824
- by MS ArticlesNot for posting – maybe keep it to write a tutorial on writing a mass spec method section. I should probably start with a HOW TO write your proteomics methods paper's method section. But I'm just all around annoyed with this manuscript as well as whoever peer reviewed it. And the editor, and maybe whatever this journal is. I'm also probably annoyed with […]
- by MS ArticlesMicrobial metabolites play a critical role in regulating ecosystems, including the human body and its microbiota. However, understanding the physiologically relevant role of these molecules, especially through liquid chromatography tandem mass spectrometry (LC-MS/MS)-based untargeted metabolomics, poses significant challenges and often requires manual parsing of a large amount of literature, databases, and webpages. To address this gap, we established the Collaborative […]
- by MS ArticlesJournal of the American Society for Mass SpectrometryDOI: 10.1021/jasms.5c00395
Murray Mass Spectrometry Group
Research group of Kermit Murray at Louisiana State University where we use lasers for sampling and imaging and study the chemistry and physics of laser ablation.
