- by MS ArticlesABSTRACT Rationale Differential ion mobility spectrometry (DMS) provides distinct potential in separation of gas phase ions. However, the resolving power still limits the widespread application of DMS technology and inspires to design tandem DMS for improvement of the performance. Methods A robust tandem DMS module was fabricated to enhance the separation performance of the DMS system. To achieve the optimal […]
- by MS ArticlesProteins are the functional effectors of virtually all biological processes, and accurately measuring their abundance and dynamics is essential for understanding development and disease. Although mRNA levels have historically been used as proxies for protein expression, growing evidence, especially from studies of the human cerebral cortex, has revealed widespread discordance between transcript and protein abundance. To directly address this limitation, […]
- by MS ArticlesJournal of the American Society for Mass SpectrometryDOI: 10.1021/jasms.4c00500
- by MS ArticlesJournal of the American Society for Mass SpectrometryDOI: 10.1021/jasms.5c00016
- by MS ArticlesThe fast-advancing mass spectrometry and related technologies have greatly extended the depth of coverage in large-scale proteomics studies, including single-cell applications. As sample numbers grow rapidly, it is often challenging to interpret the proteins with missing values that are often presented as "NA" (not available). It could be the evidence of no expression, low expression below the detection threshold, or […]
- by MS ArticlesPhase separation of biomolecular condensates is often assumed to be driven by interactions involving nucleic acids and intrinsically disordered regions (IDRs) of proteins. PGL-3 is a component of P granules, biomolecular condensates in the C. elegans germline, that contains two structured domains in tandem (D1-D2), an internal IDR, and a C-terminal IDR rich with RGG motifs. Theoretical and in vitro […]
- by MS ArticlesNon-target screening (NTS) using liquid chromatography–high-resolution mass spectrometry (LC-HRMS) is crucial for identifying organic compounds and patterns in complex environmental samples. However, discrepancies in data processing between peak-picking algorithms (“feature profile” approaches) remain a critical challenge in achieving consistent and reproducible results. An alternative approach employs multi-way chemometric methods to directly produce “component profiles,” allowing efficient decomposition and evaluation of LC-HRMS datasets, […]
- by MS ArticlesPublication date: 1 January 2026Source: Talanta, Volume 296Author(s): Lola Alez-Martin, Pascal Houzé, Rania Joomun, Nathalie Mignet, Yannis-Nicolas François, Rabah Gahoual
- by MS ArticlesAnalytical ChemistryDOI: 10.1021/acs.analchem.5c02166
- by MS ArticlesAnalytical ChemistryDOI: 10.1021/acs.analchem.5c00417
- by MS ArticlesAnalytical ChemistryDOI: 10.1021/acs.analchem.5c02394
- by MS ArticlesJ. Anal. At. Spectrom., 2025, Accepted ManuscriptDOI: 10.1039/D5JA00140D, Critical Review Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Kattathu J MathewFactors on which the accuracy and precision realized in isotope amount ratio measurements using thermal ionization mass spectrometry (TIMS) instrumentation are described, and the measurement of Pu materials is emphasized….The content of this RSS […]
- by MS Articles Check out the above (click to expand) – Yes, that is the bizarre nomenclature used by our friends at SpectroNaut (PG.normal word you'd expect AND the funnest-to-parse [ mf'ing brackets ] AND a space after the second bracket ] at the beginning of each sample name)! And in the "EG.PrecursorID" which roughly possibly translates to "peptide sequence with the addition of […]
- by MS ArticlesJournal of the American Society for Mass SpectrometryDOI: 10.1021/jasms.5c00103
- by MS ArticlesABSTRACT The mirabegron drug substance was shown to have potential genotoxic impurity (PGI); hence, it needs to develop the method for the determination of the 2-(2-Nitrophenyl) ethylamine hydrochloride (4-NPE RC-2) PGI at a 30-ppm limit considering the maximum daily dose of 50 mg/day and a 1.5 mg per day TTC limit as per ICH M7 guideline. A simple high-performance liquid chromatography (HPLC) […]
- by MS ArticlesAnalytical ChemistryDOI: 10.1021/acs.analchem.5c03067
- by MS ArticlesAnal. Methods, 2025, Accepted ManuscriptDOI: 10.1039/D5AY00724K, CommunicationHanxu Ji, Jingjing Xu, Yufeng Li, Xiaoxiao Wu, Diyao Jiang, Xiuming Mei, Miao Yang, Yuwei Qiang, Jungui Zhou, Chi ZhangWe developed a novel mass spectrometry immunoassay for the ultrasensitive and selective detection of deoxynivalenol by introducing nucleic-acid-amplification techniques. By selecting thymine as mass tag, the primer DNA modified on…The content of this RSS Feed […]
- by MS ArticlesPublication date: Available online 23 June 2025Source: Journal of Chromatography AAuthor(s): Ning Zhang, Yingxia Guo, Yijin Wang, Luyao Yu, Chunpeng Feng, Jiye Tian, Lei Yin, Meiyun Shi
- by MS ArticlesPublication date: Available online 22 June 2025Source: Journal of Chromatography AAuthor(s): Yanan Li, Ziping Liu, Xiuquan Yue, Shicheng Jiang
- by MS ArticlesCorrection to: Development and analysis of 49 perfluoroalkyl and polyfluoroalkyl substances (PFASs) in contact lenses using liquid chromatography‑tandem mass spectrometry (LC–MS/MS)
Murray Mass Spectrometry Group
Research group of Kermit Murray at Louisiana State University where we use lasers for sampling and imaging and study the chemistry and physics of laser ablation.
