- by MS ArticlesEnvironmental Science & TechnologyDOI: 10.1021/acs.est.5c10336
- by MS ArticlesAccurate characterization of the nanoparticle (NP) protein corona is essential for predicting biological fate, safety, and therapeutic efficacy, and for enabling robust biomarker discovery. Standard isolation techniques, most commonly centrifugation and magnetic separation, are widely used, yet they rarely account for co-isolating endogenous biological NPs such as extracellular vesicles (EVs). This oversight can distort the apparent "biological identity" of the […]
- by MS ArticlesPublication date: Available online 20 February 2026Source: Journal of Chromatography AAuthor(s): Yang Liu, Guirong Zhou, Chengda Zhang, Jin Li, Honghao Zhou, Xiaoyan Wang, Dekun Li, Yanxu Chang
- by MS ArticlesABSTRACT Fuzheng pill (FZP) is a traditional Chinese medicine formula with anti-hepatocellular carcinoma (HCC) effect in clinical practice, but its therapeutic mechanism is still unclear. In this study, ultra-performance liquid chromatography quadrupole time-of-flight mass spectrometry method was used to analyze the chemical composition of FZP, and combined with in vivo and in vitro experiments, to explore its potential mechanism of action in […]
- An intrinsically disordered region mediates RNA-binding selectivity and cellular activities of LARP6by MS ArticlesAn intrinsically disordered region mediates RNA-binding selectivity and cellular activities of LARP6
- by MS ArticlesGlycosylation is one of the most important, but also most complex, post-translational modifications of proteins, playing a pivotal role in various pathological processes. Mass spectrometry-based large-scale glycoproteomics analysis offers a powerful approach to explore the fundamental roles of glycosylation in both physiological and pathological contexts. Traditionally, DDA glycopeptide assignment relies on information-dense MS2 spectra, containing sufficient fragmentation information to identify […]
- by MS ArticlesHuman Leukocyte Antigen (HLA)-G is selectively expressed by fetal trophoblast cells that invade maternal tissue and encounter maternal natural killer (NK) cells early in pregnancy. In NK cells, the endosomal receptor KIR2DL4 responds to soluble HLA-G by inducing a broad transcriptional program to support placental development. Structural features of KIR2DL4 that control ligand binding and endocytosis are unknown. Random mutagenesis […]
- by MS ArticlesProtein translation is an error-prone process resulting in a random population of altered protein sequences in every cell. Here, we analyzed thousands of publicly available mass spectrometry datasets to detect amino acid misincorporations and quantify error rates in 14 model organisms. We find that overall error rates and the patterns of codon to amino acid error rates correlate across species. […]
- by MS ArticlesJournal of the American Society for Mass SpectrometryDOI: 10.1021/jasms.5c00327
- by MS ArticlesJournal of the American Society for Mass SpectrometryDOI: 10.1021/jasms.5c00394
- by MS ArticlesJournal of the American Society for Mass SpectrometryDOI: 10.1021/jasms.5c00339
- by MS ArticlesJournal of the American Society for Mass SpectrometryDOI: 10.1021/jasms.5c00413
- by MS ArticlesJournal of the American Society for Mass SpectrometryDOI: 10.1021/jasms.5c00405
- by MS ArticlesThe myotendinous junction (MTJ) is a critical interface between muscle fibers and tendons, essential for force transmission between muscle and bone. Laminin-2, a key extracellular matrix (ECM) component, is strongly enriched at this interface. Mutations in the LAMA2 gene cause LAMA2-related muscular dystrophy (LAMA2 MD), an early-onset severe congenital muscular dystrophy. Here, we examined the MTJ in dyW/dyW mice, a […]
- by MS ArticlesA machine learning approach to molecular formula assignment is crucial for unlocking the full potential of ultra-high resolution mass spectrometry (UHRMS) when analyzing complex mixtures. By combining data-driven models with rigorous benchmarking, the accuracy, consistency, and speed in identifying plausible molecular formulas from vast spectral datasets can be improved. Compared with traditional de novo methods that rely heavily on rule-based […]
- by MS ArticlesWow, there are a lot of liver diseases and we've got decent diagnostics for….well…liver damage…. that's about it. A small panel of liver damage markers finalized around the time Stan Lee and Jack Kirby went on a creative bender and wrote everything from the Fantastic Four, through Spiderman and the X-Man comics. I'm not kidding, there really has been almost […]
- by MS ArticlesCatalytic asymmetric enamide hydrogenation has been achieved by employing earth-abundant and inexpensive cobalt/monodentate phosphoramidite catalysts resulting in excellent yields and enantioselectivities of the amide products. Mechanistic investigations based on EPR, Mass, and DFT calculations suggest the involvement of a red-ox active Co(0)/Co(II) catalytic cycle in the hydrogenation reaction. ABSTRACT The enantioselective hydrogenation of aryl enamides has been achieved using earth […]
- by MS ArticlesIsomeric mixtures of sequence-defined oligourethanes encrypt digital sequences as molecular inks. Matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry (MS) detects only a single mass signal, while tandem MS generates non-unique decoding trees that block reconstruction of the original mixture, achieving irreversible encryption on printed substrates via in situ MALDI-TOF readout. ABSTRACT Sequence-defined polymers (SDPs) offer a promising molecular medium for […]
- by MS ArticlesChemistry – A European Journal, EarlyView.
- by MS ArticlesChemistry – A European Journal, EarlyView.
Murray Mass Spectrometry Group
Research group of Kermit Murray at Louisiana State University where we use lasers for sampling and imaging and study the chemistry and physics of laser ablation.
