- by MS ArticlesJournal of the American Society for Mass SpectrometryDOI: 10.1021/jasms.4c00474
- by MS ArticlesBackground: While operative and perioperative care continues to improve for single ventricle congenital heart disease (SV), long-term morbidities and mortality remain high. Importantly, phosphodiesterase-5 inhibitor therapies (PDE5i) are increasingly used, however, little is known regarding the direct myocardial effects of PDE5i therapy in the SV population. Objectives: Our group has previously demonstrated that the failing SV myocardium is characterized by […]
- by MS ArticlesAnalytical ChemistryDOI: 10.1021/acs.analchem.4c06949
- by MS ArticlesAnalytical ChemistryDOI: 10.1021/acs.analchem.5c00386
- by MS ArticlesAnalytical ChemistryDOI: 10.1021/acs.analchem.5c00429
- by MS ArticlesJournal of Mass Spectrometry, Volume 60, Issue 4, April 2025.
- by MS ArticlesAge-related vascular changes accompany or precede the development of Alzheimer's disease (AD) pathology. The comorbidity of AD and arterial stiffening may suggest that vascular changes have a pathogenic role. Carotid artery mechanics and hemodynamics have been associated with age-related cognitive decline. However, the impact of hemodynamics and vascular mechanics on regional vulnerability within the brain have not been thoroughly explored. […]
- by MS ArticlesFor an old post on what a Lab Developed Test (LDT) is vs an In Vitro Diagnostic (IVD) you can go here. And…in what was an altogether extremely bad day for the FDA with thousands of people finding out when they tried to use their badges and they simply didn't work – they also lost a federal appeal in this recent […]
- by MS ArticlesABSTRACT Rationale Matrix effects by secondary ion mass spectrometry (SIMS) are empirically corrected by calibration using matrix-matched reference materials. However, conventional parametric regression cannot estimate the prediction uncertainty to account for the difference in compositions of new data and reference materials. Applying Gaussian process regression (GPR), a nonparametric probabilistic method, enables the correction for matrix effect while providing quantitative prediction […]
- by MS ArticlesABSTRACT The cold/hot properties of Chinese materia medica (CMM) are the core theory of traditional Chinese medicine (TCM). This study aims to investigate the cold/hot properties of CMM and find the possible mechanisms related to CMM properties using liquid chromatography-mass spectrometry (LC-MS)-based metabolomics combined with network pharmacology analysis. Typical cold and hot CMMs were given to mice by intragastric administration. […]
- by MS ArticlesABSTRACT Tripterygium glycosides (TGs), the primary active components of Tripterygium wilfordii, have demonstrated therapeutic efficacy in treating diabetic kidney disease (DKD). However, the precise mechanisms underlying their action remain elusive, limiting the full realization of their medicinal potential. This study employed serum metabolomics based on liquid chromatography–mass spectrometry (LC-MS) analysis to elucidate the mechanisms by which TGs combat DKD. We […]
- by MS ArticlesJournal of Agricultural and Food ChemistryDOI: 10.1021/acs.jafc.5c00349
- by MS ArticlesJournal of the American Society for Mass SpectrometryDOI: 10.1021/jasms.4c00447
- by MS ArticlesPublication date: Available online 30 March 2025Source: International Journal of Mass SpectrometryAuthor(s): Xiao-Fei Gao, Wei Xiao, Meng Qiu, Zhi-Gang Cheng, Xiang-Zhao Chen
- by MS ArticlesYeah! Proteomics is bigtime! Check out this 1) Instanovo is finally out and 2) 2 people I know were interviewed about it and they seem to think it's smart! Instanovo final paper here.
- by MS ArticlesAnalytical ChemistryDOI: 10.1021/acs.analchem.5c00284
- by MS ArticlesJournal of Mass Spectrometry, Volume 60, Issue 4, April 2025.
- by MS ArticlesHistones, the core components of nucleosomes, play an important role in chromatin structure and function through post-translational modifications (PTMs) that regulate gene expression without altering the DNA sequence. Sugarcane (Saccharum spp.), a highly polyploid and economically significant crop, has a complex genome with a limited understanding of histone PTMs. In this study, we employed mass spectrometry to characterise the PTMs […]
- by MS ArticlesYou know – I was really pumped when my kid's puppy was like "HEY HEY HEY GUY I HATE, WAKE UP OR I'M ABSOLUTELY GOING TO TAKE A DUMP IN YOUR APARTMENT!!" So we walked in the pouring rain without either of our coats until she found the absolute perfect place to poop about 3 blocks from our apartment at 4am. And […]
- by MS ArticlesHistorical artifacts preserved in museums are invaluable cultural treasures, yet they are often vulnerable to biodeterioration caused by microbial colonization. This study presents the first comprehensive investigation of microbial communities inhabiting heritage artifacts from Argentina's Museum of Independence. By integrating advanced microscopy with phenotypic and genomic characterization, we analyzed samples collected from wooden objects, textiles, architectural elements, and exterior walls. […]
Murray Mass Spectrometry Group
Research group of Kermit Murray at Louisiana State University where we use lasers for sampling and imaging and study the chemistry and physics of laser ablation.
