Mass spectrometry RSS feeds from journals and social media.
- by MS ArticlesMolecular glue degraders (MGDs) are proximity-inducing molecules that promote the destruction of disease-causing proteins by stabilizing novel interfaces between E3 ubiquitin ligases and target proteins. The rational design of MGDs remains exceptionally challenging, historically relying on serendipitous discoveries. Here, we deployed a high-throughput, mass spectrometry (MS)-based screen evaluating thousands of cereblon (CRBN)-directed compounds to expedite the identification of novel neosubstrates. This workflow led to the discovery of NE26394, a first-in-class MGD that selectively eliminates cyclin-dependent kinase 4 (CDK4), a critical […]
- by MS ArticlesAnalyst, 2026, Accepted ManuscriptDOI: 10.1039/D6AN00421K, PaperYang Liu, Zhengyang Guo, Siyang Qin, Xuxiao Zhao, Xiaopei Wu, Jing Jing, Jianghai LuIn this study, the metabolic profiles of MK-3984, a selective androgen receptor modulator (SARM) targeting muscle and bone tissues, were comprehensively investigated for the first time using Quadrupole Orbitrap LC-MS/MS…The content of this RSS Feed (c) The Royal Society of Chemistry
- by MS ArticlesChemistry â A European Journal, Volume 32, Issue 23, 16 June 2026.
- by MS ArticlesChemistry â A European Journal, EarlyView.
- by MS ArticlesInositol phosphates (InsPs) and inositol pyrophosphates (PP-InsPs) are key regulators of cellular signaling and metabolism, yet developmental changes in the InsP/PP-InsP network in eukaryotic systems remain poorly understood. Here, we combine isomer-resolved capillary electrophoresis-mass spectrometry (CE-MS) with genetic perturbations to characterize InsP metabolism during the Drosophila melanogaster development. Our analyses reveal extensive developmental reprogramming of the InsP pathway, with early developmental stages exhibiting broad lower-order isomer diversity that progressively narrows into a more restricted metabolic state enriched in Ins(1,3,4,5,6)P5, InsP6, […]
- by MS ArticlesPublication date: 1 December 2026Source: Talanta, Volume 310Author(s): EliĂŠzer de Oliveira, Carla Beatriz Grespan Bottoli
- by MS ArticlesScaling covalent ligand discovery through dynamic combinatorial library-versus-proteome screening
- by MS ArticlesJournal of Mass Spectrometry, Volume 61, Issue 7, July 2026.
- by MS ArticlesCapelin (Mallotus villosus), a key forage fish in the Northwest Atlantic, links zooplankton to predators including commercial fishes, seabirds, and marine mammals, yet its life-cycle movements in the Gulf of St. Lawrence (GSL) remain poorly understood. Between 2022 and 2024, otoliths from 927 individuals collected during and after spawning were analysed by Laser Ablation Inductively Coupled Plasma Mass Spectrometry (LA-ICP-MS). Building on previous work on regional structuring, seven trace elements (Li, B, Mg, K, Zn, Sr, Ba) were used to […]
- by MS ArticlesABSTRACT Rationale Nitrilases are widely used as biocatalysts in pharmaceutical manufacturing because of their high stereoselectivity and mild reaction conditions. However, residual nitrilase in final drug products may compromise product quality and safety, highlighting the need for sensitive and reliable analytical methods for its monitoring and control. Methods In this study, a liquid chromatographyâtandem mass spectrometry (LCâMS/MS) method was developed for the determination of residual nitrilase in pharmaceutical formulations. Results Recombinant nitrilase expressed in Escherichia coli was purified by Ni2+ […]
- by MS ArticlesABSTRACT Rationale Ametryn poses significant risks to aquatic ecosystems, but conventional MRM methods suffer from matrix interference and limited sensitivity. To overcome these limitations, we established a more selective and sensitive UHPLC-MS3 approach that effectively suppresses background noise and enhances signal-to-noise ratio, enabling reliable quantification of ametryn in zebrafish tissues. Methods A novel UHPLC-MS3 method with electrospray ionization was developed. Quantification employed the MS3 transition m/z 228.0âââ186.1âââ158.0. Five zebrafish tissues (liver, muscle, brain, intestine, gill) were analyzed following sample preparation. […]
- by MS ArticlesConstructing atomically coupled WâOâRu interfacial units on RuO2 triggers a dynamic strain evolution during the oxygen evolution reaction. An initial tensile strain secures structural stability, while a self-adjusting transition to interfacial compression optimizes catalytic activity. This dynamic strain engineering effectively decouples the long-standing activity-stability trade-off, enabling highly efficient and durable acidic water oxidation. ABSTRACT Developing highly active and durable acidic oxygen evolution reaction (OER) electrocatalysts remains a central challenge for proton-exchange membrane water electrolysis (PEMWE). Here, we combine theory-guided design, […]
- by MS ArticlesManaging plastic pollution is challenging because current physical and chemical recycling methods are inefficient and environmentally intensive. Biological recycling approaches have been framed as sustainable alternatives but are challenging to optimize due to a lack of process analytical technologies that provide real-time data on microbial plastic metabolism. In this study, we used Piscinibacter sakaiensis 201-F6, a model bacterium with a well-studied polyethylene terephthalate (PET) metabolism, to validate non-destructive Raman spectroscopy methods to monitor plastic biodegradation by tracking metabolite production. Cells […]
- by MS ArticlesLiquid chromatography-mass spectrometry (LC-MS) untargeted metabolomics detects thousands of metabolic features, but converting these chemical signals into metabolite set-level biological knowledge remains challenging. This is because most features lack unambiguous metabolite identities. Conventional metabolite set enrichment analysis (MSEA) generally requires identified metabolites and metabolite-level ranked inputs, leaving much of the untargeted feature space unused. Here, we present FeatureMSEA, a feature rank-based framework for metabolite set enrichment directly from metabolic features with ambiguous annotations. FeatureMSEA integrates multi-evidence feature-to-metabolite annotation, feature rank-based […]
- by MS ArticlesMelanocortin 2 receptor (MC2R) is a G protein-coupled receptor (GPCR) for adrenocorticotropic hormone (ACTH), and its trafficking and signalling are associated with the melanocortin receptor accessory protein (MRAP). Mutations in either MC2R or MRAP disrupt this signalling and cause familial glucocorticoid deficiency. Here, we combine native mass spectrometry (MS) and hydrogen deuterium exchange mass spectrometry (HDX MS) to uncover how MRAP association and post-translational modification status shape the conformations of MC2R. Using native MS, we demonstrate that MC2R associates with […]
- by MS ArticlesPost-translational modifications usually occur under enzymatic control as a mechanism for regulation of protein activity or localization, but can also occur spontaneously during protein aging and degradation. In contrast, there are few examples of spontaneous post-translational modifications with a significant role in the stability or biochemical function of a bacterial protein. Here we show that a spontaneous post-translational modification is structurally encoded and functionally important in a bacterial solute-binding protein. We show that the solute-binding protein SAR11_0655 from the abundant […]
- by MS ArticlesABSTRACT Rationale Schisandrol B (Sol B) is a major bioactive lignan compound extracted from the dried fruits of Schisandra chinensis (Turcz.) Baill. with comprehensive pharmacological activities. The study aims to investigate the metabolic stability and metabolic characteristics of Sol B in rat liver microsomes (RLMs) and human liver microsomes (HLMs) and further clarify the metabolic differences among different species. Method The in vitro incubation systems included 5âÎźM Sol B and 0.5âmg/mL HLMs or RLMs in the presence of NADPH (5âmM) at […]
- by MS ArticlesABSTRACT Rationale Teriparatide (TPT) is a synthetic peptide primarily used in the clinical treatment of osteoporosis, with its reference materials available from both synthetic and recombinant DNA origin used for generic drug preparations. Considering the potential toxicological effects of structurally related impurities, systematic characterisation of the impurity profiles of TPT reference materials arising from different synthetic sources is essential for regulatory evaluations of generic drugs' safety and efficacy. Methods One commercially available chemical synthesis material and two recombinant synthesis pharmacopoeia […]
- by MS ArticlesHigh-resolution mass spectrometry is routinely used for the analysis of complex samples in pharmaceutical, environmental, and omics related studies. Such applications require instrumentation to be capable of combining sub-ppm mass accuracy, high resolving power, rapid full m/z range acquisition, and a wide dynamic range. Achieving these requirements simultaneously places constraints on analyzer design and performance. Multi-reflecting time-of-flight (MRT) based analyzers have been previously reported as a means of extending effective flight path length in compact TOF designs. Here, further instrument […]
- by MS ArticlesThe roles of reactive oxygen species (ROS) as signaling molecules and inhibitors of phytoplankton growth are well documented. While phytoplankton physiological mechanisms for ROS detoxification are well characterized, the role of heterotrophic bacterial partners in ROS alleviation and outcomes for these bacteria remain poorly understood. Here, we examined how extracellular hydrogen peroxide (H2O2) shapes nutrient exchange between the diatom Phaeodactylum tricornutum and two phycosphere bacteria. From an initial screen of 20 bacteria, we identified a "helper" (Muricauda sp.) that enabled […]
- by MS ArticlesBackground Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-ToF MS) is widely used for sand fly identification, but its potential to detect Leishmania infections in vectors remain underexplored. This pilot study evaluated whether MALDI-ToF MS protein profiles of lab-reared Lutzomyia longipalpis and Nyssomyia neivai can discriminate Leishmania infantum-infected from uninfected females. Methodology Colonies were experimentally infected with L. infantum using membrane feeding, and females were collected at different days post-blood meal. Thoraces and legs were processed individually for MALDI-ToF MS, and […]
- by MS ArticlesLate endosome-dependent viruses, including filo- and arenaviruses, rely on host endolysosomal trafficking for productive infection. Here, we used a dual-colour Vesicular stomatitis virus (VSV) based pseudoparticle screen of CytoSorb-derived fractions to identify inhibitors of the Zaire Ebolavirus glycoprotein (GP)-mediated entry. Iterative chromatographic purification and mass spectrometry identified Laudanosine, a degradation product of the clinically used neuromuscular blocker Atracurium, as the antiviral compound. Laudanosine specifically inhibited entry mediated by Ebola, Marburg, Lymphocytic choriomeningitis and Lassa virus glycoproteins without affecting VSV-G-dependent entry. […]
- by MS ArticlesImpaired contractility and reduced myocardial energetic reserve underlie heart failure with reduced ejection fraction. Catecholaminergic inotropes such as dobutamine are used to augment cardiac output. However, dobutamine increases Ca2+ cycling, raising ATP demand and worsening energetic stress. The myotrope CK-138 increases contractility by directly activating myosin, sparing the added energetic cost of Ca2+ handling. This study compares CK-138 and dobutamine with respect to the relationship between contractile performance and myocardial energetic state, including high-energy phosphate balance, energetic efficiency, and substrate-specific […]
- by MS ArticlesEuropean Journal of Mass Spectrometry, Ahead of Print. Electron-induced ionisation cross-sections and corresponding ionisation rate coefficients have been evaluated for the CâFâ molecule. Evaluated results by using the JainâKhare semi-empirical approach of the total ionisation cross-section showing good …
- by MS ArticlesStill looking for the right equipment for your #MassSpec research?We offer a wide range of MS Consumables (e.g., spray emitters, nlc columns, ion sources), Services (e.g., filament repair) and Software Solutions (e.g., NIST, Wiley, SIMION, etc.). Visit: https://www.mswil.com/