Mass spectrometry RSS feeds from journals and social media.
- by MS ArticlesThe transition to motherhood involves profound physiological and neural changes, including adaptations in the sensory systems that support infant care. While the olfactory system plays a critical role in guiding maternal behaviors such as pup retrieval and nesting, how olfactory processing itself is reshaped during motherhood remains poorly understood. Here, we show that firsttime mothers develop a selective preference for pup urine following parturition and early postpartum care, a preference not observed for other social or neutral odors. Using odor […]
- by MS ArticlesCannabis is widely consumed worldwide, yet its health impacts remain contested due to the presence of both potentially harmful carcinogens and bioactive compounds with therapeutic promise. This study investigated the chemical composition of cannabis smoke generated from three strains when consumed via joints and bongs, with a focus on whether bong water effectively filters harmful compounds. Smoke samples were analyzed using gas chromatography mass spectrometry (GCMS). Across all samples, the smoke composition between bong and joint methods was largely consistent, […]
- by MS ArticlesAnalytical ChemistryDOI: 10.1021/acs.analchem.5c03853
- by MS ArticlesPROTEOMICS, EarlyView.
- by MS ArticlesABSTRACT Rationale Chixiaodou Danggui San (CDS), composed of Vignae semen (VS) and Angelicae sinensis radix (ASR), has been utilized for the treatment of hemorrhoids in China. However, the chemical profiling of CDS remains insufficiently explored. Therefore, it is necessary to establish an accurate and rapid method for the chemical profiling of CDS. Methods The structure elucidation of natural products using ultra-high performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry (UHPLC-QTOF-MS/MS), despite its exceptional capabilities, remains limited due to […]
- by MS ArticlesABSTRACT Rationale Suzetrigine, a recently approved NaV1.8 sodium channel blocker, shows strong potential in the treatment of neurological, psychiatric, and pain-related conditions. Its peripheral selectivity enables effective pain management while avoiding central nervous system complications and addiction risks linked to opioid use. Following FDA approval in January 2025, concerns have emerged regarding its possible misuse for performance enhancement in sports, highlighting the need for reliable detection tools in doping control. Methods An analytical procedure was designed and validated to detect […]
- by MS ArticlesEpigenetic modifications are dynamic and reversible, making them attractive targets for therapeutic intervention in cancer. Although several epigenetic drugs (epidrugs) have been clinically approved, their application in T-cell acute lymphoblastic leukemia (T-ALL) remains limited, and predictive biomarkers of response are lacking. Here, we present a mass spectrometry (MS)-based pharmacoepigenetic approach to profile histone post-translational modifications (hPTMs) to identify signatures associated with epidrug sensitivity in T-ALL. Baseline hPTM landscapes were previously established by our group for 21 T-ALL cell lines using […]
- by MS ArticlesNucleoside analogs (NAs) have been successfully used to treat viral infections. dNTP analogs are primarily DNA chain terminators, while NTP analogs, such as remdesivir, can inhibit as delayed chain terminators or when in the template strand. Determining the frequency of remdesivir triphosphate (RTP) incorporation in the presence of the competing ATP can help in understanding different modes of viral RNA-dependent RNA polymerase (RdRp) inhibition by NTP analogs. We employed enzymatic assays, mass spectrometry, and cryo-EM to show that SARS-CoV-2 RdRp […]
- by MS ArticlesPublication date: Available online 3 September 2025Source: International Journal of Mass SpectrometryAuthor(s): P.B. Armentrout, Bastiaan Poetsma, David H. Loertscher, Satish Kumar, Joost M. Bakker
- by MS ArticlesStomatin, originally discovered in red blood cells, is a member of the SPFH (Stomatin, Prohibitin, Flotillin, and HflK/C) protein family, which has long been proposed to scaffold functional membrane microdomains (FMMs) enriched in saturated lipids such as cholesterol and sphingomyelin. Stomatin has been reported to associate with a variety of proteins involved in diverse physiological processes, including ion channel regulation, membrane fusion, mechanosensory regulation and vesicle trafficking; however, the mechanisms by which it modulates these interactions remain poorly understood. Here, […]
- by MS ArticlesAnal. Methods, 2025, Advance ArticleDOI: 10.1039/D5AY00950B, PaperMengmeng Yan, Yujie Xie, Mengjie Shi, Xingqiang Wu, Kaixuan Tong, Qiaoying Chang, Hui ChenIn this study, a modified QuEChERS method for the simultaneous determination of 73 pesticides, 23 PCBs and 16 PAHs in wheat was developed by gas chromatography-triple quadrupole tandem mass spectrometry (GC-MS/MS).To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry
- by MS ArticlesPeripheral Myelin Protein 22 (PMP22) is a tetraspan membrane protein whose altered dosage causes the most common hereditary neuropathy, Charcot-Marie-Tooth disease type 1A (CMT1A). Despite its clinical significance, the physiological functions of PMP22 and the mechanism behind its tightly controlled gene dosage sensitivity remain unknown since over 30 years, in part due to limited knowledge of its protein-protein interactions (PPIs). In fact, integral membrane proteins such as PMP22 are significantly underrepresented in known cellular interactomes, likely due to limited suitability […]
- by MS ArticlesPublication date: Available online 3 September 2025Source: Analytica Chimica ActaAuthor(s): Jiacheng You, Anqi Chen, Jianxiong Qiu, Yaling Ye, Chongchong Mei, Guanghou Fu, Baiye Jin, Luhong Wen
- by MS ArticlesPublication date: Available online 3 September 2025Source: Journal of Chromatography AAuthor(s): Tiefeng Xu, Xiangjie Meng, Gangqiang Wang, Wangyang Lu
- by MS ArticlesI totally hoped this was going to be an untargeted plasma proteomics at low resolution/high speed paper, but that's okay, it's still pretty cool.Now…if the price of this fast little ion trap would come down to an appropriate price range… we'd be in business. Do you want 5ppm mass accuracy on a benchtop Orbi that's WAY slower? Or 15ppm mass accuracy on a TOF that is the same speed as this cool little ion trap? Or is 800ppm an okay […]
- by MS ArticlesI'm going to leave this here. I think it's a really intesting study, but I'm a little surprised by the conclusions. Caution is always good, and this paper is all about limitations of blood (spot?) forensics. While machine learning classifiers appear underpowered to make accurate determinations, I really wonder if a targeted analysis of specific proteins and peptides – in this same set of data – would come up with the same limitations…. Also – in case you haven't seen it, […]
- by MS ArticlesJournal of the American Society for Mass SpectrometryDOI: 10.1021/jasms.5c00234
- by MS ArticlesABSTRACT Ropivacaine is a local anesthetic commonly used in veterinary anesthesia. A liquid chromatography–mass spectrometry (LC–MS) method was developed to quantify free and total ropivacaine in dog plasma, which included rapid equilibrium dialysis. The method was validated for selectivity, specificity, matrix effect, calibration curve and range, accuracy and precision, carry-over, stability, and reinjection reproducibility according to the International Conference on Harmonization M10 guidelines. After ultra-high performance liquid chromatographic (UHPLC) separation, detection and quantification of ropivacaine was performed using a triple […]
- by MS ArticlesABSTRACT Hepatocellular carcinoma (HCC) stands as a globally common malignancy with persistently elevated incidence and mortality rates. It is known for being able to resist conventional chemotherapy. There is currently growing interest in natural products for the treatment of HCC, owing to their significant antitumor activity. Osthole, a naturally occurring O-methylated coumarin in Cnidium monnieri (L.) Cusson, showed potent antitumor effects on various types of cancer. It plays a therapeutic role in HCC by inducing apoptosis and inhibiting proliferation. Nevertheless, […]
- by MS ArticlesPROTEOMICS, EarlyView.
- by MS ArticlesNeurokine Sam2 deficiency is associated with behavioral abnormalities including heightened anxiety and fear responses across evolutionarily conserved model organisms. Here, we employed an integrated proteomics and metabolomics approach using liquid chromatography-mass spectrometry (LC-MS) to elucidate molecular signatures associated with autism spectrum disorder (ASD) in Sam2 knockout mice. Comparative analysis of blood plasma samples from Sam2 knockout and wild-type mice revealed substantial alterations in both proteomic and metabolomic profiles. Proteomic analysis identified 68 differentially expressed proteins (comprising 102 peptides), with notable […]
- by MS ArticlesAnal. Methods, 2025, Accepted ManuscriptDOI: 10.1039/D5AY00250H, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Jörg Fabian, Matthias LehrAn automated on-line dilution on-line solid-phase extraction liquid chromatography-mass spectrometry method was developed for the straightforward and versatile quantitative profiling of lipid mediators such as various eicosanoids, endocannabinoids, and arachidonic…The content of this RSS Feed (c) The Royal Society of Chemistry
- by MS ArticlesJournal of Proteome ResearchDOI: 10.1021/acs.jproteome.5c00287
- by MS ArticlesPublication date: December 2025Source: Journal of Mass Spectrometry and Advances in the Clinical Lab, Volume 38Author(s): Tjaša Dermota, Mojca Božič Mijovski, Jurij Trontelj
- by MS ArticlesPublication date: Available online 3 September 2025Source: Journal of Chromatography BAuthor(s): Yueting Li, Yan Cao, Tengteng Wang, Shengnan Cai, Yun Qiao, Chao Cheng, Jiale Gao, Jie Liu, Hongbin Xiao