Mass spectrometry RSS feeds from journals and social media.
- by MS ArticlesMan, sometimes y'all send me papers and totally ruin what was otherwise a really focused run or something. This paper is certainly the case, because it is a fix for something I had no idea was an issue. We've had ICP-MS of single cells for at least a decade. Maybe much longer? I don't know. There is even a commercial FACs coupled ICP-MS thing that I'd love to have. So when this paper popped up in my inbox with the suggestion […]
- by MS ArticlesAnalyst, 2025, Accepted ManuscriptDOI: 10.1039/D4AN01447B, PaperHongyan Bi, Mingyue Yu, Yunxing Li, Yuean ChuThe expansion of the seafood market has led to an increased probability of food fraud. The development of rapid and reliable traceability methods for aquatic food products is of utmost…The content of this RSS Feed (c) The Royal Society of Chemistry
- by MS ArticlesSynapses are essential for neuronal function and are central to numerous neurological disorders including developmental and neurodegenerative diseases. Synapses structurally constitute a very small proportion of a neuron, and their protein content is difficult to study using whole tissue preparations. Especially studying synapses on the functional level is challenging. To overcome this limitation, synapses can be captured as synaptosomes generated through enrichment of isolated nerve terminals. Such synaptosomes have a re-sealed plasma membrane and can regenerate their membrane potential and […]
- by MS ArticlesPublication date: Available online 21 January 2025Source: Journal of Chromatography AAuthor(s): Ana Castiñeira-Landeira, Samantha Sasse, Melissa Broeren, Saskia S. Sterk, A. Arrizabalaga-Larrañaga
- by MS ArticlesAbstract The use of single-guide RNA (sgRNA) for gene editing using the CRISPR Cas9 system has become a powerful technique in various fields, especially with the growing interest in such molecules as therapeutic options in the last years. An important parameter for the use of these molecules is the verification of the correct sgRNA oligonucleotide sequence. Apart from next-generation sequencing protocols, mass spectrometry (MS) has been proven as a powerful technique for this purpose. The protocol and investigations presented in […]
- by MS ArticlesJournal of the American Society for Mass SpectrometryDOI: 10.1021/jasms.4c00423
- by MS ArticlesJournal of the American Society for Mass SpectrometryDOI: 10.1021/jasms.4c00410
- by MS ArticlesAnal. Methods, 2025, Accepted ManuscriptDOI: 10.1039/D4AY02223H, PaperJia-Jia Li, Lu Kou, Jun Li, Pei-Yu Shi, Tian-Rong Guo, Quan-Wei Xiao, Min Zhang, Wenlin Wu, Yi WangA method involving gas chromatography coupled with quadrupole/orbitrap high-resolution mass spectrometry (GC-Q/Orbitrap HRMS) with QuEChERS method was developed to analyze 36 non-phthalate plasticizers in milk powder products. The samples were…The content of this RSS Feed (c) The Royal Society of Chemistry
- by MS ArticlesAnal. Methods, 2025, Accepted ManuscriptDOI: 10.1039/D4AY02040E, PaperHaiyan Gao, Yueguang Lv, Wenjing Zhao, Songying Wang, Jiayu Zhao, Yisheng Xu, Yuhan Shang, Renyu Zhang, Qiang MaRapid and accurate methods for tracing and identifying the origin of lamb are crucial for ensuring food authenticity and quality. This study developed a precise traceability method to determine the…The content of this RSS Feed (c) The Royal Society of Chemistry
- by MS ArticlesABSTRACT Rationale Panax quinquefolius L. (PQ), a commonly used traditional Chinese medicine and a food, is usually processed into various products, including white PQ, red PQ (two- or three-time steamed PQ), and black PQ (nine-time steamed PQ). Previous studies demonstrated that volatile components (VOCs) were the important active substances of PQ, which had antibacterial, antiviral, and anti-leukemia activities. However, most research had focused on ginsenosides, and few studies on the volatile components (VOCs) of PQ. Methods This study used gas […]
- by MS ArticlesNatural products (NP) are instrumental in drug development, but their discovery and validation remain challenging and laborious despite advances in both genomic and analytical technologies. In this study, we demonstrate the use of an integrated multi-modal characterization of a microbial strain library for enhanced natural product discovery. This characterization utilizes language- and transformer-based models, integrated through a cross-validate and rank approach to search a mass spectrometry (MS)-genome multi-modal dataset with high confidence. MS data are analysed using an in-house developed […]
- by MS ArticlesABSTRACT Advancements in food technology have increased the need for thorough analysis to ensure food safety, quality, and compliance with regulatory requirements. Capillary electrophoresis–mass spectrometry (CE–MS) has emerged as a powerful tool in food analysis due to its high separation efficiency, low sample consumption, and ability to handle complex matrices. However, challenges such as the use of volatile running buffers and maintaining the stability of the electrical circuit connecting the CE and MS systems have been addressed through advancements in […]
- by MS ArticlesABSTRACT A significant limitation of imaged capillary electric focusing (icIEF) is the inability to identify and characterize specific species in the electropherogram. This has led to the development of complementary ion-exchange chromatography (IEX)-based methods that are amenable to either fraction collection and subsequent characterization or online IEX coupled to mass spectrometry. To overcome this limitation while maintaining the use of icIEF, novel approaches, including an icIEF separation and fractionation technology (MauriceFlex, ProteinSimple), have been developed. This approach enables the fractionation […]
- by MS ArticlesAbstract The wide range of mass spectrometry imaging (MSI) technologies enables the spatial distributions of many analyte classes to be investigated. However, as each approach is best suited to certain analytes, combinations of different MSI techniques are increasingly being explored to obtain more chemical information from a sample. In many cases, performing a sequential analysis of the same tissue section is ideal to enable a direct correlation of multimodal data. In this work, we explored different workflows that allow sequential […]
- by MS ArticlesAnalytical ChemistryDOI: 10.1021/acs.analchem.4c05968
- by MS ArticlesAnalytical ChemistryDOI: 10.1021/acs.analchem.4c03621
- by MS ArticlesAnalytical ChemistryDOI: 10.1021/acs.analchem.4c06062
- by MS ArticlesJournal of the American Society for Mass SpectrometryDOI: 10.1021/jasms.4c00399
- by MS ArticlesJournal of the American Society for Mass SpectrometryDOI: 10.1021/jasms.4c00443
- by MS ArticlesHydrogen/deuterium exchange mass spectrometry (HX-MS) is a method used to study solution-phase protein structure and dynamics. Despite its many applications, HX-MS is limited in throughput because manual data analysis is still the norm. We previously developed HX-MS2 technology to add a second dimension of deuteration data and promote automated data processing. Data-independent acquisition (DIA) techniques enable this approach, but we require optimized methods for best performance. Using an Orbitrap Eclipse for illustration, we show that ion optics and collision energy […]
- by MS ArticlesChronic Wasting Disease (CWD) is a universally fatal, transmissible prion disease affecting cervids. Primarily found among deer populations in North America, the disease has spread across the continent and made forays into Europe and Asia as well. Currently, accurate methods for detecting CWD infection require post-mortem dissection of the lymph nodes and brainstem of affected animals. New, high-sensitivity methods of detecting CWD in living animals are sorely needed to help curb spread of this devastating disease in farmed and wild […]
- by MS ArticlesConventional human pluripotent stem cells (hPSCs) are widely used to study early embryonic development, generate somatic cells, and model diseases, with differentiation potential aligned to a post-implantation epiblast identity. In the past decade, naive hPSCs, representing a pre-implantation stage, have been derived. Naive hPSCs efficiently differentiate towards embryonic and extraembryonic lineages such as trophectoderm, primitive endoderm, and extraembryonic mesoderm, and also self-organize into blastocyst-like structures called blastoids. However, their culture typically relies on mouse embryonic fibroblasts (MEFs), which are variable, […]
- by MS ArticlesMascot Server has a lot of functionality and it's sometimes hard to know where to start. The online help now has a table of example data sets shipped with Mascot, including links to the corresponding help topics.https://www.matrixscience.com/help.html#EXAMPLES#proteomics #MassSpec
- by MS ArticlesATP-binding cassette (ABC) transporters use ATP to transport substrates across cellular membranes. In type IV ABC transporters, including many multidrug resistance (MDR) pumps, communication between the nucleotide-binding domains (NBDs) and transmembrane domains (TMDs) occurs via intracellular coupling helices. However, the precise mechanism of interdomain crosstalk and coordination between the ATP and substrate binding sites remain unclear. Combining nuclear magnetic resonance (NMR) spectroscopy, Hydrogen-Deuterium eXchange Mass Spectrometry (HDX-MS), photo-induced electron-transfer fluorescence correlation spectroscopy (PET-FCS) and functional assays, we identified a conserved […]
- by MS ArticlesEnteroendocrine cells (EECs) are rare sensory cells in the intestinal epithelium that coordinate digestive physiology by secreting a diverse repertoire of peptide hormones. These hormones are the main effectors of EEC function, and their characterization requires direct observation by mass spectrometry due to the specialized protein cleavage and posttranslational modifications that yield their mature forms. Based on the distinct subset of hormones they predominantly secrete, EECs can be categorized into subtypes. How each EEC subtype is specified, however, remains poorly […]