Mass spectrometry RSS feeds from journals and social media.
- by MS ArticlesJournal of the American Society for Mass SpectrometryDOI: 10.1021/jasms.4c00474
- by MS ArticlesBackground: While operative and perioperative care continues to improve for single ventricle congenital heart disease (SV), long-term morbidities and mortality remain high. Importantly, phosphodiesterase-5 inhibitor therapies (PDE5i) are increasingly used, however, little is known regarding the direct myocardial effects of PDE5i therapy in the SV population. Objectives: Our group has previously demonstrated that the failing SV myocardium is characterized by increased PDE5 activity and impaired mitochondrial bioenergetics. Here we sought to determine whether serum circulating factors contribute to pathological metabolic […]
- by MS ArticlesAnalytical ChemistryDOI: 10.1021/acs.analchem.4c06949
- by MS ArticlesAnalytical ChemistryDOI: 10.1021/acs.analchem.5c00386
- by MS ArticlesAnalytical ChemistryDOI: 10.1021/acs.analchem.5c00429
- by MS ArticlesJournal of Mass Spectrometry, Volume 60, Issue 4, April 2025.
- by MS ArticlesAge-related vascular changes accompany or precede the development of Alzheimer's disease (AD) pathology. The comorbidity of AD and arterial stiffening may suggest that vascular changes have a pathogenic role. Carotid artery mechanics and hemodynamics have been associated with age-related cognitive decline. However, the impact of hemodynamics and vascular mechanics on regional vulnerability within the brain have not been thoroughly explored. Despite the venous system's role in transport, the impact of age-related alterations of the brain venous circulation on cognitive impairment […]
- by MS ArticlesFor an old post on what a Lab Developed Test (LDT) is vs an In Vitro Diagnostic (IVD) you can go here. And…in what was an altogether extremely bad day for the FDA with thousands of people finding out when they tried to use their badges and they simply didn't work – they also lost a federal appeal in this recent ruling.The American Clinical Lab Association sued to overturn FDA's new rules for moving all new (?) or all (?) diagnostics […]
- by MS ArticlesABSTRACT Rationale Matrix effects by secondary ion mass spectrometry (SIMS) are empirically corrected by calibration using matrix-matched reference materials. However, conventional parametric regression cannot estimate the prediction uncertainty to account for the difference in compositions of new data and reference materials. Applying Gaussian process regression (GPR), a nonparametric probabilistic method, enables the correction for matrix effect while providing quantitative prediction uncertainty. Methods We developed GPR models for estimating instrumental mass fractionation (IMF). Magnesium isotope dataset of 17 olivine reference materials […]
- by MS ArticlesABSTRACT The cold/hot properties of Chinese materia medica (CMM) are the core theory of traditional Chinese medicine (TCM). This study aims to investigate the cold/hot properties of CMM and find the possible mechanisms related to CMM properties using liquid chromatography-mass spectrometry (LC-MS)-based metabolomics combined with network pharmacology analysis. Typical cold and hot CMMs were given to mice by intragastric administration. The metabolomics analyses showed that cold/hot CMMs induced metabolome changes by modulating arginine and proline metabolism, tricarboxylic acid cycle, fatty […]
- by MS ArticlesABSTRACT Tripterygium glycosides (TGs), the primary active components of Tripterygium wilfordii, have demonstrated therapeutic efficacy in treating diabetic kidney disease (DKD). However, the precise mechanisms underlying their action remain elusive, limiting the full realization of their medicinal potential. This study employed serum metabolomics based on liquid chromatography–mass spectrometry (LC-MS) analysis to elucidate the mechanisms by which TGs combat DKD. We evaluated the protective effects of TGs on DKD following treatment. Serum samples were collected before and after treatment, and their […]
- by MS ArticlesJournal of Agricultural and Food ChemistryDOI: 10.1021/acs.jafc.5c00349
- by MS ArticlesJournal of the American Society for Mass SpectrometryDOI: 10.1021/jasms.4c00447
- by MS ArticlesPublication date: Available online 30 March 2025Source: International Journal of Mass SpectrometryAuthor(s): Xiao-Fei Gao, Wei Xiao, Meng Qiu, Zhi-Gang Cheng, Xiang-Zhao Chen
- by MS ArticlesYeah! Proteomics is bigtime! Check out this 1) Instanovo is finally out and 2) 2 people I know were interviewed about it and they seem to think it's smart! Instanovo final paper here.
- by MS ArticlesAnalytical ChemistryDOI: 10.1021/acs.analchem.5c00284
- by MS ArticlesJournal of Mass Spectrometry, Volume 60, Issue 4, April 2025.
- by MS ArticlesHistones, the core components of nucleosomes, play an important role in chromatin structure and function through post-translational modifications (PTMs) that regulate gene expression without altering the DNA sequence. Sugarcane (Saccharum spp.), a highly polyploid and economically significant crop, has a complex genome with a limited understanding of histone PTMs. In this study, we employed mass spectrometry to characterise the PTMs of histones in internodes of field-grown commercial sugarcane, harvested at different times of the day, with a focus on histones […]
- by MS ArticlesYou know – I was really pumped when my kid's puppy was like "HEY HEY HEY GUY I HATE, WAKE UP OR I'M ABSOLUTELY GOING TO TAKE A DUMP IN YOUR APARTMENT!!" So we walked in the pouring rain without either of our coats until she found the absolute perfect place to poop about 3 blocks from our apartment at 4am. And then my Inbox was like – "HEY HEY HEY GUESS WHAT! YOU'RE GOING TO HAVE TO TOTALLY INSTALL R STUDIO […]
- by MS ArticlesHistorical artifacts preserved in museums are invaluable cultural treasures, yet they are often vulnerable to biodeterioration caused by microbial colonization. This study presents the first comprehensive investigation of microbial communities inhabiting heritage artifacts from Argentina's Museum of Independence. By integrating advanced microscopy with phenotypic and genomic characterization, we analyzed samples collected from wooden objects, textiles, architectural elements, and exterior walls. Scanning electron microscopy revealed diverse and well-structured biofilms, with intricate three-dimensional arrangements embedded in extracellular polymeric substances. A total of […]
- by MS ArticlesJournal of Agricultural and Food ChemistryDOI: 10.1021/acs.jafc.5c01483
- by MS ArticlesForwarding this one in just a second for sure! Most of what I know about the HLA/MHC immunopeptidomics / neoantigen presentation system comes from this amazing old paper in Cell Immunity. The mechanisms for processing and presentation are largely inferred from the large number of high confidence peptides they identify – but again – this is inference.If we really wanted to understand how this system worked could you just knock out each protein along the way and do proteomics and immunopeptidomics? I […]
- by MS ArticlesPublication date: Available online 28 March 2025Source: Journal of Chromatography AAuthor(s): Yanping Wei, Yujie Zhang, Yueting Hu, Fan Shui, Jia Tang, Yiyang Yu, Guocan Zheng, Jing Zeng
- by MS ArticlesZooMS (Zooarchaeology by Mass Spectrometry) offers a rapid and cost-effective method for species identification of animal remains through peptide mass fingerprinting. After mass spectrum generation, a mostly used way to perform taxonomic identification is to compare the mass fingerprints to a reference database of diagnostic peptide markers to determine the species of origin. This analytical stage, however, is tedious and error-prone, often necessitating manual examination of spectra. In this paper, we present a comprehensive approach to automate and standardize the […]
- by MS ArticlesMulticellular tumor spheroids (MCTSs) play an important role in biological studies and cancer research. There is an emerging research interest in molecular profiling and drug distribution of MCTSs by leveraging the superior sensitivity and molecular specificity of mass spectrometry imaging (MSI). Current methods for sample preparation of MCTSs can suffer from low throughput, as MCTSs are typically individually transferred from cell culture into an MSI embedding media and sectioned individually, or sometimes, a few spheroids are placed in a small […]