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J. Anal. At. Spectrom., 2025, Advance ArticleDOI: 10.1039/D5JA00085H, PaperStefaan Pommé, Sergei F. BoulygaA mathematical model is presented to calculate the expected throughput rate in a discrete ion counter with imposed non-extending dead time.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Accurately modeling enzymatic reactivity is essential for synthesis planning, mass spectrometry interpretation, and biochemical knowledge extraction, but existing reaction datasets are often incomplete or inconsistently annotated. EVODEX introduces two abstractions to address this: partial reactions, which isolate atom-mapped substrate-product transformations from complex biochemical reactions, and Electronic Reaction Operators (EROs), which encode the bonding and orbital environment of atoms undergoing change. […]

Titin-based mechanosensing is a key driver of trophic signaling in muscle, yet the downstream pathways linking titin sensing to muscle remodeling remain poorly understood. To investigate these signaling mechanisms, we utilized unilateral diaphragm denervation (UDD), an in vivo model that induces titin-stiffness-dependent hypertrophy via mechanical stretch. Using UDD in rats and mice, we characterized the longitudinal hypertrophic response and distinguished […]

ABSTRACT Rationale Differential ion mobility spectrometry (DMS) provides distinct potential in separation of gas phase ions. However, the resolving power still limits the widespread application of DMS technology and inspires to design tandem DMS for improvement of the performance. Methods A robust tandem DMS module was fabricated to enhance the separation performance of the DMS system. To achieve the optimal […]

Proteins are the functional effectors of virtually all biological processes, and accurately measuring their abundance and dynamics is essential for understanding development and disease. Although mRNA levels have historically been used as proxies for protein expression, growing evidence, especially from studies of the human cerebral cortex, has revealed widespread discordance between transcript and protein abundance. To directly address this limitation, […]

Journal of the American Society for Mass SpectrometryDOI: 10.1021/jasms.4c00500

Journal of the American Society for Mass SpectrometryDOI: 10.1021/jasms.5c00016

The fast-advancing mass spectrometry and related technologies have greatly extended the depth of coverage in large-scale proteomics studies, including single-cell applications. As sample numbers grow rapidly, it is often challenging to interpret the proteins with missing values that are often presented as "NA" (not available). It could be the evidence of no expression, low expression below the detection threshold, or […]

Phase separation of biomolecular condensates is often assumed to be driven by interactions involving nucleic acids and intrinsically disordered regions (IDRs) of proteins. PGL-3 is a component of P granules, biomolecular condensates in the C. elegans germline, that contains two structured domains in tandem (D1-D2), an internal IDR, and a C-terminal IDR rich with RGG motifs. Theoretical and in vitro […]

Non-target screening (NTS) using liquid chromatography–high-resolution mass spectrometry (LC-HRMS) is crucial for identifying organic compounds and patterns in complex environmental samples. However, discrepancies in data processing between peak-picking algorithms (“feature profile” approaches) remain a critical challenge in achieving consistent and reproducible results. An alternative approach employs multi-way chemometric methods to directly produce “component profiles,” allowing efficient decomposition and evaluation of LC-HRMS datasets, […]

Publication date: 1 January 2026Source: Talanta, Volume 296Author(s): Lola Alez-Martin, Pascal Houzé, Rania Joomun, Nathalie Mignet, Yannis-Nicolas François, Rabah Gahoual

Analytical ChemistryDOI: 10.1021/acs.analchem.5c02166

Analytical ChemistryDOI: 10.1021/acs.analchem.5c00417

Analytical ChemistryDOI: 10.1021/acs.analchem.5c02394

J. Anal. At. Spectrom., 2025, Accepted ManuscriptDOI: 10.1039/D5JA00140D, Critical Review Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Kattathu J MathewFactors on which the accuracy and precision realized in isotope amount ratio measurements using thermal ionization mass spectrometry (TIMS) instrumentation are described, and the measurement of Pu materials is emphasized….The content of this RSS […]

 Check out the above (click to expand) – Yes, that is the bizarre nomenclature used by our friends at SpectroNaut (PG.normal word you'd expect AND the funnest-to-parse [ mf'ing brackets ] AND a space after the second bracket ]  at the beginning of each sample name)! And in the "EG.PrecursorID" which roughly possibly translates to "peptide sequence with the addition of […]

Journal of the American Society for Mass SpectrometryDOI: 10.1021/jasms.5c00103

ABSTRACT The mirabegron drug substance was shown to have potential genotoxic impurity (PGI); hence, it needs to develop the method for the determination of the 2-(2-Nitrophenyl) ethylamine hydrochloride (4-NPE RC-2) PGI at a 30-ppm limit considering the maximum daily dose of 50 mg/day and a 1.5 mg per day TTC limit as per ICH M7 guideline. A simple high-performance liquid chromatography (HPLC) […]

Analytical ChemistryDOI: 10.1021/acs.analchem.5c03067

Anal. Methods, 2025, Accepted ManuscriptDOI: 10.1039/D5AY00724K, CommunicationHanxu Ji, Jingjing Xu, Yufeng Li, Xiaoxiao Wu, Diyao Jiang, Xiuming Mei, Miao Yang, Yuwei Qiang, Jungui Zhou, Chi ZhangWe developed a novel mass spectrometry immunoassay for the ultrasensitive and selective detection of deoxynivalenol by introducing nucleic-acid-amplification techniques. By selecting thymine as mass tag, the primer DNA modified on…The content of this RSS Feed […]