Monthly Archives: November 2015

Laser Ablation with Vacuum Capture for MALDI Mass Spectrometry of Tissue

F. Donnarumma, F. Cao, & K. K. Murray, J. Am. Soc. Mass Spectrom. (2015) DOI: 10.1007/s13361-015-1249-0 We have developed a laser ablation sampling technique for matrix-assisted laser desorption ionization (MALDI) mass spectrometry and tandem mass spectrometry (MS/MS) analyses of in-situ digested tissue proteins. Infrared laser ablation was used to remove biomolecules from tissue sections for …

Continue reading “Laser Ablation with Vacuum Capture for MALDI Mass Spectrometry of Tissue”

Laser desorption sample transfer for gas chromatography/mass spectrometry

C. A. Seneviratne, S. Ghorai & K. K. Murray, Rapid Commun. Mass Spectrom. in press DOI: 10.1002/rcm.7419 RATIONALE: Ambient mass spectrometry can detect small molecules directly, but complex mixtures can be a challenge. We have developed a method that incorporates small molecule separation based on laser desorption with 80 capture on a solid-phase microextraction (SPME) …

Continue reading “Laser desorption sample transfer for gas chromatography/mass spectrometry”