K.K. Murray, D.H. Russell, “Aerosol Matrix-Assisted Laser-Desorption Ionization Mass-Spectrometry, “ J. Am. Soc. Mass Spectrom. 5 (1994) 1–9. doi:10.1016/1044-0305(94)85077-1.
Abstract: A new method of liquid sample introduction for a time-of-flight mass spectrometer (TOF-MS) has been developed by applying the method of matrix-assisted laser desorption ionization to aerosols. Analyte biomolecules are dissolved in a methanol solvent along with a UVabsorbing matrix and formed into an aerosol with a pneumatic nebulizer. The aerosol particles are dried in a heated skimmer tube before ionization by pulsed 355-nm UV laser radiation. Mass analysis is achieved in a linear TOF-MS. Results for the ionization of bovine insulin (5733.5 Mw) are reported.
