- Mascot Server can create and search NIST MSP formatted spectral libraries but not BLIB — until now! We have developed an MSP to BLIB to MSP converter that allows Mascot Server to use BLIB libraries.https://www.matrixscience.com/blog/converting-blib-spectral-libraries-to-msp-and-back-again-for-use-with-mascot-server.html#proteomics #massspec
- Mascot Newsletter, January 2026:Ion intensity: peak area vs signal to noise?Duplexing deuterated water-labeled samples for protein turnover rate estimation.Role-based access with Mascot Security is useful in a variety of cases.https://www.matrixscience.com/nl/202601/newsletter.html#proteomics #massspec
- Maximize your ESI sensitivity with CoAnn’s pulled and sharpened emitters.The different emitter types offer flexibility to match various nanoLC columns and liquid infusion measurements in varieties of #MassSpec applications. Learn more: https://www.mswil.com/nano-cap-micro-lc/spray-emitters/pulled-emitters/coann-pulled-emitters/
- 🚀 EuBIC-MS Winter School 2026 in Harrachov!Join us for an intro to computational MS & a hands-on pyOpenMS session🎯 Learn workflow building blocks, explore MS data, and start scripting with open-source tools.📅 Jan 19🔗 More information: https://www.denbi.de/training-courses-2026/2008-pyopenms-for-metabolomics#MassSpec #Proteomics #EuBIC2026
- Proteomics software is prone to filling up the disk with data and temp files, which can cause weird issues. This blog article lists the most common errors in Mascot products and how to free up disk space.https://www.matrixscience.com/blog/strange-software-failures-check-your-disk-space.html#proteomics #massspec
- Mascot Newsletter, December 2025:NCBI nr FASTA replacement.Immunoregulation during pregnancy.Mascot Server as system service on Linux.https://www.matrixscience.com/nl/202512/newsletter.html#proteomics #massspec
- After a fair bit of frustration, our new excimer laser is installed! We have it coupled to an Element 2, and new laser plus sector magnet (rather than quadupole) mass spectrometry is a steep learning curve for me. Nice to spend the afternoon tinkering in the lab though.#LAICPMS #MassSpec #MPIC
- When raw data is processed into peak lists, there is a choice: how should peak intensity be calculated? Mascot Distiller defaults to peak area. The alternative, signal-to-noise (S/N), can be useful with detecting diagnostic ions.#proteomics #massspechttps://www.matrixscience.com/blog/peak-list-arcana-area-vs-signal-to-noise.html
- Mascot Newsletter, November 2025:Top-3 quant with DDA-PASEF.ZooMS peptide markers for South American Xenarthrans.Migrating from Windows 10 to Linux could extend the lifetime of your hardware.https://www.matrixscience.com/nl/202511/newsletter.html#proteomics #massspec
- The NCBI nr FASTA file of protein sequences is no longer updated. We've summarised instructions for creating it from the BLAST database — or you may be better off using TrEMBL.https://www.matrixscience.com/blog/replacements-for-ncbi-nr.html#proteomics #massspec
- Mascot Newsletter, October 2025:Spectrum-centric DIA scoring.Molecular mechanisms of SBK2 kinase on the heart.Windows update issue with IIS (resolved).https://www.matrixscience.com/nl/202510/newsletter.html#proteomics #massspec
- Der Mann hat was neues für #Lupus gefunden – oder wie @kabalak selbst sagen würde:In conclusion, this study uncovers a new dimension of immune crosstalk: a proteolytic plasma network that generates immunoactive fragments with intrinsic self-regulatory capabilities to modulate #inflammation and tissue injury in complex disease contexts. Deciphering these immunoactivities may pave the way for innovative diagnostic and therapeutic strategies in complement-driven pathologies, potentially benefiting a wide range of inflammatory and autoimmune diseases.#AutoimmuneDiseases #InflammatoryDisease #Science #SLE #proteomics #MassSpec #TeamMassSpec #LupusResearch https://www.embopress.org/doi/full/10.1038/s44318-025-00598-8
- Mascot Server can create and search NIST MSP formatted spectral libraries but not BLIB — until now! We have developed an MSP to BLIB to MSP converter that allows Mascot Server to use BLIB libraries.https://www.matrixscience.com/blog/converting-blib-spectral-libraries-to-msp-and-back-again-for-use-with-mascot-server.html#proteomics #massspec
- Mascot Newsletter, January 2026:Ion intensity: peak area vs signal to noise?Duplexing deuterated water-labeled samples for protein turnover rate estimation.Role-based access with Mascot Security is useful in a variety of cases.https://www.matrixscience.com/nl/202601/newsletter.html#proteomics #massspec
- Maximize your ESI sensitivity with CoAnn’s pulled and sharpened emitters.The different emitter types offer flexibility to match various nanoLC columns and liquid infusion measurements in varieties of #MassSpec applications. Learn more: https://www.mswil.com/nano-cap-micro-lc/spray-emitters/pulled-emitters/coann-pulled-emitters/
- 🚀 EuBIC-MS Winter School 2026 in Harrachov!Join us for an intro to computational MS & a hands-on pyOpenMS session🎯 Learn workflow building blocks, explore MS data, and start scripting with open-source tools.📅 Jan 19🔗 More information: https://www.denbi.de/training-courses-2026/2008-pyopenms-for-metabolomics#MassSpec #Proteomics #EuBIC2026
- Proteomics software is prone to filling up the disk with data and temp files, which can cause weird issues. This blog article lists the most common errors in Mascot products and how to free up disk space.https://www.matrixscience.com/blog/strange-software-failures-check-your-disk-space.html#proteomics #massspec
- Mascot Newsletter, December 2025:NCBI nr FASTA replacement.Immunoregulation during pregnancy.Mascot Server as system service on Linux.https://www.matrixscience.com/nl/202512/newsletter.html#proteomics #massspec
- After a fair bit of frustration, our new excimer laser is installed! We have it coupled to an Element 2, and new laser plus sector magnet (rather than quadupole) mass spectrometry is a steep learning curve for me. Nice to spend the afternoon tinkering in the lab though.#LAICPMS #MassSpec #MPIC
- When raw data is processed into peak lists, there is a choice: how should peak intensity be calculated? Mascot Distiller defaults to peak area. The alternative, signal-to-noise (S/N), can be useful with detecting diagnostic ions.#proteomics #massspechttps://www.matrixscience.com/blog/peak-list-arcana-area-vs-signal-to-noise.html
- Mascot Newsletter, November 2025:Top-3 quant with DDA-PASEF.ZooMS peptide markers for South American Xenarthrans.Migrating from Windows 10 to Linux could extend the lifetime of your hardware.https://www.matrixscience.com/nl/202511/newsletter.html#proteomics #massspec
- The NCBI nr FASTA file of protein sequences is no longer updated. We've summarised instructions for creating it from the BLAST database — or you may be better off using TrEMBL.https://www.matrixscience.com/blog/replacements-for-ncbi-nr.html#proteomics #massspec
- Mascot Newsletter, October 2025:Spectrum-centric DIA scoring.Molecular mechanisms of SBK2 kinase on the heart.Windows update issue with IIS (resolved).https://www.matrixscience.com/nl/202510/newsletter.html#proteomics #massspec
- Der Mann hat was neues für #Lupus gefunden – oder wie @kabalak selbst sagen würde:In conclusion, this study uncovers a new dimension of immune crosstalk: a proteolytic plasma network that generates immunoactive fragments with intrinsic self-regulatory capabilities to modulate #inflammation and tissue injury in complex disease contexts. Deciphering these immunoactivities may pave the way for innovative diagnostic and therapeutic strategies in complement-driven pathologies, potentially benefiting a wide range of inflammatory and autoimmune diseases.#AutoimmuneDiseases #InflammatoryDisease #Science #SLE #proteomics #MassSpec #TeamMassSpec #LupusResearch https://www.embopress.org/doi/full/10.1038/s44318-025-00598-8