- (RSS) (RCM) Identification and Structural Characterization of Degradation Products of Tivozanib Using LCāQāTOFāMS/MS and NMR: An In Silico Approach for Degradation and Toxicity Prediction: ABSTRACTRationaleThe present study investigated the degradation behaviour of tivozanib (TVZ), a potent tyrosine kinase inhibitor, under various stress conditions, including hydrolytic (acid, base, and neutral), oxidative, thermal, andā¦ https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/rcm.10167?af=R&utm_source=dlvr.it&utm_medium=mastodon #RapidCommunMassSpectrom #MassSpecRSS
- (RSS) (BioRxiv All) A universal buffer system for native LC-MS analysis of antibody-based therapeutics: Liquid chromatography coupled to mass spectrometry (LC-MS) is a powerful analytical technique for analyzing biological macromolecules. A long-standing challenge has been applying LC-MS at physiological pH under native conditions using volatile buffers. The predominant 'buffer' used, ammonium acetate (AmAc, pKa 4.75 for acetic acid and 9.25 forā¦ https://www.biorxiv.org/content/10.1101/2025.11.17.688837v1?rss=1&utm_source=dlvr.it&utm_medium=mastodon #BioRxiv #MassSpecRSS
- (RSS) (BioRxiv All) Crowding does not suppress the opening of a cryptic pocket: Cryptic pockets are transient structural features that provide new opportunities for therapeutic intervention, yet their dynamic properties in physiologically relevant environments remain poorly understood. We have identified one such pocket in the interferon inhibitory domain (IID) of Ebola viral protein 35 (eVP35) and demonstrated that it allosterically regulatesā¦ https://www.biorxiv.org/content/10.1101/2025.11.17.688865v1?rss=1&utm_source=dlvr.it&utm_medium=mastodon #BioRxiv #MassSpecRSS
- (RSS) (BioRxiv All) Fine-Tuning of Label-Free Single-Cell Proteomics Workflows: Mass spectrometry-based single-cell proteomics emerges as the most promising method for studying cellular heterogeneity at the global proteome level with unprecedented depth and coverage. Its widespread application remains limited due to robustness, reproducibility, and throughput requirements, still difficult to meet as analyzing large cohorts of single cells isā¦ https://www.biorxiv.org/content/10.1101/2025.11.17.688849v1?rss=1&utm_source=dlvr.it&utm_medium=mastodon #BioRxiv #MassSpecRSS
- (RSS) Tissue expansion-enhanced mass-spectrometry imaging decodes biomolecular landscapes https://www.nature.com/articles/s41580-025-00931-3?utm_source=dlvr.it&utm_medium=mastodon #nature #MassSpecRSS
- (RSS) (BioRxiv All) Development of a metabolic signature of post-weaning diarrhoea in pigs: In the agricultural sector, antibiotics have been used to improve swine growth performance. This application is banned nowadays, due to increased risk of antibiotic resistance. In piglets this results in a higher prevalence of post-weaning diarrhoea, deteriorating both animal health and performance. Our goal was to find a metabolite signature separatingā¦ https://www.biorxiv.org/content/10.1101/2025.11.17.688604v1?rss=1&utm_source=dlvr.it&utm_medium=mastodon #BioRxiv #MassSpecRSS
- (RSS) (J Ag Food Chem) [ASAP] Characterization and Chemoinformatic Prediction of Retention Indices of Metabolites in Coffee and Plantain Byproduct Flours Using Gas ChromatographyāTime-of-Flight Mass Spectrometry: Journal of Agricultural and Food ChemistryDOI: 10.1021/acs.jafc.5c11135 http://dx.doi.org/10.1021/acs.jafc.5c11135?utm_source=dlvr.it&utm_medium=mastodon #JAgFoodChem #MassSpecRSS
- (RSS) (ACS Anal Chem) [ASAP] Application and Characterization of Novel Mid-IR Glucoloop Laser for Mass Spectrometry Imaging and Small Molecule Screening: Analytical ChemistryDOI: 10.1021/acs.analchem.5c05003 http://dx.doi.org/10.1021/acs.analchem.5c05003?utm_source=dlvr.it&utm_medium=mastodon #MassSpecRSS #ACSAChem
- (RSS) (J Mass Spectrom) LCāMS/MS Assay for Quantification of DAā1241, a Novel GPR119 Agonist, in Animal and Human Plasma: Application to Preclinical Pharmacokinetic Studies: Journal of Mass Spectrometry, Volume 60, Issue 12, December 2025. https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/jms.5194?af=R&utm_source=dlvr.it&utm_medium=mastodon #JMassSpectrom #MassSpecRSS
- (RSS) (J Chrom A) Current Trends in Liquid Chromatography-Mass Spectrometry Analysis of Small Interfering RNAs: A Short Review: Publication date: Available online 17 November 2025Source: Journal of Chromatography AAuthor(s): Hiroyuki Togawa, Takao Yamaguchi, Junji Kawakami, Satoshi Obika https://www.sciencedirect.com/science/article/pii/S0021967325008945?dgcid=rss_sd_all&utm_source=dlvr.it&utm_medium=mastodon #JChrom #MassSpecRSS
- (RSS) (J An Atom Spec) Time-dependent hydride correction for accurate 240Pu/239Pu isotopic ratio measurements in Āµm-sized Pu-bearing particles using large geometry-secondary ion mass spectrometry: J. Anal. At. Spectrom., 2025, Advance ArticleDOI: 10.1039/D5JA00190K, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Anne-Laure FaurĆ©, Manon CornatonImprovement of Puā¦ http://pubs.rsc.org/en/Content/ArticleLanding/2025/JA/D5JA00190K?utm_source=dlvr.it&utm_medium=mastodon #jaas #MassSpecRSS #AtomicSpec
- (RSS) (RCM) Enhancing Chimeric Fragmentation Spectra Deconvolution Using Direct InfusionāTandem Mass Spectrometry Across HighāResolution Mass Spectrometric Platforms: ABSTRACTRationaleDirect infusion mass spectrometry (DI-MS) is a rapid analytical technique widely used in omics research and other fields. However, the complexity of DI-MS spectra frequently leads to co-fragmentation of analytes with similar m/z, resulting inā¦ https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/rcm.10170?af=R&utm_source=dlvr.it&utm_medium=mastodon #RapidCommunMassSpectrom #MassSpecRSS
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