- by Appala Naidu KotanaEuropean Journal of Mass Spectrometry, Volume 30, Issue 5-6, Page 221-234, October–December 2024. This article presents a relationship between the size of an ion crystal in a Paul trap and the radio frequency potential applied on the central ring electrode. Using a simple and elegant derivation it has been shown that the distance of an ion in the crystal from the trap center is proportional to [math] power of the applied radio frequency voltage. The validity of this power law […]
- by Shiva Kumar GogikarEuropean Journal of Mass Spectrometry, Volume 30, Issue 5-6, Page 235-245, October–December 2024. Present work describes the development of a liquid chromatography tandem mass spectrometry-based bioanalytical method for the reliable simultaneous quantification of docetaxel (DXL) and carvacrol (CVL) in the mice plasma. A rapid and sensitive bioanalytical method was developed and optimized in mice plasma using Paclitaxel as an internal standard. Validation of the bioanalytical method was performed according to the ICH M10 guideline covering the range of 9.62–1923.08 ng/mL in […]
- by Akhilesh Kumar KurilEuropean Journal of Mass Spectrometry, Volume 30, Issue 5-6, Page 209-220, October–December 2024. Mass spectrometry (MS) has become a pivotal analytical tool across various scientific disciplines due to its ability to provide detailed molecular information with high sensitivity and specificity. MS plays a crucial role in various fields, including drug discovery and development, proteomics, metabolomics, environmental analysis, and clinical diagnostics and Forensic science. In this article we are discussing the application of MS across the diverse scientific disciplines by focusing […]
- by Jin Young LimEuropean Journal of Mass Spectrometry, Volume 30, Issue 5-6, Page 254-260, October–December 2024. The dimer and trimer structures of the non-amyloidogenic rat islet amyloid polypeptide 21–37 peptide, formed in an H2O/CH3OH (1% CH3COOH) solution were investigated using electrospray ionization-tandem mass spectrometry (ESI-MS/MS). The dissociation of monomers, dimers, and trimers was investigated by MS/MS using collision-induced dissociation. The peptide bond dissociation between L7 and P8 was mainly observed in the tandem mass spectra of the monomers and oligomers, regardless of the […]
- by Renata KobetićEuropean Journal of Mass Spectrometry, Volume 30, Issue 5-6, Page 246-253, October–December 2024. Gels created by self-assembly of small organic molecules are dynamic soft materials that have unique properties and demanding characterization. Four chiral gelators, with two valinol- or leucinoloxamido arms attached to the 2,2′-positions of the proatropisomeric biphenyl group were chosen to show that the electrospray ionization mass spectrometry (ESI-MS) could be used to differentiate the gelation feature of the chiral compounds 1-4 and also to shed light on […]
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