RSS feed of mass spectrometry journals and other mass spectrometry articles and social feeds.
- The human dual specificity tyrosine phosphorylation regulated kinase 1A (DYRK1A) is implicated in the pathology of Down syndrome, microcephaly, and cancer, however the exact mechanism through which it functions is unknown. Here, we have studied the role of the Drosophila ortholog of DYRK1A, Minibrain (Mnb), in brain development. The neuroblasts (neural stem cells) that eventually give rise to differentiated neurons […]
- The clownfish – sea anemone system is a great example of symbiotic mutualism where host 'toxicity' does not impact its symbiont partner, although the underlying protection mechanism remains unclear. The regulation of nematocyst discharge in cnidarians involves N-acetylated sugars like sialic acid, that bind chemoreceptors on the tentacles of sea anemones, leading to the release of stings. It has been […]
- Publication date: Available online 11 May 2024Source: Journal of Chromatography AAuthor(s): Suo Decheng, Song Zhanteng, Xiao Zhiming, Li Yang, Liu Wuyan, Wang Junming, Fan Xia
- Journal of Agricultural and Food ChemistryDOI: 10.1021/acs.jafc.3c09347
- PROTEOMICS, EarlyView.
- Journal of Mass Spectrometry, Volume 59, Issue 6, June 2024.
- Journal of Mass Spectrometry, Volume 59, Issue 6, June 2024.
- Journal of Mass Spectrometry, Volume 59, Issue 6, June 2024.
- Journal of Mass Spectrometry, Volume 59, Issue 6, June 2024.
- Journal of Mass Spectrometry, Volume 59, Issue 6, June 2024.
- Journal of Mass Spectrometry, Volume 59, Issue 6, June 2024.
- Shengxian decoction, a traditional Chinese medicinal prescription, has been shown to alleviate doxorubicin-induced chronic heart failure. This study established an ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry method to separate and characterize the complex chemical compositions of Shengxian decoction, and the absorbed compounds in the bio-samples of the cardiotoxicity rats with chronic heart failure after its oral delivery. Note that 116 […]
- Bone resorption involves dissolution of mineral and enzymatic degradation of bone matrix. The primary enzyme is cathepsin K but other proteases including matrix metalloproteinases are involved. Some cleavage products of cathepsin K have been partially identified, including crossed-linked telopeptides of type I collagen. However, the pathway of type I bone collagen degradation has not been fully elucidated. The aim of […]
- The plasma proteome is maintained by the influx and efflux of proteins from surrounding organs and cells. To quantify the extent different organs and cells contribute to the plasma proteome composition, we developed a mass spectrometry-based proteomics strategy to infer the origin of proteins detected in human plasma in health and disease. First, we constructed an extensive human proteome atlas […]
- Among neurons, retinal ganglion cells (RGCs) are uniquely sensitive to mitochondrial dysfunction. The RGC is highly polarized, with a somatodendritic compartment in the inner retina and an axonal compartment projecting to targets in the brain. The drastically dissimilar functions of these compartments implies that mitochondria face different bioenergetic and other physiological demands. We hypothesized that compartmental differences in mitochondrial biology […]
- Analytical ChemistryDOI: 10.1021/acs.analchem.4c01119
- Thanks r/massspectrometry! I didn't know about this. I have Gary's Mass Spectrometry for Biotechnology which was a key part of Iulia Lazar's class on bioanalytical instrumentation when I was in grad school. This is on an obviously inferior -omics but I bet it's a solid read and it's like $14 in paperback!
- Abstract A multimodal approach combining inductively coupled plasma mass spectrometry (ICP-MS), single-particle ICP-MS (spICP-MS), scanning electron microscopy-energy-dispersive X-ray spectroscopy (SEM-EDS) and Raman spectroscopy enabled a deeper insight into the balance between total titanium (Ti), the soluble titanium fraction and titanium dioxide based particle fraction levels in periprosthetic tissues collected from patients undergoing revision surgery. Hydrofluoric acid usage in the sample digestion […]
- Publication date: 15 August 2024Source: Talanta, Volume 276Author(s): Eduardo Bolea-Fernandez, Ana Rua-Ibarz, Jorge Alves Anjos, Frank Vanhaecke
- If you've never done it, it absolutely sucks to kill a lab animal to get samples. Not only is it awful but an increasing body of evidence suggests that those millions of years or evolution make it not make very much sense at all to do it for many mechanisms. However, there are some systems where you absolutely have to […]
- Hello all,I'm completely new to MSDial and trying to employ it in a non-omics application to assess similarities between samples in a study of breakdown products of small molecules exposed to a mix of inorganics. The issue I'm experiencing may simply…
- Publication date: Available online 9 May 2024Source: Journal of ProteomicsAuthor(s): Kaiyuan Fan, Jin Wang, Wenqing Zhu, Xinan Zhang, Feng Deng, Yan Zhang, Shuang Zou, Lingjia Kong, He Shi, Ziling Li, Guozheng Shen, Dong Wang, Zhidong Wu, Heng Li, X.U. Zhongwei
- Collagen fibrils are the primary supporting scaffold of vertebrate tissues but how they are assembled is unclear. Here, using CRISPR-tagging of type I collagen and SILAC labelling, we elucidate the cellular mechanism for the spatiotemporal assembly of collagen fibrils, in cultured fibroblasts. Our findings reveal multifaceted trafficking of collagen, including constitutive secretion, intracellular pooling, and plasma membrane-directed fibrillogenesis. Notably, we […]
- Fragment ion intensity prediction improves the identification rate of non-tryptic peptides in timsTOF
- Secondary ion mass spectrometry