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  • Regulating enol–keto tautomerism at the single-molecule level with a confined optical field
    by Adila Adijiang
    Chem. Sci., 2025, Advance ArticleDOI: 10.1039/D5SC06085K, Edge Article Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Adila Adijiang, Yunlong Ge, Hefa Feng, Yan Yan, Xin Zuo, Haoyu Wang, Xueyan Zhao, Min Tan, Surong Zhang, Xiaona Xu, Lichuan Chen, Chuankui Wang, Zongliang Li, Dong XiangThe enol → keto tautomerism of β-diketones was realized by p-polarized UV irradiation at an extremely low intensity employing antenna electrodes, where the optical field is greatly enhanced and confined facilitating […]
  • DeepMetab: A Comprehensive and Mechanistically Informed Graph Learning Framework for End-to-End Drug Metabolism Prediction
    by Yiling Zhou Yiling Zhou
    Chem. Sci., 2025, Accepted ManuscriptDOI: 10.1039/D5SC04631A, Edge Article Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Yiling Zhou Yiling Zhou, Dongsheng Cao, Dejun Jiang, Xiao Wei, Yikun Wang, Youchao Deng, Jia-Cai YiPredicting drug metabolism remains a long-standing challenge in pharmacokinetics due to the mechanistic complexity of enzymatic transformations and the fragmented nature of current computational tools. Existing models are typically limited…The content of this RSS Feed (c) The Royal Society of Chemistry
  • Multiple Functional Bulk Passivator Pyrimidine Derivative Stabilizing Perovskite Precursors for Efficient Carbon-based Perovskite Solar Cells
    by Mengqi Geng
    Chem. Sci., 2025, Accepted ManuscriptDOI: 10.1039/D5SC05095B, Edge Article Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Mengqi Geng, Jialiang Li, Ke Wang, Le Jiang, Dan Lu, Shoaib Iqbal, Yu Gu, Lixin Chen, Tingting XuOver the past decades, perovskite solar cells (PSCs) have gained great research attention attributing to their promising future to be alternative energy sources. Even with exceptional high power conversion efficiency…The content of this RSS Feed (c) The Royal Society of Chemistry
  • Engineered Interface Coverage and Precise Cocatalyst Placement in MOF-Derived Heterojunction Photocatalysts for Selective Methane Oxidation
    by Wendi Zhao
    Chem. Sci., 2025, Accepted ManuscriptDOI: 10.1039/D5SC04771D, Edge Article Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Wendi Zhao, Kang Sun, Jiayi Xu, Zhongyuan Lin, qihui chen, Maochun Hong, Hai-Long JiangWhile rational fabrication of heterojunction photocatalysts with tunable interfaces and precise location control over cocatalyst holds great promise for enhanced photocatalysis, the synergistic integration of these parameters remains substantial challenges….The content of this RSS Feed (c) The Royal Society of Chemistry
  • Unveiling Leaching-Oxidizing-Landing Paths of Pd Single-Atom Catalyzed Suzuki-Miyaura Reaction by Ambient Mass Spectrometry
    by Yiyan Yin
    Chem. Sci., 2025, Accepted ManuscriptDOI: 10.1039/D5SC04480D, Edge Article Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Yiyan Yin, Xiaorong Wang, Xiyang Ge, Xiaotong Shen, Xiaomin Liu, Xiang Li, Jin Ouyang, Na NaThe palladium-catalyzed Suzuki-Miyaura cross-coupling (SMCC) reaction is an essential technique for C-C bond formation. It is considered to occur through two distinct pathways involving homogeneous and heterogeneous mechanisms. However, there…The content of this RSS Feed (c) The Royal Society of Chemistry
  • Cobalt-Catalyzed Direct Carbonylative 3-Acylation of (N-H)Indoles with Alkyl Halides
    by Chao Xu
    Chem. Sci., 2025, Accepted ManuscriptDOI: 10.1039/D5SC05810D, Edge Article Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Chao Xu, Zhipeng Bao, Sufang Shao, Xiao-Feng WuA cobalt-catalyzed approach to intermolecular carbonylative 3-acylation of heterocycles via C-H functionalization is described. This transformation enables the direct C-H acylation of indoles and pyrroles with alkyl halides. Notably, this…The content of this RSS Feed (c) The Royal Society of Chemistry
  • Data-Driven Recommendation of Agents, Temperature, and Equivalence Ratios for Organic Synthesis
    by Xiaoqi Sun
    Chem. Sci., 2025, Accepted ManuscriptDOI: 10.1039/D5SC04957A, Edge Article Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Xiaoqi Sun, Jiannan Liu, Babak Mahjour, Klavs F. Jensen, Connor W ColeyThe identification of suitable reaction conditions is a crucial step in organic synthesis. Computer-aided synthesis planning promises to improve the efficiency of chemistry and enable robot-assisted workflows, but there remains…The content of this RSS Feed (c) The Royal Society of Chemistry
  • Dynamic Networks of Fluorine-rich Acrylates Enable Highly Conductive and Flame-Retardant Electrolytes for Lithium Metal Batteries
    by Junyi Gan
    Chem. Sci., 2025, Accepted ManuscriptDOI: 10.1039/D5SC05270J, Edge Article Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Junyi Gan, Yao Zhao, Zhan Jiang, Chenyu Yang, Da Ke, QiChao Wang, Ye Liu, Xiaohui Zheng, Tengfei ZhouA fluorinated gel polymer electrolyte (FGPE) was synthesized via in-situ copolymerization of acrylamide (AM) and 1, 1, 1, 3, 3, 3-Hexafluoroisopropyl Acrylate (HFA). The synergistic interaction between -CF₃ and C=O…The content of this RSS Feed (c) The Royal Society of Chemistry
  • Axial Fluorine Coordination Boosts Activity and Durability of Fe Single-Atom Catalysts in Room-Temperature Na–S Batteries
    by Xue Zhong
    Chem. Sci., 2025, Accepted ManuscriptDOI: 10.1039/D5SC05972K, Edge Article Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Xue Zhong, Yujie Huang, Jieming Cai, Dongyang Cai, Zidong He, Zhenglei Geng, Wentao Deng, Guoqiang Zou, Hongshuai Hou, Xiaobo JiSingle-atom catalysts (SACS) hold promises for addressing challenges of polysulfide shuttle and sluggish sulfur reduction reaction (SRR) in room-temperature (RT) Na-S batteries. However, their structural durability under harsh electrochemical conditions…The content of this RSS Feed (c) The Royal Society […]
  • Ba3Al2B12O24: a beryllium-free member of the Sr2Be2B2O7 family with a 2∞[B12Al2O28] double-layered structure
    by Xiaorong Liu
    Chem. Sci., 2025, Advance ArticleDOI: 10.1039/D5SC03854E, Edge Article Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Xiaorong Liu, Hongping Wu, Zhanggui Hu, Jiyang Wang, Yicheng Wu, Hongwei YuA new Sr2Be2B2O7-like aluminoborate Ba3Al2B12O24 was synthesized, satisfying performance balance between large SHG response, a short cutoff edge, and appropriate birefringence.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry
  • Multicomponent Covalent Organic Frameworks: Design Strategies and Synergistic Functions
    by Xiaoyi Xu
    Chem. Sci., 2025, Accepted ManuscriptDOI: 10.1039/D5SC05394C, Perspective Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Xiaoyi Xu, Ning HuangCovalent organic frameworks (COFs) are crystalline porous polymers with modular architectures and long-range order, offering exceptional tunability in pore structure and functionality. While conventional COFs are typically constructed from one…The content of this RSS Feed (c) The Royal Society of Chemistry
  • Dual-Function Synergy in Boron-Doped Fe-N-C: Enhanced Site Density and Intrinsic Activity
    by Jinjing Tao
    Chem. Sci., 2025, Accepted ManuscriptDOI: 10.1039/D5SC05135E, Edge Article Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Jinjing Tao, Xin Guan, Xiaolong Yang, Jingsen Bai, Chuanfu Li, Xiaohui Liu, Minhua Shao, Meiling Xiao, Changpeng Liu, Wei XingAtomically dispersed transition metal, nitrogen co-doped carbon (M-N-C) is hailed as the most promising platinum alternative for oxygen reduction reaction (ORR), while their practical deployment is bottlenecked by the inferior…The content of this RSS Feed (c) The Royal Society […]
  • Machine Learning for Nonadiabatic Molecular Dynamics: Best Practices and Recent Progress
    by Carolin Müller
    Chem. Sci., 2025, Accepted ManuscriptDOI: 10.1039/D5SC05579B, Perspective Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Carolin Müller, Štěpán Sršeň, Brigitta Bachmair, Rachel Crespo-Otero, Jingbai Li, Sascha Mausenberger, Max Pinheiro, Jr., Graham Worth, Steven A. Lopez, Julia WestermayrExploring molecular excited states holds immense significance across organic chemistry, chemical biology, and materials science. Understanding the photophysical properties of molecular chromophores is crucial for designing nature-inspired functional molecules, with…The content of this RSS Feed (c) The Royal […]
  • Correction: Esterase-induced release of a theranostic prodrug in lysosomes for improved therapeutic efficacy and lower systemic toxicity
    by Sourav Dutta
    Chem. Sci., 2025, Advance ArticleDOI: 10.1039/D5SC90196K, Correction Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Sourav Dutta, Sanchita Tripathy, Somnath Bej, Sabana Parvin, Batakrishna Jana, Chitta Ranjan Patra, Amitava DasTo cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry
  • Stereoselective Ring-Opening Polymerization of Racemic Ethylglycolide: Precisely Regulated Polyester Properties via Stereomicrostructure Control
    by Jinbo Hu
    Chem. Sci., 2025, Accepted ManuscriptDOI: 10.1039/D5SC05510E, Edge Article Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Jinbo Hu, Xinyan Liu, Yeqi Du, Wenbo Wang, Tianchang Wang, Hao Zhang, Ranlong Duan, Xinchao Bian, Xuesi ChenThe development of high-performance, renewable polyesters with tunable mechanical properties is critical for advancing sustainable materials to replace petroleum-based plastics. Herein, a conceptually simple but highly effective strategy was employed…The content of this RSS Feed (c) The Royal Society of Chemistry
  • Correction: Cationic pillar[6]arene/ATP host–guest recognition: selectivity, inhibition of ATP hydrolysis, and application in multidrug resistance treatment
    by Guocan Yu
    Chem. Sci., 2025, Advance ArticleDOI: 10.1039/D5SC90190A, Correction Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Guocan Yu, Jiong Zhou, Jie Shen, Guping Tang, Feihe HuangTo cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry
  • Framework for De novo Sequencing of Peptide Mixtures via Network Analysis and Two-Dimensional Tandem Mass Spectrometry
    by MyPhuong T. Le
    Chem. Sci., 2025, Accepted ManuscriptDOI: 10.1039/D5SC03762J, Edge Article Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.MyPhuong T. Le, Yu Zhu, Eric Thomas Dziekonski, Dylan T. Holden, David F. Gleich, R. Graham CooksTwo-dimensional tandem mass spectrometry (2D MS/MS) provides in-depth biopolymer structural information previously not directly accessible with traditional one-dimensional MS/MS workflows, and in significantly less time (
  • Mechanisms of Ionization and of Chemical Reactions in Charged Microdroplets
    by Dylan T. Holden
    Chem. Sci., 2025, Accepted ManuscriptDOI: 10.1039/D5SC04781A, Perspective Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Dylan T. Holden, Brison A. Shira, Myles Edwards, Nicolás M Morato, R. Graham CooksOver the past decade the use of electrospray ionization mass spectrometry (ESI-MS) has been extended from the domain of chemical analysis to that of chemical synthesis. This development was spurred…The content of this RSS Feed (c) The Royal Society of Chemistry
  • Hierarchical hollow nanospheres of imine-based covalent organic frameworks with built-in Ag sites for fast-charging lithium metal batteries
    by Tiancun Liu
    Chem. Sci., 2025, Advance ArticleDOI: 10.1039/D5SC03645C, Edge Article Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Tiancun Liu, Xiao-Meng Lu, Song Lu, Ronghan Jiang, Min Guo, Chaofei Guo, Zhixin Yu, Yong WangLithiophilic imine-based covalent organic frameworks (ICOFs) with built-in silver (Ag) sites (Ag@ICOFs) are demonstrated to effectively guide dendrite-free lithium deposition.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal […]
  • A focus on unexpected surprises in RiPP natural product biosynthesis
    by Christopher J. Thibodeaux
    Chem. Sci., 2025, Advance ArticleDOI: 10.1039/D5SC90158H, Commentary Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Christopher J. ThibodeauxCareful examination of the enzymes involved in the biosynthesis of ribosomally-synthesized and post-translationally modified peptide (RiPP) natural products reveals unexpected synergy and surprising catalytic and biophysical properties.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

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