BioRxiv bioRxiv Subject Collection: Systems Biology This feed contains articles for bioRxiv Subject Collection "Systems Biology" Elucidating Fibroblast Growth Factor-induced kinome dynamics using targeted mass spectrometry and dynamic modeling Fibroblast growth factors (FGFs) are paracrine or endocrine signaling proteins that, activated by their ligands, elicit a wide range of health and disease-related processes, such as …
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Cell cycle oscillations driven by two interlinked bistable switches
BioRxiv bioRxiv Subject Collection: Systems Biology This feed contains articles for bioRxiv Subject Collection "Systems Biology" Cell cycle oscillations driven by two interlinked bistable switches Regular transitions between interphase and mitosis during the cell cycle are driven by changes in the activity of the enzymatic protein complex cyclin B with cyclin-dependent kinase 1 (Cdk1). At …
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Top-down Proteomics of Myosin Light Chain Isoforms Define Chamber-Specific Expression in the Human Heart
BioRxiv bioRxiv Subject Collection: Systems Biology This feed contains articles for bioRxiv Subject Collection "Systems Biology" Top-down Proteomics of Myosin Light Chain Isoforms Define Chamber-Specific Expression in the Human Heart Myosin functions as the "molecular motor" of the sarcomere and generates the contractile force necessary for cardiac muscle contraction. Myosin light chains 1 and 2 …
Prevalence of Bovine Cysticercosis, Human Taeniasis and Associated Risk Factors in Selected Towns of Silte Zone, Southern Ethiopia
BioRxiv bioRxiv Subject Collection: Systems Biology This feed contains articles for bioRxiv Subject Collection "Systems Biology" Prevalence of Bovine Cysticercosis, Human Taeniasis and Associated Risk Factors in Selected Towns of Silte Zone, Southern Ethiopia Bovine cysticercosis is an infection of cattle caused by the larval stage of Cysticercus Bovis, the human intestinal cestodes and it …
Homeostasis at different backgrounds: The roles of overlayed feedback structures in vertebrate photoadaptation
BioRxiv bioRxiv Subject Collection: Systems Biology This feed contains articles for bioRxiv Subject Collection "Systems Biology" Homeostasis at different backgrounds: The roles of overlayed feedback structures in vertebrate photoadaptation We have studied the resetting behavior of eight basic integral controller motifs with respect to different but constant backgrounds. We found that the controllers split symmetrically …
scMINER: a mutual information-based framework for identifying hidden drivers from single-cell omics data
BioRxiv bioRxiv Subject Collection: Systems Biology This feed contains articles for bioRxiv Subject Collection "Systems Biology" scMINER: a mutual information-based framework for identifying hidden drivers from single-cell omics data The sparse nature of single-cell omics data makes it challenging to dissect the wiring and rewiring of the transcriptional and signaling drivers that regulate cellular states. …
The Spread of Interferon-γ in Melanomas is Highly Spatially Confined, Driving Non-Genetic Variability in Tumor Cells
BioRxiv bioRxiv Subject Collection: Systems Biology This feed contains articles for bioRxiv Subject Collection "Systems Biology" The Spread of Interferon-γ in Melanomas is Highly Spatially Confined, Driving Non-Genetic Variability in Tumor Cells Interferon-{gamma} (IFN{gamma}) is a critical anti-tumor cytokine that has varied effects on different cell types. The global effect of IFN{gamma} in the tumor …