2002 Nobel Prize in Chemistry Shared by MS/NMR

” … Mass spectrometry is a very important analytical method used in practically all chemistry laboratories the world over. Previously only fairly small molecules could be identified, but John B. Fenn and Koichi Tanaka have developed methods that make it possible to analyse biological macromolecules as well.”

“In the method that John B. Fenn published in 1988, electrospray ionisation (ESI), charged droplets of protein solution are produced which shrink as the water evaporates. Eventually freely hovering protein ions remain. Their masses may be determined by setting them in motion and measuring their time of flight over a known distance. At the same time Koichi Tanaka introduced a different technique for causing the proteins to hover freely, soft laser desorption. A laserpulse hits the sample, which is √¢‚Ǩ≈ìblasted√¢‚Ǩ¬ù into small bits so that the molecules are released. ”

” … Through his work at the beginning of the 1980s Kurt W√ɬºthrich has made it possible to use NMR on proteins. He developed a general method of systematically assigning certain fixed points in the protein molecule, and also a principle for determining the distances between these. Using the distances, he was able to calculate the three-dimensional structure of the protein. The advantage of NMR is that proteins can be studied in solution, i.e. an environment similar to that in the living cell. … ”

ASMS Fall Workshop

Comparative and Functional Proteomics.

What Is It and How To Do It

November 7 – 8, 2002

Sheraton Hotel

Boston, Massachusetts

The deadline for registration is October 16.

For details, please visit the ASMS web site

www.asms.org

ACCOMMODATIONS: Rooms may be booked at the

Sheraton Hotel. Call (800) 325-3535. To obtain the

group rate of $175, mention ASMS. The deadline is

October 16.

Anniversary Symposium Liebig 2003

Bernhard Spengler is organizing a symposium on bioanaltical chemistry at Schloss Rauischholzhausen, May 12 – 15, 2003. Scheduled speakers include Rolf Apweiler, Charles Cantor, Franz Hillenkamp, Michael Karas, Bernhard K√ɬºnstler, Wolf Lehmann, Matthias Mann, Ingo Potrykus, Detlev Riesner, and Marvin Vestal.

More information can be found at www.liebig2003.de, or if your German is rusty, you can try a translation.