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    (RSS) (Proteomics) Metaproteomic Dataset on Semi‐Diurnal Variability of the Bacterioplankton Communities During a Spring Phytoplankton Bloom in the North Sea: PROTEOMICS, EarlyView. https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/pmic.70001?af=R&utm_source=dlvr.it&utm_medium=mastodon #MassSpecRSS
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    (RSS) (BioRxiv All) Cell-type specific iron content regulation revealed by single-cell iron quantification: Iron is crucial for cellular metabolism and cell growth. Nevertheless, in humans, both iron deficiency and disorders of iron overload are widespread. How cellular iron content varies depending upon iron availability, and how this influences cell function is poorly characterised. We developed a method to quantify metals in hundreds of cells per… https://www.biorxiv.org/content/10.1101/2025.06.22.660918v1?rss=1&utm_source=dlvr.it&utm_medium=mastodon #BioRxiv #MassSpecRSS
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    (RSS) (BioRxiv All) ADAR1 Restricts Poliovirus Infection through dual disruption of translation initiation and protein coding: Viral RNAs (vRNAs) interact with hundreds of host proteins, but how these interactions shape viral infection remains largely unknown. Here we developed a mass-spectrometry approach to identify cellular RNA-binding proteins (RBPs) that enhance or inhibit infection by modulating vRNA translation. We identified 130 RBPs that… https://www.biorxiv.org/content/10.1101/2025.06.19.660622v1?rss=1&utm_source=dlvr.it&utm_medium=mastodon #BioRxiv #MassSpecRSS
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    (RSS) (BioRxiv All) COOKIE-Pro: Covalent Inhibitor Binding Kinetics Profiling on the Proteome Scale: Covalent inhibitors are an emerging class of therapeutics, but methods to comprehensively profile their binding kinetics and selectivity across the proteome have been limited. Here we introduce COOKIE-Pro (COvalent Occupancy KInetic Enrichment via Proteomics), an unbiased method for quantifying irreversible covalent inhibitor binding kinetics on a… https://www.biorxiv.org/content/10.1101/2025.06.19.660637v1?rss=1&utm_source=dlvr.it&utm_medium=mastodon #BioRxiv #MassSpecRSS
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    (RSS) (BioRxiv All) A multimodal imaging approach for imaging the metabolic changes resulting from bronchopulmonary dysplasia: Lung tissue is composed of various functional units, each essential for maintaining the intricate functions of the lung. Disruptions in the molecular and cellular mechanisms in the lung can cause tissue fibrosis, inflammation, and severe breathing difficulties, which are common in conditions such as bronchopulmonary… https://www.biorxiv.org/content/10.1101/2025.06.16.660017v1?rss=1&utm_source=dlvr.it&utm_medium=mastodon #BioRxiv #MassSpecRSS
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    (RSS) (BioRxiv All) Proteomic Characterization of Spodoptera frugiperda Granulovirus Occlusion Bodies: Lepidopteran-infecting baculoviruses represent one of the most promising alternatives for pest biocontrol. In particular, Spodoptera frugiperda granulovirus (SfGV) infects the fall armyworm Spodoptera frugiperda, an increasingly important pest for maize and other crops around the world. SfGV has been investigated due to its capacity to enhance… https://www.biorxiv.org/content/10.1101/2025.06.19.660566v1?rss=1&utm_source=dlvr.it&utm_medium=mastodon #BioRxiv #MassSpecRSS
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    (RSS) (Proteom Res News) Estimate the protein content of over 1,000 human cell types!:  This came up when some old friends were visiting my lab this week. Where do I get these estimates for how much protein concentration should be in each single human cell? A couple of places, but the best organized place to start is the amazing Human Cell Tree Map – https://humancelltreemap.mis.mpg.de/Is is the topic of this recent PNAS paper. Now -… https://proteomicsnews.blogspot.com/2025/06/estimate-protein-content-of-over-1000.html?utm_source=dlvr.it&utm_medium=mastodon (/Proteom Res News) #proteomics
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    (RSS) (Proteom Res News) Quantitative performance of O-Link with spike-ins in human plasma!:  There is a lot to love in this short new preprint! Let's count them!1) This uses a NIST reference material and uses a very standard analytical approach to tell if one of these "next gen" proteomics things actually has quantitative accuracy. As an aside – this is one way to approach the easy and obvious SomaScam experiment that I've… https://proteomicsnews.blogspot.com/2025/06/quantitative-performance-of-o-link-with.html?utm_source=dlvr.it&utm_medium=mastodon (/Proteom Res News) #proteomics
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    (RSS) (BioRxiv All) Metabolomics-informed coarse-grained model enables prediction of cell-free protein expression dynamics: Cell-free expression systems have gained considerable attention for their potential in biomanufacturing, biosensing, and circuit prototyping. All these endeavors make use of the innate metabolic activity of cell lysates. However, our knowledge of the underlying nature of cell-free metabolism remains lacking. In this work, we… https://www.biorxiv.org/content/10.1101/2025.06.20.660830v1?rss=1&utm_source=dlvr.it&utm_medium=mastodon #BioRxiv #MassSpecRSS
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    (RSS) (BioRxiv All) DCX Enhances Glioblastoma Metabolism Through Synergistic Regulation of Glutamine Synthesis and Metabolism-Related Genes for Cellular Homeostasis: Gliomas are the most common primary intracranial tumors, comprising 81% of malignant brain tumors, and currently lack effective therapies. Recent advances in molecular biology have shown that cancer cells exploit microtubule-associated proteins (MAPs) under stress to activate various… https://www.biorxiv.org/content/10.1101/2025.06.16.660014v1?rss=1&utm_source=dlvr.it&utm_medium=mastodon #BioRxiv #MassSpecRSS
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    (RSS) (Proteom Res News) METAMORPHEUS SUPPORTS TIMSTOF DATA!!!!: AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAHHHH!!!One of the biggest challenges in adopting a new piece of hardware is that you might lose access to software that you've used for years and are very comfortable using. Losing MetaMorpheus by adopting TIMSTOFs hurt. For real. And this isn't a dig on other great software out there – I just know how to use MM and how to read the data and… https://proteomicsnews.blogspot.com/2025/06/metamorpheus-supports-timstof-data.html?utm_source=dlvr.it&utm_medium=mastodon (/Proteom Res News) #proteomics
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    (RSS) (JASMS) [ASAP] Mass Spectrometry-Driven Epitope Mapping: Application of Diethylpyrocarbonate Covalent Labeling for the Immunotherapeutic Target Programmed Cell Death Protein 1: Journal of the American Society for Mass SpectrometryDOI: 10.1021/jasms.5c00070 http://dx.doi.org/10.1021/jasms.5c00070?utm_source=dlvr.it&utm_medium=mastodon (RSS) #MassSpecRSS #JASMS

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