- (RSS) (BioRxiv All) Activity and Dynamics of p110α are not Differentially Modulated by Regulatory Subunit Isoforms: Class IA phosophoinositide kinases (PI3Ks) are master regulators of growth, metabolism, and immunity. The class IA PI3Ks are a heterodimer composed of a p110 catalytic subunit and one of five possible regulatory subunits (p85, p85{beta}, p55{gamma}, p55, p50). The regulatory subunit plays critical roles in stability, inhibition, and… https://www.biorxiv.org/content/10.1101/2025.10.16.682970v1?rss=1&utm_source=dlvr.it&utm_medium=mastodon #BioRxiv #MassSpecRSS
- (RSS) (ABioanChem) Ion mobility–mass spectrometry of palytoxin-like compounds produced by Ostreopsis cf. ovata: Palytoxin (PLTX) and its analogues from Ostreopsis cf. ovata are significant health concerns. They show potent vasoconstrictive properties, often causing seafood poisoning. PLTX analogues have chiral centers, resulting in many isomers, making their separation by liquid chromatography and identification/characterization by mass spectrometry… https://link.springer.com/article/10.1007/s00216-025-06158-7?utm_source=dlvr.it&utm_medium=mastodon #MassSpecRSS
- (RSS) (BioRxiv All) BiomarkerML: A cloud-based proteomics ML workflow for biomarker discovery: Background: High-throughput affinity and mass-spectrometry-based proteomic studies of large clinical cohorts generate high-dimensional proteomic data useful for accelerated disease biomarker discovery. A powerful approach to realizing the potential of these big, complex, and non-linear data, whilst ensuring reproducible results, is to use automated machine… https://www.biorxiv.org/content/10.1101/2025.10.16.682839v1?rss=1&utm_source=dlvr.it&utm_medium=mastodon #BioRxiv #MassSpecRSS
- (RSS) (J Proteom) Hypersensitivity and L-Asparaginase: A structural analysis of the interaction with HLA-DRB1*07:01: Publication date: Available online 17 October 2025Source: Journal of ProteomicsAuthor(s): Jhenifer Yonara de Lima, Emanuella de Castro Andreassa, Marlon Dias Mariano Santos, Paulo Costa Carvalho, Tatiana de Arruda Campos Brasil de Souza https://www.sciencedirect.com/science/article/pii/S1874391925001654?dgcid=rss_sd_all&utm_source=dlvr.it&utm_medium=mastodon #MassSpecRSS
- (RSS) (Biomed Chrom) Spatial Metabolomics Identifies Riboflavin Metabolism as a Therapeutic Target of Huangqi Guizhi Wuwu Decoction in Diabetic Nephropathy: ABSTRACTUnderstanding kidney metabolic heterogeneity is critical for unraveling diabetic nephropathy (DN) pathogenesis. While Huangqi Guizhi Wuwu decoction (HGD) shows efficacy against DN, its spatial metabolic effects remain unknown. We integrated liquid chromatography–mass… https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/bmc.70239?af=R&utm_source=dlvr.it&utm_medium=mastodon #massSpecRSS #biomedchrom
- (RSS) (BioRxiv All) Proximity Labelling Identifies Proteins Associated with HSV-2 pUL21 at Early and Late Times After Infection: pUL21 is a conserved and multifunctional alphaherpesvirus tegument protein that is critical for both early and late stages in the herpes simplex virus type 2 (HSV-2) replication cycle; however, how pUL21 participates in these activities is poorly understood. To help elucidate the role of pUL21 in these various activities,… https://www.biorxiv.org/content/10.1101/2025.10.16.682918v1?rss=1&utm_source=dlvr.it&utm_medium=mastodon #BioRxiv #MassSpecRSS
- (RSS) (BioRxiv All) Signal Attrition in Whole Cell Crosslinking Mass Spectrometry: Crosslinking mass spectrometry (XL-MS) could replace traditional techniques for sampling the cellular interactome, such as affinity pulldown MS. It generates superior interaction data that can be used to better model cellular structure and function. However, the sampling depth of current XL-MS techniques is disappointing. Poor sampling is often blamed on a… https://www.biorxiv.org/content/10.1101/2025.10.16.682930v1?rss=1&utm_source=dlvr.it&utm_medium=mastodon #BioRxiv #MassSpecRSS
- (RSS) (BioRxiv All) Shifts in ruminant fermentation during inhibition of methanogenesis are reflected in the isotope compositions of volatile fatty acids.: Ruminant animals are a major source of the potent greenhouse gas methane, but they are also a tractable target for climate solutions. Several strategies have been developed to lower methane emissions from ruminants, including feed additives that inhibit methanogenic archaea. Sustainable solutions… https://www.biorxiv.org/content/10.1101/2025.10.16.682381v1?rss=1&utm_source=dlvr.it&utm_medium=mastodon #BioRxiv #MassSpecRSS
- (RSS) (BioRxiv All) Assembly and cell-free expression of a partial genome for the synthetic cell: The de novo design and assembly of a DNA genome represents an important milestone toward the construction of a minimal synthetic cell. The genome must contain all the instructions to enable primary cellular functions, probably comprising over 150 genes with a total size over 200 kb. Here, we designed and built a partial synthetic genome that satisfies… https://www.biorxiv.org/content/10.1101/2025.10.16.682769v1?rss=1&utm_source=dlvr.it&utm_medium=mastodon #BioRxiv #MassSpecRSS
- (RSS) (ABioanChem) Influence of pre-analytical factors and biological variability on the urinary volatilome: Volatile organic compounds (VOCs) in urine have shown increasing promise as non-invasive biomarkers for the early detection and monitoring of diseases. However, their volatile nature may make them highly susceptible to pre-analytical factors, presenting significant challenges for consistent biomarker discovery and reproducibility within metabolomic… https://link.springer.com/article/10.1007/s00216-025-06137-y?utm_source=dlvr.it&utm_medium=mastodon #MassSpecRSS
- (RSS) (J Proteom) Enhancing glycopeptide annotation and glycan localization using electron activated dissociation through a multiplexed parallel reaction monitoring design of experiments: Publication date: Available online 15 October 2025Source: Journal of ProteomicsAuthor(s): Hiba Salim, Ruben Almey, Laura Pont, Fernando Benavente, Maarten Dhaenens, Estela Giménez https://www.sciencedirect.com/science/article/pii/S1874391925001733?dgcid=rss_sd_all&utm_source=dlvr.it&utm_medium=mastodon #MassSpecRSS
- (RSS) (JASMS) [ASAP] Strategies for Minimizing Interference from Metastable Water Clusters in ToF-SIMS 3D Imaging of Frozen Hydrated Biological Samples: Journal of the American Society for Mass SpectrometryDOI: 10.1021/jasms.5c00251 http://dx.doi.org/10.1021/jasms.5c00251?utm_source=dlvr.it&utm_medium=mastodon (RSS) #MassSpecRSS #JASMS
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