- (RSS) (Proteom Res News) ChiP-DIP – new post!:  WOW! Did I ever blow my initial take on this paper. Not a little, but by so much that I'm a little concerned about whether I have some level of impairment in my reading and/or comprehension right now. I'm tempted to write it off as flu like symptoms while moving my family to a new city in the winter, and hoping it isn't a brain tumor, but – if you saw that post it was way off. I'm… https://proteomicsnews.blogspot.com/2024/12/chip-dip-new-post.html?utm_source=dlvr.it&utm_medium=mastodon (/Proteom Res News) #proteomics
- (RSS) (J Chrom A) Development of a liquid chromatography–mass spectrometry based targeted metabolomics method for discovering diagnostic biomarkers in Kawasaki disease: Publication date: Available online 20 December 2024Source: Journal of Chromatography AAuthor(s): Xialin Luo, Jiaqi Tian, Qing Li, Zhonggan Jin, Xiaoyu Fan, Hong Zhang, Haitao Lv, Yi Ju https://www.sciencedirect.com/science/article/pii/S0021967324009920?dgcid=rss_sd_all&utm_source=dlvr.it&utm_medium=mastodon #JChrom #MassSpecRSS
- (RSS) (BioRxiv All) Breaking Barriers in Crosslinking Mass Spectrometry: Enhanced Throughput and Sensitivity with the Orbitrap Astral Mass Analyzer: The advancement of crosslinking mass spectrometry (CLMS) has significantly enhanced the ability to study protein-protein interactions and complex biological systems. This study evaluates the performance of the Orbitrap Astral and Eclipse mass spectrometers in CLMS workflows, focusing on the… http://biorxiv.org/cgi/content/short/2024.12.21.629875v1?rss=1&utm_source=dlvr.it&utm_medium=mastodon #BioRxiv #MassSpecRSS
- (RSS) (BioRxiv All) Multi-Tissue Metabolomics Reveal mtDNA- and Diet-Specific Metabolite Profiles in a Mouse Model of Cardiometabolic Disease: Rationale: Excess consumption of sugar- and fat-rich foods has heightened the prevalence of cardiometabolic disease, which remains a driver of cardiovascular disease- and type II diabetes-related mortality globally. Skeletal muscle insulin resistance is an early feature of cardiometabolic disease and is a… http://biorxiv.org/cgi/content/short/2024.12.19.629398v1?rss=1&utm_source=dlvr.it&utm_medium=mastodon #BioRxiv #MassSpecRSS
- (RSS) (BioRxiv All) MAETi: Mild acid elution in a tip enables quantitative immunopeptidome profiling from 25,000 cells: The identification of MHC class I presented ligands by mass spectrometry (MS)-based immunopeptidomics is an essential tool to characterize antigen processing pathways and to define targets for tumor immunotherapies. However, existing sample preparation workflows typically require large sample inputs, limiting the applicability in… http://biorxiv.org/cgi/content/short/2024.12.20.628848v1?rss=1&utm_source=dlvr.it&utm_medium=mastodon #BioRxiv #MassSpecRSS
- (RSS) (BioRxiv All) Integrating Ambient Mass Spectrometry Imaging and Spatial Transcriptomics on the Same Cancer Tissues to Identify Gene-Metabolite Correlations: The combination of spatial metabolomics and spatial transcriptomics can reveal powerful connections between gene expression and metabolism in heterogeneous tissues, but section-to-section variability can convolute data integration. We present a novel method combining Desorption… http://biorxiv.org/cgi/content/short/2024.12.20.626670v1?rss=1&utm_source=dlvr.it&utm_medium=mastodon #BioRxiv #MassSpecRSS
- (RSS) (ACS Anal Chem) [ASAP] Single-Cell Mass Spectrometry Studies of Secondary Drug Resistance of Tumor Cells: Analytical ChemistryDOI: 10.1021/acs.analchem.4c04263 http://dx.doi.org/10.1021/acs.analchem.4c04263?utm_source=dlvr.it&utm_medium=mastodon #MassSpecRSS #ACSAChem
- (RSS) (Proteom Res News) Why (and how!) to look at mass spectra! January 29th webinar!:  Today you can buy a mass spec package and – as long as nothing breaks – and you take really good notes most people can be generating really good proteomics data.When it's not working – well….that's different. Troubleshooting still seems to require an expert or a lot of work and logical exclusion of components one at a time. If your fancy neural… https://proteomicsnews.blogspot.com/2024/12/why-and-how-to-look-at-mass-spectra.html?utm_source=dlvr.it&utm_medium=mastodon (/Proteom Res News) #proteomics
- (RSS) (Proteom Res News) ChiP-DIP – Use hundreds of antibodies to avoid mass spectrometrists!:  I might have honestly ranted about this preprint at some point last year, but it just came out in Nature Genetics. I think it counts as the all time high water mark for how much work scientists are willing to do to avoid mass spectrometrists. There is, by concentration more histone protein in each typical human cell than messenger RNA.… https://proteomicsnews.blogspot.com/2024/12/chip-dip-use-hundreds-of-antibodies-to.html?utm_source=dlvr.it&utm_medium=mastodon (/Proteom Res News) #proteomics
- (RSS) (RSC A Meth) Enabling simultaneous photoluminescence spectroscopy and X-ray Footprinting Mass Spectrometry to study protein conformation and interactions: Anal. Methods, 2025, Accepted ManuscriptDOI: 10.1039/D4AY01670J, PaperSayan Gupta, Brandon Russell, Line G. Kristensen, Shawn M. Costello, James Tyler, Corie Y. Ralston, Behzad Rad, Susan MarquseeX-ray Footprinting Mass Spectrometry (XFMS) is a structural biology method that uses broadband X-rays… http://pubs.rsc.org/en/Content/ArticleLanding/2025/AY/D4AY01670J?utm_source=dlvr.it&utm_medium=mastodon #MassSpecRSS
- (RSS) (BioRxiv All) Yersinia pestis actively inhibits the production of extracellular vesicles by human neutrophils: Yersinia pestis is the etiologic agent of the plague. A hallmark of plague is subversion of the host immune response by disrupting host signaling pathways required for inflammation. This non-inflammatory environment permits bacterial colonization and has been shown to be essential for disease manifestation. Previous work has shown… http://biorxiv.org/cgi/content/short/2024.12.20.629761v1?rss=1&utm_source=dlvr.it&utm_medium=mastodon #BioRxiv #MassSpecRSS
- (RSS) (BioRxiv All) Activation and signaling characteristics of the hydroxy-carboxylic acid 3 receptor identified in human neutrophils through a microfluidic flow cell technique: Human neutrophils express numerous G protein-coupled receptors (GPCRs) of importance for immune regulation. Several of the functionally known neutrophil GPCRs, are not part of the human neutrophil proteome. To identify GPCRs not earlier shown to be expressed in human… http://biorxiv.org/cgi/content/short/2024.12.17.628937v1?rss=1&utm_source=dlvr.it&utm_medium=mastodon #BioRxiv #MassSpecRSS
Mass spectrometry websites, social media, journal feeds, and other links and items of interest to the mass spectrometry community.
