Proceedings of the National Academy of Sciences

• In This Issue
  June 16, 2026
  Proceedings of the National Academy of Sciences, Volume 123, Issue 24, June 2026.
• Heterotypic intercellular adhesion tunes efficiency of cell-on-cell migration
  June 12, 2026 by Chandrashekar KuyyamudiSuhrid GhoshCassandra G. Extavourahttps://ror.org/03vek6s52Department of Organismic and Organismic Biology, Harvard University, Cambridge, MA 02138bHHMI, Chevy Chase, MD 20815chttps://ror.org/03vek6s52Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138
  Proceedings of the National Academy of Sciences, Volume 123, Issue 24, June 2026. SignificanceCell adhesion is important for cell migration, and when cells migrate on a substrate of other cells (rather than on extracellular matrix), the adhesive properties of both cell types must be considered. However, whether and how dynamic changes …
• Conceptual priorities shape individual gaze patterns during naturalistic visual attention
  June 12, 2026 by Amanda J. HaskinsKatherine O. PackardCaroline E. Robertsonahttps://ror.org/049s0rh22Department of Psychological and Brain Sciences, Dartmouth College, Hanover, NH 03755bhttps://ror.org/0168r3w48Department of Psychology, University of California, San Diego, CA 92093
  Proceedings of the National Academy of Sciences, Volume 123, Issue 24, June 2026. SignificanceStepping into a new visual environment, we immediately start to explore that environment with our eyes. What factors shape how we selectively allocate our attention? Participants explored 360°, real-world environments while their gaze was …
• Experimental evolution of cellular miniaturization reveals a putative mechanism for cell size evolution
  June 12, 2026 by Ana GaroñaMorgane V. LemosAndrea GiomettoMarco Fumasoniahttps://ror.org/0346k0491Gulbenkian Institute for Molecular Medicine, Oeiras 2780-156, Portugalbhttps://ror.org/05bnh6r87School of Civil and Environmental Engineering, Cornell University, Ithaca, NY 14853chttps://ror.org/01c27hj86Faculdade de Medicina da Universidade de Lisboa, Lisbon 1649-028, Portugal
  Proceedings of the National Academy of Sciences, Volume 123, Issue 24, June 2026. SignificanceCell size influences nearly every aspect of cellular physiology and varies drastically among eukaryotes, yet how such diversity evolves without compromising cellular function remains unclear. Using experimental evolution in budding yeast, we …
• Transformations of the spatial activity manifold convey aversive information in CA3
  June 12, 2026 by Albert Miguel-LópezNegar NikbahktCarlos Wert-CarvajalLena Johanna GschossmannMartin PofahlHeinz BeckTatjana Tchumatchenkoahttps://ror.org/01xnwqx93Universität Bonn, Universitätsk-linikum Bonn, Institute for Experimental Epileptology and Cognition Research, Bonn 53127, Germany
  Proceedings of the National Academy of Sciences, Volume 123, Issue 24, June 2026. SignificanceThe hippocampus helps us remember where we are and how we feel in different situations. We studied how the hippocampus combines location and affective experiences by recording activity from specific hippocampal connections in mice exploring a …
• LARP1 integrates MYC and mTOR signaling to enable anabolic growth during tumor initiation
  June 12, 2026 by Pedro FuentesFlavia IannizzottoElisa BattagliaChiara BalzamoCarla TolaBerta ForcadaPau Bosch-i-CrespoFrancisco D. Morón-DuranBrandon E. FrankCarolina Martínez-HerráezZoi MastoraGabriella Manfili-MarinhoAlbert TaulerCristina SantosRamón SalazarAntonio Gentilellaahttps://ror.org/0008xqs48Laboratory of Cancer Metabolism, ONCOBELL Program, Bellvitge Biomedical Research Institute, Barcelona 08908, SpainbDepartment of Biology, University of Napoli “Federico II”, Napoli 80125, Italychttps://ror.org/01j1eb875Oncology Data Analytics Program, Catalan Institute of Oncology, L’Hospitalet de Llobregat, Barcelona 08908, Spaindhttps://ror.org/021018s57Department of Clinical Sciences, Faculty of Medicine and Universitat de Barcelona Institute of Complex Systems, University of Barcelona, Barcelona 08908, SpaineConsortium for Biomedical Research in Epidemiology and Public Health, Madrid 28029, Spainfhttps://ror.org/021018s57Department of Biochemistry and Physiology, Faculty of Pharmacy and Food Science, University of Barcelona, Barcelona 08028, Spainghttps://ror.org/021018s57Department of Clinical Sciences, Faculty of Medicine, University of Barcelona, Barcelona 08908, SpainhConsortium for Biomedical Research in Oncology, Madrid 28029, Spain
  Proceedings of the National Academy of Sciences, Volume 123, Issue 24, June 2026. SignificanceMany cancers are driven by oncogenes—mutated genes that reprogram cells toward uncontrolled growth. How and when this genetic reprogramming is turned into actual tumor mass remains unclear. Here, we show that cancer-driving mutations (MYC …
• Phosphoproteome-derived peptide libraries for deep specificity profiling of phosphatases and phospholyases
  June 12, 2026 by Katarzyna RadziwonLaura A. CampbellLauren E. MazurkiewiczSopo JalalishviliIzabelle EppingerAanika ParikhAmy M. Weeksahttps://ror.org/01y2jtd41Department of Biochemistry, University of Wisconsin–Madison, Madison, WI 53706bhttps://ror.org/01y2jtd41Department of Chemistry, University of Wisconsin–Madison, Madison, WI 53706
  Proceedings of the National Academy of Sciences, Volume 123, Issue 24, June 2026. SignificanceProtein phosphorylation regulates nearly every aspect of biology and is dynamically controlled by the opposing activities of writer and eraser enzymes. While the sequences preferences of writer enzymes have been characterized extensively, …
• Mapping ammonia emission plumes using shortwave infrared imaging spectroscopy
  June 12, 2026 by Nicholas BalasusDaniel H. CusworthJinsol KimDaniel J. VaronCharles E. MillerRiley M. DurenaCarbon Mapper, Pasadena, CA 91101bhttps://ror.org/042nb2s44Department of Aeronautics and Astronautics, Massachusetts Institute of Technology, Cambridge, MA 02139chttps://ror.org/05dxps055Jet Propulsion Laboratory, California Institute of Technology, Pasadena, CA 91101
  Proceedings of the National Academy of Sciences, Volume 123, Issue 24, June 2026. Atmospheric ammonia emissions are harmful to ecosystems and human health. These emissions have traditionally been monitored using thermal infrared spectrometers, though such techniques are limited by thermal contrast requirements, the coarse spatial …
• Correction for Ajourlou et al., Upper mantle temperatures illuminate the Iceland hotspot track and understanding of ice–Earth interactions in Greenland
  June 12, 2026
  Proceedings of the National Academy of Sciences, Volume 123, Issue 24, June 2026.
• Phase-selective Floquet engineering in a charge density wave material
  June 11, 2026 by Fei WangXuanxi CaiTeng XiaoChanghua BaoHaoyuan ZhongWanying ChenTianyun LinTianshuang ShengXiao TangHongyun ZhangPu YuZhiyuan SunShuyun Zhouahttps://ror.org/03cve4549Department of Physics, Tsinghua University, Beijing 100084, People’s Republic of Chinabhttps://ror.org/016g9tg59State Key Laboratory of Low-Dimensional Quantum Physics, Department of Physics, Tsinghua University, Beijing 100084, People’s Republic of Chinachttps://ror.org/01dq60k83Advanced Institute for Materials Research (WPI-AIMR), Tohoku University, Sendai 980-8577, Japandhttps://ror.org/03cve4549Frontier Science Center for Quantum Information, Tsinghua University, Beijing 100084, People’s Republic of China
  Proceedings of the National Academy of Sciences, Volume 123, Issue 24, June 2026. SignificanceFloquet engineering provides an emerging approach to tailor quantum materials using time-periodic drives. Here, we demonstrate Floquet engineering of TiSe2which is enabled by the spatially periodic charge density wave (CDW) transition. We …
• Development of a robust method to derive human trophoblast stem cells from late-gestation placentas and its application to preeclampsia
  June 11, 2026 by Akira OikeEri H. KobayashiYasuhiro YamamotoHirotaka HamadaSota TakahashiTakanori ShimizuAkane KitamuraAsato SekiyaNorio KobayashiShun ShibataShun EndoTetsuya SatoNaoto KubotaChie KikutakeMikita SuyamaTakahiro ArimaHiroaki Okaeahttps://ror.org/02cgss904Department of Trophoblast Research, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto 860-0811, Japanbhttps://ror.org/01dq60k83Department of Informative Genetics, Environment and Genome Research Center, Tohoku University Graduate School of Medicine, Sendai 980-8575, Japanchttps://ror.org/01dq60k83Division of Molecular Physiology and Metabolism, Tohoku University Graduate School of Medicine, Sendai, 980-8575, Japandhttps://ror.org/01dq60k83Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai 980-8575, Japanehttps://ror.org/00jmfr291Department of Mechanical Engineering, University of Michigan, Ann Arbor, MI 48109fhttps://ror.org/04zb31v77Biomedical Research Center, Saitama Medical University, Saitama 350-1241, Japanghttps://ror.org/00p4k0j84Division of Bioinformatics, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812-8582, Japanhhttps://ror.org/03nawhv43Division of Biomedical Sciences, School of Medicine, University of California, Riverside, CA 92521ihttps://ror.org/03nawhv43Center for RNA Biology and Medicine, University of California, Riverside, CA 92521jhttps://ror.org/01dq60k83Department of Molecular Oncology, Institute of Development, Aging and Cancer, Tohoku University, Sendai 980-8575, Japan
  Proceedings of the National Academy of Sciences, Volume 123, Issue 24, June 2026. SignificanceTrophoblasts play central roles in placental development and function. Although trophoblast dysfunction underlies many pregnancy complications, the molecular pathogenesis remains poorly understood due to the scarcity of appropriate …
• Strain-specific propagation of variant Creutzfeldt–Jakob disease prions in humanized neural cells
  June 11, 2026 by Melissa L. D. RaynerParineeta AroraJacqueline M. LinehanHelena RosAkin NihatFabio ArgentinaConnor PrestonChristian SchmidtJuan M. RibesPeter-Christian KlöhnSimon MeadSebastian BrandnerJohn CollingeParmjit S. Jatahttps://ror.org/03x94j517Medical Research Council Prion Unit at UCL, UCL Institute of Prion Diseases, London W1W 7FF, United Kingdombhttps://ror.org/02jx3x895Department of Pharmacology, UCL School of Pharmacy, University College London, London WC1N 1AX, United Kingdomchttps://ror.org/02jx3x895National Health Service National Prion Clinic, National Hospital for Neurology and Neurosurgery, University College London Hospitals National Health Service Foundation Trust, London WC1N 3BG, United Kingdomdhttps://ror.org/02wnqcb97Division of Neuropathology, The National Hospital for Neurology and Neurosurgery, University College National Health Service Foundation Trust, London WC1N 3BG, United Kingdomehttps://ror.org/0370htr03Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London WC1N 3BG, United Kingdom
  Proceedings of the National Academy of Sciences, Volume 123, Issue 24, June 2026. SignificancePrions are infectious protein assemblies in which conformation encodes heritable strain information. Mechanistic study of human prion propagation has been limited by the lack of suitable cell models. Here, we establish humanized neural cells …
• Glycosylation-independent functions for distinct glypican core proteins drive cell-specific responses in corticogenesis
  June 11, 2026 by Sara DouceauTanya Deutsch GuerreroChloé BorowskiChloé LourençoMargot WeberHanna KavaliovaEmma BraultCamille PonsAnne RoumierRebekka WildJulien Ferentahttps://ror.org/02en5vm52Institut du Fer à Moulin, Inserm, Sorbonne Université, Paris 75005, Francebhttps://ror.org/02en5vm52Sorbonne Université, CNRS, Inserm, Center for Neuroscience Sorbonne Université (Neuro-SU), Paris 75005, Francechttps://ror.org/01c2cjg59Sorbonne Université, CNRS, Inserm, Institut de Biologie Paris-Seine (IBPS), Paris 75005, Francedhttps://ror.org/00jjx8s55Institut de Biologie Structurale, UMR 5075, University Grenoble Alpes, CNRS, Commissariat à l’énergie atomique et aux énergies alternatives (CEA), Grenoble 38000, France
  Proceedings of the National Academy of Sciences, Volume 123, Issue 24, June 2026. SignificanceBrain development relies on precise signaling in the extracellular space, which is regulated by proteoglycans, including glypicans. It was long thought that these molecules acted solely through their sugar extensions (GAG chains). Our research …
• Subcellular metallomic networks orchestrate physiological outcomes: Single-cell mapping via an integrated SEM-FIB-TOF-SIMS platform
  June 11, 2026 by Mengzhu ChengLihong WangZiwei WangTianjiao WangJun ZhaoBin XuPing QiuTiantian LiuXiaohua HuangXing Wang DengaPeking University Institute of Advanced Agricultural Sciences, Shandong Laboratory of Advanced Agriculture Sciences in Weifang, Shandong 261325, Chinabhttps://ror.org/02v51f717School of Advanced Agricultural Sciences and School of Life Sciences, Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China
  Proceedings of the National Academy of Sciences, Volume 123, Issue 24, June 2026. SignificanceThis study introduces an integrated scanning electron microscopy–focused ion beam–time-of-flight-secondary ion mass spectrometry (SEM-FIB-TOF-SIMS) platform combining full-spectrum elemental detection, nanometer-scale resolution, and precise …
• A protective role for APP in nuclear waste clearance via lysosomal exocytosis
  June 11, 2026 by Godfried DougnonTakayoshi OtsukaYuka NakamuraAkiko SakaiTomoyuki YamanakaNoriko MatsuiAsa NakaharaAi ItoAtsushi HatanoMasaki MatsumotoHironaka IgarashiAkiyoshi KakitaMasaki UenoHideaki Matsuiahttps://ror.org/04ww21r56Department of Neuroscience of Disease, Brain Research Institute, Niigata University, Niigata 951-8585, Japanbhttps://ror.org/04ww21r56Department of System Pathology for Neurological Disorders, Brain Research Institute, Niigata University, Niigata 951-8585, Japanchttps://ror.org/04ww21r56Department of Pathology, Brain Research Institute, Niigata University, Niigata 951-8585, Japandhttps://ror.org/04ww21r56Department of Omics and Systems Biology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata 951-8510, Japanehttps://ror.org/04ww21r56Department of Biological Magnetic Resonance, Center for Integrated Human Brain Science, Brain Research Institute, Niigata University, Niigata 951-8585, Japan
  Proceedings of the National Academy of Sciences, Volume 123, Issue 24, June 2026. SignificanceResearch on Alzheimer’s disease (AD) has largely focused on amyloid-β, a fragment of the amyloid precursor protein (APP). However, the physiological functions of APP remain poorly understood. Here, we show that APP protects cells by clearing …
• Quantum algorithms for viscosity solutions to nonlinear Hamilton–Jacobi equations based on an entropy penalization method
  June 10, 2026 by Shi JinNana Liuahttps://ror.org/0220qvk04Institute of Natural Sciences, Shanghai Jiao Tong University, Shanghai 200240, Chinabhttps://ror.org/0220qvk04School of Mathematical Sciences, Shanghai Jiao Tong University, Shanghai 200240, Chinachttps://ror.org/0220qvk04Ministry of Education Key Laboratory in Scientific and Engineering Computing, Shanghai Jiao Tong University, Shanghai 200240, Chinadhttps://ror.org/0220qvk04Global College, Shanghai Jiao Tong University, Shanghai 200240, China
  Proceedings of the National Academy of Sciences, Volume 123, Issue 24, June 2026. SignificanceWe developed quantum algorithms for nonlinear Hamilton–Jacobi equations that obviated several major obstacles for nonlinear partial differential equations:valid for general convex and strongly nonlinear Hamiltonian with small dissipation;valid …
• Driven by climate change, sudden swings between wet and dry create “hydrologic whiplash”
  June 10, 2026 by Amy McDermott
  Proceedings of the National Academy of Sciences, Volume 123, Issue 24, June 2026.
• Telocyte-derived pentraxin 3 enables vascular pruning as a key driver in infantile hemangioma regression
  June 10, 2026 by Léa PechtimaldjianMarie-Laure JulliéChloé RoussonFaiza LaananiJulie ClachetYamina IdrissiMaya LootMuriel Cario-AndreSorilla PreyAlain TaiebChristine Leauté-LabrèzeThomas MathivetFrançois Moisanahttps://ror.org/02gezhp66University of Bordeaux, Inserm, Bordeaux Institute of Oncology, UMR 1312, Bordeaux F-33076, Francebhttps://ror.org/01hq89f96Service de Pathologie, Centre Hospitalier Universitaire de Bordeaux, Bordeaux F-33000, Francechttps://ror.org/01hq89f96Service de Chirurgie Pédiatrique, Centre Hospitalier Universitaire de Bordeaux, Bordeaux F-33000, FrancedCentre de Référence Maladies Rares de la Peau et des Muqueuses d’origine Génétique Sud, Bordeaux F-33000, FranceeAquiderm, Bordeaux F-33000, Francefhttps://ror.org/01hq89f96Service de dermatologie pédiatrique et adulte, Centre Hospitalier Universitaire de Bordeaux, Bordeaux F-33000, France
  Proceedings of the National Academy of Sciences, Volume 123, Issue 24, June 2026. SignificanceFor some tumors, including infantile hemangioma, spontaneous regression occurs naturally, though the cellular actors driving this process have generally remained unknown. Here, we identified a mechanism by which specialized stromal cells, …
• Dark diversity framework reconciles Darwin’s naturalization conundrum for freshwater fish invasions
  June 10, 2026 by Wen-gang ZhangMeng XuShu-ya FanJonathan A. BennettRoss N. CuthbertJaimie T. A. DickMeelis PärtelShao-peng Liahttps://ror.org/02n96ep67Research Center for Global Change and Ecological Forecasting, Zhejiang Tiantong Forest Ecosystem National Observation and Research Station, Institute of Eco-Chongming, School of Ecological and Environmental Sciences, East China Normal University, Shanghai 200241, Chinabhttps://ror.org/034t30j35Key Laboratory of Lake and Watershed Science for Water Security, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, Chinachttps://ror.org/04and7w57Key Laboratory of Prevention and Control for Aquatic Invasive Alien Species, Ministry of Agriculture and Rural Affairs, Pearl River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Guangzhou 510380, Chinadhttps://ror.org/0546hnb39Ecology, Department of Biology, University of Konstanz, Konstanz 78457, Germanyehttps://ror.org/0415vcw02The Forest Risk Research Centre, Faculty of Forestry and Wood Sciences, Czech University of Life Sciences Prague, Prague 16500, Czech Republicfhttps://ror.org/010x8gc63Department of Plant Sciences, University of Saskatchewan, Saskatoon, SK S7N5A8, Canadaghttps://ror.org/00hswnk62Research Centre in Sustainable Energy, Institute for Global Food Security, School of Biological Sciences, Queen’s University Belfast, Belfast BT95DL, United Kingdomhhttps://ror.org/03z77qz90Department of Botany, Institute of Ecology and Earth Science, University of Tartu, Tartu 50409, Estonia
  Proceedings of the National Academy of Sciences, Volume 123, Issue 24, June 2026. SignificancePredicting which exotic species will establish in new environments is a central challenge for invasion ecology. Since Darwin first posed his naturalization conundrum, ecologists have long debated whether exotic species similar or dissimilar to …
• Disruption to TFEB signaling and autophagy in newly formed oligodendrocytes leads to aberrant generation of CNS myelin
  June 10, 2026 by Daniela BarbosaAksheev BhambriMiguel VasquezYihe ZhangGabrielle SanchezKatherine J. WertNatalia V GounkoMark H. EllismanLu O. Sunahttps://ror.org/05byvp690Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390bhttps://ror.org/0168r3w48National Center for Microscopy and Imaging Research, Department of Neuroscience, University of California San Diego, La Jolla, CA 92039chttps://ror.org/05byvp690Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, TX 75390dhttps://ror.org/05byvp690Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390ehttps://ror.org/05byvp690Peter O’Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390fhttps://ror.org/05byvp690Electron Microscopy Core Facility, Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390
  Proceedings of the National Academy of Sciences, Volume 123, Issue 24, June 2026. SignificanceThe cellular and molecular mechanisms governing myelin integrity during axon ensheathment remain poorly understood. Using volume electron microscopy and a knock-in mouse line labeling newly formed oligodendrocytes and their myelin sheaths, we …

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