- Proceedings of the National Academy of Sciences, Volume 122, Issue 35, September 2025.
- by Yukun SunEmily PalmerChristopher DoughertyCade SbroccoAspen ShihJena ShieldsChris RohaDepartment of Biological and Environmental Engineering, Cornell University, Ithaca, NY 14853bDepartment of Physics, Albert Nerken School of Engineering, The Cooper Union for the Advancement of Science and Art, New York, NY 10003cDepartment of Physics, Cornell University, Ithaca, NY 14853dDepartment of Applied and Engineering Physics, Cornell University, Ithaca, NY 14853Proceedings of the National Academy of Sciences, Volume 122, Issue 35, September 2025. SignificanceThrough the action of flapping, biological flyers generate a vortex upon each wing known as the leading-edge vortex (LEV), which has been shown to enhance aerodynamic force production. However, the LEV does not grow indefinitely. Here, by …
- by Samuel W. DuGrazyna PalczewskaZhiqian DongJulie C. LauterbornBalasankara Reddy KaipaAlexander L. YanRafaĹ‚ HoĹ‚ubowiczSiyoung HaPaul Z. ChenChristine M. GallGulab ZodeDavid R. LiuKrzysztof PalczewskiaGavin Herbert Eye Institute—Robert M. Brunson Center for Translational Vision Research, Department of Ophthalmology and Visual Sciences, University of California Irvine, Irvine, CA 92697bDepartment of Physiology and Biophysics, University of California Irvine, Irvine, CA 92697cDepartment of Anatomy and Neurobiology, School of Medicine, University of California Irvine, Irvine, CA 92697dMerkin Institute of Transformative Technologies in Healthcare, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142eDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02142fHHMI, Harvard University, Cambridge, MA 02142gDavid H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139hDepartment of Chemistry, University of California Irvine, Irvine, CA 92697iDepartment of Molecular Biology and Biochemistry, University of California Irvine, Irvine, CA 92697Proceedings of the National Academy of Sciences, Volume 122, Issue 35, September 2025. SignificanceGenome editing in vivo could provide alternative therapeutic options for diseases with a genetic component. A critical step is the evaluation of delivery strategies for viral and nonviral genome editors. Current genome editing reporter models …
- by Beatriz Urda-GarcĂaJon Sánchez-ValleRosalba LeporeAlfonso ValenciaaLife Sciences Department, Barcelona Supercomputing Center, Barcelona 08034, SpainbDepartment of Medicine and Life Sciences, Universitat Pompeu Fabra, Barcelona 08003, SpaincDepartment of Biomedicine, Basel University Hospital and University of Basel, Basel 4031, SwitzerlanddCatalan Institution for Research and Advanced Studies (ICREA), Barcelona 08010, SpainProceedings of the National Academy of Sciences, Volume 122, Issue 35, September 2025. SignificanceUnderstanding why certain diseases tend to co-occur is key for improving patient outcomes. This study introduces an approach to map disease co-occurrences using large-scale RNA sequencing data, revealing that many comorbidities share a …
- by Ji-Ung JungSteve StippecMelanie H. CobbaDepartment of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390Proceedings of the National Academy of Sciences, Volume 122, Issue 35, September 2025. SignificanceThis study shows that the mechanosensitive ion channel Piezo1 activates the protein kinase WNK1, a well-studied cell volume regulator. Activation of WNK1 and its downstream kinase targets OSR1 and SPAK by Piezo1 requires an increase in …
- by Muyang LuScott W. YancoBen S. CarlsonKevin WinnerJeremy M. CohenDiego Ellis-SotoShubhi SharmaWill RogersWalter JetzaKey Laboratory of Bio-Resources and Eco-Environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, Sichuan 610065, ChinabEcology and Evolutionary Biology, Yale University, New Haven, CT 06511cCenter for Biodiversity and Global Change, Yale University, New Haven, CT 06511dMigratory Bird Center, Smithsonian’s National Zoo and Conservation Biology Institute, Washington, DC 30001eYale Center for Research Computing, Yale University, New Haven, CT 06511fDepartment of Ecology, Evolution, and Natural Resources, Rutgers University, New Brunswick, NJ 08901gDepartment of Environmental Science Policy and Management, University of California, Berkeley, CA 94720Proceedings of the National Academy of Sciences, Volume 122, Issue 35, September 2025. SignificanceThe ecological niche—the environmental conditions that an organism requires to persist—is fundamental to many inquiries in ecology and evolutionary biology, from understanding the maintenance of biodiversity to predicting the impact of climate …
- by Dylon R. StephensHo Yee Joyce FungYan HanJue LiangZhe ChenJoseph ReadyJames J. CollinsaDepartment of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390bDepartment of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX 75390cDepartment of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390dHHMI, Chevy Chase, MD 20815Proceedings of the National Academy of Sciences, Volume 122, Issue 35, September 2025. SignificanceSchistosomes cause widespread infections in humans, leading to severe chronic illnesses in endemic regions. There is no vaccine for schistosomiasis, and there has been limited success using the current standard-of-care treatment, praziquantel. …
- Proceedings of the National Academy of Sciences, Volume 122, Issue 35, September 2025.
- by Zhi-Wei LiuMeng-Qi MaBo-Wen SunLiang LiWang JiangHan-Xiang ZangZhe BaiYang DongShao-Chun ZhangXiang-Dong ChenChong-Wen ZouGuang-Can GuoFang-Wen SunaDepartment of Optics and Optical Engineering, School of Physical Sciences, Laboratory of Quantum Information, University of Science and Technology of China, Hefei 230026, People’s Republic of ChinabChinese Academy of Sciences Center For Excellence in Quantum Information and Quantum Physics, University of Science and Technology of China, Hefei 230026, People’s Republic of ChinacDepartment of Accelerator Science and Engineering Physics, School of Nuclear Science and Technology, National Synchrotron Radiation Laboratory, University of Science and Technology of China, Hefei 230029, People’s Republic of ChinadHefei National Laboratory, University of Science and Technology of China, Hefei 230088, People’s Republic of ChinaProceedings of the National Academy of Sciences, Volume 122, Issue 35, September 2025. SignificanceThe modulation of electromagnetic field–matter interaction at micro/nanoscale is crucial for a variety of studies ranging from nanophotonics to quantum information science. Traditionally, subwavelength structures are fabricated to modify the …
- by Daniel S. SearaJonathan ColenMichel FruchartYael AvniDavid G. MartinVincenzo VitelliaJames Franck Institute, University of Chicago, Chicago, IL 60637bDepartment of Physics, University of Chicago, Chicago, IL 60637cJoint Institute on Advanced Computing for Environmental Studies, Old Dominion University, Norfolk, VA 23529dGulliver, CNRS, École SupĂ©rieure de Physique et Chimie Industrielles, UniversitĂ© Paris Sciences & Lettres, Paris 75005, FranceeLeinweber Institute for Theoretical Physics, University of Chicago, Chicago, IL 60637fEnrico Fermi Institute, University of Chicago, Chicago, IL 60637Proceedings of the National Academy of Sciences, Volume 122, Issue 35, September 2025. SignificanceIn communities of living organisms, dynamic behavior is often driven by social interactions. Hydrodynamics simplifies the description of systems composed of many interacting constituents. While hydrodynamic models incorporating social …
- by Shivansh MahajanAshley E. PallYancheng E. LiTimothy L. StemmlerDouglas C. ReesWilliam M. ClemonsaDivision of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125bDepartment of Pharmaceutical Sciences, Wayne State University, Detroit, MI 48202cHHMI, Chevy Chase, MD 20815dChan Zuckerberg Initiative, Redwood City, CA 94063Proceedings of the National Academy of Sciences, Volume 122, Issue 35, September 2025. SignificanceArsenic toxicity arises from the ability of trivalent arsenite to tightly bind thiol groups, thus disrupting cellular processes. Many bacteria can detoxify arsenite via efflux through the membrane transporter ArsB. In some species, a …
- by Amy RiceAndriana C. ZourouMyriam L. CottenRichard W. PastoraLaboratory of Computational Biology, National Heart, Lung, Blood Institute, National Institutes of Health, Bethesda, MD 20892bDepartment of Applied Science, William & Mary, Williamsburg, VA 23185cDepartment of Biochemistry and Biophysics, Oregon State University, Corvallis, OR 97331Proceedings of the National Academy of Sciences, Volume 122, Issue 35, September 2025. SignificanceMembrane active peptides are cationic amphipathic molecules that disrupt biological membranes to perform their function. Antimicrobial peptides, which are permeabilizing, kill bacteria and cancer cells, making them promising candidates to …
- Proceedings of the National Academy of Sciences, Volume 122, Issue 35, September 2025.
- by Zhixin WanCun LiYing ZhouYifei YuMan Chun ChiuJingjing HuangShuxin ZhangXiaoxin ZhuQiaoshuai LanYanlin DengWei XueChengfan JiangJiali WuZijun ZhaoJian-Piao CaiLin HuangYong ZhangXiaojuan LiuZheng ZhangHin ChuLinqi ZhangZhiwei ChenKelvin Kai-Wang ToKwok-Yung YuenHans CleversJie ZhouaDepartment of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, ChinabCentre for Virology, Vaccinology and Therapeutics, Hong Kong Science and Technology Park, Hong Kong, ChinacBiomOrgan Ltd., Hong Kong, ChinadClinical Stem Cell Research Center, Peking University Third Hospital, Beijing 100191, ChinaeInstitute for Hepatology, National Clinical Research Center for Infectious Disease, Shenzhen Third People’s Hospital, Shenzhen 518112, ChinafState Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong, ChinagPandemic Research Alliance Unit at the University of Hong Kong, Hong Kong, ChinahCenter for Global Health and Infectious Diseases, Comprehensive Acquired Immunodeficiency Syndrome Research Center and Beijing Advanced Innovation Center for Structural Biology, School of Medicine, and Vanke School of Public Health, Tsinghua University, Beijing 100084, ChinaiOncode Institute, Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences, and University Medical Center Utrecht, Utrecht 3584 CT, the NetherlandsjRoche Pharmaceutical Research and Early Development, Basel CH-4070, SwitzerlandProceedings of the National Academy of Sciences, Volume 122, Issue 35, September 2025. SignificanceVIR-7831, a class 3 anti-SARS-CoV-2 mAb with verified clinical effectiveness, was withdrawn since it showed diminished potency against Omicron variants in cell-line-based neutralization assays. The underestimated potency of VIR-7831 in …
- by Malia MarksYara KyrychenkoJohan GärdeboJon RoozenbeekaDepartment of Psychology, University of Cambridge, Cambridge CB2 3EB, United KingdombCambridge Centre for History and Economics, University of Cambridge, Cambridge CB5 8AB, United KingdomProceedings of the National Academy of Sciences, Volume 122, Issue 35, September 2025. Social media are often said to exacerbate polarization by platforming hostility between groups. However, positive social emotions like ingroup solidarity may also drive social media engagement, particularly after major threats such as military invasions …
- Proceedings of the National Academy of Sciences, Volume 122, Issue 35, September 2025.
- Proceedings of the National Academy of Sciences, Volume 122, Issue 35, September 2025.
- Proceedings of the National Academy of Sciences, Volume 122, Issue 35, September 2025.
- by Weijia XuNebojsa JojicSudha RaoChris BrockettBill DolanaMicrosoft Research, Redmond, WA 98052Proceedings of the National Academy of Sciences, Volume 122, Issue 35, September 2025. SignificanceReading through a set of texts generated by large language models (LLMs) under the same prompt can be a disappointing experience. The first might seem convincingly like a novel, creative work by a human writer. Read more, though, and the lack …
- by Chenhui FeiShun GuoYibing LiJingbo LiuaState Key Laboratory of Lithospheric and Environmental Coevolution, Institute of Geology and Geophysics, Chinese Academy of Sciences, Beijing 100029, ChinabMarine Science and Technology College, Zhejiang Ocean University, Zhoushan 316022, ChinacCollege of Earth and Planetary Sciences, University of Chinese Academy of Sciences, Beijing 100049, ChinaProceedings of the National Academy of Sciences, Volume 122, Issue 35, September 2025. SignificanceAbiotic organic synthesis in geological processes is closely linked to the Earth’s carbon cycle and the origin of early life. Our research revealed that the infiltration of ferrous chloride–rich silicic fluids into dolomitic marble induced a …
Mass spectrometry websites, social media, journal feeds, and other links and items of interest to the mass spectrometry community.
