- Proceedings of the National Academy of Sciences, Volume 122, Issue 16, April 2025.
- Proceedings of the National Academy of Sciences, Volume 122, Issue 16, April 2025.
- by Esmerina TiliTeresa L. CommissoVeronica BalattiJean-Jacques MichailleGerard J. NuovoCarlo M. CroceaDepartment of Anesthesiology, Wexner Medical Center, College of Medicine, The Ohio State University, Columbus, OH 43210bDepartment of Cancer Biology and Genetics, The Ohio State University Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210cGnome, Powell, OH 43065Proceedings of the National Academy of Sciences, Volume 122, Issue 16, April 2025. SignificanceIn this manuscript, we show thatmiR-155, a gene highly expressed in different hematological malignancies and solid tumors, modifies the expression of two important genes, namely ICOSL and MHC-I in diffuse large B cell lymphoma. ICOSL and MHC-…
- by Aleksander TworakRoman SmidakCarolline Rodrigues MenezesSamuel W. DuSusie SuhElliot H. ChoiSanae S. ImanishiZhiqian DongDominik LewandowskiKristen E. FongGabriela GrigoreanAntonio F. M. PintoQianlan XuDorota Skowronska-KrawczykSeth BlackshawYoshikazu ImanishiKrzysztof PalczewskiaDepartment of Ophthalmology, Gavin Herbert Eye Institute, University of California, Irvine, CA 92697bDepartment of Physiology and Biophysics, University of California, Irvine, CA 92697cDepartment of Chemistry, University of California, Irvine, CA 92697dDepartment of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697eDepartment of Ophthalmology, and Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN 46202fProteomics Core Facility, Genome Center, University of California, Davis, CA 95616gClayton Foundation Laboratories for Peptide Biology, Salk Institute for Biological Studies, La Jolla, CA 92037hDepartment of Ophthalmology, Johns Hopkins University, Baltimore, MD 21205iDepartment of Neurology, Institute for Cell Engineering, Kavli Neuroscience Discovery Institute, Johns Hopkins University, Baltimore, MD 21205jSolomon H. Snyder Department of Neuroscience, Johns Hopkins University, Baltimore, MD 21205Proceedings of the National Academy of Sciences, Volume 122, Issue 16, April 2025. SignificanceMutations in the membrane frizzled-related protein (MFRP) gene are associated with disorders affecting ocular development and vision. However, the role of MFRP in eye biology remains unclear. Our study on the biochemical properties of MFRP and …
- by Shufeng SunBiqing LiangAdam KoplasIrina TikhonenkoMaxence NachuryAlexey KhodjakovHaixin SuiaWadsworth Center, New York State Department of Health, Albany, NY 12237bDepartment of Biomedical Sciences, School of Public Health, University at Albany, Albany, NY 12237cDepartment of Ophthalmology, School of Medicine, University of California at San Francisco, San Francisco, CA 94158Proceedings of the National Academy of Sciences, Volume 122, Issue 16, April 2025. SignificancePrimary cilia are micrometers-long and 250-nm thin microtubule-based antennas responsible for transducing numerous signaling pathways in vertebrate cells. The formation of cilia, their maintenance, and functionality require highly specialized …
- by Huimin ZhangYouhang LiSameer Bikram ShahShibo LiQingrong LiJoshua OaksTinghong LvLinda Z. ShiHailong WangDong WangXiaohua WuaDepartment of Molecular and Cellular Biology, The Scripps Research Institute, La Jolla, CA 92037bCollege of Life Science, Capital Normal University, Beijing 100037, ChinacDepartment of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, CA 92093dThe Institute of Engineering in Medicine, University of California, San Diego, CA 92093Proceedings of the National Academy of Sciences, Volume 122, Issue 16, April 2025. SignificanceThe MRE11/RAD50/NBS1 (MRN) complex plays multiple roles in the maintenance of genome stability, requiring coordinated regulation of its activities, though the underlying mechanisms are not fully understood. In this study, we identified …
- by Yung-Hsin HuangJulia A. BelkRuochi ZhangNatasha E. WeiserZachary ChiangMatthew G. JonesPaul S. MischelJason D. BuenrostroHoward Y. ChangaDepartment of Dermatology, Center for Personal Dynamic Regulomes and Program in Epithelial Biology, Stanford University School of Medicine, Stanford, CA 94305bBroad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142cDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138dGene Regulation Observatory, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142eDepartment of Pathology, Stanford University, Stanford, CA 94305fSarafan Chemistry, Engineering, and Medicine for Human Health, Stanford University, Stanford, CA 94305gHoward Hughes Medical Institute, Stanford University, Stanford, CA 94305Proceedings of the National Academy of Sciences, Volume 122, Issue 16, April 2025. SignificanceThe spatial organization of cells within tissues plays a critical role in maintaining normal function and is often disrupted in disease. Understanding how cells are organized in complex tissues has been advanced by technologies that analyze …
- by Irina TopchiyBernat KocsisaDepartment Psychiatry, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215bDepartment Psychiatry, Basic Neuroscience Division, McLean Hospital, Harvard Medical School, Boston, MA 02478Proceedings of the National Academy of Sciences, Volume 122, Issue 16, April 2025. SignificanceOur study provided solid evidence showing the CB1 agonist effect on oscillations during sleep. We found that CB1-receptor activation leads to drastic restructuring of active stages of sleep, i.e., the spindle-rich intermediate sleep (IS) …
- by Kanishka SenarathIsaac J. FisherWonjo JangSumin LuAsuka InoueEvi KostenisAngeline M. LyonNevin A. LambertaDepartment of Pharmacology and Toxicology, Medical College of Georgia, Augusta University, Augusta, GA 30912bJames Tarpo Jr. and Margaret Tarpo Department of Chemistry, Purdue University, West Lafayette, IN 47907cMolecular and Cellular Biochemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, JapandDepartment of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606-8501, JapaneMolecular, Cellular and Pharmacobiology Section, Institute for Pharmaceutical Biology, University of Bonn, Bonn 53115, GermanyfDepartment of Biological Sciences, Purdue University, West Lafayette, IN 47907Proceedings of the National Academy of Sciences, Volume 122, Issue 16, April 2025. SignificanceMany important physiological processes are regulated by GPCR-mediated activation of Gqheterotrimers and PLCβ enzymes. Ion channels and other membrane proteins are regulated by PIP2 in the plasma membrane, and inositol 1,4,5-trisphosphate (IP3)…
- by Swati PantStephanie W. TamStephen B. LongaStructural Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065bGraduate Program in Biochemistry and Structural Biology, Cell and Developmental Biology, and Molecular Biology, Weill Cornell Medicine Graduate School of Medical Sciences, New York, NY 10065cGraduate Program in Physiology, Biophysics, and Systems Biology, Weill Cornell Medicine Graduate School of Medical Sciences, New York, NY 10065Proceedings of the National Academy of Sciences, Volume 122, Issue 16, April 2025. SignificanceÎł-aminobutyric acid (GABA) is the principal inhibitory neurotransmitter in the central nervous system. Extracellular GABA is primarily sensed by GABABG-protein-coupled receptors and GABAApentameric chloride channels. We show the chloride …
- by Biao QiuOlga BoudkeraDepartment of Physiology & Biophysics, Weill Cornell Medicine, New York, NY 10021bHHMI, Weill Cornell Medicine, New York, NY 10021Proceedings of the National Academy of Sciences, Volume 122, Issue 16, April 2025. SignificanceHuman excitatory amino acid transporter 3 (EAAT3) pumps L-glutamate, L-aspartate, and L-cysteine into cells using ion gradients. Its dysfunction is associated with neurological pathologies, and it is activated in cancers. Here, we examine the …
- Proceedings of the National Academy of Sciences, Volume 122, Issue 16, April 2025.
- by Giovanni RabuffoHouefa-Armelle LokossouZengmin LiAbolfazl Ziaee-MehrMeysam HashemiPascale P. QuilichiniAntoine GhestemOuafae ArabMonique EsclapezParul VermaAshish RajAlessandro GozziPierpaolo SorrentinoKai-Hsiang ChuangTeodora-Adriana Perles-BarbacaruAngèle ViolaViktor K. JirsaChristophe BernardaAix Marseille Univ, INSERM, INS, Inst Neurosci Syst, Marseille, FrancebCenter for Magnetic Resonance in Biology and Medicine, Aix Marseille University, CNRS, Marseille 13005, FrancecQueensland Brain Institute, The University of Queensland, Brisbane, QLD 4067, AustraliadDepartment of Radiology, University of California, San Francisco, CA 94143eFunctional Neuroimaging Laboratory, Center for Neuroscience and Cognitive Systems, Istituto Italiano di Tecnologia, Rovereto 38068, ItalyProceedings of the National Academy of Sciences, Volume 122, Issue 16, April 2025. SignificanceSpecific changes in one region can influence the activity throughout the entire brain, a phenomenon known asdiaschisis. This study combines advanced imaging techniques and personalized brain simulations in mice to investigate how targeted …
- by Sidney XiangDaniel M. RomeroMisha TeplitskiyaUniversity of Michigan School of Information, Ann Arbor, MI 48109bCenter for the Study of Complex Systems, University of Michigan, Ann Arbor, MI 48109cDepartment of Electrical Engineering and Computer Science, University of Michigan, Ann Arbor, MI 48109Proceedings of the National Academy of Sciences, Volume 122, Issue 16, April 2025. SignificanceInterdisciplinary research is essential to solving the world’s most pressing problems, there are concerns that scientific institutions like journals select against it. Analyzing peer review data from 128,950 science and technology manuscripts, …
- by Fredrik StridfeldtVikash PandeyHanna KylhammarMoein Talebian GevariPrattakorn MetemVipin AgrawalAndrĂ© GörgensDoste R. MamandJennifer GilbertLukas PalmgrenMargaret N. HolmeOskar GustafssonSamir El AndaloussiDhrubaditya MitraApurba DevaDepartment of Applied Physics, Kungliga Tekniska Högskolan Royal Institute of Technology, Stockholm 11419, SwedenbNordita, Kungliga Tekniska Högskolan Royal Institute of Technology and Stockholm University, Stockholm 11419, SwedencDepartment of Electrical Engineering, Uppsala University, Uppsala 75237, SwedendDivision of Applied Electrochemistry, Kungliga Tekniska Högskolan Royal Institute of Technology, Stockholm 11419, SwedeneDepartment of Physics, Stockholm University, Stockholm 11419, SwedenfDepartment of Materials Science and Engineering, Northwestern University, Evanston, IL 60208gDepartment of Laboratory Medicine, Division of Biomolecular and Cellular Medicine, Karolinska Institutet, Stockholm 17177, SwedenhDepartment of Cellular Therapy and Allogeneic Stem Cell Transplantation, Karolinska University Hospital Huddinge and Karolinska Comprehensive Cancer Center, Stockholm 17177, SwedeniInstitute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen 45147, GermanyjBreast Center, Karolinska Comprehensive Cancer Center, Karolinska University Hospital, Stockholm 75105, SwedenkKarolinska Advanced Therapy Medicinal Products Center, ANA Futura, Huddinge 17177, SwedenlDivision of Chemical Biology, Department of Life Sciences, Chalmers University of Technology, Gothenburg 41296, SwedenProceedings of the National Academy of Sciences, Volume 122, Issue 16, April 2025. SignificanceThe purpose of this study is to better understand extracellular vesicles and their nanomechanical properties. This is vital as elasticity is believed to influence cellular interaction and by extension how intercellular communication works. Our …
- by Yuan ShenJĂ©rĂ©my O’ByrneAndreas SchoenitAnanyo MaitraRenĂ©-Marc MègeRaphaĂ«l VoituriezBenoit LadouxaUniversitĂ© Paris CitĂ©, CNRS, Institut Jacques Monod, Paris F-75013, FrancebLaboratoire Jean Perrin, CNRS, Sorbonne UniversitĂ©, Paris 75005, FrancecLaboratoire de Physique ThĂ©orique et ModĂ©lisation, CNRS/CY Cergy Paris UniversitĂ©, Cergy-Pontoise cedex F-95032, FrancedDepartment of Physics, Friedrich-Alexander Universität Erlangen-NĂĽrnberg, Erlangen 91058, GermanyeMax-Planck-Zentrum fĂĽr Physik und Medizin, Erlangen 91054, GermanyProceedings of the National Academy of Sciences, Volume 122, Issue 16, April 2025. SignificanceDuring embryonic development and wound healing, epithelial cells usually display in-plane polarity over large spatial scales and move coherently. However, most in vitro studies have examined the fluid-like chaotic dynamics of epithelial cells, …
- Proceedings of the National Academy of Sciences, Volume 122, Issue 16, April 2025.
- by Yorihiro IwasakiMonica ReyesAnna Ryabets-LienhardBarbara GalesAgnès LinglartDanny E. MillerIsidro B. SaluskyMurat BastepeHarald JĂĽppneraEndocrine Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114bDivision of Endocrinology, Metabolism & Nephrology, Tazuke Kofukai Medical Research Institute, Kitano Hospital, Osaka 5308480, JapancCenter for Endocrinology, Diabetes, and Metabolism, Children’s Hospital Los Angeles, University of Southern California Keck School of Medicine, Los Angeles, CA 90027dDepartment of Pediatrics, Division of Pediatric Nephrology, University of California, Los Angeles, Geffen School of Medicine, Los Angeles, CA 90095eUniversitĂ© Paris-Saclay, INSERM, Physiologie et Physiopathologie Endocriniennes, Le Kremlin-BicĂŞtre 94276, FrancefAssistance Publique-HĂ´pitaux de Paris, Centre de RĂ©fĂ©rence des Maladies du MĂ©tabolisme du Calcium et du Phosphate and Service d’Endocrinologie d’Endocrinologie et Diabète de l’enfant, HĂ´pital BicĂŞtre, Le Kremlin-BicĂŞtre 94276, FrancegDivision of Genetic Medicine, Department of Pediatrics, University of Washington and Seattle Children’s Hospital, Seattle, WA 98195hDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, WA 98195iBrotman Baty Institute for Precision Medicine, University of Washington, Seattle, WA 98195jPediatric Nephrology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114Proceedings of the National Academy of Sciences, Volume 122, Issue 16, April 2025. SignificancePseudohypoparathyroidism type 1B (PHP1B) is a disorder caused by end-organ hormone resistance due to epigenetic alterations atGNAS,a complex locus encoding Gsα as well as other sense and antisense RNAs. The promoters of these transcripts are …
- by Bingyuan KeXinghui WangaCollege of Physics and Information Engineering, Institute of Micro–Nano Devices and Solar Cells, Fuzhou University, Fuzhou 350108, ChinabFujian Science & Technology Innovation Laboratory for Optoelectronic Information of China, Fuzhou, Fujian 350108, ChinacJiangsu Collaborative Innovation Center of Photovoltaic Science and Engineering, Changzhou 213000, ChinaProceedings of the National Academy of Sciences, Volume 122, Issue 16, April 2025. SignificanceThe drive toward higher integration and miniaturization in microelectronic devices necessitates a shift in thin-film microbattery designs from universal to tailored on-chip integration. This shift imposes stricter design criteria and …
- by Xi ChenMin ShuaiBingchen ZhongVikina MartinezEva KorblovaMatthew A. GlaserJoseph E. MaclennanDavid M. WalbaNoel A. ClarkaDepartment of Physics and Soft Materials Research Center, University of Colorado, Boulder, CO 80309bDepartment of Chemistry and Soft Materials Research Center, University of Colorado, Boulder, CO 80309Proceedings of the National Academy of Sciences, Volume 122, Issue 16, April 2025. SignificanceThe recent discovery of ferroelectric nematic liquids has provided a pathway into exploration of the ferroelectric nematic realm, a space of exotic soft matter liquid crystal phases and phenomena based on the spontaneous self-organization of …
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