- Proceedings of the National Academy of Sciences, Volume 121, Issue 51, December 2024.
- by Ning ZhangDamini SoodSpencer C. GuoNanhao ChenAdam AntoszewskiTegan MarianchukSupratim DeyYunxian XiaoLu HongXiangda PengMichael BaxaCarrie PartchLee-Ping WangTobin R. SosnickAaron R. DinnerAndy LiWangaDepartment of Chemistry and Biochemistry, University of California, Merced, CA 95343bDepartment of Chemistry and James Franck Institute, University of Chicago, Chicago, IL 60637cDepartment of Chemistry, University of California, Davis, CA 95616dGraduate Program in Biophysical Sciences, University of Chicago, Chicago, IL 60637eDepartment of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL 60637fDepartment of Chemistry and Biochemistry, University of California, Santa Cruz, CA 95064gCenter for Cellular and Biomolecular Machines, University of California, Merced, CA 95343Proceedings of the National Academy of Sciences, Volume 121, Issue 51, December 2024. SignificanceCircadian clocks foretell the coming of day and night in diverse organisms by preparing metabolic processes for sunrise and sunset. These ubiquitous systems are composed of proteins that undergo temporally separated protein–protein …
- by Tuo ShiYeeun KimJuan LlamasXizi WangPeter FabianThomas P. LozitoNeil SegilKsenia GnedevaJ. Gage CrumpaDepartment of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles CA 90033bCaruso Department of Otolaryngology-Head and Neck Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033Proceedings of the National Academy of Sciences, Volume 121, Issue 51, December 2024. SignificanceThe ability of cells to change fate to replace missing cells is a common feature of regenerative vertebrates. The molecular underpinnings of such transdifferentiation remain poorly understood. By comparing the epigenetic landscapes of inner …
- by Erik HenzeJacqueline J. EhrlichJanice L. RobertsonEric GelsleichterToshimitsu KawateaDepartment of Molecular Medicine, Cornell University, Ithaca, NY 14853bDepartment of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, MO 63110Proceedings of the National Academy of Sciences, Volume 121, Issue 51, December 2024. SignificanceSignaling metabolites, such as adenosine triphosphate (ATP), are released through membrane channels to effectively clear dying cells in the body. Pannexin 1 (Panx1) serves as such a signal releaser and plays a pivotal role in immune response. …
- by Chang NiuHuanyu ZhangChuanlong XuWenjie HuYunzhuo WuYu WuYadi WangTong WuYi ZhuYinyan ZhuWenbin WangYizheng WuLifeng YinJiang XiaoWeichao YuHangwen GuoJian ShenaState Key Laboratory of Surface Physics and Institute for Nanoelectronic Devices and Quantum Computing, Fudan University, Shanghai 200433, ChinabDepartment of Physics, Fudan University, Shanghai 200433, ChinacShanghai Research Center for Quantum Sciences, Shanghai 201315, ChinadZhangjiang Fudan International Innovation Center, Fudan University, Shanghai 201210, ChinaeHefei National Laboratory, Hefei 230088, ChinafCollaborative Innovation Center of Advanced Microstructures, Nanjing 210093, ChinaProceedings of the National Academy of Sciences, Volume 121, Issue 51, December 2024. SignificanceNatural physical systems evolve with certain global quantities being minimized or maximized due to physical laws. For example, charges in conductors redistribute to reach electrostatic equilibrium, minimizing electrostatic energy, and gases …
- by Xinlu ChenJohn M. UrbanJens WurlitzerXiuting WeiJin HanSarah E. O’ConnorJeffrey D. RudolfTobias G. KöllnerFeng ChenaDepartment of Plant Sciences, University of Tennessee, Knoxville, TN 37996bHHMI Research Laboratories, Carnegie Institution for Science, Baltimore, MD 21218cDepartment of Embryology, Carnegie Institution for Science, Baltimore, MD 21218dDepartment of Natural Product Biosynthesis, Max-Planck-Institute for Chemical Ecology, Jena 07745, GermanyeDepartment of Chemistry, University of Florida, Gainesville, FL 32611Proceedings of the National Academy of Sciences, Volume 121, Issue 51, December 2024. SignificanceInsects, the most speciose group of animals, rely on infochemicals for communication. Terpenoids are a diverse class of insect infochemicals. Yet our understanding of terpenoid biosynthesis in insects is very limited. Here, we report that …
- by Liana MkrtchyanHarutyun SahakyanJodene EldstromTatev KarapetyanAstghik AbrahamyanKaren NazaryanJĂĽrgen R. SchwarzMatthias KneusselDavid FedidaVitya VardanyanaMolecular Neuroscience Group, Institute of Molecular Biology, Yerevan 0014, ArmeniabLaboratory of Computational Modeling of Biological Processes, Institute of Molecular Biology, Yerevan 0014, ArmeniacDepartment of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, BC V6T 1Z3, CanadadInstitute for Molecular Neurogenetics, Center for Molecular Neurobiology Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg 20251, GermanyProceedings of the National Academy of Sciences, Volume 121, Issue 51, December 2024. SignificanceThe latest atomic resolution structures of KCNQ channels feature a narrow cavity region not sufficiently wide to accommodate fully hydrated K+ions. The mechanism of K+permeation through this constriction and the functional impact of the …
- by Josefa CruzEnric UreñaLuis P. IñiguezManuel IrimiaXavier Franch-MarroDavid MartĂnaInstitute of Evolutionary Biology, Spanish National Research Council (CSIC)-Universitat Pompeu Fabra, Barcelona 08003, SpainbCentre for Genomic Regulation, The Barcelona Institute of Science and Technology, Barcelona 08003, SpaincUniversitat Pompeu Fabra, Barcelona 08002, SpaindInstituciĂł Catalana de Recerca i Estudis Avançats, Barcelona 08010, SpainProceedings of the National Academy of Sciences, Volume 121, Issue 51, December 2024. SignificanceInDrosophila, precise temporal regulation of gene expression is essential for development. Our research elucidates the mechanisms by which the transcription factor Ecdysone inducible protein 93F (E93) serves as the specific determinant for …
- by Julien Lie-PanisLĂ©o FitouchiNicolas BaumardJean-Baptiste AndrĂ©aMax Planck Research Group Dynamics of Social Behavior, Max Planck Institute for Evolutionary Biology, 24306 Plön, GermanybDepartment of Social and Behavioral Sciences, Institute for Advanced Studies in Toulouse, Toulouse School of Economics, University of Toulouse Capitole, 31080 Toulouse, FrancecInstitut Jean Nicod, DĂ©partement d’études Cognitives, Ecole Normale SupĂ©rieure, UniversitĂ© Paris Sciences & Lettres, Ecole des hautes Ă©tudes en sciences sociales, CNRS, 75005 Paris, FranceProceedings of the National Academy of Sciences, Volume 121, Issue 51, December 2024. SignificanceInstitutions explain why humans exhibit such high levels of cooperation compared to other species. From small communities to large nation-states, they promote cooperation by rewarding prosocial conduct and punishing acts of selfishness. Yet …
- by Huijing YuGuanli XiaoMingyao GuLiting ZhangMing XiaShimin MoYuying ZhaoChaoliang WeiaShenzhen Key Laboratory of Metabolism and Cardiovascular Homeostasis, Shenzhen University Medical School, Shenzhen University, Shenzhen, Guangdong 518055, ChinabSchool of Pharmacy, Shenzhen University Medical School, Shenzhen University, Shenzhen, Guangdong 518060, ChinacDepartment of Pharmacy, Shenzhen Longhua District Central Hospital, Shenzhen, Guangdong 518110, ChinadGuangzhou Institute of Pediatrics, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, Guangdong 510623, ChinaePKU- Nanjing Institute of Translational Medicine, Nanjing Raygen Health, Nanjing, Jiangsu 210031, ChinaProceedings of the National Academy of Sciences, Volume 121, Issue 51, December 2024. SignificanceThis study uncovered a switching of migration mode from pauses state to directional movement in various epithelial tumor cells induced by pERK transition activity. Both pERK transition and directional mode could be mimicked in constitutive ERK …
- by Min SongEun Ju ShinHyojung SeoAlireza SoltaniNicholas A. SteinmetzDaeyeol LeeMin Whan JungSe-Bum PaikaDepartment of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology, Daejeon 34141, Republic of KoreabDepartment of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 34141, Republic of KoreacCenter for Synaptic Brain Dysfunctions, Institute for Basic Science, Daejeon 34141, Republic of KoreadDepartment of Psychiatry, Yale University, New Haven, CT 06520eDepartment of Psychological and Brain Sciences, Dartmouth College, Hanover, NH 03755fDepartment of Neurobiology and Biophysics, University of Washington, Seattle, WA 98195gZanvyl Krieger Mind/Brain Institute, Johns Hopkins University, Baltimore, MD 21218hKavli Discovery Neuroscience Institute, Johns Hopkins University, Baltimore, MD 21218iDepartment of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, MD 21218jDepartment of Neuroscience, Johns Hopkins University, Baltimore, MD 21218kDepartment of Brain and Cognitive Sciences, Korea Advanced Institute of Science and Technology, Daejeon 34141, Republic of KoreaProceedings of the National Academy of Sciences, Volume 121, Issue 51, December 2024. SignificanceA gradual increase in the intrinsic timescales of cortical activity along the anatomical hierarchy is considered to reflect the functional specialization of cortical circuits. However, it remains unknown whether this gradient of timescales is …
- by San To ChanEliot FriedaMechanics and Materials Unit, Okinawa Institute of Science and Technology Graduate University, Onna, Okinawa 904-0495, JapanProceedings of the National Academy of Sciences, Volume 121, Issue 51, December 2024. SignificanceWhen analyzing artworks, discerning the visual clarity of compositions is pivotal. Inspired by the perceptual tactics of digital artists, we introduce a metric for quantifying clarity through a unique method of comparing original images with …
- by Zhancong LiangLiyuan ZhouYuqing ChangYiming QinChak K. ChanaDivision of Physical Science and Engineering, King Abdullah University of Science and Technology, Thuwal 23955-6900, Saudi ArabiabSchool of Energy and Environment, City University of Hong Kong, Hong Kong, ChinaProceedings of the National Academy of Sciences, Volume 121, Issue 51, December 2024. SignificanceBiomass-burning organic aerosol(s) (BBOA) not only significantly impact Earth’s climate by absorbing solar radiation but also generate excited triplet states (3BBOA*) that react with other atmospheric molecules, known as photosensitization. …
- by Lauren N. WoodieAhren J. AlbertoBrianna M. KrusenLily C. MelinkMitchell A. LazaraDivision of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104Proceedings of the National Academy of Sciences, Volume 121, Issue 51, December 2024. SignificanceMaintaining synchrony between the external environment and the precise orchestration of circadian rhythmicity among tissues within an organism is crucial for overall health and well-being. Here, we report that the REV-ERBα/β nuclear receptors …
- by Svetoslav NikolovKushal RamakrishnaAndrew RohskopfMani LokamaniJulien TranchidaJohn CarpenterAttila CangiMitchell A. WoodaComputational Multiscale Department, Sandia National Laboratories, Albuquerque, NM 87123bCenter for Advanced Systems Understanding, D-02826 Görlitz, GermanycHelmholtz-Zentrum Dresden-Rossendorf, D-01328 Dresden, GermanydFrench Alternative Energies and Atomic Energy Commission, Energy Division, Research Institute for Nuclear Systems for Low Carbon Energy Production, Department of Fuel Studies, 13018 Saint Paul Les Durance, FranceProceedings of the National Academy of Sciences, Volume 121, Issue 51, December 2024. SignificanceDespite the importance of magnetism in numerous materials, magnetic effects have been absent in molecular-dynamics studies. Herein, we implement a molecular-spin dynamics methodology to accurately resolve, across large regions of phase-space, …
- by Chong LiuRobbie GeJun ChenHongmei GuoTyler A. BartholomeDebabrata MaitiHaibo GeaDepartment of Chemistry and Biochemistry, Texas Tech University, Lubbock, TX 79409bDepartment of Chemistry, Indian Institute of Technology Bombay, Mumbai 400076, IndiaProceedings of the National Academy of Sciences, Volume 121, Issue 51, December 2024. SignificanceThe motivation driving the intensive efforts of synthetic chemists lies in the exploration of novel chiral pharmaceutical candidates. Especially, achieving efficient skeletal construction and introducing chiral diversity is a significant goal …
- by Hao YangAjay SharmaMichael J. DalyBrian M. HoffmanaDepartment of Chemistry, Northwestern University, Evanston, IL 60208bDepartment of Pathology, School of Medicine, Uniformed Services University of the Health Science, Bethesda, MD 20814cDepartment of Molecular Biosciences, Northwestern University, Evanston, IL 60208Proceedings of the National Academy of Sciences, Volume 121, Issue 51, December 2024. SignificanceThis study reveals the mechanism for protein radioprotection by the superb Mn-based MDP antioxidant containing Pi and decapeptide DP1, designed through considerations ofDeinococcus radioduranslow molecular-weight Mn-antioxidants: The …
- by Hui LuoHongli XuanDong WangZiwan DuZhongyang LiKejun BuSonghao GuoYuhong MaoFujun LanFuyang LiuYanfeng YinWenming TianQingyang HuGang LiuHaozhe LiuQiaoshi ZengYang DingYongping FuQian LiShengye JinWenge YangHo-Kwang MaoXujie LĂĽaCenter for High Pressure Science and Technology Advanced Research, Shanghai 201203, ChinabState Key Laboratory of New Ceramics and Fine Processing, School of Materials Science and Engineering, Tsinghua University, Beijing 100084, ChinacState Key Laboratory of Molecular Reaction Dynamics and Dynamics Research Center for Energy and Environmental Materials, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, Liaoning 116023, ChinadShanghai Key Laboratory MFree, Institute for Shanghai Advanced Research in Physical Sciences, Shanghai 201203, ChinaeBeijing National Laboratory for Molecular Science, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, ChinaProceedings of the National Academy of Sciences, Volume 121, Issue 51, December 2024. SignificanceA key challenge in the field of high-pressure research has been the preservation of the desirable characteristics of materials achieved under high pressure, as the unique structures and enhanced properties tend to revert to their original …
- by Jiuyin XuYouwei XuLi HouXinheng HeYang LiJing ZhaoXue MengJames Jiqi WangYanli WuHeng ZhangYunhai LiWen HuQingning YuanKai WuXi ChengYi JiangYu XiaH. Eric XuCanrong WuaState Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, ChinabSchool of Life Science and Technology, ShanghaiTech University, Shanghai 201210, ChinacUniversity of Chinese Academy of Sciences, Beijing 100049, ChinadSchool of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210023, ChinaeMOE Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Department of Chemistry, Tsinghua University, Beijing 10084, ChinafDivision of Cardiology, Department of Internal Medicine and Hubei Key Laboratory of Genetics and Molecular Mechanism of Cardiologic Disorders, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, ChinagSchool of Life Sciences, Xiamen University, Xiamen 361005, ChinahResearch Center for Medicinal Structural Biology, National Research Center for Translational Medicine at Shanghai, State Key Laboratory of Medical Genomics, Ruijin Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200025, ChinaiLingang Laboratory, Shanghai 200031, ChinaProceedings of the National Academy of Sciences, Volume 121, Issue 51, December 2024. SignificanceDP2, a key anti-inflammatory and antiallergic drug target, particularly in diseases like allergic asthma, remains a focus of intense therapeutic interest. Despite several DP2-targeted drugs reaching clinical trials, none has been approved yet. …
- by Jie MeiJipeng JiangZhao LiYue PanKe XuXinglong GaoJing YuanLili LiYufei WangLiuxiang WangAilin ZhaoShasha JiangXinlian WangShaoqiong YiShilin LiYueguang XueYongfu MaYang LiuYawei WangJuan LiChunying ChenYing LiuaNew Cornerstone Science Laboratory, Chinese Academy of Sciences Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety and Chinese Academy of Sciences Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, ChinabResearch Unit of Nanoscience and Technology, Chinese Academy of Medical Sciences, Beijing 100190, ChinacSchool of Nano Science and Technology, University of Chinese Academy of Sciences, Beijing 100049, ChinadDepartment of Thoracic Surgery, First Medical Center of Chinese People’s Liberation Army General Hospital, Beijing 100853, ChinaeState Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, ChinafDepartment of Pathology, First Medical Center of Chinese People’s Liberation Army General Hospital, Beijing 100853, ChinagNational Institutes for Food and Drug Control, Beijing 102629, ChinahThird Medical Center of Chinese People’s Liberation Army General Hospital, Beijing 100039, ChinaiNational Center for Protein Sciences, Beijing 102206, ChinaProceedings of the National Academy of Sciences, Volume 121, Issue 51, December 2024. SignificancePerfluoroalkyl and polyfluoroalkyl substances (PFAS) are widely used in industrial and domestic products. Sustained PFAS exposure has raised serious concerns due to its potential carcinogenic properties. As one of the most common types of PFAS,…
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