RSS feed of mass spectrometry journals and other mass spectrometry articles and social feeds.
- Publication date: Available online 20 January 2025Source: International Journal of Mass SpectrometryAuthor(s): Scott M. Simpson, Eric J. Commendatore, Hou U. Ung
- In Alzheimer's disease (AD) and other tauopathies, tau dissociates from microtubules and forms toxic aggregates that contribute to neurodegeneration. Although some of the pathological interactions of tau have been identified from postmortem brain tissue, these studies are limited by their inability to capture transient interactions. To investigate the interactome of aggregate-prone fragments of tau, we applied an in vitro proximity […]
- Journal of the American Society for Mass SpectrometryDOI: 10.1021/jasms.4c00471
- Background: Synaptic dysfunction plays an important role in Alzheimer's disease (AD) and is an emerging imaging and fluid biomarker. Here, we aimed to assess the regional expression of synaptic vesicle glycoprotein 2A (SV2A) in the brain and extracellular vesicles of AD patients and its associations with the APOE e4 allele, amyloid-, tau pathologies, and other synaptic markers. Methods: Mass spectrometry-based […]
- Man, sometimes y'all send me papers and totally ruin what was otherwise a really focused run or something. This paper is certainly the case, because it is a fix for something I had no idea was an issue. We've had ICP-MS of single cells for at least a decade. Maybe much longer? I don't know. There is even a commercial FACs […]
- Analyst, 2025, Accepted ManuscriptDOI: 10.1039/D4AN01447B, PaperHongyan Bi, Mingyue Yu, Yunxing Li, Yuean ChuThe expansion of the seafood market has led to an increased probability of food fraud. The development of rapid and reliable traceability methods for aquatic food products is of utmost…The content of this RSS Feed (c) The Royal Society of Chemistry
- Synapses are essential for neuronal function and are central to numerous neurological disorders including developmental and neurodegenerative diseases. Synapses structurally constitute a very small proportion of a neuron, and their protein content is difficult to study using whole tissue preparations. Especially studying synapses on the functional level is challenging. To overcome this limitation, synapses can be captured as synaptosomes generated […]
- Publication date: Available online 21 January 2025Source: Journal of Chromatography AAuthor(s): Ana Castiñeira-Landeira, Samantha Sasse, Melissa Broeren, Saskia S. Sterk, A. Arrizabalaga-Larrañaga
- Abstract The use of single-guide RNA (sgRNA) for gene editing using the CRISPR Cas9 system has become a powerful technique in various fields, especially with the growing interest in such molecules as therapeutic options in the last years. An important parameter for the use of these molecules is the verification of the correct sgRNA oligonucleotide sequence. Apart from next-generation sequencing […]
- Journal of the American Society for Mass SpectrometryDOI: 10.1021/jasms.4c00423
- Journal of the American Society for Mass SpectrometryDOI: 10.1021/jasms.4c00410
- Anal. Methods, 2025, Accepted ManuscriptDOI: 10.1039/D4AY02223H, PaperJia-Jia Li, Lu Kou, Jun Li, Pei-Yu Shi, Tian-Rong Guo, Quan-Wei Xiao, Min Zhang, Wenlin Wu, Yi WangA method involving gas chromatography coupled with quadrupole/orbitrap high-resolution mass spectrometry (GC-Q/Orbitrap HRMS) with QuEChERS method was developed to analyze 36 non-phthalate plasticizers in milk powder products. The samples were…The content of this RSS Feed (c) The […]
- Anal. Methods, 2025, Accepted ManuscriptDOI: 10.1039/D4AY02040E, PaperHaiyan Gao, Yueguang Lv, Wenjing Zhao, Songying Wang, Jiayu Zhao, Yisheng Xu, Yuhan Shang, Renyu Zhang, Qiang MaRapid and accurate methods for tracing and identifying the origin of lamb are crucial for ensuring food authenticity and quality. This study developed a precise traceability method to determine the…The content of this RSS Feed (c) The […]
- ABSTRACT Rationale Panax quinquefolius L. (PQ), a commonly used traditional Chinese medicine and a food, is usually processed into various products, including white PQ, red PQ (two- or three-time steamed PQ), and black PQ (nine-time steamed PQ). Previous studies demonstrated that volatile components (VOCs) were the important active substances of PQ, which had antibacterial, antiviral, and anti-leukemia activities. However, most […]
- Natural products (NP) are instrumental in drug development, but their discovery and validation remain challenging and laborious despite advances in both genomic and analytical technologies. In this study, we demonstrate the use of an integrated multi-modal characterization of a microbial strain library for enhanced natural product discovery. This characterization utilizes language- and transformer-based models, integrated through a cross-validate and rank […]
- ABSTRACT Advancements in food technology have increased the need for thorough analysis to ensure food safety, quality, and compliance with regulatory requirements. Capillary electrophoresis–mass spectrometry (CE–MS) has emerged as a powerful tool in food analysis due to its high separation efficiency, low sample consumption, and ability to handle complex matrices. However, challenges such as the use of volatile running buffers […]
- ABSTRACT A significant limitation of imaged capillary electric focusing (icIEF) is the inability to identify and characterize specific species in the electropherogram. This has led to the development of complementary ion-exchange chromatography (IEX)-based methods that are amenable to either fraction collection and subsequent characterization or online IEX coupled to mass spectrometry. To overcome this limitation while maintaining the use of […]
- Abstract The wide range of mass spectrometry imaging (MSI) technologies enables the spatial distributions of many analyte classes to be investigated. However, as each approach is best suited to certain analytes, combinations of different MSI techniques are increasingly being explored to obtain more chemical information from a sample. In many cases, performing a sequential analysis of the same tissue section […]
- Analytical ChemistryDOI: 10.1021/acs.analchem.4c05968
- Analytical ChemistryDOI: 10.1021/acs.analchem.4c03621
- Analytical ChemistryDOI: 10.1021/acs.analchem.4c06062
- Journal of the American Society for Mass SpectrometryDOI: 10.1021/jasms.4c00399
- Journal of the American Society for Mass SpectrometryDOI: 10.1021/jasms.4c00443
- Hydrogen/deuterium exchange mass spectrometry (HX-MS) is a method used to study solution-phase protein structure and dynamics. Despite its many applications, HX-MS is limited in throughput because manual data analysis is still the norm. We previously developed HX-MS2 technology to add a second dimension of deuteration data and promote automated data processing. Data-independent acquisition (DIA) techniques enable this approach, but we […]
- Chronic Wasting Disease (CWD) is a universally fatal, transmissible prion disease affecting cervids. Primarily found among deer populations in North America, the disease has spread across the continent and made forays into Europe and Asia as well. Currently, accurate methods for detecting CWD infection require post-mortem dissection of the lymph nodes and brainstem of affected animals. New, high-sensitivity methods of […]