RSS feed of mass spectrometry journals and other mass spectrometry articles and social feeds.
- J. Anal. At. Spectrom., 2026, Advance ArticleDOI: 10.1039/D5JA00455A, Technical Note Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Isabel Abad-Alvaro, InĂŠs LĂĄzaro-FernĂĄndez, Eduardo Bolea, Francisco LabordaPreparation and characterization of PVC model micro/nanoplastics to be used in risk assessment studies by methodology based on single particle inductively coupled plasma mass spectrometry (SP-ICP-MS).To cite this article […]
- Brazenly borrowed from this whitepaper. If I have a super power as a person or a scientist, it is that I'm very okay with being wrong. It helps that it happens all the time and the fact that I have friends and a domestic partner who are way way way smarter than me. I'm used to be the dumbest person in […]
- Astrocytes are a subset of glial cells in the central nervous system (CNS) that support numerous processes essential for brain function. Their functional diversity is thought to arise from specialized subpopulations with distinct molecular profiles. Although single-cell and single-nucleus RNA sequencing (scRNA-seq and snRNA-seq) have greatly advanced our understanding of astrocyte transcriptomic heterogeneity, mRNA abundance does not always correlate with […]
- Journal of the American Society for Mass SpectrometryDOI: 10.1021/jasms.6c00022
- Journal of the American Society for Mass SpectrometryDOI: 10.1021/jasms.6c00020
- ABSTRACT Mass spectrometry (MS) has emerged as a premier method used to characterize the sequences of proteins. Top-down proteomics aims to capture the multiple sources of structural diversity reflected in proteins, such as those that arise from alternative RNA splicing events or the addition of post-translational modifications. Tandem MS (i.e., MS/MS) represents a critical component of a top-down proteomics experiment, […]
- Analytical ChemistryDOI: 10.1021/acs.analchem.5c03229
- Inositol phosphates (InsPs) and inositol pyrophosphates (PP-InsPs) are conserved signalling molecules, but their evolutionary origin and diversification in the green lineage remain poorly understood. Here we investigated the InsP network in the streptophyte alga Chara braunii, a key lineage close to the origin of land plants. Using capillary electrophoresis-electrospray ionization mass spectrometry, we detected a broad spectrum of InsP and […]
- Methanol-driven esterification of volatile short-chain fatty acids in thermal desorption-based analysis
- ABSTRACT Rationale While ambient mass spectrometry imaging (MSI) is essential for biological analysis, its sensitivity remains constrained by ion transmission losses due to collisions and gas dynamics. Methods Here, a high-performance desorption electrospray ionization (DESI) MSI system featuring a high-efficiency dual-stage ion funnel (DIF) was developed. To optimize the system configuration, a hybrid multiphysics simulation model was constructed by coupling […]
- ABSTRACT Rationale Taiwan produces high-value specialty coffee on a limited scale, whereas Brazil is the largest global supplier and a major source of imports to Taiwan. For food authenticity, differentiation of roasted coffee from these origins is important. However, few metabolomics-based traceability studies have yet been conducted on Taiwan-roasted coffee. Methods In this study, metabolic profiling was applied to evaluate […]
- ABSTRACT Rationale Chromatographic and electrophoretic methods reliably distinguish the heterozygous and homozygous sickle cell states with hemoglobin variants appearing at consistent percentages with specific retention or migration times. However, co-migrating variants alter the overall hemoglobin profile, complicating interpretation in compound heterozygous conditions such as βS/βD-Punjab since these variants electrophoretically migrate close to each other. These cases often require hematological correlation […]
- Chemistry â A European Journal, Volume 32, Issue 12, 23 March 2026.
- Chemistry â A European Journal, Volume 32, Issue 12, 23 March 2026.
- Â This is the first time ABRF has happened in a city that I live in! Man, once upon a time there were so many proteomics people that we had competing initiatives. We were standardizing methods and standardizing standards and comparing software and it was all a lot of fun and it all kind of stopped. But you know what you […]
- The subcellular distribution of lysosomes, the main degradative organelles of mammalian cells, responds to metabolic cues in a highly dynamic way. While lysosomal positioning due to amino acid levels is well-characterized, cholesterol-dependent regulation of lysosomal motility is incompletely understood. We explored impaired lysosomal cholesterol export using a mass spectrometry-based multi-OMICs approach, identifying widespread reallocation of resources and signaling pathway modulation. […]
- Linker histones are essential for chromatin compaction, yet how they contribute to higher-order fiber assembly remains poorly understood. Here, we determined cryo-electron microscopy structures of Arabidopsis dodeca-nucleosome fibers containing distinct H2A/H3 variants and linker histone H1.3, revealing a noncanonical binding mode that a laterally positioned H1.3 connects the acidic patch of one nucleosome and the DNA of the neighboring nucleosome, […]
- NMDA receptors play key roles in brain development, plasticity and diseases. While glutamate and glycine co-gated GluN2-containing NMDARs have been extensively characterized, little is known regarding GluN3A-containing NMDARs that form receptors gated by glycine only. Here, combining native purification, mass spectrometry, cryo-EM and electrophysiology, we provide key insights on the molecular logic of GluN3A-NMDARs. We demonstrate that native GluN3A receptors […]
-  4 people have sent me this new preprint and I've had to go "…oh…it's in my draft's folder…" but the power went out in my building while I was at a conference and it's sort of a mess and I'm grumpy, so Imma post this. So…sometimes I see these papers where someone does something like – 1) Get better results than anyone […]
- Analytical ChemistryDOI: 10.1021/acs.analchem.5c08032
- Analytical ChemistryDOI: 10.1021/acs.analchem.6c00057
- Journal of Mass Spectrometry, Volume 61, Issue 4, April 2026.
- Journal of Mass Spectrometry, Volume 61, Issue 4, April 2026.
- Open modification search (OMS) strategies have gained popularity in mass spectrometry-based proteomics for identification of peptides carrying unknown or unexpected post-translational modifications. However, most OMS search engines report only the overall mass difference between the precursor and the matched peptide and do not explicitly identify or score combinations of multiple modifications at the peptide-spectrum match (PSM) level, leaving the interpretation […]
- ABSTRACT Background Online analysis of complex gas mixtures is often hindered by spectral congestion resulting from extensive fragmentation in traditional electron ionization (EI) sources. Although photoionization (PI) provides clean mass spectra by preserving molecular ion integrity, its comprehensive detection is limited by an inherent ionization selectivity toward species with low ionization energies. Methods To address these challenges, a dual-ionization source […]