RSS feed of mass spectrometry journals and other mass spectrometry articles and social feeds.
- An effective vaccine for Human Immunodeficiency Virus type-1 (HIV-1) has yet to be developed, and detailed characterization of functional Env glycoprotein, the primary antigenic target on virions, has remained elusive. While engineered Env trimers recapitulate many aspects of functional Env, key differences in antigenicity and dynamic behavior have been reported. Here, cryo-electron tomography and subtomogram averaging of HIV-1 virus-like particles […]
- Propolis, a resinous substance produced by Apis mellifera, is rich in polyphenols and flavonoids and exhibits diverse biological activities, including antioxidant and antimicrobial effects. This study aimed to characterize the chemical composition of Thai propolis and evaluate its free radical scavenging activity. Ethanolic (EEP) and aqueous (WEP) extracts were prepared and analyzed. Gas chromatography-mass spectrometry (GC-MS) identified major constituents of […]
- Publication date: March 2026Source: International Journal of Mass Spectrometry, Volume 521Author(s): M. Azizi, B. Ghasemi, O. Kakuee, A. Biganeh
- Single-particle chemical analysis reveals organic-rich detonation soot products
- Electrospray ionization (ESI)-based native mass spectrometry (MS) has been extensively used to study non-covalent protein complexes and their structural aspects in the gas phase. As such it has a stable place in the portfolio of modern structural biology and biopharmaceutical analysis techniques. It is also promising as an approach to deliver pro-teins and their assemblies into the gas phase for […]
- Publication date: Available online 9 January 2026Source: TalantaAuthor(s): Shuo Gao, Xiaoxuan Han, Xiaoxu Huo, XiaoFeng Dong, Chunguang Liu, Yong Tian
- Publication date: Available online 9 January 2026Source: Journal of ProteomicsAuthor(s): Jean Armengaud
- Journal of the American Society for Mass SpectrometryDOI: 10.1021/jasms.5c00378
- Journal of the American Society for Mass SpectrometryDOI: 10.1021/jasms.5c00430
- Gadolinium (Gd) complexes, used as contrast agents in magnetic resonance imaging (MRI), along with other rare earth elements (REE), are emerging contaminants in natural waters. The quantification of these compounds is a challenge due to their low concentrations. In this study, an extraction and preconcentration method was optimized and validated for the simultaneous determination of REE, including anthropogenic Gd, in […]
- Trace metals and metal homeostasis play an essential role in cell metabolism, and an imbalance in this careful balance leads to pathological changes. In neurodegenerative diseases such as Parkinson’s disease, trace metals and metal species are increasingly recognized as key factors in disease progression in mechanisms such as ferroptosis. In this study, we combined modern analytical techniques like Fourier transform […]
- Charge detection mass spectrometry (CDMS) enables direct measurement of mass and charge for individual ions and overcomes fundamental limitations of conventional electrospray mass spectrometry for large, heterogeneous biomolecules. Messenger RNAs (mRNAs) represent a particularly challenging analytical target, as transcripts often span thousands of nucleotides, exhibit substantial heterogeneity, and form higher-order oligomers that are difficult to assess using existing workflows. Here, […]
- Metal homeostasis is a complex process wherein essential metals serving structural, catalytic and regulatory roles are acquired, trafficked, and exported once they are present in excess. Understanding changes in metal content and localization in heterogenous tissue types is critical to understanding fundamental physiology as well as a growing number of disease states. Laser ablation inductively coupled plasma time-of-flight mass spectrometry […]
- Annexins are Ca2+ and membrane-binding proteins conserved across eukaryotes and involved in diverse membrane-associated processes, including unconventional protein secretion (UPS). In the intestinal parasite Giardia lamblia, annexins are represented by a family of 21 proteins termed alpha-giardins, all of which lack classical signal peptides yet are detected at the parasite surface and in the secretome. Here, we present a comprehensive […]
- The regulation of gene expression requires precise control of chromatin-associated complexes that respond to diverse structural and epigenetic cues. The Rpd3 Large (Rpd3L) complex is a Sin3 histone deacetylase (HDAC) complex that dynamically adapt to chromatin states to reinforce transcriptional silencing, yet the mechanisms governing the catalytic activation in chromatin context-dependent manner remain unclear. Here we present the cryo-EM structure […]
- Spectral library search (SLS) is a major approach for peptide identification from tandem mass spectrometry data, with performance depending substantially on the accuracy of the underlying Spectrum-Spectrum Matching (SSM) scoring functions. However, detailed comparative studies remain limited by the absence of comprehensive benchmark datasets. We propose new methods to build SSM scoring functions benchmarks and construct a benchmark dataset with […]
- Publication date: Available online 9 January 2026Source: International Journal of Mass SpectrometryAuthor(s): Luciana Rivera Molina, Robert Brand, Calum Bochenek, Chrys Wesdemiotis
- Publication date: Available online 8 January 2026Source: International Journal of Mass SpectrometryAuthor(s): Zhe Fang, Lei Wang, Kai Li, Chaogang Wang, Lizhi Ren, Yaqiang Li, Yihui Wang, Ming Chen, Haizhou Wang
- Publication date: Available online 8 January 2026Source: International Journal of Mass SpectrometryAuthor(s): Lasini Amunugama, Jared B. Shaw
- We investigated how seed proteolysis was enhanced by germination, by subsequent homogenisation (disrupting sprout compartments), and by co-incubation of homogenates from different species. Mass spectrometry of released peptides tracked proteolytic signatures from chickpea, lentil, mung and broccoli proteins, in soaked seeds, in sprouted seeds, and after sprout homogenisation followed by incubation alone or in mixture with other sprouts. The proteolytic […]
- J. Anal. At. Spectrom., 2026, Accepted ManuscriptDOI: 10.1039/D5JA00337G, Technical NoteLouise Darricau, Jérôme Aléon, Maximilien Verdier, Virginie Sellier, Josselin Gorny, Smail Mostefaoui, Cyrielle Jardin, Arnaud Mangeret, Arnaud Duverger, Nicolas Ait-Ouabbas, David Suhard, Gilles Montavon, Alkiviadis GourgiotisThis study presents an analytical protocol for the quantitative imaging of 226Ra by Nanoscale Secondary Ion Mass Spectrometry (NanoSIMS), based on the synthesis and characterization of […]
- Publication date: 15 May 2026Source: Talanta, Volume 302Author(s): Annika Haase, Gertrud Morlock
- Publication date: Available online 8 January 2026Source: TalantaAuthor(s): Xiaoyu Wei, Xudong Wang, Ming Xu
- Journal of the American Society for Mass SpectrometryDOI: 10.1021/jasms.5c00340
- Journal of the American Society for Mass SpectrometryDOI: 10.1021/jasms.5c00276