Combined RSS Items
- To ensure their survival in the face of stressors, cells have evolved stress response programs. While several transcriptional stress responses have been elucidated, little is known about the impact of stressors on membrane transport and the protein composition of the cell surface. Yet, the dynamic remodeling of the surfaceome by processes such as endocytosis is likely central for the adaptation to stress as it shapes cellular responses by influencing ion uptake and numerous signaling cascades. Indeed, we show that different […]
- Analytical ChemistryDOI: 10.1021/acs.analchem.5c05404
- Analytical ChemistryDOI: 10.1021/acs.analchem.5c06797
- Publication date: April 2026Source: International Journal of Mass Spectrometry, Volume 522Author(s):
- Publication date: April 2026Source: International Journal of Mass Spectrometry, Volume 522Author(s):
- Publication date: Available online 27 February 2026Source: TalantaAuthor(s): Tahereh Tehrani, Laura Pont, Bibiana Juan, Antonio-JosĂŠ Trujillo, Fernando Benavente
- Publication date: Available online 26 February 2026Source: Journal of Chromatography BAuthor(s): Julia Baumli, Ăgnes M. MĂłricz, Claudia Cimpoiu
- Publication date: Available online 27 February 2026Source: Clinica Chimica ActaAuthor(s): Jamie Ashby, Daniel McEntee, Dhananjay Sakrikar, Luke Ouverson, Rhiannon Stanton, Nia Marrott, Roshani R. Patel, Cristina Simion, Syreeta Allen, Manisha Bhutani, David M. Foureau, Kaleb B. McLendon, Andrew S. Neish, Habib El-Khoury, Irene M. Ghobrial, David Barnidge, Gabriella Lakos, Mark Perkins, Stephen Harding, Oscar Berlanga
- ABSTRACT This study aims to develop an ultra high-performance liquid chromatographyâmass spectrometry (UPLC-MS/MS) method to quantify clobazam, perampanel, and lacosamide plasma concentrations in pediatric epilepsy patients. Elution was performed using a gradient elution program, with a mobile phase composed of 0.01% formic acid in water and 0.01% formic acid in acetonitrile. The flow rate was 0.6âmL/min. The injector temperature was 10°C. The injection volume was 4âÎźL. Linearity, sensitivity, precision, accuracy, specificity, carryover, and extraction recovery were evaluated. Therapeutic drug monitoring […]
- ABSTRACT Capsaicin, a transient receptor potential vanilloid 1 (TRPV1) agonist, is used topically for neuropathic pain. Its minimal systemic absorption necessitates highly sensitive quantification methods to accurately assess systemic exposure. This study aimed to develop and validate a simple, rapid, and highly sensitive liquid chromatographyâtandem mass spectrometry (LC-MS/MS) method for the quantification of capsaicin in human plasma. Plasma samples (50âÎźL) were prepared by a simple protein precipitation using acetonitrile, with capsaicin-d3 as the internal standard (IS). Chromatographic separation was performed […]
- Journal of Mass Spectrometry, Volume 61, Issue 3, March 2026.
- Journal of Mass Spectrometry, Volume 61, Issue 3, March 2026.
- Journal of Mass Spectrometry, Volume 61, Issue 3, March 2026.
- Journal of Mass Spectrometry, Volume 61, Issue 3, March 2026.
- Journal of Mass Spectrometry, Volume 61, Issue 3, March 2026.
- Imaging Mass SpectrometryâBased Assessment of ER, PR, and HER2 Protein Expression in Breast CancerPROTEOMICS, EarlyView.
- Gene expression is governed by dynamic switches between repressive and activating transcriptional states. Among the molecules mediating these transitions, chromatin readers and transcription factors play pivotal roles. However, how they assemble with regulatory machineries to enable crosstalk between gene repression and activation remains unknown. Here, we use an integrative structural dynamics approach – combining cryo-EM, crosslinking mass spectrometry, fragment-resolved protein interactome mapping and crystallography – to show how the dual-role chromatin reader Cti6 and transcription factors Ash1 and Ume6 engage […]
- Influenza virus remains a major public health threat, highlighting the need to identify host proteins that regulate viral replication. In this study, we identify several mitochondrial proteins that influence virus-cell interactions using a Convolutional Neural Network (CNN) and a proximity labeling approach. Using CNN, we analyzed cell morphology and morphological changes of nucleus, mitochondria, and endoplasmic reticulum before and after influenza infection. Among these, mitochondrial morphology provided the clearest separation between infected and uninfected cells, achieving the highest classification precision […]
- J. Anal. At. Spectrom., 2026, Accepted ManuscriptDOI: 10.1039/D5JA00487J, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Thomas Roth, Francesca Quinto, Markus Plaschke, Karin Hain, Peter Steier, Natalia Palina, Sylvia Moisei-Rabung, Horst GeckeisA novel sample preparation procedure for highly sensitive concurrent analysis of 236U, 237Np, 239Pu and 240Pu from river and sea water samples with Accelerator Mass Spectrometry (AMS) was developed. A…The content of this RSS Feed (c) The Royal Society of Chemistry
- Publication date: Available online 25 February 2026Source: Journal of Chromatography BAuthor(s): Ankitha K. Puthiyaveettil, Sujay Ramaprasad, Deepalakshmi D. Putchen
- Â I haven't had the chance to put time into this, but I want to. The abstract suggests that maybe doing all the BCA quan steps might not be necessary for some experiments.Â
- Analyst, 2026, Accepted ManuscriptDOI: 10.1039/D5AN01344E, PaperBing Liu, Wennuo Xu, Tingyuan Zheng, Quan Zhong Li, Jingjing ZhaoTo investigate the characteristics of changes in human urine metabolites of meclofenoxate by using metabolomics technology based on ultra performance liquid chromatography-Q Exactive HF Orbitrap mass spectrometry (UHPLC-Q Exactive HF…The content of this RSS Feed (c) The Royal Society of Chemistry
- Analytical ChemistryDOI: 10.1021/acs.analchem.5c06891
- ABSTRACT Rationale Postblast analyses of military and terrorist events will benefit from the capacity to learn more about the explosive materials used in an event. Here stable isotope ratio analyses (δ13C, δ15N) can provide additional information to complement identification of the explosive components. Methods Controlled detonations using different types of military-grade explosives were conducted in 55-gal barrels. Additionally, soil analyses were conducted following Mark-84 field detonations. Swab materials and soils were purified to analyze explosive compounds using established HPLC and […]
- Rapid Communications in Mass Spectrometry, Volume 40, Issue 10, 30 May 2026.