Science First Release

• Device-scaling constraints imposed by the van der Waals gap formed in two-dimensional materials
  April 16, 2026 by Mahdi Pourfath and Tibor Grasser
  Science, Ahead of Print.
• Protein-templated synthesis of dinucleotide repeat DNA by an antiphage reverse transcriptase
  April 16, 2026 by Pujuan Deng, Hyunbin Lee, Carlo Armijo, Haoqing Wang, Alex Gao
  Science, Ahead of Print.
• Reimagining human-centric drug development with new approach methodologies
  April 16, 2026 by Xuekun Wu, Matthew A. Wu, James Zou, Nicole Kleinstreuer, Joseph C. Wu
  Science, Ahead of Print.
• A high-throughput selection system for fast-acting covalent protein drugs
  April 2, 2026 by Qiongxuan Fan, Jiahao Mei, Tian Li, Chuanlong Zang, Mengjiao Li, Jing Tang, You Xu, Ge Yu, Dandan Liu, Kai Chen, Bing Yang, Jing Huang, Ting Zhou, Bobo Dang
  Science, Ahead of Print.
• Divergent and programmable skeletal remodeling of complex macrocycles with a small method set
  April 2, 2026 by Ali Nikbakht, Xinghan Li, Jing Wan, Can Qin, Amir H. Hoveyda
  Science, Ahead of Print.
• High-temperature memristors enabled by interfacial engineering
  March 26, 2026 by Jian Zhao, Cameron S. Jorgensen, Krishnamurthy Mahalingam, Cynthia Bowers, Wataru Sugimoto, Kai Ito, Seung Ju Kim, Ruoyu Zhao, Yichun Xu, Han-Ting Liao, Rajiv K. Kalia, Aiichiro Nakano, Kohei Shimamura, Fuyuki Shimojo, Priya Vashishta, Ajit K. Roy, Ning Ge, Miao Hu, R. Stanley Williams, Qiangfei Xia, Sabyasachi Ganguli, J. Joshua Yang
  Science, Ahead of Print.
• Human DHX29 detects nonoptimal codon usage to regulate mRNA stability
  March 19, 2026 by Fabian Hia, Yitong Wu, Masanori Yoshinaga, Sakurako Goto-Ito, Wakana Iwasaki, Koshi Imami, Hirotaka Toh, Peixun Han, Ting Cai, Takayuki Ohira, Akira Fukao, Daron M Standley, Yuichi Shichino, Masaki Takegawa, Toshinobu Fujiwara, Tsutomu Suzuki, Shintaro Iwasaki, Michael C. Bassik, Takuhiro Ito, Osamu Takeuchi
  Science, Ahead of Print.
• Unstructured transcription factor interactions enable emergent specificity
  March 19, 2026 by Abrar A. Abidi, Claudia Cattoglio, Natalie N. Tang, Vinson B. Fan, Gina M. Dailey, Amir D. Hay, Prasanthi Kunamaneni, Daniel E. Milkie, Xavier Darzacq, Eric Betzig, Robert Tjian, Thomas G. W. Graham
  Science, Ahead of Print.
• Microglia Rank signaling regulates GnRH neuronal function and the hypothalamic-pituitary-gonadal axis
  March 12, 2026 by Alejandro Collado-Sole, Nozha Borjini, Jing Zhai, Francisco Ruiz-Pino, Gonzalo Soria-Alcaide, Cintia Folgueira, Celia García-Vilela, Beatriz Romero-de la Rosa, Victor Lopez, Yassine Zouaghi, An Jacobs, Bella Mora-Romero, Alexandra Barranco, Guillermo Yoldi, Karine Rizzoti, Guadalupe Sabio, Gema Perez-Chacon, Patricia G. Santamaria, Jose Antonio Esteban, Nathalie Journiac, Vincent Prevot, Alberto Pascual, Rafael Fernández-Chacón, Manuel Tena-Sempere, Nelly Pitteloud, Eva Gonzalez-Suarez
  Science, Ahead of Print.
• A deep-time landscape of plant cis-regulatory sequence evolution
  March 12, 2026 by Kirk R. Amundson, Anat Hendelman, Danielle Ciren, Hailong Yang, Amber E. de Neve, Shai Tal, Adar Sulema, David Jackson, Madelaine E. Bartlett, Zachary B. Lippman, Idan Efroni
  Science, Ahead of Print.
• A unified platform for nucleoside analog synthesis
  March 5, 2026 by Matthew J. Anketell, Ethan Fung, Wenbin Liu, Mahesh Shinde, Cyndi Qixin He, Kurtis W. C. Ng, Steven M. Silverman, Louis-Charles Campeau, Ralph Pantophlet, Robert Britton
  Science, Ahead of Print.
• A molecule with half-Möbius topology
  March 5, 2026 by Igor Rončević, Fabian Paschke, Yueze Gao, Leonard-Alexander Lieske, Lene A. Gödde, Stefano Barison, Samuele Piccinelli, Alberto Baiardi, Ivano Tavernelli, Jascha Repp, Florian Albrecht, Harry L. Anderson, Leo Gross
  Science, Ahead of Print.
• Deeper detection limits in astronomical imaging using self-supervised spatiotemporal denoising
  February 19, 2026 by Yuduo Guo, Hao Zhang, Mingyu Li, Fujiang Yu, Yunjing Wu, Yuhan Hao, Song Huang, Yongming Liang, Xiaojing Lin, Xinyang Li, Jiamin Wu, Zheng Cai, Qionghai Dai
  Science, Ahead of Print.
• Rapid directed evolution guided by protein language models and epistatic interactions
  February 19, 2026 by Vincent Q. Tran, Matthew Nemeth, Liam J. Bartie, Sita S. Chandrasekaran, Alison Fanton, Hyungseok C. Moon, Brian L. Hie, Silvana Konermann, Patrick D. Hsu
  Science, Ahead of Print.
• Mucosal vaccination in mice provides protection from diverse respiratory threats
  February 19, 2026 by Haibo Zhang, Katharine Floyd, Zhuoqing Fang, Filipe Araujo Hoffmann, Audrey Lee, Heather Marie Froggatt, Gurpreet Bharj, Xia Xie, Haleigh B. Eppler, Jordan Mariah Santagata, Yanli Wang, Mengyun Hu Christopher B. Fox, Prabhu S. Arunachalam, Ralph Baric, Mehul S. Suthar, Bali Pulendran
  Science, Ahead of Print.
• Rewiring STAT signaling from the cell surface with Trikine immunotherapeutics
  February 19, 2026 by Grayson E. Rodriguez, Yang Zhao, Yoko Nishiga, Frank Peprah, Jiao Shen, Gita C. Abhiraman, Masato Ogishi Chenyu Zhang, Justin Saco, Deepa Waghray, Mamatha Serasanambati, Leonel Torres, Brandon W. Simone, Leon Su, Steven C. Wilson, Aerin Yang, Qinli Sun, Lora Picton, Robert A. Saxton, Vidit Bhandarkar, Madeline J. Lee, Elizabeth Andrews, Hua Jiang, Matthias Obenaus, Michelle Yen, Tavus Atajanova, Catherine A. Blish, Stefani Spranger, E. John Wherry, Amanda Kirane, Antoni Ribas, David H. Raulet, Anusha Kalbasi, Stephanie K. Dougan, Michael Dougan, Julien Sage, K. Christopher Garcia
  Science, Ahead of Print.
• Molecular solar thermal energy storage in Dewar pyrimidone beyond 1.6 MJ/kg
  February 12, 2026 by Han P. Q. Nguyen, Alexander J. Maertens, Benjamin A. Baker, Nathan M.-W. Wu, Zihao Ye, Qingyang Zhou, Qianfeng Qiu, Navneet Kaur, David B. Berkinsky, Katherine E. Shulenberger, K. N. Houk, Grace G. D. Han
  Science, Ahead of Print.

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