- (RSS) (BioRxiv All) Target validation uncouples TSPO from 19-Atriol-mediated inhibition of steroidogenesis and reveals true enzymatic targets: The mitochondrial translocator protein (TSPO) was once proposed to mediate mitochondrial cholesterol import for steroid hormone biosynthesis, but genetic deletion studies in multiple models have refuted this role. Nevertheless, the idea that pharmacological ligands of TSPO can modulate steroid output… https://www.biorxiv.org/content/10.1101/2025.09.25.678677v1?rss=1&utm_source=dlvr.it&utm_medium=mastodon #BioRxiv #MassSpecRSS
- (RSS) (Proteomics Show)Ep 92 – Dr. Mathieu Lavallée-Adam: For a special US HUPO sponsored episode highlighting the upcoming HUPO Meeting in Toronto, Ben and Ben sit down to talk with one of the organizers, Dr. Mathieu Lavallée-Adam, University of Ottawa.Keywords: bioinformatics; hockey; Toronto https://podcasters.spotify.com/pod/show/theproteomicsshow/episodes/Ep-92—Dr–Mathieu-Lavalle-Adam-e38n4bb?utm_source=dlvr.it&utm_medium=mastodon
- (RSS) (BioRxiv All) Couples in the deep: dissolved organic and microbial communities in the oxygenated hypolimnion of a deep freshwater lake: The interaction between dissolved organic matter (DOM) and microbial communities is a critical yet understudied driver of biogeochemical cycling in aquatic ecosystems. Understanding these interactions is essential for elucidating the chemical and microbial dynamics that sustain ecosystem functionings. Here, we… https://www.biorxiv.org/content/10.1101/2025.09.23.678040v1?rss=1&utm_source=dlvr.it&utm_medium=mastodon #BioRxiv #MassSpecRSS
- (RSS) (BioRxiv All) Genetic landscape of DNMT3A R882H reveals mechanism of aberrant oligomerization: DNA methyltransferase 3A (DNMT3A) is a de novo DNA methyltransferase that is recurrently mutated in hematological malignancies and developmental disorders. The most prevalent mutation, R882H, compromises DNMT3A activity in a dominant-negative manner, but its precise biochemical mechanism has been debated. Here, we use paired deep mutational scanning… https://www.biorxiv.org/content/10.1101/2025.09.24.678339v1?rss=1&utm_source=dlvr.it&utm_medium=mastodon #BioRxiv #MassSpecRSS
- (RSS) (ACS Anal Chem) [ASAP] MALDI Mass Spectrometry Imaging of Metal Ions and Metabolites in Tissues Using a Bifunctional Matrix: Analytical ChemistryDOI: 10.1021/acs.analchem.5c02995 http://dx.doi.org/10.1021/acs.analchem.5c02995?utm_source=dlvr.it&utm_medium=mastodon #MassSpecRSS #ACSAChem
- (RSS) (BioRxiv All) Proteome-based investigation of O-GlcNAcylation in a C. elegans model of Ageing and Alzheimer's disease: Functional Support for Earlier Hypothesis-Generating Findings: The monosaccharide N-acetyl-glucosamine (GlcNAc), which dynamically modifies serine and threonine residues of nuclear and cytoplasmic proteins, is a key regulator of numerous biological processes. Investigating O-GlcNAc modification in vivo and in vitro remains… https://www.biorxiv.org/content/10.1101/2025.09.22.677859v1?rss=1&utm_source=dlvr.it&utm_medium=mastodon #BioRxiv #MassSpecRSS
- (RSS) (J Sep Sci) Systematic Analysis of Chemical Constituents and Pharmacokinetics of Baihe Dihuang Decoction In Vivo by UHPLC‐MS/MS: ABSTRACTBaihe Dihuang decoction (BDD), composed of Lilii Bulbus and Rehmanniae Radix, is a classical Chinese herbal formula. It demonstrates clinical applications in treating emotional disorders and anxiety. In this study, we characterized the chemical basis of BDD in vitro and elucidated its metabolic pathways,… https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/jssc.70281?af=R&utm_source=dlvr.it&utm_medium=mastodon #JSepSci #MassSpecRSS
- (RSS) (J Sep Sci) Simultaneous Quantification of a Novel β‐Carboline Alkaloid Derivative and Its Three Metabolites in Rat Plasma by UHPLC‐MS/MS and Its Application to a Pharmacokinetic Study: ABSTRACT1-Methyl-9-(3-pyridinylmethyl)-9H-pyrido[3,4-b] indole (HMYB) is a novel semi-synthetic alkaloid derived from β-carboline harmane, which has been proven to be effective in treatment of encopresis. But the pharmacokinetic characteristics of HMYB… https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/jssc.70282?af=R&utm_source=dlvr.it&utm_medium=mastodon #JSepSci #MassSpecRSS
- (RSS) (CEJ) Products of the Phenyl Radical (C6H5, X2A1) – Acetylene (C2H2, X1Σg+) Reaction in the 800‐1,200 K Temperature Range: Chemistry – A European Journal, EarlyView. https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/chem.202502477?af=R&utm_source=dlvr.it&utm_medium=mastodon (/CEJ)
- (RSS) (BioRxiv All) Mycothiol Conjugation Drives Biotransformation and Biodefluorination of Fluorotelomer Carboxylic Acids by Actinomycetota and Sludge Microbiomes: Microbial breakdown of poly- and perfluoroalkyl substances (PFASs) remains poorly understood, often hindered by mass balance discrepancies and unexplained fluoride release. Here we identify a previously unrecognized PFAS biodefluorination mechanism mediated by mycothiol (MSH), a… https://www.biorxiv.org/content/10.1101/2025.09.24.678248v1?rss=1&utm_source=dlvr.it&utm_medium=mastodon #BioRxiv #MassSpecRSS
- (RSS) (J Chrom A) Liquid Chromatography – Mass Spectrometry analysis of intact Ribonucleic Acid through hydrogen bonding of alkylamines: Publication date: Available online 24 September 2025Source: Journal of Chromatography AAuthor(s): Robert L. Ross, J. Michael Sutton, Keeley Murphy, Roberto Gamez, Ryan Cowley, Shanhua Lin, Min Du, Michael G. Bartlett https://www.sciencedirect.com/science/article/pii/S0021967325007514?dgcid=rss_sd_all&utm_source=dlvr.it&utm_medium=mastodon #JChrom #MassSpecRSS
- (RSS) (IJMS) Development of a laser desorption ionization – ion mobility – mass spectrometry method to accelerate the cyclic peptides stereochemistry determination workflow: Publication date: Available online 23 September 2025Source: International Journal of Mass SpectrometryAuthor(s): Jia-Xuan Yan, Wendy Zhong https://www.sciencedirect.com/science/article/pii/S138738062500137X?dgcid=rss_sd_all&utm_source=dlvr.it&utm_medium=mastodon #ijms #MassSpecRSS
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