- Proceedings of the National Academy of Sciences, Volume 123, Issue 27, July 2026.
- by Owen D. JarmanNitin BohraPeter ClausNicole PacziaTobias J. Erbahttps://ror.org/05r7n9c40Department of Biochemistry and Synthetic Metabolism, Max Planck Institute for Terrestrial Microbiology, 35043 Marburg, Germanybhttps://ror.org/01bwma613Max Planck School Matter to Life, 69120 Heidelberg, Germanychttps://ror.org/05r7n9c40Core Facility for Metabolomics and Small Molecule Mass Spectrometry, Max Planck Institute for Terrestrial Microbiology, 35043 Marburg, GermanydCenter for Synthetic Microbiology, Philipps University Marburg, 35043 Marburg, GermanyeMicrobes-for-Climate Cluster of Excellence, Synmikro, 35043 Marburg, GermanyProceedings of the National Academy of Sciences, Volume 123, Issue 27, July 2026. SignificanceA key goal of bottom–up synthetic biology is to construct cell-free systems with life-like, autonomous, and self-sustaining capabilities. Achieving this requires an efficient and controllable energy supply. In this work, we integrate a custom-…
- by Celso MartinsHarry BoothClàudia Salat-CanelaZena HadjivasiliouAleksandar Vješticaahttps://ror.org/019whta54Center for Integrative Genomics, Faculty of Biology and Medicine, University of Lausanne, Lausanne CH-1015, Switzerlandbhttps://ror.org/04tnbqb63Mathematical and Physical Biology Laboratory, The Francis Crick Institute, London NW1 1AT, United Kingdomchttps://ror.org/02jx3x895London Centre for Nanotechnology, University College London, London WC1H 0AH, United Kingdomdhttps://ror.org/02jx3x895Department of Physics and Astronomy, University College London, London WC1E 6BT, United Kingdomehttps://ror.org/02jx3x895Institute for the Physics of Living Systems, University College London, London WC1E 6BT, United KingdomProceedings of the National Academy of Sciences, Volume 123, Issue 27, July 2026. SignificanceThe emergence of distinct male and female gametes is a recurrent transition in the evolution of sexual reproduction, yet how differences between initially equivalent gametes first arise remains poorly understood beyond theoretical models. …
- by Albert C. SoewongsonoAmmon ThompsonMichael J. Landisahttps://ror.org/01yc7t268Department of Biology, Washington University in St. Louis, St. Louis, MO 63130bhttps://ror.org/040vxhp34Oak Ridge Institute for Science and Education, Oak Ridge, TN 37831Proceedings of the National Academy of Sciences, Volume 123, Issue 27, July 2026. SignificanceViral infections can spread among distinct locations by human travel. Being able to identify the source of a local outbreak, and whether it was triggered by infected visitors or individuals returning home, is crucial. We designed a …
- by Shupeng LiJohn A. RogersYonggang HuangaDepartment of Civil and Environmental Engineering, Northwestern University, Evanston, IL 60208bDepartments of Mechanical Engineering, Northwestern University, Evanston, IL 60208cQuerrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208dDepartment of Materials Science and Engineering, Northwestern University, Evanston, IL 60208eDepartment of Biomedical Engineering, Northwestern University, Evanston, IL 60208fDepartment of Neurological Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611Proceedings of the National Academy of Sciences, Volume 123, Issue 27, July 2026. SignificanceMedical-grade wearable devices require mounting strategies that ensure stable skin contact for accurate, long-term measurements while allowing gentle removal to avoid skin damage. Suction-based mounting is an attractive adhesive-free approach, …
- by Joseph H. EmersonKaren NavarroCheryl A. Olmanahttps://ror.org/017zqws13Department of Neuroscience, University of Minnesota, Minneapolis, MN 55455bhttps://ror.org/017zqws13Department of Psychology, University of Minnesota, Minneapolis, MN 55455chttps://ror.org/017zqws13Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, MN 55455Proceedings of the National Academy of Sciences, Volume 123, Issue 27, July 2026. SignificanceOur sensory experience requires interpretation: the brain uses both hyperlocal and large-scale scene cues to process sensory inputs. In the primary visual cortex (V1), this contextual modulation arises from a mixture of intra- and …
- by Kush K. YadavMenuka BhandariHassan M. MahsoubYoung Bin ParkHuong Van LeJae Mun ChoiHannah M. BrownGireesh RajashekaraScott P. KenneyXiang-Jin MengaDepartment of Animal Sciences, College of Food, Agricultural and Environmental Sciences, Wooster, OH 44691bhttps://ror.org/02smfhw86Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061cResearch and Analytics Service Core, College of Food, Agricultural and Environmental Sciences, Wooster, OH 44691dCalici Co., Ltd., Cambridge, MA 02142ehttps://ror.org/047426m28Department of Pathobiology, College of Veterinary Medicine, Veterinary Medicine Basic Sciences Building, University of Illinois Urbana-Champaign, Urbana, IL 61802fhttps://ror.org/00rs6vg23Center for Food Animal Health, Department of Animal Sciences, College of Food, Agricultural and Environmental Sciences, The Ohio State University, Wooster, OH 44691Proceedings of the National Academy of Sciences, Volume 123, Issue 27, July 2026. SignificanceHepatitis E virus (HEV) infection is associated with severe maternal and fetal complications during pregnancy, yet the underlying mechanisms driving this vulnerability remain poorly defined. We demonstrate that fatty acids and lipids play an …
- by Foster BirnbaumAmy E. Keatingahttps://ror.org/042nb2s44Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139bhttps://ror.org/042nb2s44Computational and Systems Biology, Massachusetts Institute of Technology, Cambridge, MA 02139chttps://ror.org/042nb2s44Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139Proceedings of the National Academy of Sciences, Volume 123, Issue 27, July 2026. SignificanceMachine learning has revolutionized the design of novel proteins by facilitating the generation of protein sequences that adopt desired structures. State-of-the-art sequence design models optimize the similarity of designed sequences to native …
- by Muhamet IbrahimiEbrahim JahanbakhshAthanasia C. TzikaMichel C. Milinkovitchahttps://ror.org/01swzsf04Laboratory of Artificial & Natural Evolution, Department of Genetics & Evolution, University of Geneva, Geneva 1211, Switzerlandbhttps://ror.org/002n09z45Swiss Institute of Bioinformatics, Geneva 1211, SwitzerlandProceedings of the National Academy of Sciences, Volume 123, Issue 27, July 2026. SignificanceThe dynamics of development and resulting spatial arrangement of hairs, feathers, and scales widely varies across vertebrate species. A classical description, known as expansion-induction, proposed that hair follicle precursors form in …
- by Mauro A. GarciaAnna Farrell-ShermanBeril AydinJunlin ZhuoEmily J. FrayAnna M. ZinsserJun LaiKirsten SowersHaoyue LiBrianna M. LopezAnthony Abeyta-LopezTifany ChuDonald LubbeckMoonki ChaeNiklas BachmannJoseph VarrialeDylan H. WestfallRebecca HohThomas DalhuisenFrancesco R. SimonettiMichael J. PelusoSteven G. DeeksRobert F. SilicianoLillian B. CohnJanet D. Silicianoahttps://ror.org/00za53h95Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205bhttps://ror.org/007ps6h72Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109chttps://ror.org/00cvxb145Department of Global Health, University of Washington, Seattle, WA 98105dhttps://ror.org/043mz5j54Department of Medicine, University of California, San Franisco, CA 94118ehttps://ror.org/006w34k90Howard Hughes Medical Institute, Baltimore, MD 21205Proceedings of the National Academy of Sciences, Volume 123, Issue 27, July 2026. SignificancePreventing viral rebound after treatment interruption is the goal of HIV-1 cure research, but the latent proviruses responsible remain undefined. Although rebound is initiated in lymphoid tissues, we found rebound viruses are genetically …
- by Théo MorfoisseSéverine BecuweMarie PaluCassandra Potier-WatkinsGhislaine Dehaene-LambertzStanislas Dehaeneahttps://ror.org/04ex24z53Chair of Experimental Cognitive Psychology, Collège de France, Paris 75005, Francebhttps://ror.org/03xjwb503Cognitive NeuroImaging Unit, Commissariat à l’Energie atomique et aux énergies alternatives, INSERM, Université Paris-Sud, Université Paris-Saclay, NeuroSpin Center, Gif-sur-Yvette 91191, FranceProceedings of the National Academy of Sciences, Volume 123, Issue 27, July 2026. SignificanceHow the child’s brain changes with schooling, as it acquires the abstract concepts of mathematics, remains unclear. By longitudinally tracking children’s brain responses to mathematical sentences from preschool through early elementary school, …
- by Na LiuGuohu HanFusheng ZhangQianhui GuYuanyuan LiuJing JiaXiaoren ZhuMinbin Chenahttps://ror.org/03jc41j30Department of Radiotherapy and Oncology, Affiliated Kunshan Hospital of Jiangsu University, Kunshan 215300, Chinabhttps://ror.org/03jc41j30Department of Oncology, Medical School of Jiangsu University, Zhenjiang 212013, Chinachttps://ror.org/03tqb8s11Department of Oncology, Jingjiang, People’s Hospital Affiliated with Yangzhou University, Jingjiang 214500, Chinadhttps://ror.org/02z1vqm45Department of Hepatobiliary and Pancreatic Surgery, Peking University First Hospital, Beijing 100034, Chinaehttps://ror.org/01kzsq416Department of Radiotherapy and Oncology, Suzhou Medical College of Soochow University, The First People’s Hospital of Kunshan, Kunshan 215300, ChinaProceedings of the National Academy of Sciences, Volume 123, Issue 27, July 2026. SignificanceNon-small-cell lung cancer (NSCLC) represents a leading cause of cancer-related mortality worldwide owing to its aggressive nature and resistance to therapies. This study identifies TMED9 as a critical oncogenic driver that facilitates NSCLC …
- by Roderick MacKinnonChristoph A. Haselwandterahttps://ror.org/0420db125Laboratory of Molecular Neurobiology and Biophysics, HHMI, The Rockefeller University, New York, NY 10065bhttps://ror.org/03taz7m60Department of Physics and Astronomy, University of Southern California, Los Angeles, CA 90089chttps://ror.org/03taz7m60Department of Quantitative and Computational Biology, University of Southern California, Los Angeles, CA 90089Proceedings of the National Academy of Sciences, Volume 123, Issue 27, July 2026. Recent data suggest that many membrane proteins spontaneously organize into spatial patterns through weak noncovalent interactions. These weak interactions are protein type-specific and underlie the formation of higher-order transient structures (HOTS), …
- by Archisman PanigrahiVladislav PoliakovLeonid Levitovahttps://ror.org/042nb2s44Department of Physics, Massachusetts Institute of Technology, Cambridge, MA 02139Proceedings of the National Academy of Sciences, Volume 123, Issue 27, July 2026. SignificanceDetermining the symmetry and topology of superconducting order parameter is essential for identifying new quantum materials with potential applications in quantum information and dissipationless electronic transport technologies. The …
- by Kristy M. FerraroAnn C. Thresherahttps://ror.org/04haebc03Department of Biology, Memorial University of Newfoundland, St. John’s, NL A1C 5S7, Canadabhttps://ror.org/00jmfr291School of the Environment and Sustainability, University of Michigan, Ann Arbor, MI 48109cDepartment of Philosophy and Religion, Northeastern University, Boston, MA 02115dSchool of Public Policy, Northeastern University, Boston, MA 02120Proceedings of the National Academy of Sciences, Volume 123, Issue 27, July 2026.
- by Henrique S. LimaRodrigo M. PereiraLuca MoriconiKatepalli R. SreenivasanConstantino Tsallisahttps://ror.org/02wnmk332Centro Brasileiro de Pesquisas FíÃsicas, Rio de Janeiro 22290-180, RJ, Brazilbhttps://ror.org/02rjhbb08Instituto de Física, Universidade Federal Fluminense, Niterói 24210-346, RJ, Brazilchttps://ror.org/03490as77Instituto de Física, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-909, RJ, Brazildhttps://ror.org/0190ak572Department of Mechanical and Aerospace Engineering, New York University, New York, NY 11201ehttps://ror.org/0190ak572Department of Physics, Courant Institute of Mathematical Sciences, New York University, New York, NY 10012fhttps://ror.org/01arysc35Santa Fe Institute, Santa Fe, NM 87501ghttps://ror.org/023dz9m50Complexity Science Hub Vienna, Vienna 1030, Austriahhttps://ror.org/03a64bh57Dipartimento di Fisica Ettore Majorana, University of Catania, Catania 95131, ItalyProceedings of the National Academy of Sciences, Volume 123, Issue 27, July 2026. SignificanceFluid turbulence, a subject of immense practical relevance, belongs to the domain of nonequilibrium statistical mechanics. However, the precise nature of such a statistical system is unclear. This paper provides convincing evidence that …
- by Aidan ZentnerEthan V. HalingstadCameron ChalkMichael P. BrennerArvind MuruganErik WinfreeKrishna Shrinivasahttps://ror.org/03vek6s52School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138bDepartment of Chemical and Biological Engineering, Northwestern University, Evanston, IL 60208cCenter for Synthetic Biology, Northwestern University, Evanston, IL 60208dNSF-Simons National Institute for Theory and Mathematics in Biology, Chicago, IL 60611ehttps://ror.org/05dxps055Computation and Neural Systems, California Institute of Technology, Pasadena, CA 91125fhttps://ror.org/03vek6s52Department of Physics, Harvard University, Cambridge, MA 02138ghttps://ror.org/024mw5h28Department of Physics, University of Chicago, Chicago, IL 60637Proceedings of the National Academy of Sciences, Volume 123, Issue 27, July 2026. SignificanceIn living cells, biomolecules self-organize into compartments called condensates that form by phase transitions, often around surfaces such as DNA and membranes. Typically viewed as concentrating mechanisms, we show that the physics underlying …
- by Abdalla G. AliaXinyue HuYuzhe GuJanviere YauGuangnan TianJulie L. SemmelhackKokoro SaitoHiromu TanimotoKoki TsuyuzakiShintaro NaganosTomoyuki MiyashitaMinoru SaitoeYukinori Hiranoahttps://ror.org/00q4vv597Division of Life Science, The Hong Kong University of Science and Technology, Kowloon, Hong Kong Special Administrative Regionbhttps://ror.org/02pttbw34Division of Neurology and Developmental Neuroscience, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030chttps://ror.org/05cz92x43Cain Pediatric Neurology Research Foundation Laboratories, Jan and Dan Duncan Neurological Research Institute, Texas Children’s Hospital, Houston, TX 77030dBiomedical Sciences Program, School of Science, University of Science and Technology, Zewail City of Science, Technology and Innovation, Giza 12578, EgypteDepartment of Integrative Life Sciences, Graduate School of Life Sciences, Tohoku University, Sendai 980-8577, Japanfhttps://ror.org/01hjzeq58Data Science Core, Chiba University, Chiba 260-0856, Japanghttps://ror.org/00vya8493Learning and Memory Project, Tokyo Metropolitan Institute of Medical Science, Tokyo 156-8506, Japanhhttps://ror.org/02pc6pc55Department of Molecular Membrane Biology, Faculty of Pharmaceutical Sciences, Okayama University, Okayama 700-8530, JapanProceedings of the National Academy of Sciences, Volume 123, Issue 27, July 2026. SignificanceHow stress induces long-lasting internal states leading to anxiety and phobia remains poorly understood. In this study, we demonstrate that a genetically tractable model organism,Drosophila melanogaster, exhibits stress-induced claustrophobia-…
- by Jiaqi ZhuGary Z. WangHugo D. PintoSean E. HealtonLaxmi N. MishraArthur I. SkoultchiStephen P. Goffahttps://ror.org/01esghr10Department of Biochemistry and Molecular Biophysics, Columbia University Medical Center, New York, NY 10032bhttps://ror.org/01esghr10Department of Microbiology and Immunology, Columbia University Medical Center, New York, NY 10032chttps://ror.org/01esghr10Aaron Diamond AIDS Research Center, Department of Medicine, Columbia University Medical Center, New York, NY 10032dhttps://ror.org/05cf8a891Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461Proceedings of the National Academy of Sciences, Volume 123, Issue 27, July 2026. SignificanceDuring early stages of retroviral infection, core and H1 histones are rapidly deposited onto unintegrated viral DNAs upon nuclear entry. These unintegrated viral DNAs are transcriptionally silenced through histone posttranslational …
- by Chuan LiuThomas L. GoûtYandi HuWeiqiang LiShichao AnZehao ZhouSong CaiHuazhang ZhaoJinren NiJames J. De YoreoDonald J. DePaoloahttps://ror.org/02v51f717Key Laboratory of Water and Sediment Sciences, Ministry of Education; College of Environmental Sciences and Engineering, Peking University, Beijing 100871, People’s Republic of ChinabSouthwest United Graduate School, Kunming 650092, People’s Republic of Chinachttps://ror.org/01rxvg760State Key Laboratory of Critical Earth Material Cycling and Mineral Deposits, School of Earth Sciences and Engineering, Nanjing University, Nanjing, Jiangsu 210093, People’s Republic of Chinadhttps://ror.org/05h992307Physical Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99352ehttps://ror.org/00cvxb145Department of Materials Science and Engineering, University of Washington, Seattle, WA 98195fhttps://ror.org/02jbv0t02Energy Geosciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720Proceedings of the National Academy of Sciences, Volume 123, Issue 27, July 2026. SignificanceStable isotopes are widely used to reconstruct Earth’s history. Accurate applications require mechanistic knowledge of isotope fractionation during crystal formation via nucleation followed by growth, but isotope fractionation during …
Mass spectrometry websites, social media, journal feeds, and other links and items of interest to the mass spectrometry community.
