RSS feed of mass spectrometry journals and other mass spectrometry articles and social feeds.
- Publication date: Available online 25 April 2025Source: Journal of Chromatography AAuthor(s): Yelena Sapozhnikova, Kevin Stroski
- As part of the non-sponsored sporadic "B-sides" series*, Ben and Ben sit down and talk with Dr. Sue Weintraub, University of Texas Health Science Center at San Antonio.(* this series is where we put guests we want to talk to but who do not fit within any sponsored series, but is still proteomics…. mostly)
- Janus Kinase 2 (JAK2) has been linked to various neutrophil functions, but the intracellular mechanisms underlying its modulation are unknown. Neutrophils are essential cells for host defense. Neutrophil effector functions include migration, reactive oxygen species (ROS) production, degranulation, and neutrophil extracellular trap (NET) formation. The goal of this study was to elucidate the signaling mechanism through which JAK2 modulates neutrophil […]
- Environmental Science & TechnologyDOI: 10.1021/acs.est.5c00886
- Analytical ChemistryDOI: 10.1021/acs.analchem.5c01648
- Analytical ChemistryDOI: 10.1021/acs.analchem.5c00578
- ABSTRACT The participants of the 12th International Atomic Energy Agency (IAEA) meeting on stable isotope reference materials reached a consensus, acknowledging the existence and use of two carbon isotope delta scales: the VPDB (Vienna Peedee belemnite) scale and the VPDB-LSVEC (LSVEC – lithium carbonate prepared by H. J. Svec). Conversion models between the two scales can be established and used […]
- ABSTRACT Rationale Iron deficiency plagues reproductive-aged women across the world, and blood loss during menstruation is proposed as the driving force. To assess if other factors related to reproduction influence Fe and Cu isotope variation in females, we measured Fe and Cu isotope compositions in the bones of chimpanzees and bonobos. Methods To do this, we optimize the protocol for […]
- Metabolic engineering requires selection markers for transformant generation. However, use of antibiotic resistance is of concern for potential horizontal gene transfer in the environment. Herbicide resistance markers are an alternative for photosynthetic cell line engineering as these agents are plant-specific with resistance mechanisms that can be generated from mutations of endogenous genes. Here, we developed norflurazon and oxyfluorfen resistance markers […]
- Standard antibiotic susceptibility tests (ASTs) often fail to accurately predict treatment outcomes because they do not account for biofilm-specific mechanisms of reduced susceptibility. In the present study, we explored alternative approaches to predict tobramycin susceptibility of Pseudomonas aeruginosa biofilms that were experimentally evolved in physiologically relevant conditions. To this end, we used four analytical methods, whole-genome sequencing (WGS), matrix-assisted laser […]
- Publication date: Available online 23 April 2025Source: Journal of Chromatography AAuthor(s): Haiyan Gao, Yuncheng Ge, Lili Tong, Lei Yin, Qiang Ma
- Understanding the spatial–temporal molecular dynamics of wound healing is crucial for devising effective treatments. Three-dimensional mass spectrometry imaging (3D MSI) enables the comprehensive visualization of molecular distribution throughout skin layers, offering valuable insights into the wound healing process. However, traditional 3D MSI often faces challenges in maintaining data integrity and accurate image registration in the third dimension. To address this, […]
- Traditional methods for diagnosing bacterial or fungal infections, such as cell culture, are comprehensive but time-consuming and subjective. Microbial volatile organic compound (VOC) analysis offers a faster alternative, though challenges such as low concentrations and chemical heterogeneity persist. Gas chromatography-mass spectrometry (GC–MS), while highly sensitive, requires lengthy sample preparation. This study presents a novel approach using proton transfer-reaction mass spectrometry […]
- Recent studies evidence an altered bioenergetic profile and higher adipogenic commitment in the MSCs from neonates of mothers with obesity. We hypothesize that these alterations may also affect the secretome of these cells. The aim of this study was to characterize the redox and adipogenic secretome of MSCs from the offspring of women with obesity compared to the ones from […]
- Analytical ChemistryDOI: 10.1021/acs.analchem.5c01223
- Analytical ChemistryDOI: 10.1021/acs.analchem.5c00714
- J. Anal. At. Spectrom., 2025, Accepted ManuscriptDOI: 10.1039/D5JA00107B, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Sarah Szakas, Jordan Stanberry, N. Alex Zirakparvar, Hunter B. Andrews, Daniel R. Dunlap, Matt Darnell, Brian W. Ticknor, Lorianne Rebecca Shultz-Johnson, Shawna Tazik, Benjamin T ManardParticle analysis has benefitted from the advent of single particle inductively coupled […]
- Publication date: Available online 23 April 2025Source: International Journal of Mass SpectrometryAuthor(s): Richmond A. Adomako, Michael B. Owusu, Rebekah Oberdick, Kwabena Senyah, Perfect Asare, Laurence A. Angel
- Publication date: Available online 23 April 2025Source: Journal of Mass Spectrometry and Advances in the Clinical LabAuthor(s): Thomas G. Rosano, S.M.Touhidul Islam, John M. Rumberger, Robert M. Konetchy, Michelle Wood, Joseph A. Sorce, Karl A. Robstad, Heather Long
- ABSTRACT Cancer is the leading cause of death worldwide characterized by patient heterogeneity and complex tumor microenvironment. While the genomics-based testing has transformed modern medicine, the challenge of diverse clinical outcomes highlights unmet needs for precision oncology. As functional molecules regulating cellular processes, proteins hold great promise as biomarkers and drug targets. Mass spectrometry (MS)-based clinical proteomics has illuminated the […]
- Ultimately, most tandem mass spectrometry (MS/MS) proteomics experiments aim to not just detect but also quantify the proteins in a given complex sample. Here, we describe an extension to the Crux MS/MS analysis toolkit to enable label-free quantification of peptides. We demonstrate that Crux's new quantification command, which is modeled after the algorithms implemented in the widely used FlashLFQ software, […]
- Agilent have published an application note for recommended MassHunter Qualitative Analysis settings when searching DDA peak lists with Mascot Server. We've added it to a new help page for Agilent instruments.https://www.matrixscience.com/help/instruments_agilent.html#proteomics #MassSpec
- FBXO42 is a poorly characterized F-box protein that is essential in 15% of cancer cell lines from diverse tissue types. FBXO42 has been implicated in the regulation of mitosis and p53 signaling. High-throughput approaches indicate that FBXO42 function correlates with that of CCDC6, and that the two proteins interact physically, but the relationship between these proteins is not understood. Through […]
- PACS1 syndrome is a neurodevelopmental disorder resulting from a unique de novo p.R203W variant in Phosphofurin Acidic Cluster Sorting protein 1 (PACS1). PACS1 encodes a multifunctional sorting protein required for localizing furin to the trans-Golgi network. Although few studies have started to investigate the impact of the PACS1 p.R203W variant, the mechanisms by which the variant affects neurodevelopment are still […]
- Objective: Diabetic ketoacidosis (DKA) stands as the most common acute hyperglycaemic complication with a relatively high mortality rate among children diagnosed with type 1 diabetes (T1D). Previous studies have shed light on gut dysbiosis in newly-onset T1D children, but research targeting the gut microbiota and microbial metabolites in patients with DKA remains scarce. Methods: Shotgun metagenomic analysis was conducted on […]