RSS feed of mass spectrometry journals and other mass spectrometry articles and social feeds.
- This workdeveloped and fully validated a novel UHPLC-MS3 method for sensitive andselective quantification of pyraclostrobin in zebrafish liver tissues, andsuccessfully applied it to assess its hepatic bioaccumulation after 50 µg/Laqueous exposure. ABSTRACT Pyraclostrobin, a widely applied methoxyacrylate fungicide, poses considerable risks to aquatic ecosystems due to its environmental persistence and bioaccumulation potential. Understanding its tissue-specific residue profile in aquatic organisms […]
- Iron is an essential component of cellular biology. Thus, iron's low bioavailability is a key evolutionary pressure guiding microbial dynamics in the marine environment. Among marine bacteria, Microbulbifer is an underexplored and functionally versatile bacterial genus, which is commonly associated with sponges, algae, corals and sediments. Previously, genome analyses have revealed that Microbulbifer spp. can degrade polymers and synthesize natural […]
- Journal of the American Society for Mass SpectrometryDOI: 10.1021/jasms.5c00316
- Data-independent acquisition (DIA) has become the preferred data acquisition method for mass spectrometry-based proteomics, yet, reproducible workflows for differential expression (DE) analysis and reporting results remain limited. We present DiaReport, an R package that performs precursor- and protein-level DE analysis from DIA-NN output using MSqRob and QFeatures, while generating high-quality, interactive HTML reports through Quarto. DiaReport integrates precursor data, filtering […]
- Analyst, 2026, Accepted ManuscriptDOI: 10.1039/D6AN00012F, PaperYinghao Cao, Yuting Tan, Chang Li, Erping Long, Lin WangAchieving high spatial resolution is critical for revealing tissue-specific metabolite distributions in mass spectrometry imaging (MSI), yet practical constraints often limit achievable resolution. While deep learning offers promising post-acquisition enhancement,…The content of this RSS Feed (c) The Royal Society of Chemistry
- XA-Novo: high-throughput mass spectrometry-based de novo sequencing technology for monoclonal antibodies and antibody mixtures
- Ambient metabolomics techniques such as laser-assisted rapid evaporative ionization mass spectrometry (LA-REIMS) enable fast, preparation-free fingerprinting of biological samples but are inherently limited by spectral congestion in the absence of chromatographic separation. While ion mobility spectrometry provides additional gas-phase separation, maintaining ion transmission under the transient signals characteristic of laser desorption remains analytically challenging. Here, we define operating conditions for […]
- Environmental Science & TechnologyDOI: 10.1021/acs.est.6c00394
- Publication date: Available online 12 March 2026Source: Journal of Chromatography BAuthor(s): Ibrahim Choucair
- Publication date: 1 August 2026Source: Talanta, Volume 305Author(s): Olha Dushna, Andrzej Gawor, Leszek Pączek, Ewa Bulska, Renata Bilewicz
- Doxycycline is a tetracycline-class antibiotic used for malarial prophylaxis and as an occasional partner drug in malaria treatment. Several lines of evidence suggest that doxycycline's antimalarial mechanism of action is through inhibiting the prokaryotic 70S ribosomes of the apicoplast, a non-photosynthetic plastid present in most apicomplexan species including Plasmodium and Toxoplasma. At lower concentrations (10 M) doxycycline has rapid schizonticidal […]
- Chemoproteomics is a popular approach for the identification of small molecule-protein interactions in biological systems. Several chemoproteomics workflows leverage functionalized chemical probes and mass spectrometry to measure protein engagement through direct protein enrichment or competition using a range of small molecule concentrations. Statistical methods for analysis of such dose-response chemoproteomics datasets are limited. For example, existing methods rely on fixed […]
- Journal of the American Society for Mass SpectrometryDOI: 10.1021/jasms.5c00432
- Analytical ChemistryDOI: 10.1021/acs.analchem.5c06656
- Background: Rapid and accurate identification of urinary tract infection (UTI) pathogens is critical for effective treatment and combating antimicrobial resistance. Conventional culture-based diagnostics are slow, and standard tandem mass spectrometry workflows are resource-intensive. Methods: We present a proof-of-concept workflow that integrates high-resolution data-independent acquisition (DIA) MS/MS on the Thermo Scientific Orbitrap Astral with MS1-only spectra from the Orbitrap Exploris 480. […]
- Analyst, 2026, Advance ArticleDOI: 10.1039/D6AN00119J, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.A. Dawson McLachlan, Rashne Vakharia, Emir Nazdrajić, Diana M. Cárdenas-Soracá, Leslie M. Bragg, Mark R. Servos, W. Scott HopkinsA novel hybrid workflow including chiral LC and differential mobility spectrometry was used to separate and quantify the enantiomers of a set […]
- Protein lipidation is a widespread strategy for anchoring proteins to cellular membranes across all domains of life, yet the mechanisms underlying this process in archaea remain poorly understood. Recently, the first archaeal enzymes involved in lipobox-containing protein (lipoprotein) biogenesis, AliA and AliB, were identified and characterized in the model archaeon Haloferax volcanii. Although these paralogs share significant sequence similarity, distinct […]
- Structural dynamics and immunogenicity of the recombinant and outer membrane vesicle-embedded Meningococcal antigen NadA
- Anal. Methods, 2026, Advance ArticleDOI: 10.1039/D5AY01489A, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Hans S. A. Yates, James F. Carter, Jiali Zhang, Mary T. Fletcher, Viviene S. Santiago, Natasha L. HungerfordThe analysis of rare or atypical sugars is not encompassed by standard sugar methodology. With greater selectivity, this new method covers 80 […]
- J. Anal. At. Spectrom., 2026, Accepted ManuscriptDOI: 10.1039/D5JA00415B, PaperZhekun Wang, Zhongjun Zhao, Zhihao He, Xiaoqin Jiang, Yanting Yang, Jianxiong Dai, Ziqiu Su, Xing Guo, Yixiang DuanIon mobility spectrometry-mass spectrometry (IMS-MS) is a powerful tool used in the separation, detection, and characterization of ions. Electrospray ionization (ESI) coupled with IMS-MS has been widely employed in metabolomics,…The content of this RSS Feed […]
- Publication date: Available online 11 March 2026Source: Journal of Chromatography BAuthor(s): Apurva Patil, Michaela Austel, Michael G. Bartlett
- ABSTRACT Rationale Protein phosphorylation plays a central role in regulating cellular signaling, and its dysregulation is closely linked to diseases such as cancer and neurodegeneration. Mass spectrometry–based phosphoproteomics allows comprehensive mapping of phosphorylation; however, detecting low-abundance and poor ionization phosphopeptides remains a challenge. High-field asymmetric waveform ion mobility spectrometry (FAIMS) offers orthogonal gas-phase fractionation, enhancing phosphopeptide detection. However, FAIMS and […]
- ABSTRACT Rationale Nitrogen mustards (HN1, HN2 and HN3) and N,N-dialkylaminoethyl-2-chlorides (where alkyl = methyl, ethyl, isopropyl, or propyl) contain reactive chloride bonds that react with phenol in environmental samples to form phenolic reaction products. Identifying these products is crucial for the Chemical Weapons Convention (CWC) verification, as they serve as markers for the presence of scheduled chemicals. Methods Phenolic reaction products of […]
- We developed a novel domino polymerization to synthesize reductively degradable poly(disulfide)s with tunable side chains. A novel monomer bearing thiolactone and pyridyl disulfide groups reacts with various amines, enabling continuous ring-opening and disulfide exchange. The resulting polymers show reductive degradability, pH-responsive solubility, and can form degradable gels, offering versatile applications. ABSTRACT The environmental persistence of conventional plastics has driven the […]
- Protein phosphorylation is a key regulator of signaling, with mass spectrometry (MS) based phosphoproteomics serving as the premier technology for its analysis. However, phosphorylation profiling is hindered by acquisition biases: Data-Dependent Acquisition (DDA) suffers from stochastic undersampling and missing values, while Data-Independent Acquisition (DIA) faces computational bottlenecks and inefficiencies from vast spectral libraries. We present PhosSight, a unified deep learning […]