BioCurious Blog comments on American Chemical Society President E. Ann Nalley’s recent letter arguing against open access to journal articles that report on research funded by the NIH. Nalley objects to the “available after six months” policy, arguing that it will lead to lost revenues. It’s still too early to guage the effect on journal profits, but all issues of the Journal of the American Society of Mass Spectrometry are openly availble after one year. The flip side of open access is that it may lead to increased readership and higher impact factor, both of which can increase publisher profits.