BioRxiv
bioRxiv Subject Collection: Systems Biology
This feed contains articles for bioRxiv Subject Collection "Systems Biology"
Higher-order co-mutation interactions in mitochondrial genomes
Studies of pair-wise co-mutation of mitochondrial genome have already provided ample evidences about roles of genetic interactions in manifestation of phenotype under altered environmental conditions. High-altitude is one such condition which causes mitochondrial genome to undergo natural selection. Here, we provide a method to construct and analyse higher-order interactions, namely, 3-uniform hypergraphs of mitochondrial genes for different altitude populations to decipher the role of co-mutating variable sites beyond pair-wise interactions. While the weights distribution of such gene hyperedges manifested power-law for all the altitudes regions, we identified specific genes for each altitude based on highest gene hyperedge weight. This framework of higher-order interaction hypergraphs provides a promising avenue for future investigation of nuclear genomes in context of phenotypic association and genetic disorders.
Verma, R. K., Jalan, S., Shinde, P., Mishra, A.
February 14, 2023
http://biorxiv.org/cgi/content/short/2023.02.13.528359v1?rss=1