{"id":2903,"date":"1993-09-15T17:33:27","date_gmt":"1993-09-15T22:33:27","guid":{"rendered":"https:\/\/kermitmurray.com\/research\/?p=2903"},"modified":"2024-02-20T09:39:00","modified_gmt":"2024-02-20T15:39:00","slug":"liquid-sample-introduction-for-matrix-assisted-laser-desorption-ionization","status":"publish","type":"post","link":"https:\/\/kermitmurray.com\/research\/1993\/09\/liquid-sample-introduction-for-matrix-assisted-laser-desorption-ionization\/","title":{"rendered":"Liquid Sample Introduction for Matrix-Assisted Laser Desorption Ionization"},"content":{"rendered":"\n

K.K. Murray, D.H. Russell, Liquid Sample Introduction for Matrix-Assisted Laser Desorption Ionization, Anal. Chem., 65 (1993) 2534-2537; http:\/\/10.1021\/<\/a>ac00066a023<\/a>.<\/p>\n\n\n\n

Abstract<\/h4>\n\n\n\n
\"\"
Aerosol MALDI apparatus at Texas A&M University<\/figcaption><\/figure><\/div>\n\n\n\n

In this paper initial results are presented for a new liquid introduction method for a mass spectrometer based on the application of MALDI to aerosols. Details of the method will be presented in future publications. Aerosols are formed using a continuous pneumatic aerosol generator from an acidified methanol solution containing the matrix and analyte. The solvent is removed by passing the aerosol through a heated tube to form a collimated beam of dried particles. Ions are formed by irradiating the aerosol with pulsed UV radiation in the source region of a linear TOF MS. The advantages of the aerosol MALDI TOF method are (1) liquid flow capacity of 0.5 mL\/min, (2) rapid acquisition of the entire mass spectrum, and (3) ionization of large peptides and proteins. In this paper, the aerosol MALDI mass spectra of gramicidin S and lysozyme (chicken egg white) are presented. Flow injection mass spectra of gramicidin S are presented to demonstrate the feasibility of coupling aerosol MALDI with HPLC.<\/p>\n\n\n\n

\"Kermit
Kermit Murray at Texas A&M University in 1993<\/figcaption><\/figure>\n\n\n\n
\"AMALDI
Texas A&M Aerosol MALDI instrument side view<\/figcaption><\/figure>\n\n\n\n
\"TAMU
Aerosol MALDI instrument at Texas A&M University, showing the flight tube (right) and ion source (left).<\/figcaption><\/figure>\n\n\n\n
\"AMALDI
Aerosol MALDI Instrument at Texas A&M University, 1992.<\/figcaption><\/figure>\n\n\n\n
\"TAMU
Roots blower and backing pump at Texas A&M University, 1992<\/figcaption><\/figure>\n","protected":false},"excerpt":{"rendered":"

K.K. Murray, D.H. Russell, Liquid Sample Introduction for Matrix-Assisted Laser Desorption Ionization, Anal. Chem., 65 (1993) 2534-2537; http:\/\/10.1021\/ac00066a023. Abstract In this paper initial results are presented for a new liquid introduction method for a mass spectrometer based on the application of MALDI to aerosols. Details of the method will be presented in future publications. Aerosols … <\/p>\n

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