{"id":2653,"date":"2019-06-10T17:10:54","date_gmt":"2019-06-10T22:10:54","guid":{"rendered":"https:\/\/kermitmurray.com\/murray\/?p=2653"},"modified":"2024-02-20T09:38:59","modified_gmt":"2024-02-20T15:38:59","slug":"asms-2019-deep-uv-la-sampling-for-ms","status":"publish","type":"post","link":"https:\/\/kermitmurray.com\/research\/2019\/06\/asms-2019-deep-uv-la-sampling-for-ms\/","title":{"rendered":"ASMS 2019: Deep-ultraviolet Laser Ablation Sampling for Mass Spectrometry"},"content":{"rendered":"\n<div class=\"wp-block-caxton-grid relative\"><div class=\"absolute absolute--fill\"><div class=\"cover bg-center absolute absolute--fill\" style=\"background-color:;background-image:linear-gradient( );\"><\/div><div class=\"absolute absolute--fill\" style=\"background-color:;background-image:linear-gradient( );opacity:1;\"><\/div><\/div><div class=\"relative caxton-columns caxton-grid-block\" style=\"padding-top:0;padding-left:0;padding-bottom:0;padding-right:0;grid-template-columns:repeat(12, 1fr)\" data-tablet-css=\"padding-left:em;padding-right:em;\" data-mobile-css=\"padding-left:em;padding-right:em;\">\n<div class=\"wp-block-caxton-section relative\" style=\"grid-area:span 1\/span 12\"><div class=\"absolute absolute--fill\"><div class=\"cover bg-center absolute absolute--fill\" style=\"background-color:;background-image:linear-gradient( );\"><\/div><div class=\"absolute absolute--fill\" style=\"background-color:;background-image:linear-gradient( );opacity:1;\"><\/div><\/div><div class=\"relative caxton-section-block\" style=\"padding-top:5px;padding-left:5px;padding-bottom:5px;padding-right:5px\" data-mobile-css=\"padding-left:1em;padding-right:1em;\" data-tablet-css=\"padding-left:1em;padding-right:1em;\">\n<p><strong>MOG 03:10pm<\/strong><br><em>Deep-ultraviolet Laser Ablation Sampling for Mass Spectrometry<\/em><br>Remilekun O. Lawal; Fabrizio Donnarumma; Kermit K. Murray<\/p>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"alignright is-resized\"><a href=\"https:\/\/kermitmurray.com\/murray\/?attachment_id=2654\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/kermitmurray.com\/murray\/wp-content\/uploads\/2019\/08\/DUVLA-Photo.jpg\" alt=\"193 nm excimer laser ablation setup\" class=\"wp-image-2654\" width=\"583\" height=\"383\" srcset=\"https:\/\/kermitmurray.com\/research\/wp-content\/uploads\/2019\/08\/DUVLA-Photo.jpg 777w, https:\/\/kermitmurray.com\/research\/wp-content\/uploads\/2019\/08\/DUVLA-Photo-300x197.jpg 300w, https:\/\/kermitmurray.com\/research\/wp-content\/uploads\/2019\/08\/DUVLA-Photo-768x504.jpg 768w\" sizes=\"auto, (max-width: 583px) 100vw, 583px\" \/><\/a><figcaption>193 nm excimer laser ablation setup<\/figcaption><\/figure><\/div>\n\n\n\n<p>High resolution sampling of biological systems is crucial to revealing the differences in proteins and metabolites amongst heterogeneous cells. Laser ablation sampling for mass spectrometry is a powerful method for analyzing biomolecules in\u2000tissue under ambient conditions with high spatial control while eliminating the need for external matrices. It allows off-line analysis by liquid chromatography tandem mass spectrometry and can be combined with mass spectrometry imaging for region of interest selection. The most efficient lasers currently used for ablation sampling use mid-infrared wavelengths that are diffraction limited to spot sizes tens of micrometers in diameter. Short wavelength lasers can be focused to order of magnitude smaller spot sizes for efficient ablation with minimal thermal damage to adjacent sample areas.<\/p>\n<\/div><\/div>\n<\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":2654,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[13,79,78],"tags":[64,11,151],"class_list":["post-2653","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-conference","category-last","category-research-areas","tag-ablation","tag-asms","tag-uv","entry"],"_links":{"self":[{"href":"https:\/\/kermitmurray.com\/research\/wp-json\/wp\/v2\/posts\/2653","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kermitmurray.com\/research\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kermitmurray.com\/research\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kermitmurray.com\/research\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kermitmurray.com\/research\/wp-json\/wp\/v2\/comments?post=2653"}],"version-history":[{"count":1,"href":"https:\/\/kermitmurray.com\/research\/wp-json\/wp\/v2\/posts\/2653\/revisions"}],"predecessor-version":[{"id":2655,"href":"https:\/\/kermitmurray.com\/research\/wp-json\/wp\/v2\/posts\/2653\/revisions\/2655"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/kermitmurray.com\/research\/wp-json\/wp\/v2\/media\/2654"}],"wp:attachment":[{"href":"https:\/\/kermitmurray.com\/research\/wp-json\/wp\/v2\/media?parent=2653"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kermitmurray.com\/research\/wp-json\/wp\/v2\/categories?post=2653"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kermitmurray.com\/research\/wp-json\/wp\/v2\/tags?post=2653"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}