Charge remote fragmentation: Difference between revisions

Revision as of 17:29, 15 June 2013

Charge remote fragmentation
IUPAC RECOMMENDATIONS 2013
Fragmentation of an ion in which the cleaved bond is isolated from the apparent charge site by a distance of several bond lengths.
Related Term(s): charge-mediated fragmentation
Reference(s): A. Savagnac, H. Aurelle, C. Casas, F. Couderc, P. Gavard, D. Prome, J. C. Prome. Chem. Phys. Lipids 51, 31 (1989). (http://dx.doi.org/10.1016/0009-3084(89)90063-7 ) K. B. Tomer, N. J. Jensen, M. L. Gross, J. Whitney. Biomed. Environ. Mass Spectrom. 13, 265 (1986). (http://dx.doi.org/10.1002/bms.1200130602 )
From Definitions of Terms Relating to Mass Spectrometry (IUPAC Recommendations 2013); DOI: 10.1351/PAC-REC-06-04-06 © IUPAC 2013.
Index of Recommended Terms

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 K. B. Tomer, N. J. Jensen, M. L. Gross, J. Whitney. Biomed. Environ. Mass Spectrom. 13, 265 (1986). (http://dx.doi.org/10.1002/bms.1200130602 )
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-Decompositions that occur without any obvious involvement of the charge site.  These reactions may be of closed-shell species and have thermal analogies or be of radical ions and be radical-site induced.  One requirement is a stable charge site, which is usually closed shell, stable, and localized (e.g., -COO-, -COOLi2+, -OHNa+, -SO3-, etc.).  The reactions are particularly useful in locating functional groups in aliphatic chains such as in fatty acids, surfactants, lipids, steroids but also occur for peptides and other biomolecules.  Many charge-remote fragmentations require high-energy collisional activation but others have low-energy requirements and are seen at metastable-ion decompostions or under low-energy collisional conditions.
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