{"id":2153,"date":"2022-11-22T21:29:49","date_gmt":"2022-11-23T03:29:49","guid":{"rendered":"https:\/\/kermitmurray.com\/msblog\/?page_id=2153"},"modified":"2024-12-15T16:47:55","modified_gmt":"2024-12-15T22:47:55","slug":"feeds","status":"publish","type":"page","link":"https:\/\/kermitmurray.com\/msblog\/","title":{"rendered":"Mass Spectrometry Feeds"},"content":{"rendered":"\n<div class=\"wp-block-caxton-grid relative\"><div class=\"absolute absolute--fill\"><div class=\"absolute absolute--fill cover bg-center\" style=\"background-color:;background-image:linear-gradient( );\"><\/div><div class=\"absolute absolute--fill\" style=\"background-color:;background-image:linear-gradient( );opacity:1;\"><\/div><\/div><div class=\"relative caxton-columns caxton-grid-block\" style=\"padding-top:0;padding-left:0;padding-bottom:0;padding-right:0;grid-template-columns:repeat(12, 1fr)\" data-tablet-css=\"padding-left:em;padding-right:em;\" data-mobile-css=\"padding-left:em;padding-right:em;\">\n<div class=\"wp-block-caxton-section relative\" style=\"grid-area:span 1\/span 4\"><div class=\"absolute absolute--fill\"><div class=\"absolute absolute--fill cover bg-center\" style=\"background-color:;background-image:linear-gradient( );\"><\/div><div class=\"absolute absolute--fill\" style=\"background-color:;background-image:linear-gradient( );opacity:1;\"><\/div><\/div><div class=\"relative caxton-section-block\" style=\"padding-top:5px;padding-left:5px;padding-bottom:5px;padding-right:5px\" data-mobile-css=\"padding-left:1em;padding-right:1em;\" data-tablet-css=\"padding-left:1em;padding-right:1em;\">\n<p><strong><a rel=\"noreferrer noopener\" href=\"http:\/\/feeds.dlvr.it\/9955ac8f23264bf1bc2bea45b368a84d.xml\" target=\"_blank\">Combined RSS Source<\/a><\/strong><\/p>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-caxton-section relative\" style=\"grid-area:span 1\/span 4\"><div class=\"absolute absolute--fill\"><div class=\"absolute absolute--fill cover bg-center\" style=\"background-color:;background-image:linear-gradient( );\"><\/div><div class=\"absolute absolute--fill\" style=\"background-color:;background-image:linear-gradient( );opacity:1;\"><\/div><\/div><div class=\"relative caxton-section-block\" style=\"padding-top:5px;padding-left:5px;padding-bottom:5px;padding-right:5px\" data-mobile-css=\"padding-left:1em;padding-right:1em;\" data-tablet-css=\"padding-left:1em;padding-right:1em;\">\n<p><a href=\"https:\/\/kermitmurray.com\/msblog\/journal-feeds\/journal-feeds\/\" data-type=\"page\" data-id=\"1513\" target=\"_blank\" rel=\"noreferrer noopener\">Individual Journal Feeds<\/a><\/p>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-caxton-section relative\" style=\"grid-area:span 1\/span 4\"><div class=\"absolute absolute--fill\"><div class=\"absolute absolute--fill cover bg-center\" style=\"background-color:;background-image:linear-gradient( );\"><\/div><div class=\"absolute absolute--fill\" style=\"background-color:;background-image:linear-gradient( );opacity:1;\"><\/div><\/div><div class=\"relative caxton-section-block\" style=\"padding-top:5px;padding-left:5px;padding-bottom:5px;padding-right:5px\" data-mobile-css=\"padding-left:1em;padding-right:1em;\" data-tablet-css=\"padding-left:1em;padding-right:1em;\">\n<p><a href=\"https:\/\/kermitmurray.com\/msblog\/links\/social-feeds\/\" data-type=\"page\" data-id=\"2457\">Individual Social Feeds<\/a><\/p>\n<\/div><\/div>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-caxton-grid relative\"><div class=\"absolute absolute--fill\"><div class=\"absolute absolute--fill cover bg-center\" style=\"background-color:;background-image:linear-gradient( );\"><\/div><div class=\"absolute absolute--fill\" style=\"background-color:;background-image:linear-gradient( );opacity:1;\"><\/div><\/div><div class=\"relative caxton-columns caxton-grid-block\" style=\"padding-top:0;padding-left:0;padding-bottom:0;padding-right:0;grid-template-columns:repeat(12, 1fr)\" data-tablet-css=\"padding-left:em;padding-right:em;\" data-mobile-css=\"padding-left:em;padding-right:em;\">\n<div class=\"wp-block-caxton-section relative\" style=\"grid-area:span 1\/span 12\"><div class=\"absolute absolute--fill\"><div class=\"absolute absolute--fill cover bg-center\" style=\"background-color:;background-image:linear-gradient( );\"><\/div><div class=\"absolute absolute--fill\" style=\"background-color:;background-image:linear-gradient( );opacity:1;\"><\/div><\/div><div class=\"relative caxton-section-block\" style=\"padding-top:5px;padding-left:5px;padding-bottom:5px;padding-right:5px\" data-mobile-css=\"padding-left:1em;padding-right:1em;\" data-tablet-css=\"padding-left:1em;padding-right:1em;\">\n<div class=\"wp-block-caxton-grid relative\"><div class=\"absolute absolute--fill\"><div class=\"absolute absolute--fill cover bg-center\" style=\"background-color:;background-image:linear-gradient( );\"><\/div><div class=\"absolute absolute--fill\" style=\"background-color:;background-image:linear-gradient( );opacity:1;\"><\/div><\/div><div class=\"relative caxton-columns caxton-grid-block\" style=\"padding-top:0;padding-left:0;padding-bottom:0;padding-right:0;grid-template-columns:repeat(12, 1fr)\" data-tablet-css=\"padding-left:em;padding-right:em;\" data-mobile-css=\"padding-left:em;padding-right:em;\">\n<div class=\"wp-block-caxton-section relative\" style=\"grid-area:span 1\/span 4\"><div class=\"absolute absolute--fill\"><div class=\"absolute absolute--fill cover bg-center\" style=\"background-color:;background-image:linear-gradient( );\"><\/div><div class=\"absolute absolute--fill\" style=\"background-color:;background-image:linear-gradient( );opacity:1;\"><\/div><\/div><div class=\"relative caxton-section-block\" style=\"padding-top:5px;padding-left:5px;padding-bottom:5px;padding-right:5px\" data-mobile-css=\"padding-left:1em;padding-right:1em;\" data-tablet-css=\"padding-left:1em;padding-right:1em;\">\n<p><strong><a href=\"https:\/\/mastodon.online\/@kkmurray@techhub.social\" target=\"_blank\" rel=\"noreferrer noopener\">Mastodon<\/a><\/strong><\/p>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-caxton-section relative\" style=\"grid-area:span 1\/span 4\"><div class=\"absolute absolute--fill\"><div class=\"absolute absolute--fill cover bg-center\" style=\"background-color:;background-image:linear-gradient( );\"><\/div><div class=\"absolute absolute--fill\" style=\"background-color:;background-image:linear-gradient( );opacity:1;\"><\/div><\/div><div class=\"relative caxton-section-block\" style=\"padding-top:5px;padding-left:5px;padding-bottom:5px;padding-right:5px\" data-mobile-css=\"padding-left:1em;padding-right:1em;\" data-tablet-css=\"padding-left:1em;padding-right:1em;\">\n<p><strong><a href=\"https:\/\/twitter.com\/kermitmurray\" target=\"_blank\" rel=\"noreferrer noopener\">Twitter<\/a><\/strong><\/p>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-caxton-section relative\" style=\"grid-area:span 1\/span 4\"><div class=\"absolute absolute--fill\"><div class=\"absolute absolute--fill cover bg-center\" style=\"background-color:;background-image:linear-gradient( );\"><\/div><div class=\"absolute absolute--fill\" style=\"background-color:;background-image:linear-gradient( );opacity:1;\"><\/div><\/div><div class=\"relative caxton-section-block\" style=\"padding-top:5px;padding-left:5px;padding-bottom:5px;padding-right:5px\" data-mobile-css=\"padding-left:1em;padding-right:1em;\" data-tablet-css=\"padding-left:1em;padding-right:1em;\">\n<p><strong><a href=\"https:\/\/bsky.app\/profile\/kkmurray.bsky.social\">Bluesky<\/a><\/strong><\/p>\n<\/div><\/div>\n<\/div><\/div>\n<\/div><\/div>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-caxton-grid relative\"><div class=\"absolute absolute--fill\"><div class=\"absolute absolute--fill cover bg-center\" style=\"background-color:;background-image:linear-gradient( );\"><\/div><div class=\"absolute absolute--fill\" style=\"background-color:;background-image:linear-gradient( );opacity:1;\"><\/div><\/div><div class=\"relative caxton-columns caxton-grid-block\" style=\"padding-top:0;padding-left:0;padding-bottom:0;padding-right:0;grid-template-columns:repeat(12, 1fr)\" data-tablet-css=\"padding-left:em;padding-right:em;\" data-mobile-css=\"padding-left:em;padding-right:em;\">\n<div class=\"wp-block-caxton-section relative\" style=\"grid-area:span 1\/span 12\"><div class=\"absolute absolute--fill\"><div class=\"absolute absolute--fill cover bg-center\" style=\"background-color:;background-image:linear-gradient( );\"><\/div><div class=\"absolute absolute--fill\" style=\"background-color:;background-image:linear-gradient( );opacity:1;\"><\/div><\/div><div class=\"relative caxton-section-block\" style=\"padding-top:5px;padding-left:5px;padding-bottom:5px;padding-right:5px\" data-mobile-css=\"padding-left:1em;padding-right:1em;\" data-tablet-css=\"padding-left:1em;padding-right:1em;\">\n<h3 class=\"wp-block-heading\">Combined RSS Items<\/h3>\n<\/div><\/div>\n<\/div><\/div>\n\n\n<ul class=\"has-dates has-excerpts wp-block-rss\"><li class='wp-block-rss__item'><div class='wp-block-rss__item-title'><a href='http:\/\/dlvr.it\/TTVgS9'>Muscle spatial lipidomics identifies early ALS signatures in presymptomatic SOD1G93A mice<\/a><\/div><time datetime=\"2026-07-13T06:06:38-05:00\" class=\"wp-block-rss__item-publish-date\">July 13, 2026<\/time> <div class=\"wp-block-rss__item-excerpt\">Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease whose diagnosis often remains delayed. Skeletal muscle is increasingly recognized as an early contributor to ALS pathology. Using lipid imaging mass spectrometry (LIMS) in Tibialis anterior muscle from hSOD1G93A mice across disease stages, we identified fiber-type-specific and sex-dependent lipid remodeling. Lipid alterations were detected at the presymptomatic stage, preceding motor neuron loss and clinical symptoms. LIMS distinguished fast-twitch oxidative-glycolytic (type IIA) and glycolytic (type IIB\/IIX) fibers and revealed their differential vulnerability [&hellip;]<\/div><\/li><li class='wp-block-rss__item'><div class='wp-block-rss__item-title'><a href='http:\/\/dlvr.it\/TTVV7L'>Evaluation of pilocarpine effects on sweat proteome<\/a><\/div><time datetime=\"2026-07-13T00:06:14-05:00\" class=\"wp-block-rss__item-publish-date\">July 13, 2026<\/time> <div class=\"wp-block-rss__item-excerpt\">Publication date: Available online 12 July 2026Source: Journal of ProteomicsAuthor(s): S. Wislet, C. Le Goff, Massonet Ph, S. Hody, J.L. Croisier, V. D\u2019orio, J.F. Kaux, G. Mazzucchelli, R. Cloots<\/div><\/li><li class='wp-block-rss__item'><div class='wp-block-rss__item-title'><a href='http:\/\/dlvr.it\/TTVSSb'>Community-driven advances in computational mass spectrometry: The perspective of EuBIC-MS members<\/a><\/div><time datetime=\"2026-07-12T23:03:33-05:00\" class=\"wp-block-rss__item-publish-date\">July 12, 2026<\/time> <div class=\"wp-block-rss__item-excerpt\">Publication date: Available online 11 July 2026Source: Journal of ProteomicsAuthor(s): Dirk Winkelhardt, Julia P. Schessner, Sven Berres, Alireza Nameni, Armin Soleymaniniya, Ayla Schr\u00f6der, Caroline Jachmann, Douwe Schulte, Georg Wallmann, Henry Webel, Johannes Rainer, Katerina Nastou, Laurent Gatto, Magnus Palmblad, Maike Weber, Omar Shouman, Pavel Sinitcyn, Ralf Gabriels, Robbe Devreese, Tim Van Den Bossche<\/div><\/li><li class='wp-block-rss__item'><div class='wp-block-rss__item-title'><a href='http:\/\/dlvr.it\/TTVKvy'>onsite: An Integrated Framework for Phosphosite Localization and False Localization Rate Estimation<\/a><\/div><time datetime=\"2026-07-12T18:56:23-05:00\" class=\"wp-block-rss__item-publish-date\">July 12, 2026<\/time> <div class=\"wp-block-rss__item-excerpt\">With the rapid development of mass spectrometry-based proteomics, the volume of phosphoproteomic data has increased substantially. However, accurate localization of phosphorylation sites and standardized statistical validation remain critical analytical bottlenecks. To address the lack of standardized cross-algorithm evaluation, we introduce onsite, a unified and open-source Python framework. onsite integrates an alanine-decoy strategy to estimate the false localization rate (FLR) across three algorithms: AScore, PhosphoRS, and pyLucXor. This modular architecture efficiently processes large-scale datasets and enables global FLR calculation. Benchmarking on [&hellip;]<\/div><\/li><li class='wp-block-rss__item'><div class='wp-block-rss__item-title'><a href='http:\/\/dlvr.it\/TTVJBM'>The most common epilepsy-causing mutation in EEF1A2 (E122K) perturbs the translation of specific transcripts but not the rate of global protein synthesis<\/a><\/div><time datetime=\"2026-07-12T18:00:43-05:00\" class=\"wp-block-rss__item-publish-date\">July 12, 2026<\/time> <div class=\"wp-block-rss__item-excerpt\">Heterozygous de novo missense mutations in the EEF1A2 gene encoding translation elongation factor eEF1A2 result in neurodevelopmental disorders, typically characterised by early onset epilepsy and intellectual disability (ID). The E122K mutation is the most commonly reported missense mutation and is amongst the more severe in terms of epilepsy and ID. Here we made use of a recently developed mouse model which recapitulates the E122K mutation to examine how mutations in EEF1A2 might disrupt neuronal gene expression. Primary neurons from mutant [&hellip;]<\/div><\/li><li class='wp-block-rss__item'><div class='wp-block-rss__item-title'><a href='http:\/\/dlvr.it\/TTV1wV'>Development and Validation of a UPLC\u2013MS\/MS for Determination of Loureirin D in Rat Plasma and Its Application to Pharmacokinetics<\/a><\/div><time datetime=\"2026-07-12T11:09:52-05:00\" class=\"wp-block-rss__item-publish-date\">July 12, 2026<\/time> <div class=\"wp-block-rss__item-excerpt\">ABSTRACT Loureirin D is a bioactive dihydrochalcone isolated from Dracaena resin with very high therapeutic value. A sensitive and high-throughput ultra-performance liquid chromatography\u2013mass spectrometry (UPLC\u2013MS\/MS) method was developed for the quantitative analysis of loureirin D in rat plasma with only 50\u2009\u03bcL of sample per assay. Sample extraction was protein precipitation using acetonitrile, and isoscoparin was used as internal standard (IS). Separation was achieved on the BEH C18 column with a gradient mobile phase of 0.1% (v\/v) aqueous formic acid and [&hellip;]<\/div><\/li><li class='wp-block-rss__item'><div class='wp-block-rss__item-title'><a href='http:\/\/dlvr.it\/TTV0Cj'>Overcoming Stability Challenge During the Quantification of SHR6508 in Human Plasma by LC\u2013MS\/MS<\/a><\/div><time datetime=\"2026-07-12T10:18:42-05:00\" class=\"wp-block-rss__item-publish-date\">July 12, 2026<\/time> <div class=\"wp-block-rss__item-excerpt\">ABSTRACT SHR6508, a novel calcimimetic agent, is currently being developed for treating secondary hyperparathyroidism in chronic kidney disease (CKD) patients requiring maintenance hemodialysis. For the purpose of quantifying SHR6508 in human plasma, a sensitive and reliable LC\u2013MS\/MS method was first developed and successfully validated. Since SHR6508 is a disulfide bond-containing peptide, ascorbic acid was supplemented into blood samples during collection to prevent thiol-disulfide exchange reactions. Plasma matrix samples were processed by protein precipitation with a water\u2013acetonitrile solution (1:4, v\/v) containing [&hellip;]<\/div><\/li><li class='wp-block-rss__item'><div class='wp-block-rss__item-title'><a href='http:\/\/dlvr.it\/TTTkry'>Interstellar Ice Chemistry Yields Elusive Sulfinothioic Acid (HS(O)SH)<\/a><\/div><time datetime=\"2026-07-12T05:03:27-05:00\" class=\"wp-block-rss__item-publish-date\">July 12, 2026<\/time> <div class=\"wp-block-rss__item-excerpt\">Hot chemistry in cold ices reveals the previously elusive sulfinothioic acid molecule, HS(O)SH, prepared through nonequilibrium chemistry in low-temperature ices and identified with isomer selective photoionization reflectron time-of-flight mass spectrometry combined with isotopic labeling. ABSTRACT Low-oxidation-state sulfur oxyacids are key yet experimentally elusive intermediates in interstellar sulfur chemistry; even the simplest member, sulfinothioic acid (HS(O)SH), has neither been detected in space nor isolated terrestrially. The S\u2013S(O) motif, also present in biological systems, can be reduced to form disulfide bridges (RSSR\u2019), [&hellip;]<\/div><\/li><li class='wp-block-rss__item'><div class='wp-block-rss__item-title'><a href='http:\/\/dlvr.it\/TTTXJ4'>Generative AI for environmental mass spectrometry: Opportunities and challenges<\/a><\/div><time datetime=\"2026-07-11T23:07:57-05:00\" class=\"wp-block-rss__item-publish-date\">July 11, 2026<\/time> <div class=\"wp-block-rss__item-excerpt\">Publication date: October 2026Source: TrAC Trends in Analytical Chemistry, Volume 203Author(s): Wen Li, Bin Hu<\/div><\/li><li class='wp-block-rss__item'><div class='wp-block-rss__item-title'><a href='http:\/\/dlvr.it\/TTTTMJ'>Glycosylation Signatures of Thyroglobulin in Papillary Thyroid Carcinoma<\/a><\/div><time datetime=\"2026-07-11T21:41:38-05:00\" class=\"wp-block-rss__item-publish-date\">July 11, 2026<\/time> <div class=\"wp-block-rss__item-excerpt\">This study investigated site-specific N-glycosylation alterations in thyroglobulin from patients with papillary thyroid carcinoma using nano-LC\u2013MS\/MS. Advanced bioinformatics and machine learning identified these unique glycan signatures, establishing the Asn1365-HexNAc(3)Hex(6) glycoform as a highly predictive diagnostic biomarker (AUC\u00a0=\u00a00.83). ABSTRACT Thyroglobulin (Tg) is a clinically established biomarker for thyroid cancer; however, its diagnostic specificity remains limited due to confounding benign conditions. This study investigated changes in the site-specific N-glycosylation profiles of thyroglobulin protein derived from papillary thyroid cancer and adjacent healthy tissues. [&hellip;]<\/div><\/li><li class='wp-block-rss__item'><div class='wp-block-rss__item-title'><a href='http:\/\/dlvr.it\/TTTS4R'>Chiral HPLC Separation of Phosphonothrixin and Phosphonate Derivatives and Electronic Circular Dichroism Characterization of the Isolated Enantiomers<\/a><\/div><time datetime=\"2026-07-11T21:03:31-05:00\" class=\"wp-block-rss__item-publish-date\">July 11, 2026<\/time> <div class=\"wp-block-rss__item-excerpt\">Natural compound phosphonothrixin&#039;s herbicidal activity resides exclusively in its (S)-enantiomer, yet existing enantioselective syntheses are cumbersome, and direct chiral LC separation is hampered by the compound&#039;s high polarity, lack of aromatic groups, and metal chelation\u2013induced peak tailing. By employing a zwitterionic sulfohexyl quinidine carbamate, stationary phase reliable analytical and preparative chiral separations were achieved, enantiomers isolated, and absolute configurations assigned by optical rotation and ECD spectroscopy. ABSTRACT Phosphonothrixin (PPX), a phosphonate natural product known for its potent herbicidal activity, has [&hellip;]<\/div><\/li><li class='wp-block-rss__item'><div class='wp-block-rss__item-title'><a href='http:\/\/dlvr.it\/TTTQ37'>Evaluation of Surface Acoustic Wave Nebulization for NEMS Mass Spectrometry<\/a><\/div><time datetime=\"2026-07-11T20:03:21-05:00\" class=\"wp-block-rss__item-publish-date\">July 11, 2026<\/time> <div class=\"wp-block-rss__item-excerpt\">Journal of Mass Spectrometry, Volume 61, Issue 8, August 2026.<\/div><\/li><li class='wp-block-rss__item'><div class='wp-block-rss__item-title'><a href='http:\/\/dlvr.it\/TTTMh3'>Systemic Exposure and Multicomponent Pharmacokinetics of Mailuoning Oral Liquid: Integrated Ultra\u2010High\u2010Performance Liquid Chromatography\u2010High\u2010Resolution Mass Spectrometry Profiling and Ultra\u2010High\u2010Performance Liquid Chromatography\u2010Tandem Mass Spectrometry Quantification<\/a><\/div><time datetime=\"2026-07-11T18:56:38-05:00\" class=\"wp-block-rss__item-publish-date\">July 11, 2026<\/time> <div class=\"wp-block-rss__item-excerpt\">This study established the first comprehensive pharmacokinetic profile of Mailuoning Oral Liquid by tracking 39 compounds in rats, identifying 15 key systemic markers via UHPLC-HRMS and validated UHPLC-MS\/MS assays. Dose-dependent absorption was observed, providing an evidence base for dose refinement and clinical application. ABSTRACT Mailuoning oral liquid (MLN) is a state-approved multi-herb formula that has been prescribed for 25 years to clear heat, nourish yin, invigorate blood, and resolve stasis. Although randomized controlled trials and real-world evidence support its efficacy [&hellip;]<\/div><\/li><li class='wp-block-rss__item'><div class='wp-block-rss__item-title'><a href='http:\/\/dlvr.it\/TTTKdT'>Comprehensive Chemical Profiling and Quantitative Determination of Solanum americanum Mill. and S. nigrum Linn. Combined by UHPLC\u2010HRMS With Feature\u2010Based Molecular Networking<\/a><\/div><time datetime=\"2026-07-11T18:00:27-05:00\" class=\"wp-block-rss__item-publish-date\">July 11, 2026<\/time> <div class=\"wp-block-rss__item-excerpt\">ABSTRACT Solanum americanum Mill. and S. nigrum Linn. are traditional Solanaceae-derived herbal medicines. Their sprouts and mature fruits are utilized as both vegetables and medicinal herbs. Although S. americanum Mill. is classified as a primary variety of S. nigrum Linn., significant pharmacological variations and incompletely characterized phytochemical profiles differentiate their applications. In this study, UHPLC\/LTQ-Orbitrap mass spectrometry (HRMS) (Thermo Fisher Scientific, USA), assisted with feature-based molecular networking, was applied for in-depth profiling of S. americanum Mill. and S. nigrum Linn. [&hellip;]<\/div><\/li><li class='wp-block-rss__item'><div class='wp-block-rss__item-title'><a href='http:\/\/dlvr.it\/TTTHfr'>Determination of Pyrrolizidine Alkaloids and Their N\u2011Oxides in Bee Pollen by Accelerated Solvent Extraction Followed by Magnetic Covalent Organic Framework\u2010Based Offline Purification and Ultra\u2010High\u2010Performance Liquid Chromatography\u2010Tandem Mass Spectrometry<\/a><\/div><time datetime=\"2026-07-11T17:03:15-05:00\" class=\"wp-block-rss__item-publish-date\">July 11, 2026<\/time> <div class=\"wp-block-rss__item-excerpt\">ABSTRACT Pyrrolizidine alkaloids (PAs) and their N-oxides (PANOs) are naturally occurring toxic plant metabolites that have attracted widespread attention due to their potential food safety hazards. In this study, an efficient analytical method for determining PAs\/PANOs in bee pollen was established by combining accelerated solvent extraction (ASE) with ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS\/MS). A magnetic covalent organic framework material (Fe3O4@COF-TAPB-TFP) was synthesized and used as an adsorbent for offline purification to reduce matrix interference and improve detection sensitivity. [&hellip;]<\/div><\/li><li class='wp-block-rss__item'><div class='wp-block-rss__item-title'><a href='http:\/\/dlvr.it\/TTTFPj'>Quantitative Profiling and Metabolic Study of Caffeoylquinic Acids and Their Metabolites by Liquid Chromatography\u2010Tandem Mass Spectrometry in Rats and Laying Hens<\/a><\/div><time datetime=\"2026-07-11T16:00:32-05:00\" class=\"wp-block-rss__item-publish-date\">July 11, 2026<\/time> <div class=\"wp-block-rss__item-excerpt\">ABSTRACT Caffeoylquinic acids are natural polyphenolic compounds with notable antioxidant and anti-inflammatory activities. This study developed and validated a sensitive high-performance liquid chromatography-tandem mass spectrometry method for the simultaneous quantification of isochlorogenic acid A (ICQA) and 22 metabolites in serum. The method exhibited excellent sensitivity with limits of quantification of 0.625\u20131.25 \u00b5g\/L (signal-to-noise ratio = 10), inter\/intra-day precision below 15%, and comprehensive coverage of phase I\/II and microbial metabolites. Application of the method in rats and laying hens demonstrated its [&hellip;]<\/div><\/li><li class='wp-block-rss__item'><div class='wp-block-rss__item-title'><a href='http:\/\/dlvr.it\/TTTCQH'>Incorporation of Co\u2010Cyromazine Complexes Onto Halloysite Nanotubes as a Spin\u2010Tip Solid\u2010Phase Extraction Sorbent for Determining Hydrophilic B Vitamins in Functional Foods<\/a><\/div><time datetime=\"2026-07-11T15:08:20-05:00\" class=\"wp-block-rss__item-publish-date\">July 11, 2026<\/time> <div class=\"wp-block-rss__item-excerpt\">ABSTRACT Quantifying hydrophilic B vitamins (B1 [(thiamine], B2 [riboflavin], and B3 [nicotinic acid]) in complex functional food matrices presents a significant challenge. Conventional sorbents, such as C18, often exhibit poor retention and low recoveries (50%\u201360%) due to weak hydrophilic interactions. To efficiently extract these target analytes from functional foods, a new sorbent with tailored hydrophilic affinity has been developed by incorporating Co-cyromazine complexes onto halloysite nanotubes. This composite was employed as the sorbent for a spin-tip solid-phase extraction method, which [&hellip;]<\/div><\/li><li class='wp-block-rss__item'><div class='wp-block-rss__item-title'><a href='http:\/\/dlvr.it\/TTT8Mz'>New spatial mass spectrometry technology alert &#8211; Tippy Tapping-Mode ESI!<\/a><\/div><time datetime=\"2026-07-11T14:00:34-05:00\" class=\"wp-block-rss__item-publish-date\">July 11, 2026<\/time> <div class=\"wp-block-rss__item-excerpt\">Are you interested in getting into spatial mass spectrometry but all the super expensive commercial technologies aren&#039;t doing it for you?\u00a0Why don&#039;t you&#8230;..introducing Tappy-mode scanning ESI!\u00a0What&#039;s that? Okay, they didn&#039;t invent it for this paper, but they explain it better than I can!\u00a0Wait a minute. Is it just like this except really fast and with an electrospray plume in the middle?\u00a0Close enough!\u00a0Okay, but analogies aside, we can move tissues at incredibly absurdly high resolutions. Think about the stages they use [&hellip;]<\/div><\/li><li class='wp-block-rss__item'><div class='wp-block-rss__item-title'><a href='http:\/\/dlvr.it\/TTT5Yk'>DNA Methylation and Proteomic Profiling of Postmortem Brain Tissue Reveals Epigenetic Dysregulation and Neuroinflammatory in Fragile X-associated Tremor\/Ataxia Syndrome (FXTAS)<\/a><\/div><time datetime=\"2026-07-11T13:00:49-05:00\" class=\"wp-block-rss__item-publish-date\">July 11, 2026<\/time> <div class=\"wp-block-rss__item-excerpt\">Background: Fragile X-associated Tremor\/Ataxia Syndrome (FXTAS) is a late-onset neurodegenerative disorder caused by FMR1 premutation CGG repeat expansions (55-200 repeats). The epigenetic landscape of the FXTAS brain remains uncharacterized. We performed genome-wide DNA methylation profiling of postmortem prefrontal cortex tissue to identify differentially methylated positions (DMPs) and candidate genes, and sought protein-level support for a neuroinflammatory signal. Methods: DNA methylation was profiled in postmortem prefrontal cortex (Brodmann area 9) from 27 male FXTAS cases and 29 male controls using the [&hellip;]<\/div><\/li><li class='wp-block-rss__item'><div class='wp-block-rss__item-title'><a href='http:\/\/dlvr.it\/TTT37N'>Circulating extracellular vesicles in plasma carry accessible molecular signatures of aging in mice<\/a><\/div><time datetime=\"2026-07-11T12:07:36-05:00\" class=\"wp-block-rss__item-publish-date\">July 11, 2026<\/time> <div class=\"wp-block-rss__item-excerpt\">Cells release membrane-bound extracellular vesicles into the bloodstream laden with proteins that may reflect their physiological state. How this circulating EV proteome changes across life remains poorly understood. Identifying molecular signatures of aging in accessible biofluids could facilitate earlier intervention and monitoring of age-related disease. Many circulating aging proteome studies rely on affinity-based platforms which suffer from poor cross-species translation, ambiguous signal attribution, and inconsistent agreement between platforms. Here, we present a characterization of the aging plasma EV proteome from [&hellip;]<\/div><\/li><li class='wp-block-rss__item'><div class='wp-block-rss__item-title'><a href='http:\/\/dlvr.it\/TTT0PN'>Metabolomic signatures support the diagnostics of peritoneal endometriosis using generalised linear models<\/a><\/div><time datetime=\"2026-07-11T11:07:52-05:00\" class=\"wp-block-rss__item-publish-date\">July 11, 2026<\/time> <div class=\"wp-block-rss__item-excerpt\">Endometriosis, a common inflammatory gynecological disorder affecting up to 10% of women worldwide, is characterized by the presence of endometrium-like tissue outside the uterus. Current diagnostic methods, such as ultrasound and MRI, effectively detect ovarian and deep endometriosis but fail to detect more common peritoneal type. Diagnosing peritoneal endometriosis currently necessitates invasive laparoscopy and histological confirmation. Despite numerous efforts, no new reliable biomarkers have successfully transitioned into routine clinical use. This study aimed to investigate the use of targeted metabolomics [&hellip;]<\/div><\/li><li class='wp-block-rss__item'><div class='wp-block-rss__item-title'><a href='http:\/\/dlvr.it\/TTSxl3'>Reduced LANCL1-AS1 in old human skeletal muscle diminishes mitochondrial activity, shortens mt-mRNA poly(A) tails, and suppresses myogenesis<\/a><\/div><time datetime=\"2026-07-11T10:12:37-05:00\" class=\"wp-block-rss__item-publish-date\">July 11, 2026<\/time> <div class=\"wp-block-rss__item-excerpt\">Regeneration of skeletal muscle preserves muscle mass and function, which decline with age. Here, we sought to identify long noncoding (lnc)RNAs involved in skeletal muscle myogenesis and potentially relevant to muscle aging. Cross-sectional analysis of skeletal muscle transcriptomes from healthy 22-through 89-year-old individuals revealed lncRNA LANCL1-AS1 among the top declining transcripts. Conversely, LANCL1-AS1 increased robustly during skeletal myogenesis and promoted myogenic differentiation in culture. Affinity pulldown by ChIRP followed by mass spectrometry revealed that LANCL1-AS1 associated with the mitochondrial protein [&hellip;]<\/div><\/li><li class='wp-block-rss__item'><div class='wp-block-rss__item-title'><a href='http:\/\/dlvr.it\/TTStgG'>Optimizing chemical information retrieval from in-field proton transfer reaction time-of-flight mass spectrometry breath analysis to discover compounds correlated to tetrachloroethylene concentration<\/a><\/div><time datetime=\"2026-07-11T09:08:20-05:00\" class=\"wp-block-rss__item-publish-date\">July 11, 2026<\/time> <div class=\"wp-block-rss__item-excerpt\">Publication date: 1 January 2027Source: Talanta, Volume 311Author(s): Wenjing Ma, Marwan Alajlouni, Dustin Schrecongost, Sa Liu, Robert E. Synovec<\/div><\/li><li class='wp-block-rss__item'><div class='wp-block-rss__item-title'><a href='http:\/\/dlvr.it\/TTSrDp'>Deep Learning Outperforms Descriptor\u2010Based Classification of Food Items Using Chromatography\u2013Mass Spectrometry Data<\/a><\/div><time datetime=\"2026-07-11T08:11:36-05:00\" class=\"wp-block-rss__item-publish-date\">July 11, 2026<\/time> <div class=\"wp-block-rss__item-excerpt\">ABSTRACT Rationale Food classification and adulteration detection are challenged by the complexity of chemical matrices. Traditional descriptor-based methods fail to capture interactions in chromatography\u2013mass spectrometry (CMS) data. This study compares a convolutional neural network (CNN) against a random forest (RF) baseline using engineered descriptors to classify 15 food items to demonstrate deep learning advantage for objective, scalable food authentication. Methods Three thousand CMS spectra is computationally simulated (200 per class) based on FooDB compound profiles. Six engineered descriptors (mean intensity, [&hellip;]<\/div><\/li><li class='wp-block-rss__item'><div class='wp-block-rss__item-title'><a href='http:\/\/dlvr.it\/TTSnZS'>A Comparative Study of MALDI MSI Versus DESI MSI Applied to Questioned Document Examination<\/a><\/div><time datetime=\"2026-07-11T07:08:36-05:00\" class=\"wp-block-rss__item-publish-date\">July 11, 2026<\/time> <div class=\"wp-block-rss__item-excerpt\">ABSTRACT Rationale In forensic investigations, questioned document examination (QDE) provides critical information for document authentication and the detection of forgeries. Conventional QDE approaches often require separate analyses of inks and of any potential fingerprints. This study compares two mass spectrometry imaging (MSI) techniques for QDE, enabling the simultaneous analysis of inks and fingerprints deposited onto paper, providing chemical and biometric information from a single sample. Methods Two mock forgery samples containing two ballpoint pen inks, printed ink and latent fingerprints [&hellip;]<\/div><\/li><\/ul>\n\n\n<p><a rel=\"me noopener\" href=\"https:\/\/mastodon.online\/@kkmurray\" target=\"_blank\"> &#8212;- <\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>&#8212;-<\/p>\n","protected":false},"author":1,"featured_media":3214,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-2153","page","type-page","status-publish","has-post-thumbnail","hentry","entry"],"_links":{"self":[{"href":"https:\/\/kermitmurray.com\/msblog\/wp-json\/wp\/v2\/pages\/2153","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kermitmurray.com\/msblog\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/kermitmurray.com\/msblog\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/kermitmurray.com\/msblog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kermitmurray.com\/msblog\/wp-json\/wp\/v2\/comments?post=2153"}],"version-history":[{"count":15,"href":"https:\/\/kermitmurray.com\/msblog\/wp-json\/wp\/v2\/pages\/2153\/revisions"}],"predecessor-version":[{"id":4777,"href":"https:\/\/kermitmurray.com\/msblog\/wp-json\/wp\/v2\/pages\/2153\/revisions\/4777"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/kermitmurray.com\/msblog\/wp-json\/wp\/v2\/media\/3214"}],"wp:attachment":[{"href":"https:\/\/kermitmurray.com\/msblog\/wp-json\/wp\/v2\/media?parent=2153"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}