{"id":2028,"date":"2019-07-04T09:39:52","date_gmt":"2019-07-04T14:39:52","guid":{"rendered":"https:\/\/kermitmurray.com\/msblog\/?page_id=2028"},"modified":"2022-12-19T15:57:17","modified_gmt":"2022-12-19T21:57:17","slug":"mass-spectrometry-articles","status":"publish","type":"page","link":"https:\/\/kermitmurray.com\/msblog\/links\/journal-feeds\/mass-spectrometry-journals\/mass-spectrometry-articles\/","title":{"rendered":"Mass Spectrometry Articles"},"content":{"rendered":"\n<div class=\"wp-block-caxton-grid relative\"><div class=\"absolute absolute--fill\"><div class=\"absolute absolute--fill cover bg-center\" style=\"background-color:;background-image:linear-gradient( );\"><\/div><div class=\"absolute absolute--fill\" style=\"background-color:;background-image:linear-gradient( );opacity:1;\"><\/div><\/div><div class=\"relative caxton-columns caxton-grid-block\" style=\"padding-top:0;padding-left:0;padding-bottom:0;padding-right:0;grid-template-columns:repeat(12, 1fr)\" data-tablet-css=\"padding-left:em;padding-right:em;\" data-mobile-css=\"padding-left:em;padding-right:em;\">\n<div class=\"wp-block-caxton-section relative\" style=\"grid-area:span 1\/span 12\"><div class=\"absolute absolute--fill\"><div class=\"absolute absolute--fill cover bg-center\" style=\"background-color:;background-image:linear-gradient( );\"><\/div><div class=\"absolute absolute--fill\" style=\"background-color:;background-image:linear-gradient( );opacity:1;\"><\/div><\/div><div class=\"relative caxton-section-block\" style=\"padding-top:5px;padding-left:5px;padding-bottom:5px;padding-right:5px\" data-mobile-css=\"padding-left:1em;padding-right:1em;\" data-tablet-css=\"padding-left:1em;padding-right:1em;\">\n<div class=\"wp-block-caxton-super-icon\"><div class=\" tl\" style=\"margin-top:0.5em;margin-bottom:0.5em;\"><a href=\"http:\/\/feeds.dlvr.it\/9955ac8f23264bf1bc2bea45b368a84d.xml\" class=\"no-underline caxton-icon  fas fa-wifi\" data-hover-css=\"color:#555;background-color:#767676;\" style=\"color:#ee802f;background-color:#FFF;font-size:28px;border:12px  solid #FFF;padding:0.1em;border-radius:50px;;;\" data-mobile-css=\"\" data-tablet-css=\"\" data-desktop-css=\"font-size:28px;\"><span style=\"display:none;\">&nbsp;<\/span><\/a><\/div><\/div>\n\n\n\n<p>RSS feed of mass spectrometry journals and other mass spectrometry articles and social feeds.<\/p>\n<\/div><\/div>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-caxton-grid relative\"><div class=\"absolute absolute--fill\"><div class=\"absolute absolute--fill cover bg-center\" style=\"background-color:;background-image:linear-gradient( );\"><\/div><div class=\"absolute absolute--fill\" style=\"background-color:;background-image:linear-gradient( );opacity:1;\"><\/div><\/div><div class=\"relative caxton-columns caxton-grid-block\" style=\"padding-top:0;padding-left:0;padding-bottom:0;padding-right:0;grid-template-columns:repeat(12, 1fr)\" data-tablet-css=\"padding-left:em;padding-right:em;\" data-mobile-css=\"padding-left:em;padding-right:em;\">\n<div class=\"wp-block-caxton-section relative\" style=\"grid-area:span 1\/span 12\"><div class=\"absolute absolute--fill\"><div class=\"absolute absolute--fill cover bg-center\" style=\"background-color:;background-image:linear-gradient( );\"><\/div><div class=\"absolute absolute--fill\" style=\"background-color:;background-image:linear-gradient( );opacity:1;\"><\/div><\/div><div class=\"relative caxton-section-block\" style=\"padding-top:5px;padding-left:5px;padding-bottom:5px;padding-right:5px\" data-mobile-css=\"padding-left:1em;padding-right:1em;\" data-tablet-css=\"padding-left:1em;padding-right:1em;\"><ul class=\"has-dates has-excerpts wp-block-rss\"><li class='wp-block-rss__item'><div class='wp-block-rss__item-title'><a href='http:\/\/dlvr.it\/TS9fzV'>Heart\u2010Cutting Two\u2010Dimensional Liquid Chromatography\u2010Isotope Ratio Mass Spectrometry for Compound\u2010Specific \u03b413C Analysis of Water\u2010Soluble B Vitamins in Complex Supplement Matrices<\/a><\/div><time datetime=\"2026-04-22T20:03:37-05:00\" class=\"wp-block-rss__item-publish-date\">April 22, 2026<\/time> <div class=\"wp-block-rss__item-excerpt\">ABSTRACT Compound-specific stable carbon isotope analysis by one-dimensional liquid chromatography-isotope ratio mass spectrometry (LC-IRMS) is fundamentally constrained by the requirement for fully aqueous mobile phases, which limits chromatographic selectivity and prevents effective separation of analytes from complex sample matrices. Here, a heart-cutting two-dimensional LC-IRMS method (2D-LC-IRMS) is presented for the first compound-specific \u03b4 13C analysis of the water-soluble vitamins B5 [&hellip;]<\/div><\/li><li class='wp-block-rss__item'><div class='wp-block-rss__item-title'><a href='http:\/\/dlvr.it\/TS9cZq'>Study on the Mechanism of Component Evolution and Viscosity Change Based on Temperature Differences in In\u2010Situ Combustion of Paraffinic Heavy Oil<\/a><\/div><time datetime=\"2026-04-22T18:56:34-05:00\" class=\"wp-block-rss__item-publish-date\">April 22, 2026<\/time> <div class=\"wp-block-rss__item-excerpt\">ABSTRACT This study investigated the relationship between component evolution and viscosity reduction in the Menggulin paraffinic crude oil reservoir under reservoir conditions using gas chromatography-mass spectrometry and viscosity measurements at reservoir temperature (37.2\u00b0C). Results show stage-dependent compositional transformation: in 250\u2013400\u00b0C medium-temperature oxidation, C6-C9 components are fully combusted, with displaced oil dominated by residual alkanes and oxygenates, yielding limited viscosity reduction. [&hellip;]<\/div><\/li><li class='wp-block-rss__item'><div class='wp-block-rss__item-title'><a href='http:\/\/dlvr.it\/TS9ZNt'>A Green and Fast Ultra\u2010High Performance Supercritical Fluid Chromatography\u2010Tandem Mass Spectrometry Assay for Sensitive Quantification of Monomethoxy\u2010pentaethylene Glycol Amine in Rat Plasma: Application to Pharmacokinetic Study<\/a><\/div><time datetime=\"2026-04-22T18:00:36-05:00\" class=\"wp-block-rss__item-publish-date\">April 22, 2026<\/time> <div class=\"wp-block-rss__item-excerpt\">A green and rapid ultrahigh performance supercritical fluid chromatographytandem mass spectrometry (UHPSFCMS\/MS) method is developed for quantifying monomethoxypentaethylene glycol amine (MPEG5NH2) in rat plasma. The method achieves baseline separation within 3.4min, excellent linearity (r = 0.9965), and a lower limit of quantification of 5ng\/mL. Representative mass spectra confirm the reliability of this approach for pharmacokinetic studies. ABSTRACT Here we present [&hellip;]<\/div><\/li><li class='wp-block-rss__item'><div class='wp-block-rss__item-title'><a href='http:\/\/dlvr.it\/TS9Wvh'>Residual Status of 25 Veterinary Drugs and Dietary Exposure Assessment of Commercially Available Pork in Guiyang<\/a><\/div><time datetime=\"2026-04-22T17:00:38-05:00\" class=\"wp-block-rss__item-publish-date\">April 22, 2026<\/time> <div class=\"wp-block-rss__item-excerpt\">ABSTRACT Intensive farming practices have necessitated the extensive use of veterinary drugs, raising significant concerns regarding residue contamination. Consequently, long-term monitoring of residues and the evaluation of dietary exposure risks are essential. In this study, 326 pork samples were collected from local supermarkets between October 2024 and April 2025. Methods were developed for the analysis of 25 veterinary drugs (including [&hellip;]<\/div><\/li><li class='wp-block-rss__item'><div class='wp-block-rss__item-title'><a href='http:\/\/dlvr.it\/TS9LR9'>A framework for the exploration of subcellular compartmentalization of RNA-binding proteins<\/a><\/div><time datetime=\"2026-04-22T14:00:35-05:00\" class=\"wp-block-rss__item-publish-date\">April 22, 2026<\/time> <div class=\"wp-block-rss__item-excerpt\">A framework for the exploration of subcellular compartmentalization of RNA-binding proteins<\/div><\/li><li class='wp-block-rss__item'><div class='wp-block-rss__item-title'><a href='http:\/\/dlvr.it\/TS9HCt'>Parallel Analysis of Acidic and Basic Proteoforms in Cell Lysates via Native Cation and Anion Exchange Chromatography\u2014Native Mass Spectrometry<\/a><\/div><time datetime=\"2026-04-22T13:00:35-05:00\" class=\"wp-block-rss__item-publish-date\">April 22, 2026<\/time> <div class=\"wp-block-rss__item-excerpt\">PROTEOMICS, EarlyView.<\/div><\/li><li class='wp-block-rss__item'><div class='wp-block-rss__item-title'><a href='http:\/\/dlvr.it\/TS94QL'>Ant abaecin-2 is a context-dependent copper-binding effector that can be either inhibitory or protective<\/a><\/div><time datetime=\"2026-04-22T09:08:34-05:00\" class=\"wp-block-rss__item-publish-date\">April 22, 2026<\/time> <div class=\"wp-block-rss__item-excerpt\">Host defense peptides (HDPs) are important components of the innate immune system that are used to combat pathogens and often rely on metal binding for their function. However, controlling trace nutrients such as transition metals may have other roles in host-symbiont interactions beyond poisoning harmful pathogens. This study characterizes the evolution, structural properties, and biochemical activity of the novel hymenopteran [&hellip;]<\/div><\/li><li class='wp-block-rss__item'><div class='wp-block-rss__item-title'><a href='http:\/\/dlvr.it\/TS9225'>Structural and chemical properties of insects&#039; chitin-containing extracellular matrices<\/a><\/div><time datetime=\"2026-04-22T08:11:34-05:00\" class=\"wp-block-rss__item-publish-date\">April 22, 2026<\/time> <div class=\"wp-block-rss__item-excerpt\">Insects&#039; body barriers rely on specialized extracellular matrices that protect against harmful environmental influences. The outer barrier is the cuticle, which is composed of chitin, cuticle proteins and lipids. The peritrophic matrix (PM) serves as an inner barrier lining the midgut epithelium. It is composed of chitin fibers that are organized by PM proteins. While cuticle and PM proteins have [&hellip;]<\/div><\/li><li class='wp-block-rss__item'><div class='wp-block-rss__item-title'><a href='http:\/\/dlvr.it\/TS8zfy'>Cellular remodeling during photosymbiosis establishment revealed by single-cell dual proteomics<\/a><\/div><time datetime=\"2026-04-22T07:08:35-05:00\" class=\"wp-block-rss__item-publish-date\">April 22, 2026<\/time> <div class=\"wp-block-rss__item-excerpt\">Endosymbiosis of phytoplankton in heterotrophic hosts is ecologically important and has led to key evolutionary innovations. However, the dynamic molecular processes underlying endosymbiosis establishment remain poorly understood. Here, using large-particle sorting and liquid chromatography-tandem mass spectrometry, we unravel heterogeneous changes in proteomes of the cosmopolitan ciliate Paramecium and algal endosymbiont Chlorella from engulfment to stable endosymbiosis. The initial digestion sees [&hellip;]<\/div><\/li><li class='wp-block-rss__item'><div class='wp-block-rss__item-title'><a href='http:\/\/dlvr.it\/TS8q6S'>Systematic mass-spectrometry-guided metabolic fingerprinting elucidates diversity of specialized metabolites across the Brassicaceae<\/a><\/div><time datetime=\"2026-04-22T01:04:15-05:00\" class=\"wp-block-rss__item-publish-date\">April 22, 2026<\/time> <div class=\"wp-block-rss__item-excerpt\">Plants produce diverse bouquets of specialized metabolites (SMs), yet only a fraction of the vast phytochemical space has been explored to date. Comparative analysis of SM profiles can reveal hotspots of biochemical novelty, while systematic profiling across taxonomic levels does presently not cover large plant families. To study core and accessory SM profiles in the Brassicaceae plant family, we fingerprinted [&hellip;]<\/div><\/li><li class='wp-block-rss__item'><div class='wp-block-rss__item-title'><a href='http:\/\/dlvr.it\/TS8mXx'>Atomic spectrometry update: review of advances in atomic spectrometry and related techniques<\/a><\/div><time datetime=\"2026-04-21T23:04:10-05:00\" class=\"wp-block-rss__item-publish-date\">April 21, 2026<\/time> <div class=\"wp-block-rss__item-excerpt\">J. Anal. At. Spectrom., 2026, Advance ArticleDOI: 10.1039\/D6JA90018F, Atomic Spectrometry UpdateE. Hywel Evans, Jorge Pisonero, Clare M. M. Smith, Rex N. TaylorThis review covers advances in atomic spectrometric techniques, including atomic emission, absorption, fluorescence and mass spectrometry. Material on speciation and coupled techniques is not covered as this is included in a separate ASU review.To cite this article before page [&hellip;]<\/div><\/li><li class='wp-block-rss__item'><div class='wp-block-rss__item-title'><a href='http:\/\/dlvr.it\/TS8gCl'>Structure-Function Analysis of the FCRL5-IgG1 Fc Complex Reveals an Unappreciated Effect of Fc-Silent Antibodies on B cells<\/a><\/div><time datetime=\"2026-04-21T20:03:34-05:00\" class=\"wp-block-rss__item-publish-date\">April 21, 2026<\/time> <div class=\"wp-block-rss__item-excerpt\">Human Fc receptor-like 5 (FCRL5) is a low-affinity IgG Fc receptor expressed on various B cell subsets and a potential therapeutic target. We discovered that commonly used Fc-silencing mutations, designed to prevent interactions between the Fc{gamma} receptors on immune cells and the Fc domain of therapeutic IgG, do not prevent binding to FCRL5. As a result, unintended interactions between Fc-silent [&hellip;]<\/div><\/li><li class='wp-block-rss__item'><div class='wp-block-rss__item-title'><a href='http:\/\/dlvr.it\/TS8ckH'>Multidimensional and Hybrid Separation Strategies for Body Fluids and Tissues: Comparative Performance and Translational Considerations<\/a><\/div><time datetime=\"2026-04-21T18:57:16-05:00\" class=\"wp-block-rss__item-publish-date\">April 21, 2026<\/time> <div class=\"wp-block-rss__item-excerpt\">ABSTRACT Analytical technologies for body fluids and tissues have advanced substantially over the past decade, particularly in chromatographic, electrophoretic and ion-mobility\u2013based separation strategies designed to address matrix complexity and structural isomerism. Improvements in stationary-phase chemistry, multidimensional liquid chromatography, capillary electrophoresis and mobility-integrated mass spectrometry have enhanced peak capacity, structural discrimination, remains the selection and validation of separation strategies capable of [&hellip;]<\/div><\/li><li class='wp-block-rss__item'><div class='wp-block-rss__item-title'><a href='http:\/\/dlvr.it\/TS8ZNT'>Analysis of Major Impurities in Tolterodine Tartrate Tablets by 2D\u2010UPLC\u2010Q\u2010TOF\/MS<\/a><\/div><time datetime=\"2026-04-21T18:00:35-05:00\" class=\"wp-block-rss__item-publish-date\">April 21, 2026<\/time> <div class=\"wp-block-rss__item-excerpt\">ABSTRACT Rationale Impurity profiling is critical for the quality control and safety assessment of pharmaceutical formulations. Tolterodine tartrate tablets contain unknown impurities that are not documented in standard literature or pharmacopoeias. Identifying these impurities and determining their origin is essential for optimizing the manufacturing process and ensuring product stability. Methods A comprehensive two-dimensional liquid chromatography-mass spectrometry (2D-LC\/MS) method was developed. [&hellip;]<\/div><\/li><li class='wp-block-rss__item'><div class='wp-block-rss__item-title'><a href='http:\/\/dlvr.it\/TS8WdJ'>Chemical Profiling and Virtual Pharmacological Analysis of Asplenium ruprechtii Sa. Kurata<\/a><\/div><time datetime=\"2026-04-21T17:00:35-05:00\" class=\"wp-block-rss__item-publish-date\">April 21, 2026<\/time> <div class=\"wp-block-rss__item-excerpt\">ABSTRACT Rationale Asplenium ruprechtii Sa. Kurata (\u201cGuo shan jue\u201d), a traditional Chinese folk medicine, is widely used to treat thromboangiitis obliterans, hemiplegia, traumatic bleeding, neurodermatitis, and lower limb ulcers. However, its chemical composition remains incompletely characterized\u2014previous studies have identified 80 major components, while trace-level constituents (critical for the \u201cmulticomponent, multitarget\u201d efficacy of traditional Chinese medicine) remain unexploited. Methods In this [&hellip;]<\/div><\/li><li class='wp-block-rss__item'><div class='wp-block-rss__item-title'><a href='http:\/\/dlvr.it\/TS8SpL'>Seeding patient-derived tau induces tauopathy-specific aggregation and lysosomal disruption in human cells<\/a><\/div><time datetime=\"2026-04-21T16:00:35-05:00\" class=\"wp-block-rss__item-publish-date\">April 21, 2026<\/time> <div class=\"wp-block-rss__item-excerpt\">Background: Tau aggregation is the defining feature of tauopathies, however, the mechanisms by which distinct tau strains drive disease-specific responses remain unclear. Existing models largely rely on recombinant tau seeding or tau overexpression, which fail to capture the biochemical diversity of pathological tau. The aim of this study was to develop a robust and reproducible human cell-based model of disease-specific [&hellip;]<\/div><\/li><li class='wp-block-rss__item'><div class='wp-block-rss__item-title'><a href='http:\/\/dlvr.it\/TS8QCJ'>Evaluation and clinical application of an accurate isotope dilution liquid chromatography-tandem mass spectrometry method for serum glycocholic acid<\/a><\/div><time datetime=\"2026-04-21T15:09:10-05:00\" class=\"wp-block-rss__item-publish-date\">April 21, 2026<\/time> <div class=\"wp-block-rss__item-excerpt\">Publication date: Available online 20 April 2026Source: Clinica Chimica ActaAuthor(s): Zhonggan Jin, Yuanzhu Ou, Ming Zong, Zhihan Ye, Zhizheng Li, Sujie Zhang, Hewei Sun, Xiaoyu Fan, Xialin Luo, Lingli Jiang, Yi Ju<\/div><\/li><li class='wp-block-rss__item'><div class='wp-block-rss__item-title'><a href='http:\/\/dlvr.it\/TS8LRs'>Letter to the editor regarding: \u201cHeat-resistant cryoglobulin investigated through dynamic cryoaggregation assay and mass spectrometry\u201d. Clinica Chimica acta 586(2026) 120935<\/a><\/div><time datetime=\"2026-04-21T14:00:34-05:00\" class=\"wp-block-rss__item-publish-date\">April 21, 2026<\/time> <div class=\"wp-block-rss__item-excerpt\">Publication date: Available online 19 April 2026Source: Clinica Chimica ActaAuthor(s): Lei Wang, Xingli Xu, Hongchen Zhou, Feng Zhang, Huahui Li<\/div><\/li><li class='wp-block-rss__item'><div class='wp-block-rss__item-title'><a href='http:\/\/dlvr.it\/TS8HM0'>&lt;em&gt;In Vivo&lt;\/em&gt; Release of Titanium-Containing Nanoparticles from 3D-Printed Hydroxyapatite-Coated Implants Using Single-Particle Inductively Coupled Plasma Mass Spectrometry<\/a><\/div><time datetime=\"2026-04-21T13:00:34-05:00\" class=\"wp-block-rss__item-publish-date\">April 21, 2026<\/time> <div class=\"wp-block-rss__item-excerpt\">Publication date: Available online 20 April 2026Source: TalantaAuthor(s): Qianlin Wang, Danmei Zhao, Guohui Xing, Conghui Sun, Yifan Cai, Nian Liu, Linnan Ke, Lihong Liu, Bin He, Ligang Hu<\/div><\/li><li class='wp-block-rss__item'><div class='wp-block-rss__item-title'><a href='http:\/\/dlvr.it\/TS8Dxn'>Bypassing Hydrogenation Pathway for Sustainable Nitrate Water Remediation via Direct N\u2500N Coupling<\/a><\/div><time datetime=\"2026-04-21T12:07:10-05:00\" class=\"wp-block-rss__item-publish-date\">April 21, 2026<\/time> <div class=\"wp-block-rss__item-excerpt\">An alternative to the conventional hydrogenation pathway for NO3 \u2212 remediation is established via HCOOH-driven proton-coupled electron transfer on a bimetallic Sn3\/Pd catalyst. The triangular Sn3 ensembles thermodynamically favor direct N\u2500N coupling while kinetically suppressing N\u2500H formation, achieving 97.4% N2 selectivity. This design bypasses the conventional hydrogenation route, overcoming the longstanding NH3 byproduct challenge. ABSTRACT Catalytic nitrate (NO3 \u2212) reduction [&hellip;]<\/div><\/li><li class='wp-block-rss__item'><div class='wp-block-rss__item-title'><a href='http:\/\/dlvr.it\/TS8B6m'>Mass spectrometry-based single-cell metabolomics and metabolic tracing analysis<\/a><\/div><time datetime=\"2026-04-21T11:07:35-05:00\" class=\"wp-block-rss__item-publish-date\">April 21, 2026<\/time> <div class=\"wp-block-rss__item-excerpt\">Publication date: July 2026Source: TrAC Trends in Analytical Chemistry, Volume 200Author(s): Xinying Zhu, Jia Yi, Liang Qiao<\/div><\/li><li class='wp-block-rss__item'><div class='wp-block-rss__item-title'><a href='http:\/\/dlvr.it\/TS87TJ'>SugarBase: mapping glycomolecule precursors in microbes<\/a><\/div><time datetime=\"2026-04-21T10:12:35-05:00\" class=\"wp-block-rss__item-publish-date\">April 21, 2026<\/time> <div class=\"wp-block-rss__item-excerpt\">Glycan biosynthesis relies on nucleotide-activated sugars, essential metabolites across all domains of life, yet their usage in microbes is poorly understood. Here we present SugarBase, a mass spectrometry and bioinformatic pipeline for untargeted exploration of microbial nucleotide sugar networks. SugarBase resolves the chemical complexity of microbial metabolism by combining narrow-window DIA fragmentation with a chemistry-informed parent ion identification algorithm. Applying [&hellip;]<\/div><\/li><li class='wp-block-rss__item'><div class='wp-block-rss__item-title'><a href='http:\/\/dlvr.it\/TS84W2'>diagFDR: Verifiable False Discovery Rate Reporting in Proteomics via Scope, Calibration, and Stability Diagnostics<\/a><\/div><time datetime=\"2026-04-21T09:09:18-05:00\" class=\"wp-block-rss__item-publish-date\">April 21, 2026<\/time> <div class=\"wp-block-rss__item-excerpt\">In mass spectrometry-based proteomics, false discovery rate (FDR) control underpins the credibility of peptide and protein identifications. In contemporary workflows, including multi-run Data Independent Acquisition (DIA), deep learning-assisted scoring, library-free searches, and extensive post-processing, the statement &quot;1% FDR&quot; has become increasingly ambiguous, potentially referring to different statistical entities, multiple-testing scopes, and null models. We propose a standardized framework requiring explicit [&hellip;]<\/div><\/li><li class='wp-block-rss__item'><div class='wp-block-rss__item-title'><a href='http:\/\/dlvr.it\/TS828d'>Selective Hydrolytic Defluorination of Branched Perfluorooctanoic Acid Isomers by a Haloacid Dehalogenase<\/a><\/div><time datetime=\"2026-04-21T08:12:14-05:00\" class=\"wp-block-rss__item-publish-date\">April 21, 2026<\/time> <div class=\"wp-block-rss__item-excerpt\">Per- and polyfluoroalkyl substances (PFAS) are highly resistant to enzymatic C-F bond cleavage, and hydrolytic defluorination of long-chain PFAS has rarely been demonstrated. Here, we report selective hydrolytic defluorination of branched perfluorooctanoic acid (PFOA) isomers by a haloacid dehalogenase (4A) from Delftia acidovorans strain D4B. A fluoride-specific riboswitch biosensor was used for initial substrate screening, followed by scaled-up assays in [&hellip;]<\/div><\/li><li class='wp-block-rss__item'><div class='wp-block-rss__item-title'><a href='http:\/\/dlvr.it\/TS7zgp'>The inner nuclear membrane protein SUN1 regulates cullin-3 neddylation to maintain insulin signaling<\/a><\/div><time datetime=\"2026-04-21T07:09:16-05:00\" class=\"wp-block-rss__item-publish-date\">April 21, 2026<\/time> <div class=\"wp-block-rss__item-excerpt\">Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most prevalent chronic liver disease and strongly linked to obesity and insulin resistance. We previously reported that the common nuclear envelope variant rs6461378 (g.842031C&gt;T; SUN1 H118Y) associated with MASLD and related traits including insulin resistance. To gain insight into how wildtype (WT) and H118Y SUN1 might differentially impact insulin signaling, we performed [&hellip;]<\/div><\/li><\/ul><\/div><\/div>\n<\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":1759,"parent":2597,"menu_order":-1,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-2028","page","type-page","status-publish","has-post-thumbnail","hentry","entry"],"_links":{"self":[{"href":"https:\/\/kermitmurray.com\/msblog\/wp-json\/wp\/v2\/pages\/2028","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kermitmurray.com\/msblog\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/kermitmurray.com\/msblog\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/kermitmurray.com\/msblog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kermitmurray.com\/msblog\/wp-json\/wp\/v2\/comments?post=2028"}],"version-history":[{"count":10,"href":"https:\/\/kermitmurray.com\/msblog\/wp-json\/wp\/v2\/pages\/2028\/revisions"}],"predecessor-version":[{"id":2589,"href":"https:\/\/kermitmurray.com\/msblog\/wp-json\/wp\/v2\/pages\/2028\/revisions\/2589"}],"up":[{"embeddable":true,"href":"https:\/\/kermitmurray.com\/msblog\/wp-json\/wp\/v2\/pages\/2597"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/kermitmurray.com\/msblog\/wp-json\/wp\/v2\/media\/1759"}],"wp:attachment":[{"href":"https:\/\/kermitmurray.com\/msblog\/wp-json\/wp\/v2\/media?parent=2028"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}