{"id":1467,"date":"2017-07-21T11:31:25","date_gmt":"2017-07-21T16:31:25","guid":{"rendered":"http:\/\/mass-spec.lsu.edu\/blog\/?page_id=1467"},"modified":"2017-08-02T20:28:08","modified_gmt":"2017-08-03T01:28:08","slug":"cell","status":"publish","type":"page","link":"https:\/\/kermitmurray.com\/msblog\/links\/journal-feeds\/biochemistry-journal-feeds\/cell\/","title":{"rendered":"Cell"},"content":{"rendered":"<p><a href=\"http:\/\/www.cell.com\/cell\/home\" target=\"_blank\">Home<\/a><\/p>\n<ul class=\"su-feed\"><li><a href=\"https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(26)00698-7?rss=yes\" target=\"_self\" title=\"In this issue of Cell, Guo et al. report the development of a new exon-skipping, RNA-editing-based therapy for Duchenne muscular dystrophy. The dual mechanism of action through both ADAR-dependent and -independent pathways has the potential to be more effective and require a lower dosing frequency than currently available ASO-based exon-skipping treatments.\">Rewriting Duchenne muscular dystrophy therapy<\/a><\/li><li><a href=\"https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(26)00655-0?rss=yes\" target=\"_self\" title=\"Alzheimer\u2019s disease is driven by pathological brain changes that progressively impair memory and cognition, with current treatment options being limited. Advances in early, biomarker-based diagnosis and amyloid-targeting and other disease-modifying approaches are beginning to slow disease progression in clinical studies.\">Recent advances in Alzheimer\u2019s disease: From molecular mechanisms to therapeutic strategies<\/a><\/li><li><a href=\"https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(26)00705-1?rss=yes\" target=\"_self\" title=\"Human aging is a heterogeneous, multi-system process that spans molecular, tissue, and physiological decline. In this issue of Cell, Li et al. integrate clinical data, multi-omics, and organ-associated signatures to construct a multi-layer framework for quantifying biological aging across scales.\">Bridging omics and physiology to build multimodal clocks of human aging<\/a><\/li><li><a href=\"https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(26)00518-0?rss=yes\" target=\"_self\" title=\"Mammalian eyes receive constant visible light yet lack photosynthesis. Xing et al. engineer an intact thylakoid grana nanoparticle enabling light-driven NADPH production within corneal cells, restoring antioxidant defenses and interrupting inflammatory cycles in dry eye disease. This work positions borrowed photosynthesis as a therapeutic strategy for oxidative, light-exposed tissue pathologies.\">Photosynthetic medicine: Engineering a plant-derived nanofoundry to power mammalian cells<\/a><\/li><li><a href=\"https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(26)00709-9?rss=yes\" target=\"_self\" title=\"In settings of persistent antigen, such as autoimmunity and chronic infection, stem-like CD8 T cells sustain antigen-specific immune responses. Here, LEF1 and niche-derived factors are identified as essential regulators of T cell stemness across chronic diseases.\">LEF1 and niche factors determine T cell stemness across chronic diseases<\/a><\/li><li><a href=\"https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(26)00707-5?rss=yes\" target=\"_self\" title=\"(Cell 189, 3465\u20133480.e1\u2013e23; May 28, 2026)\">Electromagnetic field-inducible in vivo gene switch for remote spatiotemporal control of gene expression<\/a><\/li><li><a href=\"https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(26)00706-3?rss=yes\" target=\"_self\" title=\"(Cell 187, 7470\u20137491.e1\u2013e20; December 26, 2024)\">Multimodal targeting chimeras enable integrated immunotherapy leveraging tumor-immune microenvironment<\/a><\/li><li><a href=\"https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(26)00644-6?rss=yes\" target=\"_self\" title=\"The morphological homogeneity of the middle Pleistocene hominin Homo naledi is reflected in its dental proteome, with no evidence supporting confident identification of male individuals, and the detection of both derived and ancestral amino acid substitutions in Homo naledi.\">Proteomic analysis of dental enamel from 20 Homo naledi individuals shows no male markers<\/a><\/li><li><a href=\"https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(26)00591-X?rss=yes\" target=\"_self\" title=\"A CRISPR-Cas9-generated gene-modified mouse library provides a platform for systematic in vivo screening of influenza host factors, identifying 17 genes, including Arhgef28 and Lasp1, whose ablation protects mice from influenza A virus infection.\">A CRISPR knockout mouse library for functional genomics in influenza research<\/a><\/li><li><a href=\"https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(26)00590-8?rss=yes\" target=\"_self\" title=\"CANVAS is a computational platform that decodes spatial tumor ecosystems from routine H&amp;E histopathology to enable population-level prognostic modeling and immunotherapy response.\">Cellular architecture and neighborhood-informed virtual spatial tumor profiling from histopathology<\/a><\/li><li><a href=\"https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(26)00589-1?rss=yes\" target=\"_self\" title=\"Circular ADAR-recruiting RNAs enable programmable exon skipping to bypass out-of-frame mutations in Duchenne muscular dystrophy and restore dystrophin expression. LEAPER 2.0 shows sustained efficacy in nonhuman primates and early clinical promise in patients, supporting circ-arRNA-mediated RNA editing as a translatable therapeutic strategy.\">Long-term reversal of Duchenne muscular dystrophy via circular arRNA-guided exon skipping in monkeys and humans<\/a><\/li><li><a href=\"https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(26)00514-3?rss=yes\" target=\"_self\" title=\"LEAPER 3.0, a structurally optimized dual-bulge ADAR-recruiting RNA design platform, achieves precise and efficient endogenous A-to-I RNA editing across diverse ADAR contexts.\">RNA structure programs endogenous ADAR for precise and efficient editing<\/a><\/li><li><a href=\"https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(26)00581-7?rss=yes\" target=\"_self\" title=\"Senescent cell states arise across brain-barrier cell types during development but diverge in duration and function. Endothelial cells and macrophages enter a transient, inflammatory state, whereas choroid plexus epithelial cells maintain a persistent, non-inflammatory state supporting long-term barrier function. These cells are required for brain-barrier formation and function.\">Persistent and transient senescent cells contribute to brain-barrier development<\/a><\/li><li><a href=\"https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(26)00524-6?rss=yes\" target=\"_self\" title=\"Paleogenomic analysis of cave lions spanning &gt;100 kya shows that extinct cave lions formed a long-diverged evolutionary lineage from modern lions, with distinct demographic histories and lineage-specific functional variation. Evidence of Late Pleistocene gene flow between cave and modern lions provides insight into the ecology and extinction dynamics of one of the Northern Hemisphere\u2019s most influential megafaunal predators.\">Paleogenomes reveal the evolutionary relationship between modern and cave lions<\/a><\/li><li><a href=\"https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(26)00567-2?rss=yes\" target=\"_self\" title=\"Ruptoblasts are a cytotoxic glandular cell type that undergoes explosive cell death, ruptosis, releasing potent, broad-spectrum agents capable of killing nearby cells. Ruptosis is triggered by the hormone and cytokine activin and driven by ER-derived calcium release amplified by the actomyosin cytoskeleton.\">Explosive cytotoxicity of ruptoblasts bridges hormone surveillance and immune defense<\/a><\/li><li><a href=\"https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(26)00523-4?rss=yes\" target=\"_self\" title=\"Cryo-EM structures of Wnt3a\/Fzd8-CRD\/LRP6-E3E4 reveal assembly and activation mechanisms of the Wnt signalosome extracellular complex.\">Structural basis of Wnt signalosome extracellular complex assembly<\/a><\/li><li><a href=\"https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(26)00519-2?rss=yes\" target=\"_self\" title=\"Through farnesylation-driven phase separation, KRAS forms cytoplasmic condensates that facilitate its processing and signaling, driving tumor growth and impacting G12C inhibition efficacy.\">Farnesylation-driven KRAS phase separation promotes colon tumor growth<\/a><\/li><li><a href=\"https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(26)00512-X?rss=yes\" target=\"_self\" title=\"Li et al. identified SCARF2 as an intracellular receptor for HBV entry that directs internalized HBV to nuclear pore complexes and facilitates nucleocapsid release from endosomes.\">Scavenger receptor class F member 2 is an intracellular receptor for hepatitis B virus<\/a><\/li><li><a href=\"https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(26)00505-2?rss=yes\" target=\"_self\" title=\"Nociceptive sensory neurons are engaged during lung adenocarcinoma tumorigenesis, suppressing tertiary lymphoid structure formation and blunting anti-tumor immunity. This study reveals CGRP signaling as a druggable, smoking-linked vulnerability for enhancing immunotherapy response in lung cancer preclinical models.\">Nociceptive innervation limits tertiary lymphoid structures to promote lung cancer<\/a><\/li><li><a href=\"https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(26)00469-1?rss=yes\" target=\"_self\" title=\"Therapeutic delivery of LEAF, a chloroplast-derived nanoscale thylakoid supercomplex system, enables mammalian corneal cells to generate photosynthetic NADPH and ATP that suppress oxidative stress and inflammation. LEAF functions intracellularly and extracellularly to restore redox balance, establishing a light-driven therapeutic strategy with a cross-kingdom, prolonged endosymbiosis-like interaction.\">Transplanting light-dependent reactions for mammalian eye photosynthesis<\/a><\/li><\/ul>\n<p><a href=\"http:\/\/www.cell.com\/cell\/current.rss\" target=\"_blank\">More<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Home More<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":1524,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-1467","page","type-page","status-publish","hentry","entry"],"_links":{"self":[{"href":"https:\/\/kermitmurray.com\/msblog\/wp-json\/wp\/v2\/pages\/1467","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kermitmurray.com\/msblog\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/kermitmurray.com\/msblog\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/kermitmurray.com\/msblog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kermitmurray.com\/msblog\/wp-json\/wp\/v2\/comments?post=1467"}],"version-history":[{"count":2,"href":"https:\/\/kermitmurray.com\/msblog\/wp-json\/wp\/v2\/pages\/1467\/revisions"}],"predecessor-version":[{"id":1587,"href":"https:\/\/kermitmurray.com\/msblog\/wp-json\/wp\/v2\/pages\/1467\/revisions\/1587"}],"up":[{"embeddable":true,"href":"https:\/\/kermitmurray.com\/msblog\/wp-json\/wp\/v2\/pages\/1524"}],"wp:attachment":[{"href":"https:\/\/kermitmurray.com\/msblog\/wp-json\/wp\/v2\/media?parent=1467"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}