{"id":1467,"date":"2017-07-21T11:31:25","date_gmt":"2017-07-21T16:31:25","guid":{"rendered":"http:\/\/mass-spec.lsu.edu\/blog\/?page_id=1467"},"modified":"2017-08-02T20:28:08","modified_gmt":"2017-08-03T01:28:08","slug":"cell","status":"publish","type":"page","link":"https:\/\/kermitmurray.com\/msblog\/links\/journal-feeds\/biochemistry-journal-feeds\/cell\/","title":{"rendered":"Cell"},"content":{"rendered":"<p><a href=\"http:\/\/www.cell.com\/cell\/home\" target=\"_blank\">Home<\/a><\/p>\n<ul class=\"su-feed\"><li><a href=\"https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(26)00509-X?rss=yes\" target=\"_self\" title=\"Passive transfer of IgG from long COVID patients induces pain behavior accompanied by intraepidermal nerve fiber damage in mice.\">A causal link between autoantibodies and neurological symptoms in long COVID<\/a><\/li><li><a href=\"https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(26)00455-1?rss=yes\" target=\"_self\" title=\"Aging is marked by a systemic loss of tissue homeostasis. This review focuses on mesenchymal drift, where cells progressively lose lineage identity and acquire mesenchymal traits, as a convergent framework that integrates and fuels the hallmarks of aging, forming a potentially targetable molecular network to restore identity and counter multiple age-related pathologies.\">Mesenchymal drift: A convergent framework for the hallmarks of aging<\/a><\/li><li><a href=\"https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(26)00511-8?rss=yes\" target=\"_self\" title=\"Long COVID is a heterogeneous, multi-system disease that poses challenges for patients, health systems, and economies. Two papers in Cell and Cell Reports Medicine from independent groups suggest that autoantibodies in a subset of long COVID patients can directly drive symptoms such as pain, fatigue, or neurocognitive problems.\">Autoantibodies in long COVID: A mechanistic foothold in a heterogeneous disease<\/a><\/li><li><a href=\"https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(26)00513-1?rss=yes\" target=\"_self\" title=\"In this issue of Cell, Mao et al. reveal that B cells play an unexpected, immune-independent role in exercise physiology by facilitating multi-organ communication. Secreting TGF-\u03b21, they transcriptionally reprogram hepatic glutamine metabolism via GLS2 and SLC7A5, preserving skeletal muscle glutamate levels, which sustain mitochondrial function, Ca2\u207a signaling, and ATP production, enhancing exercise capacity.\">B cells just got a workout<\/a><\/li><li><a href=\"https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(26)00510-6?rss=yes\" target=\"_self\" title=\"Two studies in this issue of Cell, by Bintu et al. and Brann et al., overturn the long-standing zonal model of olfactory receptor organization. Using image-based spatial transcriptomics, they reveal that receptors occupy reproducible positions along continuous gradients, coupling receptor choice to axonal targeting through a shared molecular code.\">Spatial transcriptomics redraws the olfactory map<\/a><\/li><li><a href=\"https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(26)00521-0?rss=yes\" target=\"_self\" title=\"(Cell 189, 2821\u20132833.e1\u2013e9; May 14, 2026)\">Transplantation of encapsulated mitochondria alleviates dysfunction in mitochondrial and Parkinson\u2019s disease models<\/a><\/li><li><a href=\"https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(26)00462-9?rss=yes\" target=\"_self\" title=\"Drought drives Streptomyces enrichment in roots, not by a plant \u201ccry for help\u201d but via the triggering of host immunity suppression and iron uptake, where intra-genus interactions dictate strain-level outcomes, including growth benefits.\">Streptomyces enrichment in roots during drought is uncoupled from plant benefit and is driven by host suppression of iron uptake and immunity<\/a><\/li><li><a href=\"https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(26)00385-5?rss=yes\" target=\"_self\" title=\"A large-scale multi-cohort proteogenomic study identifies genetic loci influencing circulating protein levels, revealing pathways and cell types that regulate the circulating proteome and highlighting disease insights and evidence for potential therapeutic opportunities.\">Multi-cohort proteogenomic analyses reveal genetic effects across the proteome and diseasome<\/a><\/li><li><a href=\"https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(26)00438-1?rss=yes\" target=\"_self\" title=\"By integrating functional and structural approaches with AI-based analysis of autoantibodies against type-I IFNs, these neutralizing autoantibodies\u2014linked to severe viral diseases in humans\u2014are shown to arise from pre-existing autoimmunity driven by prolonged germinal center affinity maturation.\">Affinity-matured B cell responses neutralizing type-I interferons underlie severe viral infections<\/a><\/li><li><a href=\"https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(26)00399-5?rss=yes\" target=\"_self\" title=\"Ma et al. developed long-term single-particle tracking of ErbB family receptors in living cells using upconverting nanoparticles. They discovered constitutive HER2 and HER3 homodimerization and showed how oncogenic mutations and ligand stimulation affect dimerization dynamics, offering new insights into the mechanisms of oncogenic signaling and the ErbB receptor interaction network.\">ErbB family receptor dimerization dynamics and dysregulation via long-term single-molecule imaging<\/a><\/li><li><a href=\"https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(26)00389-2?rss=yes\" target=\"_self\" title=\"Comprehensive atlases of olfactory sensory neuron distribution and axonal projection reveal a precise topographical organization and define spatial domains activated by social odors.\">Spatial organization and detection of social odors in mouse primary olfactory system<\/a><\/li><li><a href=\"https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(26)00387-9?rss=yes\" target=\"_self\" title=\"Dorsoventral epithelial position induces graded expression of a transcriptional program that maps each of the 1,100 olfactory sensory neuron subtypes to stereotyped spatial distributions in the epithelium, thereby building a precise receptor map in the nose that aligns with the glomerular map in the olfactory bulb.\">A spatial code governs olfactory receptor choice and aligns sensory maps in the nose and brain<\/a><\/li><li><a href=\"https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(26)00398-3?rss=yes\" target=\"_self\" title=\"An unbiased niche-labeling method, SAMENT, maps cellular and molecular features of metastatic niches and highlights the role of ER\u03b1\u207a niche macrophages in preventing T cell infiltration, thereby promoting bone metastasis.\">Unbiased niche labeling maps immune-excluded niche in bone metastasis<\/a><\/li><li><a href=\"https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(26)00386-7?rss=yes\" target=\"_self\" title=\"During myogenesis, inner nuclear membrane buds export extremely long sarcomeric transcripts. UIF controls RNA cargo targeting into these buds, and ESCRT-III remodeling is required to internalize UIF and its cargo, revealing a non-canonical pathway for exporting large transcripts.\">Nuclear envelope budding enables export of large transcripts in muscle cells<\/a><\/li><li><a href=\"https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(26)00337-5?rss=yes\" target=\"_self\" title=\"Translation profiling reveals how microbes allocate cellular resources in complex communities. The microbial interaction and niche determination (MIND) framework links functional prioritization to competition and substrate preferences, enabling the rational design of targeted prebiotic and probiotic interventions to selectively manipulate microbiomes across environmental and host-associated systems.\">Predicting competition and substrate preferences for targeted microbiome alteration<\/a><\/li><li><a href=\"https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(26)00340-5?rss=yes\" target=\"_self\" title=\"B cells regulate exercise capacity through immune-independent liver-muscle metabolic signaling, and B cell deficiency limits muscle performance. Mechanistically, B cell-secreted TGF-\u03b21 increases hepatic glutamine-to-glutamate conversion, raising glutamate in blood and muscle. This promotes muscle calcium signaling and mitochondrial function, positively regulating exercise capacity.\">B cell deficiency limits exercise capacity by remodeling liver glutamate metabolism<\/a><\/li><li><a href=\"https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(26)00330-2?rss=yes\" target=\"_self\" title=\"The EMF-inducible gene switch (Ei) platform provides precise spatiotemporal control of gene expression through Cyb5b-mediated calcium oscillations. This system enables Ei-OSK-driven in vivo rejuvenation reprogramming, Ei-mutant APP expression in the context of Alzheimer\u2019s disease, and behavioral rescue in depression through Ei-Tph2-mediated neuromodulation.\">Electromagnetic field-inducible in vivo gene switch for remote spatiotemporal control of gene expression<\/a><\/li><li><a href=\"https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(26)00287-4?rss=yes\" target=\"_self\" title=\"Rational design of cannabinoid receptor agonists that uncouple therapeutic analgesia from unwanted on-target effects, establishing a blueprint for next-generation non-opioid therapeutics.\">Rational design of Gi-biased CB1 agonist with reduced side effects<\/a><\/li><li><a href=\"https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(26)00275-8?rss=yes\" target=\"_self\" title=\"Kinase activators are difficult to develop despite their therapeutic promise. Here, we report the discovery of small-molecule p21-activated kinase 1 (PAK1) allosteric activators using a rational, peptide-guided strategy targeting the autoinhibitory mechanism. These compounds exhibit therapeutic efficacy in hypertrophic cardiomyopathy, underscoring the potential of this strategy for therapeutic kinase activator discovery.\">Rational discovery of therapeutic PAK1 allosteric activators<\/a><\/li><li><a href=\"https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(26)00273-4?rss=yes\" target=\"_self\" title=\"A scalable experimental and computational platform for mapping all organs and cell types in the mouse body, enabling comprehensive analysis of tissue organization and disease responses.\">Whole-body molecular and cellular mapping of the laboratory mouse<\/a><\/li><\/ul>\n<p><a href=\"http:\/\/www.cell.com\/cell\/current.rss\" target=\"_blank\">More<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Home More<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":1524,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-1467","page","type-page","status-publish","hentry","entry"],"_links":{"self":[{"href":"https:\/\/kermitmurray.com\/msblog\/wp-json\/wp\/v2\/pages\/1467","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kermitmurray.com\/msblog\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/kermitmurray.com\/msblog\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/kermitmurray.com\/msblog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kermitmurray.com\/msblog\/wp-json\/wp\/v2\/comments?post=1467"}],"version-history":[{"count":2,"href":"https:\/\/kermitmurray.com\/msblog\/wp-json\/wp\/v2\/pages\/1467\/revisions"}],"predecessor-version":[{"id":1587,"href":"https:\/\/kermitmurray.com\/msblog\/wp-json\/wp\/v2\/pages\/1467\/revisions\/1587"}],"up":[{"embeddable":true,"href":"https:\/\/kermitmurray.com\/msblog\/wp-json\/wp\/v2\/pages\/1524"}],"wp:attachment":[{"href":"https:\/\/kermitmurray.com\/msblog\/wp-json\/wp\/v2\/media?parent=1467"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}