{"id":1467,"date":"2017-07-21T11:31:25","date_gmt":"2017-07-21T16:31:25","guid":{"rendered":"http:\/\/mass-spec.lsu.edu\/blog\/?page_id=1467"},"modified":"2017-08-02T20:28:08","modified_gmt":"2017-08-03T01:28:08","slug":"cell","status":"publish","type":"page","link":"https:\/\/kermitmurray.com\/msblog\/links\/journal-feeds\/biochemistry-journal-feeds\/cell\/","title":{"rendered":"Cell"},"content":{"rendered":"<p><a href=\"http:\/\/www.cell.com\/cell\/home\" target=\"_blank\">Home<\/a><\/p>\n<ul class=\"su-feed\"><li><a href=\"https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(26)00520-9?rss=yes\" target=\"_self\" title=\"Transposable elements, far from being genomic clutter, have emerged as dynamic genomic regulators that shape when, where, and how genes are turned on across development and disease.\">Transposable element DNA and RNA: Drivers of gene expression, evolution, and disease<\/a><\/li><li><a href=\"https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(26)00588-X?rss=yes\" target=\"_self\" title=\"RNA velocity can predict the direction of cell-state change, but the regulatory programs shaping these changes remain difficult to identify. In this issue of Cell, Wang et al. introduce RegVelo, a framework that integrates gene regulatory networks into RNA velocity analysis to nominate candidate regulators that may bias cell fate.\">Connecting transcriptional control to RNA velocity and cell fate<\/a><\/li><li><a href=\"https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(26)00574-X?rss=yes\" target=\"_self\" title=\"In this issue of Cell, Chen et al. analyze angiosperm genomes to map whole-genome duplication events, revealing non-random waves of polyploidy linked to climatic shifts and periods of low diversity. They suggest polyploids may have preferentially established during periods of environmental stress, shaping plant evolutionary history across multiple global events.\">Catching waves of polyploids<\/a><\/li><li><a href=\"https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(26)00570-2?rss=yes\" target=\"_self\" title=\"T cells live or die by their metabolism, yet one nutrient can serve very different ends. In this issue of Cell, Kelly et al. show that cysteine\u2019s sulfur is partitioned between glutathione and iron-sulfur cluster synthesis. This routing drives CD8+ T cell proliferation, effector function, and anti-tumor immunity.\">Cysteine\u2019s metabolic fork: Sulfur partitioning shapes T cell function<\/a><\/li><li><a href=\"https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(26)00587-8?rss=yes\" target=\"_self\" title=\"Cellular senescence comprises diverse cell states emerging across human tissues during aging and disease. Integrating single-cell and spatial multi-omics with AI-driven analyses enables systematic mapping of senescent cell heterogeneity (\u201csenotypes\u201d), revealing tissue-specific programs and microenvironmental interactions. These advances provide frameworks for biomarker discovery and development of targeted senotherapeutic strategies.\">Charting human cellular senescence in aging and disease<\/a><\/li><li><a href=\"https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(26)00573-8?rss=yes\" target=\"_self\" title=\"D&amp;D-seq, a single-cell immune-tethering strategy, captures weak and transient DNA-protein interactions to enable integrated, genome-wide analysis of transcription factor binding across chromatin states.\">Single-cell mapping of regulatory DNA-protein interactions<\/a><\/li><li><a href=\"https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(26)00580-5?rss=yes\" target=\"_self\" title=\"(Cell 189, 3071\u20133090.e1\u2013e27; May 14, 2026)\">Fronto-insular circuit mechanisms of accelerated intermittent theta burst stimulation<\/a><\/li><li><a href=\"https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(26)00457-5?rss=yes\" target=\"_self\" title=\"RegVelo introduces an end-to-end generative framework that jointly infers gene regulatory networks and developmental dynamics. It serves as an actionable in silico \u201ccell,\u201d enabling researchers to simulate regulatory perturbations and generate testable hypotheses about the mechanisms underlying cell fate decisions.\">RegVelo: Gene-regulatory-informed dynamics of single cells<\/a><\/li><li><a href=\"https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(26)00397-1?rss=yes\" target=\"_self\" title=\"From the dating of 132 ancient whole-genome duplication events across 470 angiosperms, paleopolyploidization events cluster around pivotal periods of environmental upheaval and extinction, notably the Middle Miocene Disruption, the Eocene-Oligocene Transition, the Paleocene-Eocene Thermal Maximum, the Cretaceous-Paleogene extinction, and different oceanic anoxic events.\">The rise of polyploids during environmental upheaval<\/a><\/li><li><a href=\"https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(26)00440-X?rss=yes\" target=\"_self\" title=\"A host-filtering and decontamination pipeline was benchmarked and applied to 16,369 tumor genomes, providing a high-resolution atlas of the cancer microbiome. Although most cancer types lacked a detectable microbiome, orodigestive cancers harbored complex multi-kingdom microbial communities that varied by site, subtype, and somatic mutation burden, linking the tumor microbiome to host phenotype and tumor genomic context.\">Biodiversity and biogeography of the multi-kingdom cancer microbiome<\/a><\/li><li><a href=\"https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(26)00383-1?rss=yes\" target=\"_self\" title=\"Donor-derived CD8\u207a CAR TSCM cells exhibit enhanced expansion and a favorable safety profile, inducing complete responses at low doses without lymphodepletion. Their distinctive in vivo behavior and differentiation trajectory establish TSCM cells as a robust and safe platform for next-generation CAR T cell therapy.\">Distinct in vivo dynamics of donor-derived stem cell memory CAR T cells post-allogeneic HSCT relapse<\/a><\/li><li><a href=\"https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(26)00393-4?rss=yes\" target=\"_self\" title=\"Ethylene receptors function as ER redox sensors. Redox-dependent disulfide bond dynamics modulate receptor stability and activity, thereby tuning ethylene signaling for environmental adaptation. ER redox sensing may represent an ancestral receptor function that predates substantial ethylene biosynthesis.\">Sensing endoplasmic reticulum redox state by ethylene receptors<\/a><\/li><li><a href=\"https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(26)00345-4?rss=yes\" target=\"_self\" title=\"CRISPR perturbation of \u223c4 million gene pairs in human HAP1 cells maps \u223c89,000 genetic interactions, revealing a hierarchical network that links genes to complexes, pathways, and cellular processes and elucidates the genes underlying cancer cell genetic dependencies.\">Global genetic interaction network of a human cell maps conserved principles and informs functional interpretation of gene co-essentiality profiles<\/a><\/li><li><a href=\"https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(26)00388-0?rss=yes\" target=\"_self\" title=\"MARCH7 prevents ferroptosis by regulating intracellular iron release and extracellular iron uptake. A small molecule stabilizer, EmodAn, offers robust cardioprotection, highlighting MARCH7 as a promising target for treating ferroptosis-related diseases.\">Stabilizing MARCH7 as a ferro-guardian against ferroptosis<\/a><\/li><li><a href=\"https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(26)00343-0?rss=yes\" target=\"_self\" title=\"Comparative Hi-C analysis across 1,025 species reveals that genome architecture has evolved along distinct trajectories, with plants favoring global folding and animals developing checkerboard compartmentalization, yet both converge on spatial organization as a conserved strategy for gene regulation.\">The evolution of high-order genome architecture revealed from 1,000 species<\/a><\/li><li><a href=\"https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(26)00341-7?rss=yes\" target=\"_self\" title=\"Cancer-associated somatic variants are enriched in the brain immune cells of Alzheimer\u2019s disease (AD) patients, driving them toward inflammation and proliferation, which may contribute to neuroinflammation and neurodegeneration during AD progression.\">Somatic cancer variants enriched in Alzheimer\u2019s disease microglia-like cells drive inflammatory and proliferative states<\/a><\/li><li><a href=\"https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(26)00346-6?rss=yes\" target=\"_self\" title=\"Heat stress activates a skin-hypothalamus axis via KLK14-dependent epigenetic reprogramming of LRRC7\u207a astrocytes, thereby exacerbating diet-induced metabolic dysfunction. Vitamin A reduces KLK14 levels and mitigates metabolic impairment in both mice and humans.\">A skin-hypothalamus axis couples heat stress and metabolic dysfunction<\/a><\/li><li><a href=\"https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(26)00382-X?rss=yes\" target=\"_self\" title=\"Genome-wide CRISPR activation and knockout screens in primary human CD4+ T cells systematically identify host proviral and antiviral factors modulating HIV infection, including the strongly antiviral factor PPID, which is shown to bind HIV capsid and reduce its nuclear import.\">Systematic discovery of pro- and anti-HIV host factors in primary human CD4+ T cells<\/a><\/li><li><a href=\"https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(26)00344-2?rss=yes\" target=\"_self\" title=\"An evolutionarily conserved CBASS transmembrane effector\u2014ancestral to the mammalian cGAS-STING pathway\u2014is activated by 2&#039;3&#039;-cGAMP to assemble into membrane-spanning filaments that disrupt membranes via a newly defined mechanism of vertical lipid shearing.\">2&#039;3&#039;-cGAMP-induced membrane shearing promotes broad antiphage immunity<\/a><\/li><li><a href=\"https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(26)00339-9?rss=yes\" target=\"_self\" title=\"In contrast to its barrier role in transcription factor-driven reprogramming, p53 is indispensable for efficient chemical reprogramming, where p53-competent cells preserve their genomic integrity to achieve pluripotency, whereas p53-deficient cells are selectively diminished.\">p53 safeguards chemical reprogramming of human somatic cells toward pluripotency<\/a><\/li><\/ul>\n<p><a href=\"http:\/\/www.cell.com\/cell\/current.rss\" target=\"_blank\">More<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Home More<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":1524,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-1467","page","type-page","status-publish","hentry","entry"],"_links":{"self":[{"href":"https:\/\/kermitmurray.com\/msblog\/wp-json\/wp\/v2\/pages\/1467","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kermitmurray.com\/msblog\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/kermitmurray.com\/msblog\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/kermitmurray.com\/msblog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kermitmurray.com\/msblog\/wp-json\/wp\/v2\/comments?post=1467"}],"version-history":[{"count":2,"href":"https:\/\/kermitmurray.com\/msblog\/wp-json\/wp\/v2\/pages\/1467\/revisions"}],"predecessor-version":[{"id":1587,"href":"https:\/\/kermitmurray.com\/msblog\/wp-json\/wp\/v2\/pages\/1467\/revisions\/1587"}],"up":[{"embeddable":true,"href":"https:\/\/kermitmurray.com\/msblog\/wp-json\/wp\/v2\/pages\/1524"}],"wp:attachment":[{"href":"https:\/\/kermitmurray.com\/msblog\/wp-json\/wp\/v2\/media?parent=1467"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}