{"id":1467,"date":"2017-07-21T11:31:25","date_gmt":"2017-07-21T16:31:25","guid":{"rendered":"http:\/\/mass-spec.lsu.edu\/blog\/?page_id=1467"},"modified":"2017-08-02T20:28:08","modified_gmt":"2017-08-03T01:28:08","slug":"cell","status":"publish","type":"page","link":"https:\/\/kermitmurray.com\/msblog\/links\/journal-feeds\/biochemistry-journal-feeds\/cell\/","title":{"rendered":"Cell"},"content":{"rendered":"<p><a href=\"http:\/\/www.cell.com\/cell\/home\" target=\"_blank\">Home<\/a><\/p>\n<ul class=\"su-feed\"><li><a href=\"https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(26)00113-3?rss=yes\" target=\"_self\" title=\"PLANeT is an international collaborative effort that aims to characterize the full spectrum of land plant genomic diversity.\">PLANeT: Understanding and leveraging the genome of land plants for a sustainable future<\/a><\/li><li><a href=\"https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(26)00390-9?rss=yes\" target=\"_self\" title=\"Hu et al. identify ROCK2 in liver sinusoidal endothelial cells as a key factor in liver fibrosis. Through single-cell analysis, knockout models, protein studies, and early clinical research, the authors show that ROCK2-driven endothelial cytoskeletal changes trigger angiocrine signals that activate hepatic stellate cells\u2014highlighting a potential therapeutic target.\">Angiocrine signaling drives liver fibrosis: From mechanism to early clinical translation<\/a><\/li><li><a href=\"https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(26)00395-8?rss=yes\" target=\"_self\" title=\"Uncovering ketamine\u2019s rapid antidepressant effects via somatostatin-expressing interneurons in the prefrontal cortex enables the identification of GPCR drug targets with antidepressant-like responses with fewer side effects.\">Mechanism-guided identification of antidepressant G protein-coupled receptor drug targets<\/a><\/li><li><a href=\"https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(26)00392-2?rss=yes\" target=\"_self\" title=\"(Cell 189, 2582\u20132597.e1\u2013e21; April 30, 2026)\">Bringing the genetically minimal cell to life on a computer in 4D<\/a><\/li><li><a href=\"https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(26)00391-0?rss=yes\" target=\"_self\" title=\"(Cell 182, 1156\u20131169.e1\u2013e7; September 3, 2020)\">Ubiquitin Ligase COP1 Suppresses Neuroinflammation by Degrading c\/EBP\u03b2 in Microglia<\/a><\/li><li><a href=\"https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(26)00335-1?rss=yes\" target=\"_self\" title=\"Glycosylation and deglycosylation complete nicotine biosynthesis by enabling stereoselective condensation of its two heterocyclic rings within a vacuolar membrane metabolon. This integrated biosynthetic and transport machinery is transferable to heterologous systems for efficient nicotine production and pest resistance.\">Complete biosynthesis of nicotine<\/a><\/li><li><a href=\"https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(26)00274-6?rss=yes\" target=\"_self\" title=\"The UCLA ATLAS biobank was utilized to integrate genetic data with electronic health records from individuals representing five continental and 36 fine-scale ancestries, identifying genotype-phenotype associations and highlighting populations at risk for disease. Computational predictors mitigated European bias in clinical variant curation predictors, uncovering ancestry-specific disease-gene links, and genetic factors influencing semaglutide-induced weight loss were identified. These findings demonstrate the value of well-curated, ancestrally diverse biobanks in advancing precision medicine.\">Advancing precision health discovery in a genetically diverse health system<\/a><\/li><li><a href=\"https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(26)00327-2?rss=yes\" target=\"_self\" title=\"(Cell 150, 764\u2013779; August 17, 2012)\">The BMP Inhibitor Coco Reactivates Breast Cancer Cells at Lung Metastatic Sites<\/a><\/li><li><a href=\"https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(26)00175-3?rss=yes\" target=\"_self\" title=\"A comparative analysis of cnidarian larval morphogenesis combined with active surface theory identifies a set of mesoscale mechanical modules that predict species-specific shapes. Manipulating these modules reprograms morphology, revealing how variation in tissue-scale mechanics underlies morphological diversity.\">Deciphering mechanical determinants of morphological evolution<\/a><\/li><li><a href=\"https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(26)00223-0?rss=yes\" target=\"_self\" title=\"Bulk and single-cell transcriptomics are widely used to characterize diseases and cellular states but remain underexplored for de novo drug discovery. Here, we present a strategy to screen and optimize compounds by matching disease transcriptomic profiles with compound-induced transcriptomic features predicted from chemical structures using a deep-learning model.\">Deep-learning-based de novo discovery and design of therapeutics that reverse disease-associated transcriptional phenotypes<\/a><\/li><li><a href=\"https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(26)00172-8?rss=yes\" target=\"_self\" title=\"The gut epithelium is regionally patterned to support digestive functions. In the colon, this regionalization, which is extrinsically dictated by microbiome-derived signals rather than through intrinsic stem cell programs, impacts tissue susceptibility to injury.\">Microbiome-produced nicotinic acid controls colon regional identity and injury susceptibility<\/a><\/li><li><a href=\"https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(26)00176-5?rss=yes\" target=\"_self\" title=\"Ancient DNA data from Palau reveal long-standing genetic continuity and show that the major admixture between Papuans and East Asians that occurs in many Remote Oceanians today was present among the ancestors of the first settlers more than 3,200 years ago.\">Papuan admixture predated the settlement of Palau<\/a><\/li><li><a href=\"https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(26)00161-3?rss=yes\" target=\"_self\" title=\"SelO, a conserved mitochondrial enzyme, hydrolyzes NAD+ in response to elevated matrix pH, directly regulating lipid metabolism and safeguarding mitochondrial homeostasis.\">NAD+ hydrolysis catalyzed by SelO is required for mitochondrial homeostasis<\/a><\/li><li><a href=\"https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(26)00174-1?rss=yes\" target=\"_self\" title=\"Simulating the complete cell cycle of the minimal cell provides a platform to understand the progression of complete states over time. The spatial heterogeneity of the intracellular environment can strongly affect biochemical reactions that control phenotypes.\">Bringing the genetically minimal cell to life on a computer in 4D<\/a><\/li><li><a href=\"https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(26)00166-2?rss=yes\" target=\"_self\" title=\"ROCK2 upregulation in endothelial and perivascular cells triggers fibrogenic vascular dysfunction in liver diseases. Targeting pro-fibrotic vascular ROCK2 by its selective inhibitor TDI01 exhibits anti-fibrotic potency in preclinical MASH models and clinical trials of human patients with liver fibrosis.\">Selective targeting of endothelial and perivascular angiocrine ROCK2 treats liver fibrosis<\/a><\/li><li><a href=\"https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(26)00171-6?rss=yes\" target=\"_self\" title=\"Phylogenetic-based selection analysis of viral evolution before and after spillover reveals that viral adaptation in the host reservoir is not a necessary precursor of novel zoonotic virus epidemics and pandemics, including SARS-CoV-2. In contrast, the 1977 reemergence of H1N1 influenza A virus was preceded by selection consistent with laboratory passage.\">Dynamics of natural selection preceding human viral epidemics and pandemics<\/a><\/li><li><a href=\"https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(26)00165-0?rss=yes\" target=\"_self\" title=\"McKellar et al. have discovered that some satellite viruses act as the ultimate hitchhikers. They physically become a virus inside a virus, hiding within helper virus particles by hitching a ride as a Trojan Horse and sneaking into new animal species and organs they could not reach alone, including the human brain.\">Deltaviruses spread through a viral Trojan Horse<\/a><\/li><li><a href=\"https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(26)00117-0?rss=yes\" target=\"_self\" title=\"The cryo-EM structures of Andes hantavirus (ANDV) glycoprotein tetramers, dimers of tetramers, and ADI-65534 Fab complexes on eVLPs unveil the molecular basis of New World hantavirus glycoprotein architecture, acid-induced membrane fusion, and antibody-mediated neutralization. Immunization with repRNA encoding ANDV-VLPs elicits high neutralizing-antibody titers.\">High-resolution in situ structures of hantavirus glycoprotein tetramers<\/a><\/li><li><a href=\"https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(26)00115-7?rss=yes\" target=\"_self\" title=\"Beyond its traditional role in supporting bioenergetic and biosynthetic demands, the canonical TCA cycle is also essential for nutrient clearance. When pyruvate oxidation and citrate production increase, aconitase 2 becomes essential to prevent mitochondrial citrate accumulation, which can trigger the integrated stress response and impair cell fitness.\">Citrate clearance is a major function of aconitase 2 in the canonical TCA cycle<\/a><\/li><li><a href=\"https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(26)00109-1?rss=yes\" target=\"_self\" title=\"A nutrigenomics framework identifies genetic diseases amenable to vitamin B2 and B3 therapies. This approach nominates vitamin B3 as a therapy for NAXD deficiency, a lethal neurodevelopmental disorder. In this Naxd KO mouse model, vitamin B3 rescues NAD(P)(H) metabolism, prevents brain pathology, and extends lifespan by more than 40-fold.\">Vitamin B2 and B3 nutrigenomics reveals a therapy for NAXD disease<\/a><\/li><\/ul>\n<p><a href=\"http:\/\/www.cell.com\/cell\/current.rss\" target=\"_blank\">More<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Home More<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":1524,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-1467","page","type-page","status-publish","hentry","entry"],"_links":{"self":[{"href":"https:\/\/kermitmurray.com\/msblog\/wp-json\/wp\/v2\/pages\/1467","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kermitmurray.com\/msblog\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/kermitmurray.com\/msblog\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/kermitmurray.com\/msblog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kermitmurray.com\/msblog\/wp-json\/wp\/v2\/comments?post=1467"}],"version-history":[{"count":2,"href":"https:\/\/kermitmurray.com\/msblog\/wp-json\/wp\/v2\/pages\/1467\/revisions"}],"predecessor-version":[{"id":1587,"href":"https:\/\/kermitmurray.com\/msblog\/wp-json\/wp\/v2\/pages\/1467\/revisions\/1587"}],"up":[{"embeddable":true,"href":"https:\/\/kermitmurray.com\/msblog\/wp-json\/wp\/v2\/pages\/1524"}],"wp:attachment":[{"href":"https:\/\/kermitmurray.com\/msblog\/wp-json\/wp\/v2\/media?parent=1467"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}